Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.007 | 0.2536 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.3047 | 0.3047 |
Echinococcus multilocularis | geminin | 0.0169 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.1824 | 0.5794 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0086 | 0.3769 | 0.8342 |
Schistosoma mansoni | hypothetical protein | 0.0169 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3047 | 0.3047 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0096 | 0.4491 | 1 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0096 | 0.4491 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.3047 | 1 |
Plasmodium falciparum | thioredoxin reductase | 0.0038 | 0.0139 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3047 | 0.3047 |
Mycobacterium tuberculosis | Probable reductase | 0.0086 | 0.3769 | 0.8342 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.1824 | 0.5985 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0038 | 0.0139 | 0.5 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0038 | 0.0139 | 0.5 |
Trypanosoma brucei | trypanothione reductase | 0.0038 | 0.0139 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0 | 0.5 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.3047 | 0.3047 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0086 | 0.3769 | 0.8342 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.007 | 0.2536 | 0.5509 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.1824 | 0.5985 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.007 | 0.2536 | 0.2536 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0086 | 0.3769 | 0.8342 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0394 | 0.0394 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3047 | 0.3047 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0038 | 0.0177 | 0.0177 |
Brugia malayi | Thioredoxin reductase | 0.0038 | 0.0139 | 0.0455 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.007 | 0.2536 | 0.2536 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.007 | 0.2536 | 0.2536 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.3047 | 1 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0086 | 0.3769 | 0.8342 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0086 | 0.3769 | 0.8342 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.0394 | 0.1293 |
Brugia malayi | RNA binding protein | 0.0076 | 0.3047 | 1 |
Brugia malayi | glutathione reductase | 0.0038 | 0.0139 | 0.0455 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.007 | 0.2536 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0394 | 0.0878 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0 | 0.5 |
Plasmodium vivax | glutathione reductase, putative | 0.0038 | 0.0139 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3047 | 0.3047 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0096 | 0.4491 | 1 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.007 | 0.2536 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.3047 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3047 | 0.3047 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.3047 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.3047 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.007 | 0.2536 | 0.2536 |
Plasmodium falciparum | glutathione reductase | 0.0038 | 0.0139 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.1824 | 0.5794 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0096 | 0.4491 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.007 | 0.2536 | 0.5 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0038 | 0.0177 | 0.0177 |
Schistosoma mansoni | hypothetical protein | 0.0169 | 1 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.007 | 0.2536 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 1.122 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 9.285 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 14.1254 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 22.3872 um | PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 25.1189 um | PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (binding) | = 31.6228 um | PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.