TDR Targets

Basic information

Technical information

TDR Targets ID: 1228122
Name: N-(1-cyclopropylethyl-(phenylmethyl)carbamoyl )-4-fluorobenzamide
MW: 340.391 | Formula: C20H21FN2O2
H donors: 1 H acceptors: 2 LogP: 3.76 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: Fc1ccc(cc1)C(=O)NC(=O)N(C(C1CC1)C)Cc1ccccc1
InChi: 1S/C20H21FN2O2/c1-14(16-7-8-16)23(13-15-5-3-2-4-6-15)20(25)22-19(24)17-9-11-18(21)12-10-17/h2-6,9-12,14,16H,7-8,13H2,1H3,(H,22,24,25)
InChiKey: AIBBTGCHTUPDJO-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-(1-cyclopropylethyl-(phenylmethyl)carbamoyl)-4-fluoro-benzamide
N-[(1-cyclopropylethyl-(phenylmethyl)amino)-oxomethyl]-4-fluorobenzamide
N-(benzyl-(1-cyclopropylethyl)carbamoyl)-4-fluoro-benzamide
MLS001005637
SMR000348955
Oprea1_476409
T0400-2670

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Toxoplasma gondii	Alpha-galactosidase	0.0015	0.0038	0.0107
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0019	0.0137	0.0388
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0032	0.0402	0.0918
Mycobacterium leprae	conserved hypothetical protein	0.0079	0.1349	0.3817
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0402	0.0918
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0016	0.0078	0.0094
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0054	0.0123
Brugia malayi	nuclear receptor RXR	0.0015	0.0054	0.0123
Echinococcus multilocularis	polycomb protein SCMH1	0.005	0.0756	0.091
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0019	0.0137	0.0388
Echinococcus granulosus	beta LACTamase domain containing family member	0.0079	0.1349	0.1623
Schistosoma mansoni	hypothetical protein	0.0047	0.0689	0.083
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0019	0.0137	0.1017
Brugia malayi	beta-lactamase family protein	0.0079	0.1349	0.3078
Schistosoma mansoni	hypothetical protein	0.0036	0.0467	0.0562
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0015	0.0054	0.0123
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0019	0.0137	0.1017
Brugia malayi	hypothetical protein	0.0052	0.0806	0.184
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0015	0.0054	0.0401
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0054	0.0123
Echinococcus granulosus	histone acetyltransferase MYST2	0.0057	0.0896	0.1079
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0054	0.0123
Onchocerca volvulus		0.0079	0.1349	1
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0015	0.0051	0.0061
Brugia malayi	Nuclear hormone receptor E75	0.0015	0.0054	0.0123
Brugia malayi	steroid hormone receptor	0.0032	0.0402	0.0918
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0402	0.0918
Brugia malayi	mbt repeat family protein	0.005	0.0756	0.1726
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0054	0.0123
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0019	0.0137	0.0388
Onchocerca volvulus		0.0031	0.0381	0.2825
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0079	0.1349	0.1349
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0032	0.0402	0.0484
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0019	0.0137	0.0313
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0032	0.0402	0.0484
Schistosoma mansoni	nuclear hormone receptor	0.0015	0.0054	0.0065
Schistosoma mansoni	lamin	0.0031	0.0381	0.0458
Loa Loa (eye worm)	steroid hormone receptor	0.0032	0.0402	0.0918
Trichomonas vaginalis	D-aminoacylase, putative	0.0079	0.1349	0.3567
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0369	0.0843
Wolbachia endosymbiont of Brugia malayi	enoyl-ACP reductase	0.0187	0.3533	1
Mycobacterium tuberculosis	NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase)	0.0187	0.3533	0.3533
Brugia malayi	hypothetical protein	0.0228	0.4382	1
Schistosoma mansoni	lamin	0.0031	0.0381	0.0458
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0032	0.0402	0.0484
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0032	0.0402	0.0484
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0079	0.1349	0.1349
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0016	0.0078	0.0179
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0015	0.0054	0.0065
Schistosoma mansoni	nuclear receptor	0.0015	0.0054	0.0065
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0032	0.0402	0.0918
Mycobacterium leprae	NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE)	0.0187	0.3533	1
Trichomonas vaginalis	penicillin-binding protein, putative	0.0079	0.1349	0.3567
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0019	0.0137	1
Schistosoma mansoni	nuclear hormone receptor	0.0015	0.0054	0.0065
Onchocerca volvulus		0.0032	0.0402	0.2982
Mycobacterium tuberculosis	Conserved protein	0.0079	0.1349	0.1349
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0079	0.1349	0.1349
Trypanosoma brucei	PAB1-binding protein , putative	0.0052	0.0806	0.598
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0015	0.0054	0.0065
Schistosoma mansoni	sex comb on midleg homolog	0.005	0.0756	0.091
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0019	0.0137	0.0388
Schistosoma mansoni	nuclear hormone receptor	0.0032	0.0402	0.0484
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0102	0.1824	0.2194
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0017	0.0091	0.011
Echinococcus multilocularis	histone acetyltransferase MYST2	0.0057	0.0896	0.1079
Mycobacterium leprae	Probable lipase LipE	0.0079	0.1349	0.3817
Onchocerca volvulus		0.0031	0.0381	0.2825
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0032	0.0402	0.0918
Brugia malayi	hypothetical protein	0.0015	0.0054	0.0123
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0032	0.0402	0.0918
Brugia malayi	Latrophilin receptor protein 2	0.0016	0.0078	0.0179
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0016	0.0078	0.0179
Brugia malayi	cytoplasmic intermediate filament protein	0.0017	0.0085	0.0194
Trichomonas vaginalis	D-aminoacylase, putative	0.0079	0.1349	0.3567
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0032	0.0402	0.0918
Schistosoma mansoni	coup transcription factor	0.0032	0.0402	0.0484
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0402	0.0918
Onchocerca volvulus		0.003	0.0345	0.2557
Leishmania major	hypothetical protein, conserved	0.0052	0.0806	0.598
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0054	0.0123
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0467	0.1066
Plasmodium falciparum	ataxin-2 like protein, putative	0.0052	0.0806	0.2282
Echinococcus multilocularis	cpg binding protein	0.0031	0.0379	0.0456
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0015	0.0038	0.0045
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0896	0.2046
Brugia malayi	mbt repeat family protein	0.005	0.0756	0.1726
Brugia malayi	hypothetical protein	0.0017	0.0091	0.0209
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0032	0.0402	0.0484
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0015	0.0054	0.0065
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0068	0.1131	0.136
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1349	0.3078
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0032	0.0402	0.0484
Onchocerca volvulus		0.0079	0.1349	1
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0091	0.0209
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0019	0.0137	0.0137
Loa Loa (eye worm)	hypothetical protein	0.0068	0.1131	0.258
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0806	0.184
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0023	0.022	0.0265
Mycobacterium tuberculosis	Conserved protein	0.0079	0.1349	0.1349
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0079	0.1349	0.1623
Trichomonas vaginalis	penicillin-binding protein, putative	0.0079	0.1349	0.3567
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.02	0.3814	0.459
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0078	0.0179
Echinococcus multilocularis	GPCR, family 2	0.0016	0.0078	0.0094
Brugia malayi	intermediate filament protein	0.0031	0.0381	0.0869
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0039	0.009
Loa Loa (eye worm)	hypothetical protein	0.0228	0.4382	1
Trypanosoma cruzi	PAB1-binding protein , putative	0.0052	0.0806	0.598
Schistosoma mansoni	nuclear receptor nhr-48	0.0015	0.0054	0.0065
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0032	0.0402	0.2982
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0402	0.0918
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0032	0.0402	0.0484
Onchocerca volvulus		0.0015	0.0054	0.0401
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0032	0.0402	0.0484
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0054	0.0123
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0032	0.0402	0.0918
Brugia malayi	Nuclear hormone receptor E75	0.0015	0.0054	0.0123
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0019	0.0137	0.0165
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0102	0.1824	0.2194
Loa Loa (eye worm)	DR-78	0.0015	0.0054	0.0123
Echinococcus granulosus	intermediate filament protein	0.0031	0.0381	0.0458
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0051	0.0116
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0015	0.0054	0.0065
Brugia malayi	exodeoxyribonuclease III family protein	0.0019	0.0137	0.0313
Schistosoma mansoni	hypothetical protein	0.0016	0.0078	0.0094
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0402	0.0918
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0091	0.0209
Onchocerca volvulus	Protein ultraspiracle homolog	0.0032	0.0402	0.2982
Echinococcus multilocularis	lamin dm0	0.0031	0.0381	0.0458
Trichomonas vaginalis	hypothetical protein	0.0187	0.3533	1
Schistosoma mansoni	survival motor neuron protein	0.0047	0.0689	0.083
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0015	0.0054	0.0065
Toxoplasma gondii	melibiase subfamily protein	0.0102	0.1824	0.5161
Schistosoma mansoni	scm-relatedprotein containing 4 mbt domains (sfmbt)	0.005	0.0756	0.091
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0015	0.0054	0.0065
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0015	0.0054	0.0065
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1349	0.3078
Brugia malayi	ecdysone receptor	0.0015	0.0054	0.0123
Trypanosoma cruzi	hypothetical protein, conserved	0.0079	0.1349	1
Loa Loa (eye worm)	intermediate filament protein	0.0031	0.0381	0.0869
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0056	0.0883	0.2499
Mycobacterium tuberculosis	Probable lipase LipE	0.0079	0.1349	0.1349
Schistosoma mansoni	hypothetical protein	0.0422	0.831	1
Schistosoma mansoni	cpg binding protein	0.003	0.0345	0.0415
Mycobacterium tuberculosis	Probable esterase LipL	0.0079	0.1349	0.1349
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1349	0.3078
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0031	0.0381	0.0869
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0032	0.0402	0.0484
Schistosoma mansoni	RAR-like nuclear receptor	0.0032	0.0402	0.0484
Brugia malayi	orphan nuclear receptor NR2E1	0.0015	0.0054	0.0123
Brugia malayi	Melibiase family protein	0.0068	0.1131	0.258
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0019	0.0137	0.5
Chlamydia trachomatis	enoyl-acyl-carrier protein reductase	0.0187	0.3533	1
Echinococcus granulosus	thyroid hormone receptor alpha	0.0015	0.0054	0.0065
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0032	0.0402	0.0484
Echinococcus multilocularis	Glycoside hydrolase, family 27	0.0102	0.1824	0.2194
Loa Loa (eye worm)	mbt repeat family protein	0.005	0.0756	0.1726
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0047	0.0689	0.1573
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0032	0.0402	0.0484
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0079	0.1349	0.3078
Loa Loa (eye worm)	nuclear hormone receptor	0.0015	0.0054	0.0123
Schistosoma mansoni	nuclear receptor	0.0015	0.0054	0.0065
Echinococcus granulosus	cpg binding protein	0.0031	0.0379	0.0456
Schistosoma mansoni	ap endonuclease	0.0019	0.0137	0.0165
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0032	0.0402	0.0918
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0017	0.0091	0.011
Brugia malayi	nuclear receptor NHR-88	0.0015	0.0054	0.0123
Schistosoma mansoni	thyroid hormone receptor	0.0032	0.0402	0.0484
Brugia malayi	tailless protein	0.0015	0.0054	0.0123
Echinococcus granulosus	SAM and MBT domain containing protein	0.005	0.0756	0.091
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0015	0.0051	0.0061
Echinococcus granulosus	ecdysone induced protein 78C	0.0032	0.0402	0.0484
Plasmodium falciparum	enoyl-acyl carrier reductase	0.0187	0.3533	1
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0039	0.009
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0019	0.0137	0.5
Brugia malayi	Nuclear hormone receptor-like 1	0.0017	0.0091	0.0209
Echinococcus multilocularis	SAM and MBT domain containing protein	0.005	0.0756	0.091
Schistosoma mansoni	intermediate filament proteins	0.0031	0.0381	0.0458
Echinococcus granulosus	dnaJ subfamily B	0.0422	0.831	1
Schistosoma mansoni	ap endonuclease	0.0019	0.0137	0.0165
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0054	0.0123
Schistosoma mansoni	thyroid hormone receptor	0.0032	0.0402	0.0484
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0102	0.1824	0.2194
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0017	0.0085	0.0194
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0032	0.0402	0.0484
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0054	0.0123
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0016	0.0078	0.0094
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0023	0.022	0.0265
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0032	0.0402	0.0918
Mycobacterium ulcerans	lipase LipD	0.0079	0.1349	0.3817
Onchocerca volvulus	Polycomb protein Sfmbt homolog	0.005	0.0756	0.5607
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0054	0.0123
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0032	0.0402	0.0918
Onchocerca volvulus		0.005	0.0756	0.5607
Brugia malayi	hypothetical protein	0.0017	0.0091	0.0209
Mycobacterium tuberculosis	Probable hydrolase	0.0079	0.1349	0.1349
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0015	0.0054	0.0065
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0079	0.1349	0.1623
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0032	0.0402	0.0918
Brugia malayi	nuclear hormone receptor	0.0015	0.0054	0.0123
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0068	0.1131	0.136
Schistosoma mansoni	hypothetical protein	0.0016	0.0078	0.0094
Mycobacterium ulcerans	esterase/lipase LipP	0.0079	0.1349	0.3817
Brugia malayi	hypothetical protein	0.0034	0.043	0.0981
Mycobacterium ulcerans	hypothetical protein	0.0079	0.1349	0.3817
Toxoplasma gondii	exonuclease III APE	0.0019	0.0137	0.0388
Loa Loa (eye worm)	hypothetical protein	0.005	0.0756	0.1726
Brugia malayi	CXXC zinc finger family protein	0.003	0.0345	0.0787
Brugia malayi	nuclear receptor NHR-67	0.0015	0.0054	0.0123
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0079	0.1349	0.3078
Onchocerca volvulus		0.0047	0.0689	0.5112
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0032	0.0402	0.0484
Onchocerca volvulus	Bile acid receptor homolog	0.0032	0.0402	0.2982
Onchocerca volvulus		0.0015	0.0054	0.0401
Schistosoma mansoni	myelin transcription factor 1 myt1	0.0057	0.0896	0.1079
Mycobacterium tuberculosis	Probable lipase LipD	0.0079	0.1349	0.1349
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0016	0.0078	0.0094
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0063	0.1019	0.1226
Brugia malayi	photoreceptor-specific nuclear receptor	0.0032	0.0402	0.0918
Schistosoma mansoni	zinc finger protein	0.0015	0.0054	0.0065
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0032	0.0402	0.0484
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0032	0.0402	0.0918
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0032	0.0402	0.0918
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0032	0.0402	0.0484
Onchocerca volvulus		0.0079	0.1349	1
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0032	0.0402	0.0918
Echinococcus multilocularis	dnaJ subfamily B	0.0422	0.831	1
Echinococcus granulosus	FTZ F1 alpha	0.0032	0.0402	0.0484
Brugia malayi	nuclear receptor NHR-88	0.0032	0.0402	0.0918
Brugia malayi	conserved hypotetical protein	0.0015	0.0054	0.0123
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0802	0.183
Trypanosoma cruzi	hypothetical protein, conserved	0.0079	0.1349	1
Schistosoma mansoni	retinoic acid receptor RXR	0.0032	0.0402	0.0484
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0032	0.0402	0.0918
Mycobacterium ulcerans	enoyl-(acyl carrier protein) reductase	0.0187	0.3533	1
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1349	0.3078
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0402	0.0918
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0102	0.1824	0.2194
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0019	0.0137	0.1017
Brugia malayi	Nuclear hormone receptor-like 1	0.0032	0.0402	0.0918
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0032	0.0402	0.0484
Echinococcus multilocularis	survival motor neuron protein 1	0.0228	0.4382	0.5273
Leishmania major	hypothetical protein, conserved	0.0079	0.1349	1
Schistosoma mansoni	hypothetical protein	0.0023	0.022	0.0265
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0381	0.0869
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0079	0.1349	0.1623
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0054	0.0123
Toxoplasma gondii	enoyl-acyl carrier reductase ENR	0.0187	0.3533	1
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0054	0.0123
Brugia malayi	Steroid receptor seven-up type 2	0.0032	0.0402	0.0918
Echinococcus granulosus	nuclear receptor nhr 48	0.0015	0.0054	0.0065
Plasmodium falciparum	ataxin-2 like protein, putative	0.0052	0.0806	0.2282
Schistosoma mansoni	sex comb on midleg homolog	0.005	0.0756	0.091
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0052	0.0802	0.183
Brugia malayi	hypothetical protein	0.0015	0.0054	0.0123
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0091	0.0209
Echinococcus multilocularis	ecdysone induced protein 78C	0.0032	0.0402	0.0484
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0032	0.0402	0.0918
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0032	0.0402	0.0484
Trichomonas vaginalis	alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative	0.0068	0.1131	0.2925
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0032	0.0402	0.0484
Brugia malayi	beta-lactamase	0.0079	0.1349	0.3078
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0015	0.0054	0.0065
Brugia malayi	nuclear hormone receptor	0.0032	0.0402	0.0918
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0032	0.0402	0.0484
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0015	0.0054	0.0123
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0017	0.0091	0.0209
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0052	0.0802	0.183
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0015	0.0054	0.0401
Loa Loa (eye worm)	CXXC zinc finger family protein	0.003	0.0345	0.0787
Mycobacterium ulcerans	beta-lactamase	0.0079	0.1349	0.3817
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0091	0.0209
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0402	0.0918
Trichomonas vaginalis	esterase, putative	0.0079	0.1349	0.3567
Brugia malayi	nuclear receptor RXR	0.0017	0.0091	0.0209
Brugia malayi	Intermediate filament tail domain containing protein	0.0031	0.0381	0.0869
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0032	0.0402	0.0918
Toxoplasma gondii	LsmAD domain-containing protein	0.0052	0.0806	0.2282
Echinococcus multilocularis	suppression of tumorigenicity 18 protein	0.0057	0.0896	0.1079
Echinococcus multilocularis	nuclear receptor nhr 48	0.0015	0.0054	0.0065
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0016	0.0078	0.0094
Trypanosoma cruzi	PAB1-binding protein , putative	0.0052	0.0806	0.598
Mycobacterium tuberculosis	Conserved protein	0.0079	0.1349	0.1349
Trichomonas vaginalis	D-aminoacylase, putative	0.0079	0.1349	0.3567
Echinococcus granulosus	suppression of tumorigenicity 18 protein	0.0057	0.0896	0.1079
Brugia malayi	Nuclear hormone receptor-like 1	0.0017	0.0091	0.0209
Schistosoma mansoni	hypothetical protein	0.0307	0.598	0.7196
Schistosoma mansoni	cpg binding protein	0.0031	0.0379	0.0456
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0054	0.0123
Brugia malayi	C2-HC type zinc finger protein C.e-MyT1	0.0057	0.0896	0.2046
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0019	0.0137	0.1017
Brugia malayi	nuclear hormone receptor family member odr-7	0.0015	0.0054	0.0123
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0054	0.0123
Plasmodium vivax	hypothetical protein, conserved	0.0079	0.1349	0.3817
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0015	0.0054	0.0065
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1349	0.3078
Brugia malayi	latrophilin 2 splice variant baaae	0.0036	0.0467	0.1066
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0091	0.0209
Schistosoma mansoni	hypothetical protein	0.0016	0.0078	0.0094
Echinococcus multilocularis	Alpha N acetylgalactosaminidase	0.0102	0.1824	0.2194
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0032	0.0402	0.0918
Echinococcus granulosus	polycomb protein SCMH1	0.005	0.0756	0.091
Loa Loa (eye worm)	beta-lactamase	0.0079	0.1349	0.3078
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0017	0.0091	0.011
Echinococcus multilocularis	lamin	0.0031	0.0381	0.0458
Toxoplasma gondii	ABC1 family protein	0.0079	0.1349	0.3817
Echinococcus multilocularis	musashi	0.0031	0.0381	0.0458
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0402	0.0918
Loa Loa (eye worm)	MBCTL1	0.0057	0.0896	0.2046
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0017	0.0091	0.011
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0015	0.0054	0.0123
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0032	0.0402	0.0484
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.02	0.3814	0.459
Trypanosoma brucei	hypothetical protein, conserved	0.0079	0.1349	1
Brugia malayi	beta-lactamase family protein	0.0079	0.1349	0.3078
Echinococcus granulosus	lamin	0.0031	0.0381	0.0458
Echinococcus granulosus	survival motor neuron protein 1	0.0228	0.4382	0.5273
Echinococcus granulosus	Alpha N acetylgalactosaminidase	0.0102	0.1824	0.2194
Echinococcus granulosus	GPCR family 2	0.0016	0.0078	0.0094
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0079	0.1349	0.3817
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0032	0.0402	0.0918
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1349	0.3078
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0015	0.0054	0.0065
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0032	0.0402	0.0918
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0015	0.0054	0.0123
Schistosoma mansoni	cpg binding protein	0.0031	0.0379	0.0456
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0052	0.0802	0.183
Plasmodium vivax	enoyl-acyl carrier protein reductase	0.0187	0.3533	1
Brugia malayi	ecdysteroid receptor	0.0032	0.0402	0.0918
Echinococcus multilocularis	FTZ F1 alpha	0.0032	0.0402	0.0484
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0032	0.0402	0.0484
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0019	0.0137	0.0165
Schistosoma mansoni	hypothetical protein	0.0016	0.0078	0.0094
Plasmodium vivax	ataxin-2 like protein, putative	0.0052	0.0806	0.2282
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0032	0.0402	0.0918
Echinococcus granulosus	lamin dm0	0.0031	0.0381	0.0458

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	11.2202 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249]	ChEMBL.	No reference
Potency (functional)	14.7157 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	= 25.1189 um	PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))]	ChEMBL.	No reference
Potency (functional)	25.1189 uM	PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23
Homo sapiens	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1344733

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1228122