Detailed information for compound 1233448

Basic information

Technical information
  • TDR Targets ID: 1233448
  • Name: 1-(2-chlorophenyl)-N-(6-methoxypyridin-3-yl)m ethanesulfonamide
  • MW: 312.772 | Formula: C13H13ClN2O3S
  • H donors: 1 H acceptors: 3 LogP: 2.24 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cn1)NS(=O)(=O)Cc1ccccc1Cl
  • InChi: 1S/C13H13ClN2O3S/c1-19-13-7-6-11(8-15-13)16-20(17,18)9-10-4-2-3-5-12(10)14/h2-8,16H,9H2,1H3
  • InChiKey: HCVZRDJJJMZXJL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 1-(2-chlorophenyl)-N-(6-methoxy-3-pyridyl)methanesulfonamide
  • MLS000045720
  • SMR000027677
  • ChemDiv2_005472
  • A3311/0140727
  • ZINC00111038

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens thyroid stimulating hormone receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) follicle stimulating hormone receptor Get druggable targets OG5_130089 All targets in OG5_130089
Brugia malayi follicle stimulating hormone receptor Get druggable targets OG5_130089 All targets in OG5_130089
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0303 0.1679 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0031 0.0086 0.0182
Brugia malayi hypothetical protein 0.0016 0.0003 0.0006
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.006 0.026 0.055
Onchocerca volvulus 0.006 0.026 0.0691
Brugia malayi Pre-SET motif family protein 0.006 0.026 0.055
Brugia malayi ecdysteroid receptor 0.0031 0.0086 0.0182
Schistosoma mansoni hypothetical protein 0.017 0.0901 0.1906
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0001 0.0003
Schistosoma mansoni smad1 5 8 and 0.0025 0.0053 0.0113
Brugia malayi nuclear receptor NHR-88 0.0031 0.0086 0.0182
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0282 0.1556 0.329
Schistosoma mansoni hypothetical protein 0.0034 0.0107 0.0227
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0001 0.0003
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0031 0.0086 0.0182
Schistosoma mansoni BC026374 protein (S09 family) 0.0139 0.0722 0.1527
Onchocerca volvulus Protein ultraspiracle homolog 0.0031 0.0086 0.0029
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0078 0.2979
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0049 0.0191 0.0404
Toxoplasma gondii hypothetical protein 0.0049 0.0193 0.7414
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0157 0.0925
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.0261 0.0551
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0031 0.0086 0.0182
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0078 0.0166
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0016 0.0002 0.0004
Loa Loa (eye worm) hypothetical protein 0.0016 0.0002 0.0004
Toxoplasma gondii exonuclease III APE 0.0019 0.0018 0.0632
Plasmodium falciparum phd finger protein, putative 0.0029 0.0078 1
Schistosoma mansoni transcription factor LCR-F1 0.0109 0.0543 0.1149
Loa Loa (eye worm) carboxylesterase 0.0139 0.0722 0.1527
Loa Loa (eye worm) hypothetical protein 0.0016 0.0002 0.0004
Echinococcus granulosus neuroligin 0.0139 0.0722 0.1527
Schistosoma mansoni gliotactin 0.0139 0.0722 0.1527
Brugia malayi PHD-finger family protein 0.0029 0.0078 0.0166
Brugia malayi nuclear receptor RXR 0.0016 0.0002 0.0004
Loa Loa (eye worm) jmjC domain-containing protein 0.0035 0.0114 0.0242
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0143 0.0746 0.4438
Entamoeba histolytica hypothetical protein 0.0109 0.0543 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0025 0.0053 0.0113
Brugia malayi Nuclear hormone receptor-like 1 0.0031 0.0086 0.0182
Schistosoma mansoni microtubule-associated protein tau 0.0733 0.4189 0.8857
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0018 0.0097
Brugia malayi hypothetical protein 0.0237 0.1294 0.2737
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0157 0.0925
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.02 0.0423
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0055 0.0321
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0139 0.0722 0.2622
Brugia malayi Steroid receptor seven-up type 2 0.0031 0.0086 0.0182
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0001 0.0003
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0086 0.0182
Echinococcus granulosus survival motor neuron protein 1 0.0237 0.1294 0.2737
Echinococcus granulosus acetylcholinesterase 0.0825 0.473 1
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0107 0.0227
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0031 0.0086 0.0182
Mycobacterium leprae Conserved hypothetical protein 0.0508 0.2877 1
Brugia malayi Carboxylesterase family protein 0.0825 0.473 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0366 0.2049 0.4331
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0086 0.0182
Schistosoma mansoni RAR-like nuclear receptor 0.0031 0.0086 0.0182
Leishmania major hypothetical protein, conserved 0.0025 0.0055 0.0321
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0025 0.0053 0.0113
Loa Loa (eye worm) hypothetical protein 0.0031 0.0086 0.0182
Echinococcus granulosus mothers against decapentaplegic 5 0.0025 0.0053 0.0113
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0143 0.0746 0.4438
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0031 0.0086 0.0182
Mycobacterium tuberculosis Carboxylesterase LipT 0.0139 0.0722 0.0721
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0055 0.2083
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0001 0.0003
Echinococcus granulosus jumonji domain containing protein 0.0041 0.0145 0.0307
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0078 0.0166
Entamoeba histolytica hypothetical protein 0.0109 0.0543 1
Schistosoma mansoni coup transcription factor 0.0031 0.0086 0.0182
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0421 0.2366 0.5001
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0031 0.0086 0.0182
Echinococcus granulosus para nitrobenzyl esterase 0.0139 0.0722 0.1527
Mycobacterium ulcerans hypothetical protein 0.016 0.084 0.3816
Brugia malayi hypothetical protein 0.0139 0.0722 0.1527
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0018 0.0038
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.02 0.0423
Brugia malayi Carboxylesterase family protein 0.0139 0.0722 0.1527
Brugia malayi Smad1 0.0025 0.0053 0.0113
Echinococcus multilocularis Smad4 0.0025 0.0053 0.0113
Echinococcus granulosus histone lysine methyltransferase setb 0.006 0.026 0.055
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0109 0.0543 0.1149
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0031 0.0086 0.0182
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0191 0.0404
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0109 0.0543 0.1149
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0086 0.0182
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.026 0.055
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0031 0.0086 0.0182
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0018 0.0097
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.019 0.0402
Schistosoma mansoni ap endonuclease 0.0019 0.0018 0.0038
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0002 0.0004
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0086 0.0182
Loa Loa (eye worm) hypothetical protein 0.0016 0.0002 0.0004
Schistosoma mansoni nuclear hormone receptor 0.0031 0.0086 0.0182
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0114 0.0242
Brugia malayi jmjC domain containing protein 0.0035 0.0114 0.0242
Echinococcus multilocularis acetylcholinesterase 0.0825 0.473 1
Loa Loa (eye worm) hypothetical protein 0.0139 0.0722 0.1527
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0181 0.0966 0.338
Echinococcus multilocularis acetylcholinesterase 0.0825 0.473 1
Loa Loa (eye worm) Smad1 0.0025 0.0053 0.0113
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0055 0.0321
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0031 0.0086 0.0182
Brugia malayi Bromodomain containing protein 0.0029 0.0078 0.0166
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0086 0.0182
Schistosoma mansoni neuroligin 3 (S09 family) 0.0139 0.0722 0.1527
Echinococcus multilocularis survival motor neuron protein 1 0.0237 0.1294 0.2737
Loa Loa (eye worm) carboxylesterase 0.0139 0.0722 0.1527
Schistosoma mansoni hypothetical protein 0.0109 0.0543 0.1149
Loa Loa (eye worm) hypothetical protein 0.0016 0.0002 0.0004
Brugia malayi isocitrate dehydrogenase 0.0016 0.0001 0.0003
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0139 0.0722 0.0721
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0303 0.1679 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0191 0.0404
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0031 0.0086 0.0182
Echinococcus granulosus acetylcholinesterase 0.0825 0.473 1
Entamoeba histolytica hypothetical protein 0.0109 0.0543 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.006 0.026 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0018 0.0038
Echinococcus granulosus neuropeptide s receptor 0.0472 0.2668 0.5642
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0001 0.0003
Echinococcus multilocularis FTZ F1 alpha 0.0031 0.0086 0.0182
Echinococcus granulosus ecdysone induced protein 78C 0.0031 0.0086 0.0182
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0114 0.0242
Loa Loa (eye worm) MH1 domain-containing protein 0.0025 0.0053 0.0113
Echinococcus granulosus TGF beta signal transducer SmadC 0.0025 0.0053 0.0113
Echinococcus multilocularis neuropeptide receptor A26 0.0472 0.2668 0.5642
Echinococcus multilocularis peregrin 0.0029 0.0078 0.0166
Loa Loa (eye worm) hypothetical protein 0.0139 0.0722 0.1527
Brugia malayi hypothetical protein 0.0016 0.0002 0.0004
Echinococcus multilocularis microtubule associated protein 2 0.0733 0.4189 0.8857
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0078 0.2979
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0031 0.0086 0.0182
Schistosoma mansoni hypothetical protein 0.0048 0.019 0.0402
Brugia malayi photoreceptor-specific nuclear receptor 0.0031 0.0086 0.0182
Onchocerca volvulus 0.0139 0.0722 0.2451
Loa Loa (eye worm) hypothetical protein 0.0181 0.0966 0.2043
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0031 0.0086 0.0182
Brugia malayi Carboxylesterase family protein 0.0139 0.0722 0.1527
Schistosoma mansoni steroid hormone receptor ad4bp 0.0031 0.0086 0.0182
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0825 0.473 1
Onchocerca volvulus 0.0139 0.0722 0.2451
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0001 0.0003
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0078 0.2979
Onchocerca volvulus 0.0479 0.2705 1
Mycobacterium tuberculosis RecA protein (recombinase A) [contains: endonuclease PI-MTUI (MTU RecA intein)]. 0.1339 0.7734 0.7733
Echinococcus granulosus smad 0.0025 0.0053 0.0113
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0031 0.0086 0.0182
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.006 0.026 0.055
Giardia lamblia PHD finger protein 15 0.0029 0.0078 1
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0078 0.0166
Schistosoma mansoni ap endonuclease 0.0019 0.0018 0.0038
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0191 0.0404
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0018 0.0016
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0191 0.0404
Brugia malayi nuclear hormone receptor 0.0031 0.0086 0.0182
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0016 0.0002 0.0004
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0096 0.0467 0.0988
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0018 0.0097
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0031 0.0086 0.0182
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0078 0.0166
Trichomonas vaginalis set domain proteins, putative 0.0479 0.2705 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0031 0.0086 0.0182
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0016 0.0002 0.0004
Treponema pallidum replicative DNA helicase (dnaB) 0.0388 0.2174 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0049 0.0191 0.0404
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0096 0.0467 0.0988
Plasmodium vivax SET domain protein, putative 0.006 0.026 1
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0139 0.0722 0.1527
Onchocerca volvulus 0.0139 0.0722 0.2451
Brugia malayi hypothetical protein 0.0016 0.0002 0.0004
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0191 0.0404
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0001 0.0003
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0031 0.0086 0.0182
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0055 0.6995
Schistosoma mansoni jumonji domain containing protein 0.0076 0.0352 0.0745
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0031 0.0086 0.0182
Loa Loa (eye worm) transcription factor SMAD2 0.0366 0.2049 0.4331
Loa Loa (eye worm) hypothetical protein 0.006 0.026 0.055
Loa Loa (eye worm) hypothetical protein 0.0031 0.0086 0.0182
Wolbachia endosymbiont of Brugia malayi replicative DNA helicase 0.0388 0.2174 1
Schistosoma mansoni smad1 5 8 and 0.0025 0.0053 0.0113
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0031 0.0086 0.0182
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0055 0.2083
Echinococcus multilocularis thyroid hormone receptor alpha 0.0031 0.0086 0.0182
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0002 0.0004
Loa Loa (eye worm) hypothetical protein 0.0825 0.473 1
Loa Loa (eye worm) hypothetical protein 0.005 0.0201 0.0424
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0031 0.0086 0.0182
Loa Loa (eye worm) hypothetical protein 0.0031 0.0086 0.0182
Loa Loa (eye worm) hypothetical protein 0.0031 0.0086 0.0182
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0139 0.0722 0.1527
Loa Loa (eye worm) hypothetical protein 0.0139 0.0722 0.1527
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0031 0.0086 0.0182
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0031 0.0086 0.0182
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0031 0.0086 0.0182
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0018 0.0038
Loa Loa (eye worm) hypothetical protein 0.0031 0.0086 0.0182
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.026 0.055
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.02 0.0423
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0016 0.0002 0.0004
Chlamydia trachomatis replicative DNA helicase 0.0388 0.2174 0.5
Brugia malayi Carboxylesterase family protein 0.0139 0.0722 0.1527
Echinococcus multilocularis para nitrobenzyl esterase 0.0139 0.0722 0.1527
Loa Loa (eye worm) hypothetical protein 0.0025 0.0055 0.0117
Onchocerca volvulus 0.0139 0.0722 0.2451
Loa Loa (eye worm) hypothetical protein 0.005 0.02 0.0423
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0055 0.6995
Brugia malayi MH2 domain containing protein 0.0025 0.0053 0.0113
Loa Loa (eye worm) hypothetical protein 0.0139 0.0722 0.1527
Echinococcus granulosus peregrin 0.0029 0.0078 0.0166
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0086 0.0182
Brugia malayi jmjC domain containing protein 0.0096 0.0467 0.0988
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0052 0.0211 0.125
Brugia malayi MH2 domain containing protein 0.0366 0.2049 0.4331
Leishmania major mitochondrial DNA polymerase beta 0.0303 0.1679 1
Schistosoma mansoni Smad4 0.0025 0.0053 0.0113
Echinococcus multilocularis jumonji domain containing protein 0.0041 0.0145 0.0307
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0086 0.0182
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0018 0.0038
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.006 0.026 0.055
Echinococcus multilocularis neuroligin 0.0139 0.0722 0.1527
Loa Loa (eye worm) twinkle helicase 0.0111 0.0555 0.1173
Schistosoma mansoni retinoic acid receptor RXR 0.0031 0.0086 0.0182
Echinococcus multilocularis geminin 0.017 0.0901 0.1906
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0191 0.0404
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0031 0.0086 0.0182
Echinococcus granulosus FTZ F1 alpha 0.0031 0.0086 0.0182
Loa Loa (eye worm) acetylcholinesterase 1 0.0825 0.473 1
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0139 0.0722 0.0721
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0016 0.0002 0.0004
Loa Loa (eye worm) hypothetical protein 0.0031 0.0086 0.0182
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0001 0.0003
Echinococcus granulosus carboxylesterase 5A 0.0825 0.473 1
Brugia malayi Carboxylesterase family protein 0.0825 0.473 1
Mycobacterium ulcerans replicative DNA helicase DnaB 0.0388 0.2174 1
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0086 0.0182
Echinococcus granulosus BC026374 protein S09 family 0.0139 0.0722 0.1527
Loa Loa (eye worm) hypothetical protein 0.0031 0.0086 0.0182
Echinococcus multilocularis neuropeptide s receptor 0.0472 0.2668 0.5642
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0031 0.0086 0.0182
Loa Loa (eye worm) hypothetical protein 0.0034 0.0107 0.0227
Echinococcus multilocularis smad 0.0025 0.0053 0.0113
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0031 0.0086 0.0182
Entamoeba histolytica hypothetical protein 0.0109 0.0543 1
Loa Loa (eye worm) hypothetical protein 0.0139 0.0722 0.1527
Echinococcus granulosus lysine specific demethylase 5A 0.0035 0.0114 0.0242
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0086 0.0182
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0303 0.1679 1
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0001 0.0003
Onchocerca volvulus 0.0139 0.0722 0.2451
Schistosoma mansoni survival motor neuron protein 0.0048 0.019 0.0402
Echinococcus granulosus Smad4 0.0025 0.0053 0.0113
Brugia malayi follicle stimulating hormone receptor 0.0282 0.1556 0.329
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0086 0.0182
Schistosoma mansoni acetylcholinesterase 0.0139 0.0722 0.1527
Echinococcus multilocularis mothers against decapentaplegic 5 0.0025 0.0053 0.0113
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0018 0.2123
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0086 0.0182
Loa Loa (eye worm) hypothetical protein 0.0139 0.0722 0.1527
Onchocerca volvulus 0.0048 0.019 0.0426
Brugia malayi steroid hormone receptor 0.0031 0.0086 0.0182
Schistosoma mansoni smad 0.0025 0.0053 0.0113
Echinococcus granulosus geminin 0.017 0.0901 0.1906
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0018 0.0632
Schistosoma mansoni Replicative DNA helicase 0.0388 0.2174 0.4596
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0058 0.0247 0.0522
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0139 0.0722 0.1527
Loa Loa (eye worm) hypothetical protein 0.0016 0.0002 0.0004
Schistosoma mansoni hypothetical protein 0.0029 0.0078 0.0166
Loa Loa (eye worm) carboxylesterase 0.0825 0.473 1
Echinococcus multilocularis ecdysone induced protein 78C 0.0031 0.0086 0.0182
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0139 0.0722 0.1527
Loa Loa (eye worm) hypothetical protein 0.0237 0.1294 0.2737
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0025 0.0053 0.0113
Mycobacterium ulcerans carboxylesterase, LipT 0.0139 0.0722 0.3268
Brugia malayi Carboxylesterase family protein 0.0139 0.0722 0.1527
Schistosoma mansoni smad1 5 8 and 0.0025 0.0053 0.0113
Echinococcus multilocularis carboxylesterase 5A 0.0825 0.473 1
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0139 0.0722 0.1527
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0031 0.0086 0.0182
Onchocerca volvulus 0.0031 0.0086 0.0029
Trichomonas vaginalis spcc417.12 protein, putative 0.0139 0.0722 0.2622
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0114 0.0242
Brugia malayi MH1 domain containing protein 0.0025 0.0053 0.0113
Echinococcus multilocularis BC026374 protein (S09 family) 0.0139 0.0722 0.1527
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0031 0.0086 0.0182
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.026 0.055
Brugia malayi N-terminal motif family protein 0.0181 0.0966 0.2043
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0055 0.0321
Mycobacterium tuberculosis Conserved hypothetical protein 0.016 0.084 0.0839
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0086 0.0182
Brugia malayi MH1 domain containing protein 0.0025 0.0053 0.0113
Brugia malayi Pre-SET motif family protein 0.0421 0.2366 0.5001
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0031 0.0086 0.0182
Brugia malayi MH2 domain containing protein 0.0025 0.0053 0.0113
Loa Loa (eye worm) hypothetical protein 0.0139 0.0722 0.1527
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0031 0.0086 0.0029
Loa Loa (eye worm) hypothetical protein 0.0031 0.0086 0.0182
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0191 0.0404
Echinococcus granulosus microtubule associated protein 2 0.0733 0.4189 0.8857
Loa Loa (eye worm) steroid hormone receptor 0.0031 0.0086 0.0182
Brugia malayi hypothetical protein 0.0109 0.0543 0.1149
Loa Loa (eye worm) hypothetical protein 0.0029 0.0078 0.0166
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0043 0.0157 0.0925
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0018 0.0097
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0031 0.0086 0.0182
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0043 0.0157 0.0925
Schistosoma mansoni hypothetical protein 0.017 0.0901 0.1906
Onchocerca volvulus Bile acid receptor homolog 0.0031 0.0086 0.0029
Loa Loa (eye worm) hypothetical protein 0.0825 0.473 1
Echinococcus granulosus neuropeptide receptor A26 0.0472 0.2668 0.5642
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0143 0.0746 0.4438
Brugia malayi hypothetical protein 0.0025 0.0055 0.0117

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.2332 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 4.1475 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 6.3096 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 6.3096 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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