Detailed information for compound 1232911

Basic information

Technical information
  • TDR Targets ID: 1232911
  • Name: N,N-diethyl-2-[4-[2-methyl-5-(trifluoromethyl )benzimidazol-1-yl]piperidin-1-yl]acetamide
  • MW: 396.45 | Formula: C20H27F3N4O
  • H donors: 0 H acceptors: 2 LogP: 3.48 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN(C(=O)CN1CCC(CC1)n1c(C)nc2c1ccc(c2)C(F)(F)F)CC
  • InChi: 1S/C20H27F3N4O/c1-4-26(5-2)19(28)13-25-10-8-16(9-11-25)27-14(3)24-17-12-15(20(21,22)23)6-7-18(17)27/h6-7,12,16H,4-5,8-11,13H2,1-3H3
  • InChiKey: DJXFIKHLRZDYSF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N,N-diethyl-2-[4-[2-methyl-5-(trifluoromethyl)benzimidazol-1-yl]-1-piperidyl]acetamide
  • N,N-diethyl-2-[4-[2-methyl-5-(trifluoromethyl)-1-benzimidazolyl]-1-piperidinyl]acetamide
  • N,N-diethyl-2-[4-[2-methyl-5-(trifluoromethyl)benzimidazol-1-yl]piperidin-1-yl]ethanamide
  • ASN 06358267
  • MLS000033756
  • N,N-Diethyl-2-[4-(2-methyl-5-trifluoromethyl-benzoimidazol-1-yl)-piperidin-1-yl]-acetamide
  • SMR000006458

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ubiquitin specific peptidase 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania infantum ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 Get druggable targets OG5_127431 All targets in OG5_127431
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus ubiquitin specific protease 41 Get druggable targets OG5_127431 All targets in OG5_127431
Candida albicans ubiquitin-specific protease Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Cryptosporidium parvum ubiquitin C-terminal hydrolase of the cysteine proteinase fold Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum expressed protein Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma congolense ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 Get druggable targets OG5_127431 All targets in OG5_127431
Cryptosporidium hominis ubiquitin specific protease 66 Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma brucei gambiense ubiquitin carboxyl-terminal hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum Ubiquitin carboxyl-terminal hydrolase 8, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum IPR001394,Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2,domain-containing Get druggable targets OG5_127431 All targets in OG5_127431
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis ubiquitin specific protease 41 Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania braziliensis ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania mexicana ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum ko:K01072 ubiquitin thiolesterase [EC3.1.2.15], putative Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum IPR015063,Domain of unknown function DUF1873,domain-containing Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum Ubiquitin carboxyl-terminal hydrolase 8, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania donovani ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum ubiquitin specific protease, putative ubiquitin specific peptidase 2 362 aa 378 aa 25.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium vivax histone deacetylase 1, putative 0.0093 0.0438 0.3339
Entamoeba histolytica cysteine proteinase, putative 0.023 0.13 1
Plasmodium vivax unspecified product 0.0125 0.0637 0.4878
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0052 0.0185 0.1386
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0218 0.1222 0.9397
Echinococcus granulosus cathepsin L cysteine proteinase 0.023 0.13 0.2049
Brugia malayi beta-lactamase family protein 0.0075 0.0329 0.1224
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.023 0.13 0.877
Brugia malayi Animal haem peroxidase family protein 0.013 0.067 0.2515
Plasmodium falciparum serine repeat antigen 7 0.0052 0.0185 0.1386
Loa Loa (eye worm) hypothetical protein 0.013 0.067 0.253
Schistosoma mansoni hypothetical protein 0.1033 0.6326 1
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0062 0.0347
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0051 0.0175 0.1113
Mycobacterium tuberculosis Conserved protein 0.0075 0.0329 0.0948
Entamoeba histolytica cysteine protease, putative 0.0052 0.0185 0.1422
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0446 0.2649 0.4186
Loa Loa (eye worm) histone deacetylase 0.0076 0.0331 0.1248
Trichomonas vaginalis histone deacetylase, putative 0.0093 0.0438 0.2901
Brugia malayi Cathepsin L-like precursor 0.023 0.13 0.4899
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0052 0.0185 0.0291
Giardia lamblia Cysteine protease 0.0052 0.0185 0.1812
Loa Loa (eye worm) hypothetical protein 0.0446 0.2649 1
Entamoeba histolytica cysteine proteinase, putative 0.0125 0.0637 0.49
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.023 0.13 0.877
Echinococcus multilocularis cathepsin L cysteine protease 0.023 0.13 0.1296
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0051 0.0175 0.1113
Brugia malayi beta-lactamase 0.0075 0.0329 0.1224
Schistosoma mansoni transient receptor potential channel 0.0097 0.0467 0.0737
Onchocerca volvulus Cathepsin F homolog 0.023 0.13 1
Plasmodium falciparum cysteine proteinase falcipain 3 0.023 0.13 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.0556 0.2101
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0093 0.0438 0.2901
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0062 0.0235
Onchocerca volvulus 0.0058 0.0221 0.1666
Plasmodium vivax histone deacetylase, putative 0.0076 0.0331 0.251
Brugia malayi Pyruvate kinase, M2 isozyme 0.0033 0.0062 0.0215
Echinococcus multilocularis cysteine protease 0.023 0.13 0.1296
Echinococcus granulosus cysteine protease 0.0125 0.0637 0.0999
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.0329 0.2161
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.023 0.13 0.877
Mycobacterium tuberculosis Probable hydrolase 0.0075 0.0329 0.0948
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0125 0.0637 0.1006
Trypanosoma brucei histone deacetylase, putative 0.0076 0.0331 0.1916
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.0438 0.0433
Echinococcus granulosus histone deacetylase 6 0.0076 0.0331 0.0514
Schistosoma mansoni hypothetical protein 0.0047 0.0153 0.024
Trypanosoma cruzi histone deacetylase, putative 0.0048 0.0156 0.0549
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0287 0.1656 1
Onchocerca volvulus Cathepsin L homolog 0.023 0.13 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.023 0.13 0.877
Trypanosoma brucei histone deacetylase 4 0.0076 0.0331 0.1916
Loa Loa (eye worm) hypothetical protein 0.013 0.067 0.253
Leishmania major pyruvate kinase 0.0033 0.0062 0.031
Plasmodium vivax flap endonuclease 1, putative 0.0026 0.0016 0.0083
Brugia malayi hypothetical protein 0.0049 0.0166 0.0606
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0185 0.1181
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.0922 0.6199
Schistosoma mansoni peroxidasin 0.013 0.067 0.1058
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0482 0.2876 1
Schistosoma mansoni rab6-interacting 0.0024 0.0006 0.0007
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0438 0.0692
Mycobacterium ulcerans hypothetical protein 0.0075 0.0329 1
Mycobacterium tuberculosis Probable lipase LipD 0.0075 0.0329 0.0948
Giardia lamblia Cysteine protease 0.0052 0.0185 0.1812
Entamoeba histolytica cysteine proteinase, putative 0.0158 0.0848 0.6523
Giardia lamblia Cathepsin B precursor 0.0052 0.0185 0.1812
Echinococcus multilocularis high affinity choline transporter 1 0.0339 0.1978 0.1974
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0158 0.0848 0.5693
Echinococcus granulosus ubiquitin specific protease 41 0.0051 0.0175 0.0268
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0052 0.0185 0.1812
Loa Loa (eye worm) hypothetical protein 0.013 0.067 0.253
Entamoeba histolytica hypothetical protein 0.0025 0.0011 0.0088
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0052 0.0185 0.0291
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0052 0.0185 0.0291
Plasmodium falciparum cysteine proteinase falcipain 2a 0.023 0.13 1
Echinococcus multilocularis SAM and MBT domain containing protein 0.0098 0.0471 0.0466
Trypanosoma cruzi histone deacetylase, putative 0.0076 0.0331 0.121
Loa Loa (eye worm) hypothetical protein 0.0048 0.0156 0.059
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0093 0.0438 0.2901
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0174 0.0947 0.1496
Echinococcus granulosus TRP transient receptor potential channel 0.0036 0.0083 0.0123
Giardia lamblia Cathepsin L precursor 0.0052 0.0185 0.1812
Brugia malayi latrophilin 2 splice variant baaae 0.0102 0.0497 0.1859
Schistosoma mansoni cathepsin F (C01 family) 0.0158 0.0848 0.1339
Echinococcus multilocularis cysteine protease 0.023 0.13 0.1296
Echinococcus multilocularis sodium:glucose cotransporter 2 0.0037 0.009 0.0085
Trichomonas vaginalis histone deacetylase, putative 0.0093 0.0438 0.2901
Entamoeba histolytica cysteine protease, putative 0.0125 0.0637 0.49
Leishmania major cathepsin L-like protease 0.0287 0.1656 1
Trichomonas vaginalis histone deacetylase, putative 0.0093 0.0438 0.2901
Onchocerca volvulus 0.013 0.067 0.5133
Loa Loa (eye worm) hypothetical protein 0.0049 0.0166 0.0626
Echinococcus granulosus importin subunit beta 1 0.0031 0.0048 0.0066
Toxoplasma gondii preprocathepsin c precursor, putative 0.0052 0.0185 0.1313
Trypanosoma brucei histone deacetylase 3 0.0076 0.0331 0.1916
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0052 0.0185 0.1181
Schistosoma mansoni rab6-interacting 0.0024 0.0006 0.0007
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.0115 0.0579 0.1835
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.023 0.13 0.877
Giardia lamblia Cathepsin B precursor 0.0052 0.0185 0.1812
Giardia lamblia Cathepsin L-like protease 0.0052 0.0185 0.1812
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0052 0.0185 0.0291
Trichomonas vaginalis glucosylceramidase, putative 0.0259 0.1481 1
Loa Loa (eye worm) doublecortin family protein 0.0024 0.0006 0.0021
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.098 0.6589
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0051 0.0177 0.0408
Trypanosoma brucei prolyl endopeptidase 0.0129 0.0663 0.3945
Echinococcus multilocularis sodium:myo inositol cotransporter 0.0037 0.009 0.0085
Plasmodium falciparum histone deacetylase 1 0.0093 0.0438 0.3339
Plasmodium falciparum ataxin-2 like protein, putative 0.0049 0.0166 0.1237
Echinococcus granulosus polycomb protein SCMH1 0.0098 0.0471 0.0737
Trypanosoma cruzi cruzipain precursor, putative 0.0072 0.0309 0.1127
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.0922 0.6199
Brugia malayi Sodium:solute symporter family protein 0.0037 0.009 0.0321
Echinococcus multilocularis peroxidasin 0.013 0.067 0.0665
Onchocerca volvulus 0.0052 0.0185 0.1386
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0125 0.0637 0.4258
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0075 0.0329 0.0948
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0052 0.0185 0.1386
Brugia malayi histone deacetylase 3 (HD3) 0.0093 0.0438 0.1636
Leishmania major cathepsin L-like protease 0.0287 0.1656 1
Onchocerca volvulus Dual oxidase homolog 0.013 0.067 0.5133
Entamoeba histolytica histone deacetylase, putative 0.0093 0.0438 0.3367
Loa Loa (eye worm) hypothetical protein 0.013 0.067 0.253
Brugia malayi Flap endonuclease-1 0.0026 0.0016 0.0041
Brugia malayi Animal haem peroxidase family protein 0.013 0.067 0.2515
Echinococcus multilocularis solute carrier family 5 0.0037 0.009 0.0085
Schistosoma mansoni lipoxygenase 0.01 0.048 0.0758
Echinococcus multilocularis cathepsin L 0.0125 0.0637 0.0632
Entamoeba histolytica cysteine protease, putative 0.0125 0.0637 0.49
Brugia malayi Latrophilin receptor protein 2 0.0047 0.0153 0.0557
Toxoplasma gondii pyruvate kinase PyK1 0.0033 0.0062 0.0358
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0048 0.019
Trichomonas vaginalis penicillin-binding protein, putative 0.0075 0.0329 0.2161
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0052 0.0185 0.1386
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0075 0.0329 0.0519
Schistosoma mansoni hypothetical protein 0.0047 0.0153 0.024
Echinococcus granulosus cathepsin L 0.0052 0.0185 0.0284
Trypanosoma cruzi histone deacetylase, putative 0.0076 0.0331 0.121
Trypanosoma cruzi cysteine peptidase, putative 0.0125 0.0637 0.2373
Echinococcus granulosus cathepsin l1 0.023 0.13 0.2049
Echinococcus multilocularis cathepsin l cysteine peptidase 0.023 0.13 0.1296
Trypanosoma brucei pyruvate kinase 1, putative 0.0033 0.0062 0.0281
Onchocerca volvulus 0.023 0.13 1
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0052 0.0185 0.1812
Schistosoma mansoni transient receptor potential channel 4 0.0097 0.0467 0.0737
Loa Loa (eye worm) blistered cuticle protein 3 0.013 0.067 0.253
Echinococcus granulosus cathepsin l1 0.0158 0.0848 0.1333
Trichomonas vaginalis histone deacetylase, putative 0.0093 0.0438 0.2901
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0446 0.2649 0.4186
Entamoeba histolytica cysteine proteinase, putative 0.0125 0.0637 0.49
Loa Loa (eye worm) hypothetical protein 0.0148 0.0785 0.2962
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0093 0.0438 0.1638
Echinococcus granulosus cathepsin L 0.0125 0.0637 0.0999
Plasmodium falciparum serine repeat antigen 5 0.0052 0.0185 0.1386
Schistosoma mansoni histone deacetylase hda2 0.0048 0.0156 0.0245
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0075 0.0329 0.1242
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0047 0.0153 0.0147
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0052 0.0185 0.1386
Echinococcus granulosus histone deacetylase 3 0.0093 0.0438 0.0684
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0129 0.0195
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0062 0.0235
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0052 0.0185 0.0679
Entamoeba histolytica cysteine protease, putative 0.0052 0.0185 0.1422
Brugia malayi Papain family cysteine protease containing protein 0.0125 0.0637 0.239
Loa Loa (eye worm) histone deacetylase 11 0.0048 0.0156 0.059
Toxoplasma gondii cathepsin B 0.0174 0.0947 0.7248
Brugia malayi cathepsin F-like cysteine proteinase 0.0072 0.0309 0.1146
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0051 0.0175 0.1346
Leishmania major cathepsin L-like protease 0.023 0.13 0.7836
Onchocerca volvulus 0.0037 0.009 0.0655
Loa Loa (eye worm) hypothetical protein 0.0052 0.0185 0.0698
Brugia malayi Cathepsin L-like cysteine proteinase 0.0158 0.0848 0.3188
Trypanosoma cruzi cysteine peptidase, putative 0.0287 0.1656 0.6237
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0221 0.0816
Echinococcus granulosus cathepsin l cysteine peptidase 0.023 0.13 0.2049
Onchocerca volvulus 0.023 0.13 1
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0062 0.0193
Chlamydia trachomatis pyruvate kinase 0.0033 0.0062 0.5
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0072 0.0309 0.1146
Brugia malayi Cathepsin L-like precursor 0.023 0.13 0.4899
Echinococcus granulosus beta LACTamase domain containing family member 0.0075 0.0329 0.0512
Schistosoma mansoni hypothetical protein 0.0043 0.0129 0.0202
Entamoeba histolytica cysteine protease, putative 0.0052 0.0185 0.1422
Brugia malayi Calcitonin receptor-like protein seb-1 0.015 0.0794 0.2981
Echinococcus granulosus cathepsin b 0.0446 0.2649 0.4182
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0287 0.1656 1
Brugia malayi cathepsin L-like precursor 0.0158 0.0848 0.3188
Trypanosoma brucei pyruvate kinase 1 0.0033 0.0062 0.0281
Entamoeba histolytica cysteine proteinase, putative 0.0125 0.0637 0.49
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.0922 0.6199
Giardia lamblia Encystation-specific protease 0.0052 0.0185 0.1812
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0052 0.0185 0.1181
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.023 0.13 0.877
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.023 0.13 0.877
Onchocerca volvulus Glucosylceramidase homolog 0.017 0.0922 0.7081
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0052 0.0185 0.1386
Loa Loa (eye worm) transcription factor SMAD2 0.0244 0.1383 0.5222
Brugia malayi Papain family cysteine protease containing protein 0.0052 0.0185 0.0679
Leishmania major oligopeptidase b 0.0051 0.0177 0.1008
Echinococcus multilocularis pyruvate kinase 0.0033 0.0062 0.0057
Schistosoma mansoni inositol transporter 0.0037 0.009 0.0141
Loa Loa (eye worm) hypothetical protein 0.0034 0.0069 0.026
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0051 0.0175 0.0275
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0052 0.0185 0.1386
Brugia malayi histone deacetylase 11 0.0048 0.0156 0.057
Giardia lamblia Cathepsin B precursor 0.0174 0.0947 1
Loa Loa (eye worm) hypothetical protein 0.0075 0.0329 0.1242
Schistosoma mansoni transient receptor potential channel 0.0064 0.026 0.041
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0072 0.0309 0.1165
Loa Loa (eye worm) hypothetical protein 0.0218 0.1222 0.4615
Giardia lamblia Cathepsin L precursor 0.0052 0.0185 0.1812
Trichomonas vaginalis glucosylceramidase, putative 0.0259 0.1481 1
Leishmania major pyruvate kinase 0.0033 0.0062 0.031
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0051 0.0175 0.1705
Loa Loa (eye worm) hypothetical protein 0.0024 0.0006 0.0021
Echinococcus granulosus histone deacetylase 0.0076 0.0331 0.0514
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0051 0.0175 0.0641
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0052 0.0185 0.0291
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.0329 0.2161
Loa Loa (eye worm) hypothetical protein 0.013 0.067 0.253
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.0037 0.009 0.0085
Schistosoma mansoni sex comb on midleg homolog 0.0098 0.0471 0.0744
Brugia malayi histone deacetylase 1 (HD1) 0.0093 0.0438 0.1636
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0287 0.1656 1
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0098 0.0471 0.3597
Brugia malayi cathepsin L-like cysteine proteinase 0.0052 0.0185 0.0679
Onchocerca volvulus 0.023 0.13 1
Echinococcus granulosus short transient receptor potential channel 6 0.0064 0.026 0.0403
Loa Loa (eye worm) animal heme peroxidase 0.013 0.067 0.253
Onchocerca volvulus 0.0158 0.0848 0.6508
Echinococcus granulosus peroxidasin 0.013 0.067 0.1052
Loa Loa (eye worm) hypothetical protein 0.013 0.067 0.253
Schistosoma mansoni cathepsin B (C01 family) 0.0052 0.0185 0.0291
Plasmodium falciparum histone deacetylase 2 0.0076 0.0331 0.251
Echinococcus granulosus pyruvate kinase 0.0033 0.0062 0.009
Echinococcus granulosus flap endonuclease 1 0.0026 0.0016 0.0017
Trypanosoma cruzi major cysteine proteinase, putative 0.0052 0.0185 0.0658
Loa Loa (eye worm) hypothetical protein 0.013 0.067 0.253
Entamoeba histolytica cysteine protease, putative 0.0125 0.0637 0.49
Toxoplasma gondii histone deacetylase HDAC5 0.0048 0.0156 0.1089
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0052 0.0185 0.1181
Brugia malayi Transient-receptor-potential like protein 0.0036 0.0083 0.0295
Brugia malayi N-terminal motif family protein 0.0218 0.1222 0.4604
Schistosoma mansoni loxhd1 0.0024 0.0006 0.0007
Loa Loa (eye worm) histone deacetylase 3 0.0093 0.0438 0.1653
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0259 0.1481 0.5592
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0215 0.1204 0.4523
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0075 0.0329 0.0519
Loa Loa (eye worm) MH2 domain-containing protein 0.0244 0.1383 0.5222
Loa Loa (eye worm) hypothetical protein 0.0047 0.0153 0.0577
Loa Loa (eye worm) animal heme peroxidase 0.013 0.067 0.253
Loa Loa (eye worm) hypothetical protein 0.0158 0.0848 0.3202
Brugia malayi prolyl oligopeptidase family protein 0.0129 0.0663 0.2488
Loa Loa (eye worm) hypothetical protein 0.0098 0.0471 0.1779
Trypanosoma brucei histone deacetylase 1 0.0093 0.0438 0.257
Echinococcus granulosus SAM and MBT domain containing protein 0.0098 0.0471 0.0737
Loa Loa (eye worm) hypothetical protein 0.0072 0.0309 0.1165
Mycobacterium tuberculosis Probable peptidase 0.0051 0.0177 0.0408
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.023 0.13 0.877
Mycobacterium ulcerans lipase LipD 0.0075 0.0329 1
Loa Loa (eye worm) hypothetical protein 0.0129 0.0663 0.2504
Echinococcus granulosus high affinity choline transporter 1 0.0339 0.1978 0.3121
Toxoplasma gondii histone deacetylase HDAC3 0.0093 0.0438 0.3283
Loa Loa (eye worm) mbt repeat family protein 0.0098 0.0471 0.1779
Leishmania major hypothetical protein, conserved 0.0049 0.0166 0.0938
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0052 0.0185 0.1422
Loa Loa (eye worm) histone deacetylase 7A 0.0076 0.0331 0.1248
Giardia lamblia Cathepsin B precursor 0.0052 0.0185 0.1812
Brugia malayi cathepsin L precursor 0.0052 0.0185 0.0679
Brugia malayi hypothetical protein 0.0032 0.0056 0.0191
Echinococcus granulosus GPCR family 2 0.0047 0.0153 0.0233
Entamoeba histolytica hypothetical protein 0.0043 0.0129 0.0989
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0185 0.1181
Onchocerca volvulus Peroxidasin homolog 0.013 0.067 0.5133
Plasmodium falciparum pyruvate kinase 0.0033 0.0062 0.0439
Loa Loa (eye worm) hypothetical protein 0.0093 0.0438 0.1653
Loa Loa (eye worm) hypothetical protein 0.0097 0.0467 0.1763
Entamoeba histolytica hypothetical protein 0.0043 0.0129 0.0989
Loa Loa (eye worm) hypothetical protein 0.013 0.067 0.253
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.023 0.13 0.877
Brugia malayi GH02984p 0.0339 0.1978 0.7464
Echinococcus multilocularis short transient receptor potential channel 6 0.0064 0.026 0.0255
Toxoplasma gondii histone deacetylase HDAC4 0.0048 0.0156 0.1089
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.0922 0.6199
Echinococcus multilocularis histone deacetylase 6 0.0082 0.0369 0.0363
Leishmania major cathepsin L-like protease 0.023 0.13 0.7836
Echinococcus granulosus histone deacetylase 6 0.0076 0.0331 0.0514
Trypanosoma cruzi cysteine proteinase, putative 0.0125 0.0637 0.2373
Leishmania major cysteine peptidase A (CPA) 0.023 0.13 0.7836
Schistosoma mansoni hypothetical protein 0.0047 0.0153 0.024
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0287 0.1656 1
Giardia lamblia Cysteine protease 0.0052 0.0185 0.1812
Entamoeba histolytica cysteine protease, putative 0.0052 0.0185 0.1422
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.023 0.13 0.877
Echinococcus multilocularis beta LACTamase domain containing family member 0.0075 0.0329 0.0324
Schistosoma mansoni histone deacetylase 0.0093 0.0438 0.0691
Plasmodium vivax histone deacetylase, putative 0.0048 0.0156 0.1163
Trypanosoma brucei histone deacetylase 2 0.0048 0.0156 0.0853
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0052 0.0185 0.1386
Trichomonas vaginalis glucosylceramidase, putative 0.0259 0.1481 1
Brugia malayi Animal haem peroxidase family protein 0.013 0.067 0.2515
Schistosoma mansoni cathepsin F (C01 family) 0.023 0.13 0.2054
Schistosoma mansoni hypothetical protein 0.0102 0.0497 0.0784
Onchocerca volvulus 0.023 0.13 1
Echinococcus multilocularis histone deacetylase 6 0.0076 0.0331 0.0325
Echinococcus multilocularis transient receptor potential gamma protein 0.0097 0.0467 0.0462
Entamoeba histolytica cysteine protease, putative 0.0125 0.0637 0.49
Schistosoma mansoni histone deacetylase 4 5 0.0076 0.0331 0.0521
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0051 0.0177 0.4308
Entamoeba histolytica cysteine protease, putative 0.0125 0.0637 0.49
Schistosoma mansoni histone deacetylase hda2 0.0082 0.0369 0.0581
Giardia lamblia Cathepsin L precursor 0.0052 0.0185 0.1812
Brugia malayi Papain family cysteine protease containing protein 0.0052 0.0185 0.0679
Trypanosoma brucei prolyl oligopeptidase, putative 0.0051 0.0177 0.0981
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.023 0.13 0.877
Brugia malayi Peroxidasin 0.013 0.067 0.2515
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.023 0.13 0.877
Schistosoma mansoni high-affinity choline transporter 0.0339 0.1978 0.3126
Brugia malayi cathepsin B-like cysteine proteinase 0.0446 0.2649 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0287 0.1656 1
Trypanosoma brucei hypothetical protein, conserved 0.0075 0.0329 0.1907
Brugia malayi Cathepsin L-like precursor 0.023 0.13 0.4899
Entamoeba histolytica cysteine proteinase 1, putative 0.0125 0.0637 0.49
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.1646 0.1641
Plasmodium vivax vivapain-2 0.023 0.13 1
Echinococcus multilocularis prolyl endopeptidase 0.0129 0.0663 0.0658
Mycobacterium tuberculosis Conserved protein 0.0075 0.0329 0.0948
Loa Loa (eye worm) animal heme peroxidase 0.013 0.067 0.253
Trypanosoma cruzi histone deacetylase 1, putative 0.0093 0.0438 0.1617
Plasmodium falciparum histone deacetylase, putative 0.0076 0.0331 0.251
Brugia malayi Papain family cysteine protease containing protein 0.023 0.13 0.4899
Echinococcus multilocularis cathepsin L cysteine protease 0.023 0.13 0.1296
Plasmodium falciparum cysteine proteinase falcipain 2b 0.023 0.13 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.023 0.13 0.877
Giardia lamblia Cathepsin L precursor 0.0052 0.0185 0.1812
Giardia lamblia Cathepsin L precursor 0.0052 0.0185 0.1812
Onchocerca volvulus 0.023 0.13 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0052 0.0185 0.0291
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0438 0.0692
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0052 0.0185 0.1386
Loa Loa (eye worm) hypothetical protein 0.0052 0.0185 0.0698
Trypanosoma cruzi histone deacetylase 1, putative 0.0093 0.0438 0.1617
Giardia lamblia Hypothetical protein 0.0052 0.0185 0.1812
Toxoplasma gondii HEAT repeat-containing protein 0.0031 0.0048 0.0243
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0287 0.1656 1
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0174 0.0947 0.3547
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.023 0.13 0.4909
Plasmodium vivax hypothetical protein, conserved 0.0075 0.0329 0.2498
Giardia lamblia Cathepsin B precursor 0.0174 0.0947 1
Plasmodium vivax pyruvate kinase, putative 0.0033 0.0062 0.0439
Echinococcus multilocularis ubiquitin specific protease 41 0.0051 0.0175 0.017
Echinococcus multilocularis importin subunit beta 1 0.0031 0.0048 0.0042
Schistosoma mansoni hypothetical protein 0.0047 0.0153 0.024
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0051 0.0175 0.062
Toxoplasma gondii LsmAD domain-containing protein 0.0049 0.0166 0.1164
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.023 0.13 0.877
Loa Loa (eye worm) hypothetical protein 0.0036 0.0083 0.0315
Echinococcus multilocularis pyruvate kinase 0.0033 0.0062 0.0057
Plasmodium falciparum serine repeat antigen 3 0.0052 0.0185 0.1386
Loa Loa (eye worm) hypothetical protein 0.013 0.067 0.253
Toxoplasma gondii ABC1 family protein 0.0075 0.0329 0.2435
Onchocerca volvulus 0.0098 0.0471 0.3597
Echinococcus multilocularis histone acetyltransferase MYST2 0.0112 0.0556 0.0551
Brugia malayi MH2 domain containing protein 0.0244 0.1383 0.5212
Loa Loa (eye worm) histone deacetylase 1 0.0093 0.0438 0.1653
Entamoeba histolytica cysteine protease, putative 0.0125 0.0637 0.49
Echinococcus multilocularis transient receptor potential ion channel A 0.0094 0.0447 0.0441
Loa Loa (eye worm) hypothetical protein 0.0339 0.1978 0.7469
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.1646 0.2595
Echinococcus granulosus cathepsin b 0.0446 0.2649 0.4182
Loa Loa (eye worm) hypothetical protein 0.013 0.067 0.253
Schistosoma mansoni polycystin 1-related 0.0024 0.0006 0.0007
Onchocerca volvulus Cathepsin L homolog 0.023 0.13 1
Loa Loa (eye worm) hypothetical protein 0.0061 0.024 0.0906
Loa Loa (eye worm) hypothetical protein 0.0102 0.0497 0.1876
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.0922 0.6199
Trichomonas vaginalis glucosylceramidase, putative 0.0259 0.1481 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.023 0.13 0.877
Giardia lamblia Histone deacetylase 0.0093 0.0438 0.4529
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0036 0.0083 0.0078
Echinococcus granulosus prolyl endopeptidase 0.0129 0.0663 0.1041
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0062 0.0439
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0052 0.0185 0.0291
Brugia malayi RNA, U transporter 1 0.0087 0.04 0.1493
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.0922 0.6199
Loa Loa (eye worm) hypothetical protein 0.0072 0.0309 0.1165
Schistosoma mansoni sex comb on midleg homolog 0.0098 0.0471 0.0744
Toxoplasma gondii cathepsin CPL 0.023 0.13 1
Onchocerca volvulus 0.023 0.13 1
Echinococcus multilocularis histone deacetylase 3 0.0093 0.0438 0.0433
Trichomonas vaginalis glucosylceramidase, putative 0.0259 0.1481 1
Brugia malayi hypothetical protein 0.0043 0.0129 0.0466
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0125 0.0637 0.1006
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0051 0.0177 0.0629
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0142 0.0749 0.1176
Entamoeba histolytica cysteine proteinase, putative 0.0125 0.0637 0.49
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0052 0.0185 0.1181
Onchocerca volvulus 0.0075 0.0329 0.2498
Brugia malayi mbt repeat family protein 0.0098 0.0471 0.1762
Echinococcus granulosus sodium:myo inositol cotransporter 0.0037 0.009 0.0134
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0052 0.0185 0.0291
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0446 0.2649 0.4186
Mycobacterium tuberculosis Conserved protein 0.0075 0.0329 0.0948
Plasmodium falciparum serine repeat antigen 1 0.0052 0.0185 0.1386
Brugia malayi Cathepsin L-like precursor 0.023 0.13 0.4899
Echinococcus multilocularis histone deacetylase 7 0.0076 0.0331 0.0325
Schistosoma mansoni histone deacetylase 0.0093 0.0438 0.0691
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0052 0.0185 0.1386
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.0438 0.0685
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0129 0.0663 0.1047
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.0329 0.1204
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0075 0.0329 0.0948
Giardia lamblia Hypothetical protein 0.0052 0.0185 0.1812
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.0329 0.2161
Schistosoma mansoni pyruvate kinase 0.0033 0.0062 0.0097
Brugia malayi Animal haem peroxidase family protein 0.013 0.067 0.2515
Giardia lamblia Cathepsin B precursor 0.0052 0.0185 0.1812
Plasmodium vivax vivapain-3 0.0125 0.0637 0.4878
Echinococcus multilocularis cathepsin L 0.0052 0.0185 0.018
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0048 0.019
Trichomonas vaginalis histone deacetylase, putative 0.0093 0.0438 0.2901
Plasmodium vivax vivapain-2 0.023 0.13 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.023 0.13 0.877
Entamoeba histolytica cysteine proteinase 2 0.0125 0.0637 0.49
Plasmodium vivax unspecified product 0.0072 0.0309 0.234
Echinococcus multilocularis cathepsin l cysteine peptidase 0.023 0.13 0.1296
Toxoplasma gondii histone deacetylase HDAC1 0.0076 0.0331 0.2447
Entamoeba histolytica cysteine protease, putative 0.0125 0.0637 0.49
Plasmodium vivax vivapain-1 0.0125 0.0637 0.4878
Echinococcus multilocularis snurportin 1 0.0326 0.1898 0.1893
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0062 0.0439
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.023 0.13 0.877
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0051 0.0175 0.017
Echinococcus granulosus solute carrier family 5 0.0037 0.009 0.0134
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0129 0.0663 0.1047
Trichomonas vaginalis penicillin-binding protein, putative 0.0075 0.0329 0.2161
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0062 0.0193
Loa Loa (eye worm) ctsf protein 0.023 0.13 0.4909
Loa Loa (eye worm) pigment dispersing factor receptor c 0.015 0.0794 0.2996
Trypanosoma cruzi cysteine proteinase, putative 0.0125 0.0637 0.2373
Loa Loa (eye worm) animal heme peroxidase 0.013 0.067 0.253
Onchocerca volvulus 0.0075 0.0329 0.2498
Schistosoma mansoni hypothetical protein 0.0058 0.0221 0.0348
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0051 0.0177 0.0629
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0075 0.0329 1
Loa Loa (eye worm) cathepsin B 0.0174 0.0947 0.3575
Loa Loa (eye worm) hypothetical protein 0.015 0.0794 0.2996
Schistosoma mansoni hypothetical protein 0.0024 0.0006 0.0007
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0287 0.1656 1
Trypanosoma cruzi oligopeptidase b 0.0051 0.0177 0.0629
Schistosoma mansoni cathepsin F (C01 family) 0.023 0.13 0.2054
Entamoeba histolytica cysteine protease, putative 0.0125 0.0637 0.49
Entamoeba histolytica cysteine protease, putative 0.0052 0.0185 0.1422
Brugia malayi Histone deacetylase 1 0.0093 0.0438 0.1636
Brugia malayi Cathepsin L-like precursor 0.023 0.13 0.4899
Onchocerca volvulus Peroxidase homolog 0.013 0.067 0.5133
Schistosoma mansoni sodium/solute symporter 0.0037 0.009 0.0141
Leishmania major hypothetical protein, conserved 0.0075 0.0329 0.1931
Brugia malayi hypothetical protein 0.0286 0.1646 0.6205
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0051 0.0175 0.0268
Echinococcus granulosus pyruvate kinase 0.0033 0.0062 0.009
Mycobacterium tuberculosis Probable esterase LipL 0.0075 0.0329 0.0948
Loa Loa (eye worm) hypothetical protein 0.0075 0.0329 0.1242
Loa Loa (eye worm) hypothetical protein 0.013 0.067 0.253
Echinococcus multilocularis cathepsin b 0.0446 0.2649 0.2645
Loa Loa (eye worm) flap endonuclease-1 0.0026 0.0016 0.0062
Loa Loa (eye worm) hypothetical protein 0.0075 0.0329 0.1242
Leishmania major cathepsin L-like protease 0.023 0.13 0.7836
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.0185 0.1181
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0052 0.0185 0.0698
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0438 0.0692
Onchocerca volvulus Histone deacetylase 10 homolog 0.0048 0.0156 0.1163
Trichomonas vaginalis esterase, putative 0.0075 0.0329 0.2161
Trypanosoma cruzi histone deacetylase, putative 0.0076 0.0331 0.121
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.039 0.2303 0.2299
Loa Loa (eye worm) hypothetical protein 0.0052 0.0185 0.0698
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0158 0.0848 0.5693
Echinococcus multilocularis GPCR, family 2 0.0047 0.0153 0.0147
Schistosoma mansoni histone deacetylase 1 2 3 0.0048 0.0156 0.0245
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0112 0.0556 0.2084
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0287 0.1656 1
Onchocerca volvulus Prolyl endopeptidase homolog 0.0129 0.0663 0.508
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0052 0.0185 0.1386
Echinococcus granulosus geminin 0.1033 0.6326 1
Echinococcus multilocularis histone deacetylase 8 0.0048 0.0156 0.0151
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0051 0.0175 0.0995
Brugia malayi Cathepsin L-like precursor 0.023 0.13 0.4899
Loa Loa (eye worm) hypothetical protein 0.023 0.13 0.4909
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0062 0.0235
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.023 0.13 0.877
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0052 0.0185 0.1181
Echinococcus granulosus short transient receptor potential channel 6 0.0064 0.026 0.0403
Schistosoma mansoni histone deacetylase 4 5 0.0076 0.0331 0.0521
Trypanosoma cruzi prolyl endopeptidase 0.0129 0.0663 0.2472
Brugia malayi hypothetical protein 0.013 0.067 0.2515
Brugia malayi Blistered cuticle protein 3 0.013 0.067 0.2515
Loa Loa (eye worm) hypothetical protein 0.0033 0.0062 0.0235
Echinococcus multilocularis short transient receptor potential channel 6 0.0064 0.026 0.0255
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0051 0.0175 0.017
Loa Loa (eye worm) hypothetical protein 0.0072 0.0309 0.1165
Schistosoma mansoni peroxidasin 0.013 0.067 0.1058
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0287 0.1656 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0287 0.1656 1
Loa Loa (eye worm) hypothetical protein 0.0052 0.0185 0.0698
Leishmania major cathepsin L-like protease 0.023 0.13 0.7836
Plasmodium falciparum serine repeat antigen 2 0.0052 0.0185 0.1386
Schistosoma mansoni transient receptor potential channel 0.0064 0.026 0.041
Echinococcus multilocularis flap endonuclease 1 0.0026 0.0016 0.0011
Schistosoma mansoni survival motor neuron protein 0.0058 0.0221 0.0348
Loa Loa (eye worm) MBCTL1 0.0112 0.0556 0.2101
Loa Loa (eye worm) papain family cysteine protease containing protein 0.023 0.13 0.4909
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0185 0.1181
Brugia malayi Papain family cysteine protease containing protein 0.0052 0.0185 0.0679
Echinococcus multilocularis histone deacetylase 6 0.0076 0.0331 0.0325
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.098 0.6589
Echinococcus granulosus sodium:glucose cotransporter 0.0037 0.009 0.0134
Trypanosoma cruzi cysteine protease, putative 0.0125 0.0637 0.2373
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0185 0.1181
Echinococcus multilocularis polycomb protein SCMH1 0.0098 0.0471 0.0466
Schistosoma mansoni hypothetical protein 0.0326 0.1898 0.2999
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0125 0.0637 0.3785
Loa Loa (eye worm) cysteine protease 0.023 0.13 0.4909
Onchocerca volvulus Peroxidasin homolog 0.013 0.067 0.5133
Giardia lamblia Cysteine protease 0.0052 0.0185 0.1812
Loa Loa (eye worm) hypothetical protein 0.0051 0.0175 0.0661
Schistosoma mansoni pyruvate kinase 0.0033 0.0062 0.0097
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0125 0.0637 0.1006
Echinococcus granulosus transient receptor potential ion channel A 0.0094 0.0447 0.0698
Brugia malayi Animal haem peroxidase family protein 0.013 0.067 0.2515
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.0922 0.6199
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.0438 0.0685
Trichomonas vaginalis histone deacetylase, putative 0.0093 0.0438 0.2901
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0051 0.0175 0.0268
Schistosoma mansoni inositol transporter 0.0037 0.009 0.0141
Brugia malayi Cathepsin L-like precursor 0.0158 0.0848 0.3188
Toxoplasma gondii cathepsin CPC2 0.0052 0.0185 0.1313
Loa Loa (eye worm) hypothetical protein 0.013 0.067 0.253
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0259 0.1481 0.5583
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0125 0.0637 0.4258
Entamoeba histolytica cysteine protease, putative 0.0125 0.0637 0.49
Entamoeba histolytica cysteine protease, putative 0.0125 0.0637 0.49
Schistosoma mansoni hypothetical protein 0.1033 0.6326 1
Trypanosoma cruzi major cysteine proteinase, putative 0.0109 0.0541 0.2008
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0142 0.0749 0.0744
Plasmodium falciparum serine repeat antigen 9 0.0052 0.0185 0.1386
Entamoeba histolytica cysteine proteinase, putative 0.023 0.13 1
Brugia malayi Importin beta-1 subunit 0.0031 0.0048 0.0159
Mycobacterium ulcerans esterase/lipase LipP 0.0075 0.0329 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.0185 0.1181
Schistosoma mansoni cathepsin C 0.0052 0.0185 0.0291
Onchocerca volvulus Chorion peroxidase homolog 0.013 0.067 0.5133
Echinococcus granulosus histone deacetylase 7 0.0076 0.0331 0.0514
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0026 0.0016 0.003
Plasmodium vivax serine-repeat antigen (SERA) 0.0052 0.0185 0.1386
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0174 0.0947 0.6365
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.015 0.0794 0.2981
Trypanosoma cruzi cruzipain precursor, putative 0.0287 0.1656 0.6237
Onchocerca volvulus 0.013 0.067 0.5133
Plasmodium falciparum ataxin-2 like protein, putative 0.0049 0.0166 0.1237
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0185 0.1181
Brugia malayi beta-lactamase family protein 0.0075 0.0329 0.1224
Brugia malayi mbt repeat family protein 0.0098 0.0471 0.1762
Entamoeba histolytica cysteine protease, putative 0.0125 0.0637 0.49
Plasmodium falciparum cysteine proteinase falcipain 1 0.0125 0.0637 0.4878
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0112 0.0556 0.0551
Onchocerca volvulus 0.0075 0.0329 0.2498
Schistosoma mansoni cathepsin s 0.0072 0.0309 0.0486
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0446 0.2649 1
Onchocerca volvulus 0.023 0.13 1
Brugia malayi Cathepsin L-like precursor 0.0158 0.0848 0.3188
Loa Loa (eye worm) hypothetical protein 0.0158 0.0848 0.3202
Onchocerca volvulus 0.013 0.067 0.5133
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0052 0.0185 0.1181
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0052 0.0185 0.1386
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0051 0.0175 0.0275
Trichomonas vaginalis glucosylceramidase, putative 0.0259 0.1481 1
Plasmodium vivax serine-repeat antigen (SERA) 0.0052 0.0185 0.1386
Loa Loa (eye worm) hypothetical protein 0.013 0.067 0.253
Echinococcus multilocularis histone deacetylase 0.0076 0.0331 0.0325
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0185 0.1181
Loa Loa (eye worm) hypothetical protein 0.0075 0.0329 0.1242
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0075 0.0329 0.0948
Loa Loa (eye worm) hypothetical protein 0.0052 0.0185 0.0698
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0174 0.0947 0.5687
Entamoeba histolytica Flap nuclease, putative 0.0026 0.0016 0.0125
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0446 0.2649 0.4186
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.023 0.13 0.877
Echinococcus granulosus endonuclease exonuclease phosphatase 0.039 0.2303 0.3635
Loa Loa (eye worm) beta-lactamase 0.0075 0.0329 0.1242
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0287 0.1656 1
Loa Loa (eye worm) hypothetical protein 0.013 0.067 0.253
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0052 0.0185 0.1181
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.0037 0.009 0.0577
Brugia malayi fibroinase precursor 0.0052 0.0185 0.0679
Giardia lamblia Cathepsin L-like protease 0.0052 0.0185 0.1812
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0125 0.0637 0.2373
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0051 0.0177 0.1008
Entamoeba histolytica cysteine protease, putative 0.0125 0.0637 0.49
Echinococcus multilocularis pyruvate kinase 0.0026 0.0019 0.0013
Giardia lamblia Cathepsin B precursor 0.0052 0.0185 0.1812
Trypanosoma cruzi cysteine peptidase, putative 0.0287 0.1656 0.6237
Trypanosoma cruzi PAB1-binding protein , putative 0.0049 0.0166 0.0585
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0098 0.0471 0.0744
Schistosoma mansoni cathepsin S (C01 family) 0.0052 0.0185 0.0291
Brugia malayi Cathepsin L-like precursor 0.0072 0.0309 0.1146
Onchocerca volvulus 0.0148 0.0785 0.6017
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0052 0.0185 0.0291
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0112 0.0556 0.0872
Brugia malayi cathepsin F-like cysteine proteinase 0.0052 0.0185 0.0679
Brugia malayi Histone deacetylase family protein 0.0076 0.0331 0.123
Echinococcus granulosus histone acetyltransferase MYST2 0.0112 0.0556 0.0872
Brugia malayi Pyruvate kinase, muscle isozyme 0.0033 0.0062 0.0215
Plasmodium vivax unspecified product 0.0052 0.0185 0.1386
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.023 0.13 0.877
Mycobacterium leprae Probable lipase LipE 0.0075 0.0329 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0185 0.1181
Plasmodium vivax histone deacetylase 2, putative 0.0076 0.0331 0.251
Loa Loa (eye worm) hypothetical protein 0.0075 0.0329 0.1242
Echinococcus granulosus histone deacetylase 8 0.0048 0.0156 0.0238
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0052 0.0185 0.1812
Entamoeba histolytica hypothetical protein 0.0052 0.0185 0.1422
Schistosoma mansoni importin beta-1 0.0031 0.0048 0.0074
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0047 0.0153 0.0557
Entamoeba histolytica hypothetical protein 0.0043 0.0129 0.0989
Plasmodium falciparum serine repeat antigen 8 0.0052 0.0185 0.1386
Loa Loa (eye worm) hypothetical protein 0.0028 0.0031 0.0116
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0051 0.0177 0.4308
Leishmania major histone deacetylase, putative 0.0093 0.0438 0.2592
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0052 0.0185 0.1422
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0062 0.0439
Loa Loa (eye worm) hypothetical protein 0.0031 0.0048 0.018
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0052 0.0185 0.0698
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.0037 0.009 0.0134
Plasmodium falciparum serine repeat antigen 4 0.0052 0.0185 0.1386
Leishmania major histone deacetylase, putative 0.0093 0.0438 0.2592
Loa Loa (eye worm) fibroinase 0.023 0.13 0.4909
Leishmania major histone deacetylase, putative 0.0076 0.0331 0.194
Brugia malayi cathepsin Z-like cysteine proteinase 0.0052 0.0185 0.0679
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0326 0.1898 0.7165
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0175 0.1113
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.0438 0.0433
Trypanosoma brucei oligopeptidase b 0.0051 0.0177 0.0981
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0052 0.0185 0.1386
Mycobacterium tuberculosis Probable lipase LipE 0.0075 0.0329 0.0948
Trypanosoma cruzi PAB1-binding protein , putative 0.0049 0.0166 0.0585
Echinococcus granulosus histone deacetylase 1 0.0093 0.0438 0.0684
Echinococcus granulosus histone deacetylase 6 0.0082 0.0369 0.0575
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.023 0.13 0.877
Trypanosoma cruzi cysteine peptidase, putative 0.023 0.13 0.4887
Brugia malayi hypothetical protein 0.0148 0.0785 0.2948
Echinococcus granulosus transient receptor potential gamma protein 0.0097 0.0467 0.073
Trypanosoma cruzi cysteine peptidase, putative 0.0287 0.1656 0.6237
Trypanosoma brucei PAB1-binding protein , putative 0.0049 0.0166 0.0911
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.0329 0.1204
Trichomonas vaginalis flap endonuclease-1, putative 0.0026 0.0016 0.0034
Loa Loa (eye worm) hypothetical protein 0.0158 0.0848 0.3202
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0051 0.0177 0.0981
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0052 0.0185 0.1181
Giardia lamblia Pyruvate kinase 0.0033 0.0062 0.0494
Entamoeba histolytica cysteine protease, putative 0.0125 0.0637 0.49
Leishmania major histone deacetylase, putative 0.0076 0.0331 0.194
Toxoplasma gondii histone deacetylase HDAC2 0.0093 0.0438 0.3283
Brugia malayi Histone deacetylase family protein 0.0076 0.0331 0.123
Giardia lamblia Cathepsin B precursor 0.0174 0.0947 1
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0093 0.0438 0.2901
Loa Loa (eye worm) hypothetical protein 0.0052 0.0185 0.0698
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0052 0.0185 0.1386
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0047 0.0153 0.0233
Plasmodium falciparum serine repeat antigen 6 0.0052 0.0185 0.1386
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0052 0.0185 0.1181
Loa Loa (eye worm) hypothetical protein 0.0075 0.0329 0.1242
Echinococcus multilocularis cathepsin b 0.0446 0.2649 0.2645
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0129 0.0123
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0051 0.0175 0.0968
Echinococcus granulosus snurportin 1 0.0326 0.1898 0.2994
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0052 0.0185 0.1812
Entamoeba histolytica hypothetical protein 0.0043 0.0129 0.0989
Plasmodium vivax importin-beta 2, putative 0.0031 0.0048 0.0325
Trypanosoma brucei cysteine peptidase C (CPC) 0.0174 0.0947 0.5674
Echinococcus multilocularis histone deacetylase 1 0.0093 0.0438 0.0433
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0052 0.0185 0.1181
Loa Loa (eye worm) hypothetical protein 0.0037 0.009 0.0341
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0075 0.0329 0.1224
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0125 0.0637 0.3785
Echinococcus granulosus sodium:glucose cotransporter 2 0.0037 0.009 0.0134
Entamoeba histolytica cysteine protease, putative 0.023 0.13 1
Trypanosoma cruzi cysteine peptidase, putative 0.0072 0.0309 0.1127
Loa Loa (eye worm) latrophilin receptor protein 2 0.0047 0.0153 0.0577
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0129 0.0202
Mycobacterium leprae conserved hypothetical protein 0.0075 0.0329 1
Brugia malayi Papain family cysteine protease containing protein 0.0125 0.0637 0.239
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0062 0.0347
Giardia lamblia Cathepsin L precursor 0.0052 0.0185 0.1812
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.023 0.13 0.877
Echinococcus multilocularis geminin 0.1033 0.6326 0.6324
Leishmania major cathepsin L-like protease 0.0287 0.1656 1
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0026 0.0016 0.0019
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.023 0.13 0.877
Schistosoma mansoni hypothetical protein 0.06 0.3618 0.5718
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0047 0.0153 0.0233
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0093 0.0438 0.1655
Trypanosoma cruzi histone deacetylase, putative 0.0048 0.0156 0.0549
Plasmodium falciparum importin beta, putative 0.0031 0.0048 0.0325
Leishmania major cathepsin L-like protease 0.023 0.13 0.7836
Brugia malayi cathepsin Z-like cysteine proteinase 0.0052 0.0185 0.0679
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.023 0.13 0.877
Trypanosoma cruzi oligopeptidase b 0.0051 0.0177 0.0629
Echinococcus granulosus cathepsin L cysteine protease 0.0125 0.0637 0.0999
Loa Loa (eye worm) hypothetical protein 0.0024 0.0006 0.0021
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0047 0.0153 0.0147
Loa Loa (eye worm) hypothetical protein 0.0286 0.1646 0.6213
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0051 0.0175 0.062
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0129 0.0663 0.3963
Mycobacterium ulcerans beta-lactamase 0.0075 0.0329 1
Schistosoma mansoni myelin transcription factor 1 myt1 0.0112 0.0556 0.0878
Onchocerca volvulus Cathepsin L homolog 0.0052 0.0185 0.1386
Plasmodium falciparum flap endonuclease 1 0.0026 0.0016 0.0083
Schistosoma mansoni lipoxygenase 0.0142 0.0749 0.1182
Toxoplasma gondii cathepsin CPC1 0.0052 0.0185 0.1313
Loa Loa (eye worm) hypothetical protein 0.0033 0.0063 0.0238
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0052 0.0185 0.0698
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.023 0.13 0.877
Toxoplasma gondii prolyl endopeptidase 0.0129 0.0663 0.5038
Onchocerca volvulus Peroxidase homolog 0.013 0.067 0.5133
Plasmodium vivax ataxin-2 like protein, putative 0.0049 0.0166 0.1237
Entamoeba histolytica cysteine protease, putative 0.0052 0.0185 0.1422

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 5.8584 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 6.3096 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Ubiquitin-specific Protease USP2a. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 20.7865 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 67.4555 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 70.7946 uM PUBCHEM_BIOASSAY: qHTS Assay for Iinhibitors of HIV-1 Budding by Blocking the Interaction of PTAP/TSG101. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID485342, AID485388] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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