Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | tar DNA binding protein | 0.0074 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 1 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0074 | 1 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0071 | 0.8578 | 0.8578 |
Loa Loa (eye worm) | TAR-binding protein | 0.0074 | 1 | 1 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0071 | 0.8578 | 0.8578 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0074 | 1 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0071 | 0.8578 | 0.5 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0071 | 0.8578 | 0.8578 |
Brugia malayi | TAR-binding protein | 0.0074 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 1 | 1 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0071 | 0.8578 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 1 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0074 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 1 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0071 | 0.8578 | 0.5 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0071 | 0.8578 | 0.5 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0071 | 0.8578 | 0.5 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0071 | 0.8578 | 0.8578 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0071 | 0.8578 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0074 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 16.5113 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 79.4328 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.