Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | mitogen-activated protein kinase 1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | mitogen-activated protein kinase 5 | mitogen-activated protein kinase 1 | 360 aa | 361 aa | 33.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0018 | 0.0547 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0062 | 1 | 1 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0062 | 1 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0062 | 1 | 1 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0062 | 1 | 1 |
Trypanosoma brucei | protein kinase, putative | 0.0062 | 1 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.1928 | 0.1461 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.1928 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0062 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.1928 | 0.1461 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0018 | 0.0547 | 0.0547 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0062 | 1 | 1 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0062 | 1 | 1 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0018 | 0.0547 | 0.5 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0025 | 0.1928 | 0.1461 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0062 | 1 | 1 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0062 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0025 | 0.1928 | 0.1461 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0062 | 1 | 1 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0062 | 1 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.1928 | 0.1461 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0062 | 1 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.1928 | 1 |
Brugia malayi | hypothetical protein | 0.0025 | 0.1928 | 0.1928 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0062 | 1 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0062 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0062 | 1 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0018 | 0.0547 | 0.5 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0062 | 1 | 1 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0062 | 1 | 1 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0025 | 0.1928 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0062 | 1 | 1 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0062 | 1 | 1 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0025 | 0.1928 | 0.1461 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0018 | 0.0547 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0018 | 0.0547 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 9.285 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 15.8489 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 35.4813 um | PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 44.6684 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Potency (functional) | 44.6684 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.