Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | bromodomain adjacent to zinc finger domain, 2B | Starlite/ChEMBL | No references |
Homo sapiens | glucosidase, alpha | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0776 | 0.0496 |
Plasmodium falciparum | amino acid transporter, putative | 0.0036 | 0.0295 | 0.5 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0044 | 0.0648 | 0.5 |
Brugia malayi | Sodium:neurotransmitter symporter family protein 1, putative | 0.0036 | 0.0295 | 0.0371 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0044 | 0.0648 | 0.0815 |
Echinococcus multilocularis | neutral alpha glucosidase AB | 0.0044 | 0.0648 | 0.0364 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0044 | 0.0648 | 0.5 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0044 | 0.0648 | 0.0364 |
Schistosoma mansoni | alpha-glucosidase | 0.0169 | 0.6651 | 0.6549 |
Brugia malayi | Bromodomain containing protein | 0.0091 | 0.2889 | 0.3629 |
Echinococcus multilocularis | sodium:chloride dependent neurotransmitter | 0.0239 | 1 | 1 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0043 | 0.0636 | 0.0351 |
Schistosoma mansoni | alpha glucosidase | 0.0044 | 0.0648 | 0.0364 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0913 | 0.0636 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0044 | 0.0648 | 0.5 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0044 | 0.0648 | 0.5 |
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.0044 | 0.0648 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0044 | 0.0648 | 0.5 |
Plasmodium vivax | amine transporter, putative | 0.0036 | 0.0295 | 0.5 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0072 | 0.2006 | 0.1763 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0072 | 0.2006 | 0.1763 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0036 | 0.0295 | 0.0371 |
Leishmania major | alpha glucosidase II subunit, putative | 0.0044 | 0.0648 | 0.5 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0036 | 0.0295 | 0.5 |
Brugia malayi | Bromodomain containing protein | 0.0046 | 0.0772 | 0.097 |
Plasmodium vivax | hypothetical protein, conserved | 0.0036 | 0.0295 | 0.5 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0044 | 0.0648 | 0.5 |
Schistosoma mansoni | bromodomain containing protein | 0.0076 | 0.2213 | 0.1976 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0197 | 0.796 | 0.7898 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0239 | 1 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0044 | 0.0648 | 0.5 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0044 | 0.0648 | 0.5 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0197 | 0.796 | 1 |
Plasmodium falciparum | transporter, putative | 0.0036 | 0.0295 | 0.5 |
Brugia malayi | hypothetical protein | 0.0036 | 0.0295 | 0.0371 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0044 | 0.0648 | 0.5 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0044 | 0.0648 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.2642 | 0.2418 |
Trypanosoma brucei | glucosidase, putative | 0.0044 | 0.0648 | 0.5 |
Schistosoma mansoni | alpha-glucosidase | 0.0169 | 0.6651 | 0.6549 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0044 | 0.0648 | 0.5 |
Onchocerca volvulus | 0.0114 | 0.3998 | 1 | |
Echinococcus granulosus | neutral alpha glucosidase AB | 0.0044 | 0.0648 | 0.0364 |
Loa Loa (eye worm) | hypothetical protein | 0.0239 | 1 | 1 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0197 | 0.796 | 0.7898 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0197 | 0.796 | 0.7898 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0239 | 1 | 1 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0197 | 0.796 | 0.7898 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0036 | 0.0295 | 0.0371 |
Loa Loa (eye worm) | hypothetical protein | 0.0239 | 1 | 1 |
Chlamydia trachomatis | Ssodium-dependent amino acid transporter | 0.0036 | 0.0295 | 0.5 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0043 | 0.0636 | 0.0351 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0036 | 0.0295 | 0.0371 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0239 | 1 | 1 |
Trichomonas vaginalis | sucrase-isomaltase, putative | 0.0044 | 0.0648 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.1023 | 0.075 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0036 | 0.0295 | 0.0371 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0044 | 0.0648 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 2.5119 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 997 ] | ChEMBL. | No reference |
Potency (functional) | = 2.5119 um | PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 1467, 2100, 2112, 1473, 1466 ] | ChEMBL. | No reference |
Potency (functional) | 4.1475 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Potency (functional) | = 22.3872 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] | ChEMBL. | No reference |
Potency (functional) | = 31.6228 um | PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 31.6228 um | PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 31.6228 uM | PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.