Detailed information for compound 1225033

Basic information

Technical information
  • TDR Targets ID: 1225033
  • Name: N-[(1-ethyl-5-methylpyrazol-4-yl)methyl]-3-[4 -furan-2-yl-6-(trifluoromethyl)pyrimidin-2-yl ]sulfanylpropanamide
  • MW: 439.455 | Formula: C19H20F3N5O2S
  • H donors: 1 H acceptors: 4 LogP: 2.48 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCn1ncc(c1C)CNC(=O)CCSc1nc(cc(n1)C(F)(F)F)c1ccco1
  • InChi: 1S/C19H20F3N5O2S/c1-3-27-12(2)13(11-24-27)10-23-17(28)6-8-30-18-25-14(15-5-4-7-29-15)9-16(26-18)19(20,21)22/h4-5,7,9,11H,3,6,8,10H2,1-2H3,(H,23,28)
  • InChiKey: BCBMNBLBBJRWRQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-[(1-ethyl-5-methyl-pyrazol-4-yl)methyl]-3-[4-(2-furyl)-6-(trifluoromethyl)pyrimidin-2-yl]sulfanyl-propanamide
  • N-[(1-ethyl-5-methyl-4-pyrazolyl)methyl]-3-[[4-(2-furyl)-6-(trifluoromethyl)-2-pyrimidinyl]thio]propanamide
  • N-[(1-ethyl-5-methyl-pyrazol-4-yl)methyl]-3-[[4-(2-furyl)-6-(trifluoromethyl)pyrimidin-2-yl]thio]propionamide
  • N-[(1-ethyl-5-methyl-pyrazol-4-yl)methyl]-3-[4-furan-2-yl-6-(trifluoromethyl)pyrimidin-2-yl]sulfanyl-propanamide
  • BAS 03609504
  • MLS000527092
  • N-(1-Ethyl-5-methyl-1H-pyrazol-4-ylmethyl)-3-(4-furan-2-yl-6-trifluoromethyl-pyrimidin-2-ylsulfanyl)-propionamide
  • SMR000117566

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens lamin A/C Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0015 0.0001 0.0003
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0126 0.5
Loa Loa (eye worm) nuclear hormone receptor 0.0015 0.0001 0.0003
Schistosoma mansoni thyroid hormone receptor 0.0032 0.022 0.174
Onchocerca volvulus Protein ultraspiracle homolog 0.0032 0.022 0.1042
Loa Loa (eye worm) hypothetical protein 0.0032 0.022 0.1032
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0032 0.022 0.1032
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.003 0.0141
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0017 0.0024 0.0186
Loa Loa (eye worm) hypothetical protein 0.0017 0.0024 0.0114
Brugia malayi hypothetical protein 0.0043 0.0366 0.1711
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0032 0.022 0.1029
Loa Loa (eye worm) hypothetical protein 0.0032 0.022 0.1032
Brugia malayi Steroid receptor seven-up type 2 0.0032 0.022 0.1029
Echinococcus granulosus lamin 0.0033 0.0225 0.0438
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0003 0.0015
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0032 0.022 0.174
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0032 0.022 0.174
Loa Loa (eye worm) hypothetical protein 0.0017 0.0024 0.0114
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0017 0.0024 0.0114
Loa Loa (eye worm) hypothetical protein 0.0025 0.0126 0.0592
Echinococcus multilocularis lamin 0.0033 0.0225 0.0224
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0032 0.022 0.174
Schistosoma mansoni hypothetical protein 0.0033 0.0233 0.1843
Loa Loa (eye worm) hypothetical protein 0.0049 0.0432 0.2023
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0126 0.5
Echinococcus granulosus FTZ F1 alpha 0.0412 0.5126 1
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0126 0.5
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0432 0.202
Entamoeba histolytica hypothetical protein 0.0043 0.0366 0.5
Loa Loa (eye worm) nuclear receptor NHR-67 0.0015 0.0001 0.0003
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.003 0.0137
Echinococcus granulosus intermediate filament protein 0.0033 0.0225 0.0438
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0126 0.5
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0032 0.022 0.174
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0003 0.0002
Brugia malayi nuclear receptor NHR-88 0.0032 0.022 0.1029
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0032 0.022 0.1029
Schistosoma mansoni steroid hormone receptor ad4bp 0.0032 0.022 0.174
Echinococcus granulosus lamin dm0 0.0033 0.0225 0.0438
Echinococcus multilocularis GPCR, family 2 0.0015 0.0003 0.0002
Schistosoma mansoni hypothetical protein 0.0015 0.0003 0.0019
Entamoeba histolytica hypothetical protein 0.0043 0.0366 0.5
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0113 0.1262 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0003 0.0005
Schistosoma mansoni RAR-like nuclear receptor 0.0032 0.022 0.174
Loa Loa (eye worm) hypothetical protein 0.0032 0.022 0.1032
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0366 0.0712
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0366 0.2894
Schistosoma mansoni hypothetical protein 0.0015 0.0003 0.0019
Echinococcus multilocularis thyroid hormone receptor alpha 0.0032 0.022 0.0219
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0032 0.022 0.0428
Loa Loa (eye worm) hypothetical protein 0.0032 0.022 0.1032
Loa Loa (eye worm) hypothetical protein 0.018 0.2134 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0032 0.022 0.1029
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0017 0.0024 0.0186
Loa Loa (eye worm) hypothetical protein 0.0015 0.0001 0.0003
Echinococcus multilocularis FTZ F1 alpha 0.0113 0.1262 0.1261
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0113 0.1262 0.5913
Schistosoma mansoni hypothetical protein 0.0015 0.0003 0.0019
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0015 0.0001 0.0003
Echinococcus multilocularis lamin dm0 0.0033 0.0225 0.0224
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0032 0.022 0.1032
Echinococcus granulosus muscleblind protein 0.018 0.2134 0.4162
Loa Loa (eye worm) hypothetical protein 0.0017 0.0024 0.0114
Loa Loa (eye worm) hypothetical protein 0.0015 0.0001 0.0003
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0032 0.022 0.1032
Schistosoma mansoni hypothetical protein 0.0015 0.0003 0.0019
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0003 0.0002
Loa Loa (eye worm) hypothetical protein 0.0015 0.0001 0.0003
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0032 0.022 0.0428
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0032 0.022 0.1029
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0032 0.022 0.0219
Echinococcus granulosus ecdysone induced protein 78C 0.0032 0.022 0.0428
Schistosoma mansoni retinoic acid receptor RXR 0.0032 0.022 0.174
Schistosoma mansoni hypothetical protein 0.0081 0.0847 0.6707
Schistosoma mansoni lamin 0.0033 0.0225 0.178
Loa Loa (eye worm) hypothetical protein 0.018 0.2134 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0113 0.1262 0.2461
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0225 0.1052
Loa Loa (eye worm) hypothetical protein 0.0017 0.0024 0.0114
Brugia malayi intermediate filament protein 0.0033 0.0225 0.1052
Loa Loa (eye worm) hypothetical protein 0.0015 0.0001 0.0003
Brugia malayi nuclear receptor RXR 0.0017 0.0024 0.011
Brugia malayi Nuclear hormone receptor-like 1 0.0017 0.0024 0.011
Brugia malayi hypothetical protein 0.0025 0.0126 0.0589
Loa Loa (eye worm) hypothetical protein 0.0016 0.0008 0.0036
Schistosoma mansoni hypothetical protein 0.0043 0.0366 0.2894
Onchocerca volvulus Bile acid receptor homolog 0.0032 0.022 0.1042
Brugia malayi ecdysteroid receptor 0.0032 0.022 0.1029
Brugia malayi steroid hormone receptor 0.0032 0.022 0.1029
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0032 0.022 0.1042
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0017 0.0024 0.0046
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0225 0.1056
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0126 0.5
Echinococcus granulosus GPCR family 2 0.0015 0.0003 0.0005
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0003 0.0005
Entamoeba histolytica hypothetical protein 0.0043 0.0366 0.5
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0032 0.022 0.1029
Brugia malayi N-terminal motif family protein 0.0178 0.2108 0.9878
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0016 0.0008 0.0014
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0233 0.109
Loa Loa (eye worm) hypothetical protein 0.0032 0.0218 0.102
Brugia malayi nuclear hormone receptor 0.0032 0.022 0.1029
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0032 0.022 0.1032
Echinococcus multilocularis musashi 0.0033 0.0225 0.0224
Echinococcus multilocularis ecdysone induced protein 78C 0.0032 0.022 0.0219
Loa Loa (eye worm) hypothetical protein 0.0032 0.022 0.1032
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0032 0.022 0.1029
Schistosoma mansoni nuclear hormone receptor 0.0032 0.022 0.174
Loa Loa (eye worm) hypothetical protein 0.0178 0.2108 0.9878
Echinococcus multilocularis muscleblind protein 1 0.018 0.2134 0.2133
Onchocerca volvulus 0.0033 0.0225 0.1066
Schistosoma mansoni intermediate filament proteins 0.0033 0.0225 0.178
Brugia malayi photoreceptor-specific nuclear receptor 0.0032 0.022 0.1029
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0032 0.022 0.0219
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0225 0.1056
Loa Loa (eye worm) hypothetical protein 0.0017 0.0024 0.0114
Brugia malayi hypothetical protein 0.0017 0.0024 0.011
Onchocerca volvulus 0.0032 0.022 0.1042
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0003 0.0011
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0032 0.022 0.0219
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0032 0.022 0.1029
Schistosoma mansoni coup transcription factor 0.0032 0.022 0.174
Loa Loa (eye worm) hypothetical protein 0.0015 0.0001 0.0003
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0032 0.022 0.1032
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0032 0.022 0.174
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0016 0.0008 0.0007
Brugia malayi hypothetical protein 0.0017 0.0024 0.011
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0032 0.022 0.0428
Loa Loa (eye worm) hypothetical protein 0.0015 0.0001 0.0003
Leishmania major hypothetical protein, conserved 0.0025 0.0126 0.5
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0032 0.022 0.1029
Loa Loa (eye worm) hypothetical protein 0.0015 0.0001 0.0003
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0032 0.022 0.0219
Schistosoma mansoni thyroid hormone receptor 0.0032 0.022 0.174
Loa Loa (eye worm) hypothetical protein 0.0015 0.0003 0.0015
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0017 0.0024 0.0024
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0032 0.022 0.1029
Loa Loa (eye worm) hypothetical protein 0.0113 0.1262 0.5915
Brugia malayi hypothetical protein 0.0016 0.0012 0.0054
Onchocerca volvulus 0.0033 0.0225 0.1066
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0032 0.022 0.1032
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0003 0.0011
Loa Loa (eye worm) hypothetical protein 0.0032 0.022 0.1032
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0032 0.022 0.1029
Loa Loa (eye worm) DR-78 0.0015 0.0001 0.0003
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0113 0.1262 0.1261
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0432 0.2023
Echinococcus multilocularis muscleblind protein 0.018 0.2134 0.2133
Loa Loa (eye worm) steroid hormone receptor 0.0032 0.022 0.1032
Loa Loa (eye worm) hypothetical protein 0.0015 0.0001 0.0003
Loa Loa (eye worm) hypothetical protein 0.0033 0.0233 0.1093
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0032 0.022 0.1029
Loa Loa (eye worm) hypothetical protein 0.0015 0.0001 0.0003
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0032 0.022 0.0428
Brugia malayi Muscleblind-like protein 0.018 0.2134 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0001 0.0003
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0113 0.1262 0.5913
Brugia malayi Nuclear hormone receptor-like 1 0.0017 0.0024 0.011
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0032 0.022 0.0428
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0432 0.202
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0126 0.5
Brugia malayi Nuclear hormone receptor-like 1 0.0032 0.022 0.1029
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0032 0.022 0.1032
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0178 0.2108 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.022 0.1032
Schistosoma mansoni lamin 0.0033 0.0225 0.178
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0032 0.022 0.0428
Entamoeba histolytica hypothetical protein 0.0043 0.0366 0.5
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0366 0.0365
Loa Loa (eye worm) hypothetical protein 0.0015 0.0001 0.0003
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0126 0.5
Loa Loa (eye worm) hypothetical protein 0.0033 0.0225 0.1056
Loa Loa (eye worm) hypothetical protein 0.0015 0.0001 0.0003
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0032 0.022 0.0219

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 1.122 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.2213 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 8.9125 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) 14.1254 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 16.3601 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 25.929 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) = 79.4328 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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