Detailed information for compound 1229550

Basic information

Technical information
  • TDR Targets ID: 1229550
  • Name: 6-hydroxy-1-(2-methylphenyl)-2-(2-morpholin-4 -yl-2-oxoethyl)sulfanylpyrimidin-4-one
  • MW: 361.415 | Formula: C17H19N3O4S
  • H donors: 1 H acceptors: 3 LogP: 1.33 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(N1CCOCC1)CSc1nc(=O)cc(n1c1ccccc1C)O
  • InChi: 1S/C17H19N3O4S/c1-12-4-2-3-5-13(12)20-15(22)10-14(21)18-17(20)25-11-16(23)19-6-8-24-9-7-19/h2-5,10,22H,6-9,11H2,1H3
  • InChiKey: LOHHDZWKMGQUIJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 6-hydroxy-1-(2-methylphenyl)-2-(2-morpholino-2-oxo-ethyl)sulfanyl-pyrimidin-4-one
  • 6-hydroxy-1-(2-methylphenyl)-2-[(2-morpholino-2-oxoethyl)thio]-4-pyrimidinone
  • 6-hydroxy-2-[(2-keto-2-morpholino-ethyl)thio]-1-(2-methylphenyl)pyrimidin-4-one
  • 6-hydroxy-1-(2-methylphenyl)-2-(2-morpholin-4-yl-2-oxo-ethyl)sulfanyl-pyrimidin-4-one
  • 6-hydroxy-3-(2-methylphenyl)-2-{[2-(4-morpholinyl)-2-oxoethyl]thio}-4(3H)-pyrimidinone
  • MLS000058894
  • SMR000069463

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.2236 0.2236
Schistosoma mansoni inositol monophosphatase 0.0037 0.1707 0.1681
Echinococcus granulosus jumonji domain containing protein 0.0039 0.1826 0.1826
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.0837 0.4808
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0018 0.0549 0.052
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.0837 0.4808
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0011 0.0163 0.1163
Plasmodium falciparum phd finger protein, putative 0.0028 0.1168 1
Schistosoma mansoni hypothetical protein 0.0015 0.0397 0.0368
Echinococcus multilocularis lysine specific demethylase 6a 0.0009 0.0031 0.0031
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.1168 0.3387
Echinococcus granulosus acetylcholinesterase 0.0065 0.3376 0.3376
Schistosoma mansoni gliotactin 0.0011 0.0145 0.0115
Echinococcus multilocularis PHD finger protein rhinoceros 0.0028 0.1168 0.1168
Loa Loa (eye worm) acetylcholinesterase 1 0.0065 0.3376 0.4976
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0126 0.0126
Loa Loa (eye worm) hypothetical protein 0.0033 0.1452 0.2114
Loa Loa (eye worm) hypothetical protein 0.0011 0.0145 0.0171
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.1707 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.1639 0.1613
Loa Loa (eye worm) TAR-binding protein 0.0061 0.3138 0.4622
Schistosoma mansoni jumonji domain containing protein 0.0074 0.3859 0.384
Echinococcus granulosus peregrin 0.0028 0.1168 0.1168
Schistosoma mansoni hypothetical protein 0.0177 1 1
Brugia malayi AF-10 protein 0.0009 0.0038 0.001
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0837 0.4427
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0028 0.1168 0.1141
Loa Loa (eye worm) hypothetical protein 0.0015 0.0397 0.0545
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.0837 0.4808
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0837 0.1199
Schistosoma mansoni hypothetical protein 0.0028 0.1168 0.1141
Loa Loa (eye worm) jmjC domain-containing protein 0.0058 0.2957 0.4352
Brugia malayi Carboxylesterase family protein 0.0011 0.0145 0.0171
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.3855 0.3836
Echinococcus granulosus lysine specific demethylase 6a 0.0009 0.0031 0.0031
Echinococcus multilocularis carboxylesterase 5A 0.0065 0.3376 0.3376
Brugia malayi Carboxylesterase family protein 0.0011 0.0145 0.0171
Toxoplasma gondii exonuclease III APE 0.0023 0.0837 0.24
Loa Loa (eye worm) hypothetical protein 0.0011 0.0145 0.0171
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0061 0.3138 0.4622
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0837 0.4427
Plasmodium vivax hypothetical protein, conserved 0.0028 0.1168 1
Echinococcus granulosus carboxylesterase 5A 0.0065 0.3376 0.3376
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0009 0.0038 0.0041
Echinococcus multilocularis neuroligin 0.0011 0.0145 0.0145
Schistosoma mansoni hypothetical protein 0.0015 0.0397 0.0368
Echinococcus granulosus phd:f box containing protein 0.0009 0.0031 0.0031
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0011 0.0145 0.0145
Schistosoma mansoni hypothetical protein 0.0033 0.1452 0.1426
Brugia malayi CXXC zinc finger family protein 0.0035 0.1547 0.2256
Brugia malayi PHD-finger family protein 0.0028 0.1168 0.1692
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.2361 0.3466
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.2236 0.2236
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0009 0.0038 0.002
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.1639 0.1613
Schistosoma mansoni cpg binding protein 0.0037 0.1665 0.1639
Loa Loa (eye worm) MH2 domain-containing protein 0.0122 0.6753 1
Echinococcus granulosus jumonji domain containing 1A 0.0009 0.0031 0.0031
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0397 0.0545
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0011 0.0145 0.0115
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0109 0.5954 0.5954
Schistosoma mansoni hypothetical protein 0.0015 0.0397 0.0368
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0065 0.3376 0.3355
Brugia malayi hypothetical protein 0.0109 0.5954 0.8811
Echinococcus granulosus BC026374 protein S09 family 0.0011 0.0145 0.0145
Onchocerca volvulus Alhambra homolog 0.0028 0.1168 0.7297
Echinococcus multilocularis jumonji domain containing 1A 0.0009 0.0031 0.0031
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.1707 0.1707
Brugia malayi Carboxylesterase family protein 0.0065 0.3376 0.4976
Echinococcus multilocularis phd:f box containing protein 0.0009 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0065 0.3376 0.4976
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0011 0.0148 0.0148
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.1707 0.17
Loa Loa (eye worm) hypothetical protein 0.0011 0.0145 0.0171
Schistosoma mansoni hypothetical protein 0.0177 1 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.0023 0.0837 0.5
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.1707 1
Brugia malayi PHD-finger family protein 0.0011 0.0155 0.0185
Schistosoma mansoni neuroligin 3 (S09 family) 0.0011 0.0145 0.0115
Schistosoma mansoni acetylcholinesterase 0.0011 0.0145 0.0115
Giardia lamblia PHD finger protein 15 0.0028 0.1168 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.1547 0.2256
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.2236 0.2212
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0093 0.499 0.499
Plasmodium vivax hypothetical protein, conserved 0.0011 0.0163 0.1163
Echinococcus multilocularis BC026374 protein (S09 family) 0.0011 0.0145 0.0145
Brugia malayi Carboxylesterase family protein 0.0011 0.0145 0.0171
Loa Loa (eye worm) hypothetical protein 0.0011 0.0145 0.0171
Schistosoma mansoni tar DNA-binding protein 0.0061 0.3138 0.3117
Loa Loa (eye worm) hypothetical protein 0.0011 0.0145 0.0171
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0023 0.0837 0.4808
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0837 0.7085
Schistosoma mansoni hypothetical protein 0.0015 0.0397 0.0368
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0837 0.0837
Loa Loa (eye worm) carboxylesterase 0.0065 0.3376 0.4976
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.2236 0.2212
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.1707 1
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.1707 1
Schistosoma mansoni ap endonuclease 0.0023 0.0837 0.0808
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.2236 0.2212
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.1707 1
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.1168 0.3387
Loa Loa (eye worm) transcription factor SMAD2 0.0122 0.6753 1
Schistosoma mansoni tar DNA-binding protein 0.0061 0.3138 0.3117
Brugia malayi jmjC domain containing protein 0.0093 0.499 0.7377
Brugia malayi RNA recognition motif domain containing protein 0.0061 0.3138 0.4622
Schistosoma mansoni transcription factor LCR-F1 0.0109 0.5954 0.5941
Schistosoma mansoni hypothetical protein 0.0009 0.0038 0.0007
Brugia malayi Carboxylesterase family protein 0.0011 0.0145 0.0171
Loa Loa (eye worm) hypothetical protein 0.0065 0.3376 0.4976
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0023 0.0837 0.5202
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0397 0.0545
Echinococcus multilocularis JmjC domain containing protein 4 0.0009 0.0031 0.0031
Echinococcus granulosus neuroligin 0.0011 0.0145 0.0145
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.2361 0.3466
Echinococcus granulosus JmjC domain containing protein 4 0.0009 0.0031 0.0031
Brugia malayi hypothetical protein 0.0011 0.0145 0.0171
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0837 0.1199
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0011 0.0145 0.0115
Echinococcus multilocularis acetylcholinesterase 0.0065 0.3376 0.3376
Onchocerca volvulus 0.0035 0.1547 1
Entamoeba histolytica hypothetical protein 0.0109 0.5954 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0036 0.1639 0.2392
Entamoeba histolytica hypothetical protein 0.0109 0.5954 1
Brugia malayi MH2 domain containing protein 0.0122 0.6753 1
Brugia malayi RNA binding protein 0.0061 0.3138 0.4622
Schistosoma mansoni tar DNA-binding protein 0.0061 0.3138 0.3117
Schistosoma mansoni inositol monophosphatase 0.0037 0.1707 0.1681
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.1474 1
Echinococcus multilocularis tar DNA binding protein 0.0061 0.3138 0.3138
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.1707 0.1707
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.1452 0.2114
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.1707 0.4991
Schistosoma mansoni cpg binding protein 0.0037 0.1665 0.1639
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.2236 0.2236
Loa Loa (eye worm) hypothetical protein 0.0011 0.0145 0.0171
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0009 0.0038 0.0041
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.2361 0.3466
Echinococcus multilocularis cpg binding protein 0.0037 0.1665 0.1665
Echinococcus granulosus PHD finger protein rhinoceros 0.0028 0.1168 0.1168
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0011 0.0145 0.0115
Schistosoma mansoni tar DNA-binding protein 0.0061 0.3138 0.3117
Echinococcus multilocularis lysine specific demethylase 5A 0.0034 0.1522 0.1522
Loa Loa (eye worm) inositol-1 0.0037 0.1707 0.2493
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0837 0.0837
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0397 0.0397
Schistosoma mansoni tar DNA-binding protein 0.0061 0.3138 0.3117
Echinococcus granulosus lysine specific demethylase 5A 0.0036 0.1639 0.1639
Loa Loa (eye worm) hypothetical protein 0.0011 0.0155 0.0185
Echinococcus multilocularis jumonji domain containing protein 0.0039 0.1826 0.1826
Brugia malayi Bromodomain containing protein 0.0028 0.1168 0.1692
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0011 0.0148 0.0148
Brugia malayi Inositol-1 0.0037 0.1707 0.2493
Loa Loa (eye worm) PHD-finger family protein 0.0028 0.1168 0.1692
Echinococcus granulosus GPCR family 2 0.0015 0.0397 0.0397
Echinococcus multilocularis GPCR, family 2 0.0015 0.0397 0.0397
Loa Loa (eye worm) hypothetical protein 0.0028 0.1168 0.1692
Loa Loa (eye worm) hypothetical protein 0.0011 0.0145 0.0171
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0023 0.0837 0.4427
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.1707 1
Schistosoma mansoni cpg binding protein 0.0035 0.1547 0.1521
Echinococcus granulosus para nitrobenzyl esterase 0.0011 0.0145 0.0145
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0093 0.499 0.499
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0397 0.0545
Schistosoma mansoni BC026374 protein (S09 family) 0.0011 0.0145 0.0115
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.1474 0.5
Entamoeba histolytica hypothetical protein 0.0109 0.5954 1
Loa Loa (eye worm) carboxylesterase 0.0011 0.0145 0.0171
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0397 0.0397
Brugia malayi TAR-binding protein 0.0061 0.3138 0.4622
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0397 0.0397
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.1707 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0126 0.0126
Brugia malayi jmjC domain containing protein 0.0036 0.1639 0.2392
Loa Loa (eye worm) hypothetical protein 0.0049 0.2368 0.3477
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0397 0.0397
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.2236 0.2236
Echinococcus multilocularis geminin 0.0177 1 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.3389 1
Schistosoma mansoni hypothetical protein 0.0109 0.5954 0.5941
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.2236 0.328
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.1707 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0109 0.5954 0.5954
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0126 0.0141
Echinococcus granulosus cpg binding protein 0.0037 0.1665 0.1665
Loa Loa (eye worm) RNA binding protein 0.0061 0.3138 0.4622
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.2236 0.328
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0011 0.0145 0.0145
Entamoeba histolytica hypothetical protein 0.0109 0.5954 1
Toxoplasma gondii PHD-finger domain-containing protein 0.0009 0.0038 0.002
Brugia malayi F/Y-rich N-terminus family protein 0.002 0.0666 0.0945
Echinococcus multilocularis peregrin 0.0028 0.1168 0.1168
Brugia malayi Carboxylesterase family protein 0.0065 0.3376 0.4976
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.1707 1
Schistosoma mansoni ap endonuclease 0.0023 0.0837 0.0808
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0837 0.7085
Echinococcus granulosus tar DNA binding protein 0.0061 0.3138 0.3138
Echinococcus multilocularis para nitrobenzyl esterase 0.0011 0.0145 0.0145
Loa Loa (eye worm) hypothetical protein 0.0048 0.2361 0.3466
Echinococcus granulosus acetylcholinesterase 0.0065 0.3376 0.3376
Echinococcus multilocularis acetylcholinesterase 0.0065 0.3376 0.3376
Loa Loa (eye worm) carboxylesterase 0.0011 0.0145 0.0171

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.0141 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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