TDR Targets

Basic information

Technical information

TDR Targets ID: 1225576
Name: SR-01000631345-1
MW: 290.308 | Formula: C16H16F2N2O
H donors: 1 H acceptors: 1 LogP: 3.02 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: O=C(c1cc(F)c(c(c1)F)N(C)C)NCc1ccccc1
InChi: 1S/C16H16F2N2O/c1-20(2)15-13(17)8-12(9-14(15)18)16(21)19-10-11-6-4-3-5-7-11/h3-9H,10H2,1-2H3,(H,19,21)
InChiKey: UPYNXALZZLEKIC-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

ZINC00138804
MLS000851235
N1-benzyl-4-(dimethylamino)-3,5-difluorobenzamide
SMR000457578
Oprea1_680815

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	aldehyde dehydrogenase 1 family, member A1	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Candida albicans	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	Get druggable targets OG5_126638	All targets in OG5_126638
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	Get druggable targets OG5_126638	All targets in OG5_126638
Candida albicans	Mitochondrial aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Mycobacterium ulcerans	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Leishmania braziliensis	aldehyde dehydrogenase, mitochondrial precursor	Get druggable targets OG5_126638	All targets in OG5_126638
Schistosoma mansoni	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Schistosoma japonicum	Aldehyde dehydrogenase X, mitochondrial precursor, putative	Get druggable targets OG5_126638	All targets in OG5_126638
Leishmania mexicana	aldehyde dehydrogenase, mitochondrial precursor	Get druggable targets OG5_126638	All targets in OG5_126638
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	Get druggable targets OG5_126638	All targets in OG5_126638
Schistosoma japonicum	Retinal dehydrogenase 1, putative	Get druggable targets OG5_126638	All targets in OG5_126638
Toxoplasma gondii	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Schistosoma japonicum	ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative	Get druggable targets OG5_126638	All targets in OG5_126638
Leishmania infantum	aldehyde dehydrogenase, mitochondrial precursor	Get druggable targets OG5_126638	All targets in OG5_126638
Candida albicans	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Candida albicans	Mitochondrial aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Schistosoma japonicum	Aldehyde dehydrogenase, mitochondrial precursor, putative	Get druggable targets OG5_126638	All targets in OG5_126638
Mycobacterium ulcerans	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Mycobacterium ulcerans	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Neospora caninum	hypothetical protein	Get druggable targets OG5_126638	All targets in OG5_126638
Leishmania donovani	aldehyde dehydrogenase, mitochondrial precursor	Get druggable targets OG5_126638	All targets in OG5_126638
Schistosoma mansoni	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Mycobacterium tuberculosis	Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1	aldehyde dehydrogenase 1 family, member A1	501 aa	456 aa	33.3 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0049	0.2594	0.2594
Brugia malayi	hypothetical protein	0.0071	0.3828	0.3828
Onchocerca volvulus	Rap guanine nucleotide exchange factor 1 homolog	0.0179	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0172	1
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0172	1
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0008	0.0211	0.0532
Schistosoma mansoni	camp-dependent rap1 guanine-nucleotide exchange factor	0.0006	0.0111	0.0279
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0172	1
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0128	0.0128
Treponema pallidum	gamma-glutamyl phosphate reductase	0.0004	0	0.5
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0045	0.2337	0.2337
Echinococcus granulosus	segment polarity protein dishevelled	0.0009	0.0273	0.0689
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0071	0.3828	0.9662
Trichomonas vaginalis	ras GTP exchange factor, putative	0.0006	0.0128	0.7458
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0049	0.2594	0.2594
Entamoeba histolytica	Ras guanine nucleotide exchange factor, putative	0.0006	0.0128	0.0335
Echinococcus multilocularis	tar DNA binding protein	0.0063	0.3359	0.8479
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0007	0.0172	1
Schistosoma mansoni	fyve finger-containing phosphoinositide kinase fyv1	0.0009	0.0273	0.0689
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0172	1
Schistosoma mansoni	hypothetical protein	0.0016	0.0663	0.1674
Schistosoma mansoni	hypothetical protein	0.0016	0.0663	0.1674
Echinococcus granulosus	GPCR family 2	0.0016	0.0663	0.1674
Echinococcus multilocularis	rap guanine nucleotide exchange factor 1	0.0006	0.0128	0.0324
Schistosoma mansoni	guanine-nucleotide-exchange-factor	0.0006	0.0128	0.0324
Trypanosoma cruzi	hypothetical protein	0.0006	0.0128	1
Echinococcus multilocularis	Protein son of sevenless	0.0006	0.0128	0.0324
Schistosoma mansoni	ras GTP exchange factor	0.0006	0.0128	0.0324
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0172	1
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0008	0.0211	0.0532
Schistosoma mansoni	ras GTP exchange factor son of sevenless	0.0006	0.0128	0.0324
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.3359	0.8479
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0172	1
Brugia malayi	TAR-binding protein	0.0063	0.3359	0.3359
Trypanosoma brucei	delta-1-pyrroline-5-carboxylate dehydrogenase, putative	0.0004	0	0.5
Trichomonas vaginalis	guanine nucleotide exchange factor, putative	0.0006	0.0128	0.7458
Brugia malayi	Domain found in Dishevelled, Egl-10, and Pleckstrin family protein	0.0009	0.0273	0.0273
Loa Loa (eye worm)	DIX domain-containing protein	0.0009	0.0273	0.0273
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0016	0.0663	0.1674
Entamoeba histolytica	Ras guanine nucleotide exchange factor, putative	0.0006	0.0128	0.0335
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0073	0.3962	1
Trichomonas vaginalis	helicase, putative	0.0007	0.0172	1
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0663	0.0663
Schistosoma mansoni	ras GTP exchange factor son of sevenless	0.0006	0.0128	0.0324
Entamoeba histolytica	Ras guanine nucleotide exchange factor, putative	0.0006	0.0128	0.0335
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0016	0.0663	0.1674
Echinococcus granulosus	rap guanine nucleotide exchange factor 6	0.0006	0.0128	0.0324
Echinococcus multilocularis	cpg binding protein	0.0033	0.1648	0.4159
Echinococcus granulosus	regulator of G protein signaling 7	0.0009	0.0273	0.0689
Echinococcus granulosus	regulator of G protein signaling 7	0.0009	0.0273	0.0689
Trichomonas vaginalis	ras GTP exchange factor, putative	0.0006	0.0128	0.7458
Echinococcus granulosus	Protein son of sevenless	0.0006	0.0128	0.0324
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0071	0.3828	0.9662
Trichomonas vaginalis	ras GTP exchange factor, son of sevenless, putative	0.0006	0.0128	0.7458
Entamoeba histolytica	Ras guanine nucleotide exchange factor, putative	0.0006	0.0128	0.0335
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.2337	0.5899
Giardia lamblia	Alcohol dehydrogenase	0.0004	0	0.5
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0172	1
Echinococcus multilocularis	rap guanine nucleotide exchange factor 6	0.0006	0.0128	0.0324
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0172	1
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0172	1
Echinococcus granulosus	tar DNA binding protein	0.0063	0.3359	0.8479
Schistosoma mansoni	dep domain containing protein	0.0009	0.0273	0.0689
Echinococcus multilocularis	segment polarity protein dishevelled	0.0009	0.0273	0.0689
Schistosoma mansoni	hypothetical protein	0.0016	0.0663	0.1674
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0172	1
Brugia malayi	CXXC zinc finger family protein	0.0031	0.1547	0.1547
Onchocerca volvulus		0.0009	0.0273	0.0273
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0008	0.0211	0.0532
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0073	0.3962	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.2337	0.5899
Loa Loa (eye worm)	RNA binding protein	0.0063	0.3359	0.3359
Entamoeba histolytica	Ras guanine nucleotide exchange factor, putative	0.0006	0.0128	0.0335
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0172	1
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0073	0.3962	1
Schistosoma mansoni	hypothetical protein	0.0071	0.3828	0.9662
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0059	0.3136	0.7916
Loa Loa (eye worm)	TAR-binding protein	0.0063	0.3359	0.3359
Mycobacterium leprae	PROBABLE ALDEHYDE DEHYDROGENASE (NAD+) DEPENDENT	0.0004	0	0.5
Mycobacterium leprae	PROBABLE GAMMA-GLUTAMYL PHOSPHATE REDUCTASE PROTEIN PROA (GPR) (GLUTAMATE-5-SEMIALDEHYDE DEHYDROGENASE) (GLUTAMYL-GAMMA-SEMIALDE	0.0004	0	0.5
Brugia malayi	RasGEF domain containing protein	0.0006	0.0128	0.0128
Entamoeba histolytica	Ras guanine nucleotide exchange factor, putative	0.0006	0.0128	0.0335
Echinococcus granulosus	son of sevenless 1	0.0006	0.0128	0.0324
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0008	0.0211	0.0532
Brugia malayi	hypothetical protein	0.0009	0.0273	0.0273
Brugia malayi	Domain found in Dishevelled, Egl-10, and Pleckstrin family protein	0.0009	0.0273	0.0273
Schistosoma mansoni	cpg binding protein	0.0033	0.1648	0.4159
Brugia malayi	latrophilin 2 splice variant baaae	0.0034	0.1701	0.1701
Wolbachia endosymbiont of Brugia malayi	bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase	0.0004	0	0.5
Trypanosoma cruzi	guanine nucleotide releasing protein, putative	0.0006	0.0128	1
Toxoplasma gondii	aldehyde dehydrogenase	0.0073	0.3962	1
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0273	0.0273
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0016	0.0663	0.0663
Mycobacterium leprae	PROBABLE SUCCINATE-SEMIALDEHYDE DEHYDROGENASE [NADP+] DEPENDENT (SSDH) GABD	0.0004	0	0.5
Entamoeba histolytica	hypothetical protein	0.0071	0.3828	1
Loa Loa (eye worm)	RasGEF domain-containing protein	0.0006	0.0128	0.0128
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0073	0.3962	1
Brugia malayi	RNA binding protein	0.0063	0.3359	0.3359
Loa Loa (eye worm)	histone methyltransferase	0.001	0.0319	0.0319
Schistosoma mansoni	dishevelled	0.0009	0.0273	0.0689
Entamoeba histolytica	Ras guanine nucleotide exchange factor, putative	0.0006	0.0128	0.0335
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.3359	0.8479
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0063	0.3359	0.3359
Entamoeba histolytica	Ras guanine nucleotide exchange factor, putative	0.0006	0.0128	0.0335
Schistosoma mansoni	ras GTP exchange factor son of sevenless	0.0006	0.0128	0.0324
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0031	0.1547	0.1547
Schistosoma mansoni	cpg binding protein	0.0033	0.1648	0.4159
Toxoplasma gondii	hypothetical protein	0.0009	0.0273	0.0689
Echinococcus multilocularis	regulator of G protein signaling 7	0.0009	0.0273	0.0689
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0128	0.0128
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.3359	0.8479
Brugia malayi	hypothetical protein	0.0009	0.0273	0.0273
Onchocerca volvulus	Segment polarity protein dishevelled homolog	0.0009	0.0273	0.0273
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0172	1
Loa Loa (eye worm)	hypothetical protein	0.0049	0.2594	0.2594
Loa Loa (eye worm)	RasGEF domain-containing protein	0.0006	0.0128	0.0128
Loa Loa (eye worm)	RasGEF domain-containing protein	0.0006	0.0128	0.0128
Echinococcus multilocularis	regulator of G protein signaling 7	0.0009	0.0273	0.0689
Schistosoma mansoni	hypothetical protein	0.0016	0.0663	0.1674
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0008	0.0211	0.0532
Echinococcus granulosus	rap guanine nucleotide exchange factor 1	0.0006	0.0128	0.0324
Schistosoma mansoni	dishevelled	0.0009	0.0273	0.0689
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.001	0.0319	0.0806
Onchocerca volvulus		0.0006	0.0128	0.0128
Echinococcus multilocularis	ras GTP exchange factor	0.0006	0.0128	0.0324
Schistosoma mansoni	z-protein (S1r protein)	0.0009	0.0273	0.0689
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0007	0.0172	1
Brugia malayi	RasGEF domain containing protein	0.0006	0.0128	0.0128
Trypanosoma brucei	aldehyde dehydrogenase, putative	0.0004	0	0.5
Brugia malayi	N-terminal motif family protein	0.0006	0.0128	0.0128
Trypanosoma brucei	aldehyde dehydrogenase, putative	0.0004	0	0.5
Schistosoma mansoni	hypothetical protein	0.0034	0.1701	0.4292
Brugia malayi	RNA recognition motif domain containing protein	0.0063	0.3359	0.3359
Echinococcus granulosus	ras GTP exchange factor	0.0006	0.0128	0.0324
Entamoeba histolytica	Ras guanine nucleotide exchange factor, putative	0.0006	0.0128	0.0335
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0172	1
Schistosoma mansoni	aldehyde dehydrogenase	0.0073	0.3962	1
Schistosoma mansoni	regulator of G protein signaling	0.0009	0.0273	0.0689
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0273	0.0273
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.2337	0.5899
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0073	0.3962	1
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0073	0.3962	1
Echinococcus multilocularis	GPCR, family 2	0.0016	0.0663	0.1674
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.2337	0.5899
Brugia malayi	DIX domain containing protein	0.0009	0.0273	0.0273
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0016	0.0663	0.0663
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.2337	0.5899
Echinococcus multilocularis	segment polarity protein dishevelled	0.0009	0.0273	0.0689
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.001	0.0319	0.0806
Brugia malayi	regulator of G-protein signaling egl-10	0.0009	0.0273	0.0273
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0073	0.3962	1
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0016	0.0663	0.1674
Trypanosoma brucei	aldehyde dehydrogenase family, putative	0.0004	0	0.5
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0016	0.0663	0.1674
Schistosoma mansoni	cpg binding protein	0.0031	0.1547	0.3903
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0049	0.2594	0.2594
Entamoeba histolytica	Ras guanine nucleotide exchange factor, putative	0.0006	0.0128	0.0335
Trypanosoma cruzi	hypothetical protein	0.0006	0.0128	1
Entamoeba histolytica	hypothetical protein	0.0071	0.3828	1
Echinococcus granulosus	segment polarity protein dishevelled	0.0009	0.0273	0.0689
Echinococcus multilocularis	Pleckstrin G protein, interacting region	0.0009	0.0273	0.0689
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0172	1
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0066	0.3539	0.8933
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0045	0.2337	0.2337
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0172	1
Loa Loa (eye worm)	hypothetical protein	0.0034	0.1701	0.1701
Entamoeba histolytica	Ras guanine nucleotide exchange factor, putative	0.0006	0.0128	0.0335
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.3359	0.8479
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.3359	0.8479
Entamoeba histolytica	Ras guanine nucleotide exchange factor, putative	0.0006	0.0128	0.0335
Echinococcus granulosus	Pleckstrin G protein interacting region	0.0009	0.0273	0.0689
Loa Loa (eye worm)	G protein signaling regulator EGL-10	0.0009	0.0273	0.0273
Entamoeba histolytica	hypothetical protein	0.0071	0.3828	1
Entamoeba histolytica	hypothetical protein	0.0006	0.0128	0.0335
Onchocerca volvulus	Rap guanine nucleotide exchange factor 1 homolog	0.0006	0.0128	0.0128
Trypanosoma brucei	aldehyde dehydrogenase family, putative	0.0004	0	0.5
Brugia malayi	F/Y-rich N-terminus family protein	0.0009	0.0312	0.0312
Entamoeba histolytica	hypothetical protein	0.0071	0.3828	1
Brugia malayi	RasGEF domain containing protein	0.0006	0.0128	0.0128
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0004	0.0024	0.0061
Brugia malayi	Latrophilin receptor protein 2	0.0016	0.0663	0.0663
Echinococcus multilocularis	son of sevenless 1	0.0006	0.0128	0.0324
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.2337	0.5899
Entamoeba histolytica	Ras guanine nucleotide exchange factor, putative	0.0006	0.0128	0.0335
Brugia malayi	N-terminal motif family protein	0.0006	0.0128	0.0128
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.2337	0.5899
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0273	0.0273
Loa Loa (eye worm)	hypothetical protein	0.0179	1	1
Onchocerca volvulus		0.0031	0.1547	0.1547
Schistosoma mansoni	aldehyde dehydrogenase	0.0073	0.3962	1
Schistosoma mansoni	transcription factor LCR-F1	0.0071	0.3828	0.9662
Echinococcus granulosus	cpg binding protein	0.0033	0.1648	0.4159

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	0.7079 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860]	ChEMBL.	No reference
Potency (functional)	2.6169 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	4.1475 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	= 17.7828 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))]	ChEMBL.	No reference
Potency (functional)	37.933 uM	PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411]	ChEMBL.	No reference
Potency (functional)	100 uM	PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1349337

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1225576