Detailed information for compound 1227259

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 497.577 | Formula: C23H30F3N5O2S
  • H donors: 2 H acceptors: 3 LogP: 4.5 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN(CCNC(=O)c1c(NC(=O)Cn2nc(c3c2CCCC3)C(F)(F)F)sc2c1CCCC2)C
  • InChi: 1S/C23H30F3N5O2S/c1-30(2)12-11-27-21(33)19-15-8-4-6-10-17(15)34-22(19)28-18(32)13-31-16-9-5-3-7-14(16)20(29-31)23(24,25)26/h3-13H2,1-2H3,(H,27,33)(H,28,32)
  • InChiKey: UXUSFGHVYPKOKQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi nuclear hormone receptor 0.001 0.0006 0.0096
Leishmania major cathepsin L-like protease 0.0066 0.0334 0.5246
Brugia malayi nuclear receptor NHR-88 0.001 0.0006 0.0096
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.011 0.0592 0.1339
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0049 0.083
Echinococcus multilocularis tumor protein p63 0.0668 0.387 0.387
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0017 0.0049 0.1247
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0026 0.0102 0.2577
Schistosoma mansoni cathepsin F (C01 family) 0.0012 0.0016 0.004
Mycobacterium tuberculosis Conserved protein 0.011 0.0592 0.1339
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.006 0.0301 0.5074
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0049 0.0049
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0049 0.083
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0006 0.0015
Onchocerca volvulus 0.0017 0.0049 0.0741
Plasmodium falciparum cysteine proteinase falcipain 3 0.0017 0.0049 0.1247
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0006 0.0015
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0006 0.0015
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.021 0.054
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0026 0.0102 0.1715
Onchocerca volvulus Cathepsin L homolog 0.0017 0.0049 0.0741
Onchocerca volvulus 0.0098 0.0522 0.8802
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0049 0.083
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0006 0.0096
Mycobacterium ulcerans pantoate--beta-alanine ligase 0.0582 0.3364 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0006 0.0096
Echinococcus granulosus cathepsin l1 0.0012 0.0016 0.004
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0006 0.0015
Schistosoma mansoni peptidase Clp (S14 family) 0.0076 0.0394 0.1014
Entamoeba histolytica cysteine proteinase, putative 0.0012 0.0016 0.2817
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0017 0.0049 0.1247
Onchocerca volvulus 0.011 0.0592 1
Toxoplasma gondii hypothetical protein 0.0026 0.0102 0.0158
Onchocerca volvulus 0.0017 0.0049 0.0741
Echinococcus granulosus cathepsin L cysteine proteinase 0.0017 0.0049 0.0126
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0056 1
Mycobacterium tuberculosis Conserved protein 0.011 0.0592 0.1339
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0049 0.083
Echinococcus multilocularis beta LACTamase domain containing family member 0.011 0.0592 0.0592
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0049 0.083
Brugia malayi Cathepsin L-like cysteine proteinase 0.0012 0.0016 0.0264
Brugia malayi Cathepsin L-like precursor 0.0012 0.0016 0.0264
Loa Loa (eye worm) hypothetical protein 0.0012 0.0016 0.017
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0006 0.0096
Loa Loa (eye worm) hypothetical protein 0.0012 0.0016 0.017
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0049 0.083
Brugia malayi cathepsin L-like precursor 0.0012 0.0016 0.0264
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0049 0.0049
Echinococcus granulosus peptidase Clp S14 family 0.005 0.024 0.0618
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0334 0.564
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.021 0.054
Schistosoma mansoni microtubule-associated protein tau 0.0671 0.3887 1
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0049 0.0126
Brugia malayi beta-lactamase family protein 0.011 0.0592 1
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0056 0.0937
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0049 0.083
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0334 0.564
Echinococcus granulosus microtubule associated protein 2 0.0671 0.3887 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0056 0.0937
Trypanosoma cruzi major cysteine proteinase, putative 0.0052 0.0251 0.4244
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0049 0.0126
Trichomonas vaginalis penicillin-binding protein, putative 0.011 0.0592 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.021 0.054
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0006 0.0096
Toxoplasma gondii pantoate-beta-alanine ligase 0.0582 0.3364 1
Loa Loa (eye worm) hypothetical protein 0.011 0.0592 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0334 0.564
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0076 0.0394 0.1024
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0056 0.0056
Mycobacterium leprae Probable lipase LipE 0.011 0.0592 0.1504
Trichomonas vaginalis D-aminoacylase, putative 0.011 0.0592 1
Trichomonas vaginalis D-aminoacylase, putative 0.011 0.0592 1
Leishmania major cathepsin L-like protease 0.0066 0.0334 0.5246
Loa Loa (eye worm) hypothetical protein 0.011 0.0592 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0056 0.0937
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.021 0.021
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0056 0.0937
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0006 0.0006
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0006 0.0015
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0049 0.083
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0049 0.083
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.011 0.0592 1
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0056 0.0937
Echinococcus multilocularis microtubule associated protein 2 0.0671 0.3887 0.3887
Onchocerca volvulus Cathepsin L homolog 0.0017 0.0049 0.0741
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0076 0.0394 1
Brugia malayi Cathepsin L-like precursor 0.0017 0.0049 0.083
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0049 0.8855
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0006 0.0096
Onchocerca volvulus 0.0017 0.0049 0.0741
Trichomonas vaginalis penicillin-binding protein, putative 0.011 0.0592 1
Onchocerca volvulus 0.0017 0.0049 0.0741
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0076 0.0394 0.0897
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0049 0.8855
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0056 0.0937
Mycobacterium tuberculosis Probable hydrolase 0.011 0.0592 0.1339
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0049 0.0049
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0049 0.083
Mycobacterium ulcerans esterase/lipase LipP 0.011 0.0592 0.1622
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0049 0.083
Brugia malayi Probable ClpP-like protease 0.0076 0.0394 0.6656
Entamoeba histolytica cysteine protease, putative 0.0017 0.0049 0.8855
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0026 0.0102 0.136
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0006 0.0096
Onchocerca volvulus Cathepsin F homolog 0.0017 0.0049 0.0741
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0049 0.083
Loa Loa (eye worm) hypothetical protein 0.011 0.0592 1
Echinococcus multilocularis peptidase Clp (S14 family) 0.005 0.024 0.024
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0049 0.083
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0334 0.564
Loa Loa (eye worm) hypothetical protein 0.011 0.0592 1
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0006 0.0015
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0006 0.0015
Mycobacterium ulcerans beta-lactamase 0.011 0.0592 0.1622
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0076 0.0394 0.5
Echinococcus multilocularis cysteine protease 0.0017 0.0049 0.0049
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0056 0.5
Schistosoma mansoni ap endonuclease 0.0018 0.0056 0.0143
Loa Loa (eye worm) hypothetical protein 0.011 0.0592 1
Trypanosoma cruzi hypothetical protein, conserved 0.011 0.0592 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0334 0.564
Brugia malayi steroid hormone receptor 0.001 0.0006 0.0096
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0006 0.0006
Brugia malayi Cathepsin L-like precursor 0.0017 0.0049 0.083
Mycobacterium tuberculosis Probable lipase LipE 0.011 0.0592 0.1339
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0006 0.0015
Loa Loa (eye worm) ctsf protein 0.0017 0.0049 0.0741
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0334 0.564
Onchocerca volvulus 0.0012 0.0016 0.017
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0006 0.0006
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.021 0.348
Schistosoma mansoni ap endonuclease 0.0018 0.0056 0.0143
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.021 0.054
Mycobacterium tuberculosis Conserved protein 0.011 0.0592 0.1339
Mycobacterium tuberculosis Probable lipase LipD 0.011 0.0592 0.1339
Loa Loa (eye worm) cytochrome P450 family protein 0.0026 0.0102 0.1644
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0006 0.0006
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0056 0.0117
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0006 0.0015
Brugia malayi ecdysteroid receptor 0.001 0.0006 0.0096
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0006 0.0096
Brugia malayi Cathepsin L-like precursor 0.0017 0.0049 0.083
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0006 0.0096
Loa Loa (eye worm) hypothetical protein 0.0098 0.0522 0.8802
Mycobacterium ulcerans lipase LipD 0.011 0.0592 0.1622
Trypanosoma cruzi cysteine peptidase, putative 0.0066 0.0334 0.564
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0049 0.083
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0049 0.083
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0076 0.0394 0.1024
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0334 0.564
Brugia malayi Cathepsin L-like precursor 0.0017 0.0049 0.083
Loa Loa (eye worm) beta-lactamase 0.011 0.0592 1
Loa Loa (eye worm) hypothetical protein 0.0076 0.0394 0.6624
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0056 0.0143
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0049 0.083
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0006 0.0015
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.011 0.0592 0.1524
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0076 0.0394 0.5
Trypanosoma cruzi cysteine peptidase, putative 0.0066 0.0334 0.564
Trichomonas vaginalis D-aminoacylase, putative 0.011 0.0592 1
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0076 0.0394 0.1041
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.021 0.054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0049 0.083
Trypanosoma cruzi cysteine peptidase, putative 0.0017 0.0049 0.083
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0049 0.083
Plasmodium vivax hypothetical protein, conserved 0.011 0.0592 1
Toxoplasma gondii ABC1 family protein 0.011 0.0592 0.1638
Trypanosoma cruzi hypothetical protein, conserved 0.011 0.0592 1
Loa Loa (eye worm) cysteine protease 0.0017 0.0049 0.0741
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0006 0.0096
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0006 0.0096
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.021 0.021
Onchocerca volvulus 0.011 0.0592 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0006 0.0006
Onchocerca volvulus 0.0017 0.0049 0.0741
Plasmodium vivax vivapain-2 0.0017 0.0049 0.083
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0006 0.0015
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0049 0.083
Schistosoma mansoni cellular tumor antigen P53 0.0098 0.0522 0.1343
Leishmania major cathepsin L-like protease 0.0066 0.0334 0.5246
Onchocerca volvulus 0.0017 0.0049 0.0741
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0049 0.083
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0006 0.0096
Mycobacterium tuberculosis Probable conserved lipoprotein 0.011 0.0592 0.1339
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0006 0.0096
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0056 0.085
Schistosoma mansoni nuclear hormone receptor 0.001 0.0006 0.0015
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0701 0.4065 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0049 0.083
Schistosoma mansoni thyroid hormone receptor 0.001 0.0006 0.0015
Loa Loa (eye worm) hypothetical protein 0.0012 0.0016 0.017
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0049 0.083
Toxoplasma gondii exonuclease III APE 0.0018 0.0056 0.0019
Brugia malayi beta-lactamase 0.011 0.0592 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.011 0.0592 0.1524
Trypanosoma cruzi cysteine peptidase, putative 0.0066 0.0334 0.564
Echinococcus multilocularis cysteine protease 0.0017 0.0049 0.0049
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0006 0.0096
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0049 0.083
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0006 0.0006
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.005 0.024 0.0461
Brugia malayi Cathepsin L-like precursor 0.0017 0.0049 0.083
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.005 0.024 0.0461
Plasmodium vivax vivapain-2 0.0017 0.0049 0.083
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0076 0.0394 0.0394
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0006 0.0096
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0056 0.1408
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0334 0.564
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0006 0.0006
Trypanosoma cruzi cruzipain precursor, putative 0.0066 0.0334 0.564
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0017 0.0049 0.0741
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0076 0.0394 1
Mycobacterium ulcerans hypothetical protein 0.011 0.0592 0.1622
Loa Loa (eye worm) hypothetical protein 0.011 0.0592 1
Trichomonas vaginalis esterase, putative 0.011 0.0592 1
Brugia malayi Cytochrome P450 family protein 0.0026 0.0102 0.1724
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0006 0.0096
Loa Loa (eye worm) hypothetical protein 0.0017 0.0049 0.0741
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0006 0.0006
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0006 0.0015
Brugia malayi Cathepsin L-like precursor 0.0017 0.0049 0.083
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0076 0.0394 0.1014
Echinococcus granulosus cathepsin l1 0.0017 0.0049 0.0126
Mycobacterium leprae conserved hypothetical protein 0.011 0.0592 0.1504
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0076 0.0394 0.6656
Mycobacterium tuberculosis Probable esterase LipL 0.011 0.0592 0.1339
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0076 0.0394 0.1041
Mycobacterium leprae Probable pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme) 0.0582 0.3364 1
Echinococcus granulosus cathepsin l cysteine peptidase 0.0017 0.0049 0.0126
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0017 0.0049 0.0741
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0006 0.0015
Leishmania major hypothetical protein, conserved 0.011 0.0592 1
Loa Loa (eye worm) fibroinase 0.0017 0.0049 0.0741
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.005 0.024 0.0426
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0006 0.0015
Echinococcus granulosus beta LACTamase domain containing family member 0.011 0.0592 0.1524
Onchocerca volvulus 0.011 0.0592 1
Brugia malayi beta-lactamase family protein 0.011 0.0592 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0006 0.0096
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0334 0.564
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0049 0.0049
Echinococcus granulosus FTZ F1 alpha 0.001 0.0006 0.0015
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0049 0.083
Trypanosoma brucei hypothetical protein, conserved 0.011 0.0592 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.021 0.3543
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0076 0.0394 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.011 0.0592 0.1622
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0016 0.0264
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0334 0.564
Mycobacterium tuberculosis Pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme) 0.0582 0.3364 0.8251
Schistosoma mansoni thyroid hormone receptor 0.001 0.0006 0.0015
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0006 0.0015
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0006 0.0015
Schistosoma mansoni coup transcription factor 0.001 0.0006 0.0015
Onchocerca volvulus 0.0017 0.0049 0.0741
Echinococcus granulosus tumor protein p63 0.0668 0.387 0.9957
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0006 0.0015
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0016 0.0264
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0006 0.0006
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0049 0.083
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.011 0.0592 1
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0056 0.0937
Brugia malayi Cathepsin L-like precursor 0.0012 0.0016 0.0264
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0049 0.083
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0334 0.564
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.011 0.0592 0.1339

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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