Detailed information for compound 1227401

Basic information

Technical information
  • TDR Targets ID: 1227401
  • Name: 8-(3,5-dimethylphenoxy)-7-[(3-methoxyphenyl)m ethyl]-1,3-dimethylpurine-2,6-dione
  • MW: 420.461 | Formula: C23H24N4O4
  • H donors: 0 H acceptors: 3 LogP: 3.73 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cccc(c1)Cn1c(Oc2cc(C)cc(c2)C)nc2c1c(=O)n(C)c(=O)n2C
  • InChi: 1S/C23H24N4O4/c1-14-9-15(2)11-18(10-14)31-22-24-20-19(21(28)26(4)23(29)25(20)3)27(22)13-16-7-6-8-17(12-16)30-5/h6-12H,13H2,1-5H3
  • InChiKey: YKNNVLHKDGCNIW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 8-(3,5-dimethylphenoxy)-7-[(3-methoxyphenyl)methyl]-1,3-dimethyl-purine-2,6-dione
  • 8-(3,5-dimethylphenoxy)-7-(3-methoxybenzyl)-1,3-dimethyl-xanthine
  • Oprea1_758410
  • BAS 05021999
  • ZINC00789648
  • NCGC00100282-01
  • EU-0081115

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens bromodomain adjacent to zinc finger domain, 2B Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum ko:K01549 ATP synthase [EC3.6.3.14], putative Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum Cleft lip and palate transmembrane protein 1-like protein, putative Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum expressed protein Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus multilocularis bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum Conserved hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Brugia malayi Bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus granulosus bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0506 0.0686
Loa Loa (eye worm) hypothetical protein 0.006 0.2078 0.3205
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0027 0.0825 0.3038
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0078 0.0042
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0078 0.0042
Echinococcus multilocularis GPCR, family 2 0.0019 0.0506 0.0686
Mycobacterium ulcerans beta-lactamase 0.0042 0.1379 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0042 0.1379 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0499 0.0464
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.0798 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0798 0.1154
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.034 0.2015
Loa Loa (eye worm) hypothetical protein 0.0052 0.1758 0.2693
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0043 0.1447 0.2193
Loa Loa (eye worm) hypothetical protein 0.0138 0.5068 0.7998
Mycobacterium tuberculosis Conserved protein 0.0042 0.1379 0.1347
Trichomonas vaginalis DNA helicase recq, putative 0.0015 0.034 0.2015
Leishmania major hypothetical protein, conserved 0.0042 0.1379 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0798 0.1154
Schistosoma mansoni hypothetical protein 0.0019 0.0506 0.1864
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0042 0.1379 1
Loa Loa (eye worm) hypothetical protein 0.017 0.6317 1
Trypanosoma brucei ISWI complex protein 0.0018 0.0489 0.3159
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.2078 0.3205
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.002 0.0541 0.0506
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0798 0.1154
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0043 0.1447 0.2193
Echinococcus multilocularis bloom syndrome protein 0.0027 0.083 0.1204
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0021 0.057 0.21
Brugia malayi PHD-finger family protein 0.003 0.0935 0.1373
Loa Loa (eye worm) hypothetical protein 0.0085 0.3061 0.4781
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0008 0.0078 0.0042
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0042 0.1379 0.1347
Onchocerca volvulus 0.0042 0.1379 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0042 0.1379 0.5076
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0042 0.1379 0.2084
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.1379 1
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.034 0.2015
Trichomonas vaginalis penicillin-binding protein, putative 0.0042 0.1379 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0021 0.057 0.21
Echinococcus granulosus GPCR family 2 0.0019 0.0506 0.0686
Mycobacterium ulcerans hypothetical protein 0.0042 0.1379 1
Mycobacterium tuberculosis Probable esterase LipL 0.0042 0.1379 0.1347
Schistosoma mansoni methyl-cpg binding protein mbd 0.0021 0.057 0.21
Schistosoma mansoni zinc finger protein 0.0018 0.0489 0.18
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0506 0.0686
Trichomonas vaginalis esterase, putative 0.0042 0.1379 1
Trichomonas vaginalis DNA helicase recq1, putative 0.0027 0.083 0.5778
Brugia malayi Bromodomain containing protein 0.0091 0.326 0.51
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0499 0.0464
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0008 0.0078 0.098
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0078 0.0042
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0042 0.1379 0.5076
Brugia malayi beta-lactamase 0.0042 0.1379 0.2084
Trichomonas vaginalis DNA helicase recq, putative 0.0027 0.083 0.5778
Loa Loa (eye worm) hypothetical protein 0.0042 0.1379 0.2084
Mycobacterium ulcerans lipase LipD 0.0042 0.1379 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0798 0.5537
Entamoeba histolytica acyl-coA synthetase, putative 0.0027 0.0798 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0027 0.0798 0.5537
Loa Loa (eye worm) hypothetical protein 0.0027 0.0798 0.1154
Schistosoma mansoni bromodomain containing protein 0.0076 0.2716 1
Mycobacterium tuberculosis Probable lipase LipD 0.0042 0.1379 0.1347
Echinococcus granulosus muscleblind protein 0.017 0.6317 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.1379 0.2084
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0798 0.5537
Mycobacterium ulcerans hypothetical protein 0.0027 0.0798 0.5537
Onchocerca volvulus 0.0042 0.1379 1
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.002 0.0541 0.5
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0499 0.0464
Mycobacterium tuberculosis Conserved protein 0.0042 0.1379 0.1347
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0011 0.0213 0.0215
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0042 0.1379 0.1347
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0798 0.5537
Brugia malayi Bloom's syndrome protein homolog 0.0027 0.083 0.1204
Schistosoma mansoni hypothetical protein 0.0019 0.0506 0.1864
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.0798 1
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0798 0.1154
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0506 0.0686
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0506 0.0686
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0027 0.0798 0.0765
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0011 0.0213 0.0215
Echinococcus granulosus histone lysine methyltransferase setb 0.0021 0.057 0.0789
Onchocerca volvulus 0.0027 0.0798 0.5537
Schistosoma mansoni DNA helicase recq5 0.0011 0.0213 0.0783
Echinococcus multilocularis beta LACTamase domain containing family member 0.0042 0.1379 0.2084
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0024 0.0702 1
Entamoeba histolytica recQ family helicase, putative 0.0015 0.034 0.4262
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0213 0.0215
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0027 0.0798 0.0765
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0027 0.0798 0.5537
Echinococcus multilocularis zinc finger protein 0.0024 0.0688 0.0977
Loa Loa (eye worm) hypothetical protein 0.0042 0.1379 0.2084
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0008 0.0078 0.0567
Schistosoma mansoni hypothetical protein 0.0019 0.0506 0.1864
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0018 0.0489 0.3162
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0008 0.0078 0.0042
Brugia malayi beta-lactamase family protein 0.0042 0.1379 0.2084
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0072 0.255 0.3962
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0018 0.0481 0.3489
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0027 0.0798 0.5537
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0008 0.0078 0.0042
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0798 0.5537
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0078 0.0042
Mycobacterium tuberculosis Probable hydrolase 0.0042 0.1379 0.1347
Mycobacterium tuberculosis Conserved protein 0.0042 0.1379 0.1347
Trypanosoma cruzi ISWI complex protein 0.0018 0.0489 0.3159
Mycobacterium tuberculosis Probable lipase LipE 0.0042 0.1379 0.1347
Trypanosoma brucei hypothetical protein, conserved 0.0042 0.1379 1
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0027 0.0825 0.1197
Loa Loa (eye worm) hypothetical protein 0.017 0.6317 1
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.1351 0.2039
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0008 0.0078 0.0042
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0499 0.0464
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0008 0.0078 0.0042
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0506 0.0686
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.2078 0.3205
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.2078 0.3205
Schistosoma mansoni DNA helicase recq1 0.0011 0.0213 0.0783
Giardia lamblia Sgs1 DNA helicase, putative 0.0011 0.0213 0.5
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.034 0.2015
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0213 0.1542
Loa Loa (eye worm) hypothetical protein 0.0042 0.1379 0.2084
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0008 0.0078 0.0042
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.1379 1
Plasmodium vivax acyl-CoA synthetase, putative 0.002 0.0541 0.3556
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0011 0.0213 0.2155
Echinococcus multilocularis muscleblind protein 0.017 0.6317 1
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.1379 1
Trypanosoma cruzi ISWI complex protein 0.0018 0.0489 0.3159
Loa Loa (eye worm) hypothetical protein 0.0011 0.0213 0.0215
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0011 0.0213 0.0215
Echinococcus granulosus fetal alzheimer antigen falz 0.0027 0.0825 0.1197
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0027 0.0798 0.5537
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0042 0.1379 0.1347
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0027 0.0798 0.5537
Loa Loa (eye worm) PHD-finger family protein 0.0025 0.0737 0.1055
Echinococcus multilocularis muscleblind protein 1 0.017 0.6317 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.167 0.2551
Loa Loa (eye worm) hypothetical protein 0.0042 0.1379 0.2084
Schistosoma mansoni hypothetical protein 0.0018 0.0489 0.18
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0021 0.057 0.0789
Loa Loa (eye worm) beta-lactamase 0.0042 0.1379 0.2084
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0072 0.255 0.3962
Mycobacterium leprae Probable lipase LipE 0.0042 0.1379 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0541 0.0741
Plasmodium falciparum acyl-CoA synthetase 0.002 0.0541 0.7412
Loa Loa (eye worm) hypothetical protein 0.0019 0.0506 0.0686
Echinococcus granulosus methyl CpG binding domain protein 2 0.0021 0.057 0.0789
Mycobacterium leprae conserved hypothetical protein 0.0042 0.1379 1
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.1379 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0798 0.5537
Echinococcus granulosus bloom syndrome protein 0.0027 0.083 0.1204
Loa Loa (eye worm) hypothetical protein 0.002 0.0541 0.0741
Onchocerca volvulus 0.0042 0.1379 1
Schistosoma mansoni blooms syndrome DNA helicase 0.0022 0.0609 0.2241
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0011 0.0213 0.0215
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0506 0.0686
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0008 0.0078 0.0042
Schistosoma mansoni hypothetical protein 0.0025 0.0737 0.2712
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.1379 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.1351 0.2039
Brugia malayi beta-lactamase family protein 0.0042 0.1379 0.2084
Loa Loa (eye worm) hypothetical protein 0.002 0.0541 0.0741
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0506 0.0686
Loa Loa (eye worm) hypothetical protein 0.002 0.0541 0.0741
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0042 0.1379 0.2084
Toxoplasma gondii propionate-CoA ligase 0.0008 0.0078 0.0567
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0798 0.5537
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0213 0.0215
Schistosoma mansoni hypothetical protein 0.0041 0.1351 0.4973
Loa Loa (eye worm) RecQ helicase 0.0027 0.083 0.1204
Loa Loa (eye worm) hypothetical protein 0.0042 0.1379 0.2084
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0213 0.1542
Echinococcus granulosus zinc finger protein 0.0024 0.0688 0.0977
Schistosoma mansoni zinc finger protein 0.0024 0.0688 0.2531
Schistosoma mansoni hypothetical protein 0.0019 0.0506 0.1864
Loa Loa (eye worm) bromodomain containing protein 0.0021 0.0599 0.0834
Loa Loa (eye worm) hypothetical protein 0.002 0.0541 0.0741
Echinococcus granulosus beta LACTamase domain containing family member 0.0042 0.1379 0.2084
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0027 0.0798 0.5537
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0008 0.0078 0.0567
Plasmodium vivax hypothetical protein, conserved 0.0042 0.1379 1
Brugia malayi Bromodomain containing protein 0.0046 0.1557 0.2369
Loa Loa (eye worm) hypothetical protein 0.0021 0.057 0.0789
Brugia malayi Muscleblind-like protein 0.017 0.6317 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0021 0.057 0.0789
Schistosoma mansoni acetyl-CoA synthetase 0.0008 0.0078 0.0288
Loa Loa (eye worm) hypothetical protein 0.0046 0.156 0.2375
Mycobacterium ulcerans esterase/lipase LipP 0.0042 0.1379 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.002 0.0541 0.3556
Leishmania major hypothetical protein, conserved 0.0018 0.0489 0.3159
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0011 0.0213 0.0215
Toxoplasma gondii ABC1 family protein 0.0042 0.1379 1
Schistosoma mansoni methyl-cpg binding protein mbd 0.0021 0.057 0.21
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0798 0.1154

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 7.0795 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 19.9526 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 32.6427 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 79.4328 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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