Detailed information for compound 1233461

Basic information

Technical information
  • TDR Targets ID: 1233461
  • Name: T5595552
  • MW: 424.296 | Formula: C20H20Cl2FN3O2
  • H donors: 1 H acceptors: 2 LogP: 3.39 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1cccc(c1)C(=O)NCC(=O)N1CCN(CC1)Cc1c(F)cccc1Cl
  • InChi: 1S/C20H20Cl2FN3O2/c21-15-4-1-3-14(11-15)20(28)24-12-19(27)26-9-7-25(8-10-26)13-16-17(22)5-2-6-18(16)23/h1-6,11H,7-10,12-13H2,(H,24,28)
  • InChiKey: ZMKHRJQRTMIWCL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi cysteine protease, putative 0.0388 0.303 0.2763
Loa Loa (eye worm) cathepsin B 0.0416 0.3348 0.3348
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.073 0.6933 1
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0156 0.037 0.037
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0625 0.5731 0.5731
Brugia malayi Cathepsin L-like precursor 0.073 0.6933 0.6933
Brugia malayi cathepsin L-like precursor 0.0497 0.4272 0.4272
Onchocerca volvulus 0.073 0.6933 1
Echinococcus granulosus cathepsin b 0.0998 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.073 0.6933 1
Plasmodium vivax unspecified product 0.0233 0.1247 0.1337
Brugia malayi Papain family cysteine protease containing protein 0.0156 0.037 0.037
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.073 0.6933 1
Leishmania major cathepsin L-like protease 0.073 0.6933 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.073 0.6933 0.6933
Echinococcus multilocularis cathepsin L cysteine protease 0.073 0.6933 0.6933
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0156 0.037 0.0533
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.073 0.6933 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0388 0.303 0.303
Brugia malayi cathepsin L-like cysteine proteinase 0.0156 0.037 0.037
Brugia malayi Cathepsin L-like precursor 0.0497 0.4272 0.4272
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.073 0.6933 1
Brugia malayi cathepsin Z-like cysteine proteinase 0.0156 0.037 0.037
Echinococcus granulosus cathepsin l1 0.073 0.6933 0.6933
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0156 0.037 0.0533
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0156 0.037 0.0533
Echinococcus granulosus cysteine protease 0.0388 0.303 0.303
Plasmodium vivax unspecified product 0.0388 0.303 0.4054
Trypanosoma cruzi cysteine peptidase, putative 0.0233 0.1247 0.0911
Trypanosoma cruzi cruzipain precursor, putative 0.073 0.6933 0.6815
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.073 0.6933 1
Brugia malayi fibroinase precursor 0.0156 0.037 0.037
Entamoeba histolytica cysteine proteinase 2 0.0388 0.303 0.4054
Echinococcus granulosus cathepsin L 0.0156 0.037 0.037
Schistosoma mansoni voltage-gated potassium channel 0.0181 0.0656 0.0656
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.073 0.6933 1
Echinococcus granulosus cathepsin L cysteine protease 0.0388 0.303 0.303
Loa Loa (eye worm) ctsf protein 0.073 0.6933 0.6933
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.073 0.6933 1
Onchocerca volvulus Cathepsin L homolog 0.073 0.6933 1
Brugia malayi Cathepsin L-like precursor 0.073 0.6933 0.6933
Entamoeba histolytica cysteine proteinase, putative 0.0388 0.303 0.4054
Brugia malayi cathepsin L precursor 0.0156 0.037 0.037
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0156 0.037 0.037
Echinococcus multilocularis cathepsin b 0.0998 1 1
Brugia malayi Cathepsin L-like precursor 0.073 0.6933 0.6933
Leishmania major cathepsin L-like protease 0.073 0.6933 1
Entamoeba histolytica cysteine protease, putative 0.0388 0.303 0.4054
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0388 0.303 0.303
Brugia malayi Papain family cysteine protease containing protein 0.0156 0.037 0.037
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.073 0.6933 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.073 0.6933 1
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0156 0.037 0.037
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0156 0.037 0.0533
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0998 1 1
Leishmania major cathepsin L-like protease 0.073 0.6933 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0156 0.037 0.0533
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.073 0.6933 1
Onchocerca volvulus 0.073 0.6933 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.073 0.6933 1
Brugia malayi Cathepsin L-like precursor 0.0497 0.4272 0.4272
Echinococcus granulosus cathepsin l cysteine peptidase 0.073 0.6933 0.6933
Echinococcus multilocularis cathepsin L 0.0388 0.303 0.303
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0388 0.303 0.4371
Leishmania major cysteine peptidase A (CPA) 0.073 0.6933 1
Plasmodium falciparum cysteine proteinase falcipain 3 0.073 0.6933 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0156 0.037 0.037
Brugia malayi Cathepsin L-like precursor 0.073 0.6933 0.6933
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.073 0.6933 1
Echinococcus granulosus cathepsin L 0.0388 0.303 0.303
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0156 0.037 0.0533
Trypanosoma cruzi cysteine peptidase, putative 0.073 0.6933 0.6815
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.073 0.6933 1
Entamoeba histolytica cysteine protease, putative 0.0388 0.303 0.4054
Plasmodium vivax vivapain-1 0.0388 0.303 0.4054
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.073 0.6933 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0156 0.037 0.037
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0497 0.4272 0.6162
Loa Loa (eye worm) hypothetical protein 0.0233 0.1247 0.1247
Entamoeba histolytica cysteine protease, putative 0.0388 0.303 0.4054
Onchocerca volvulus Cathepsin L homolog 0.073 0.6933 1
Onchocerca volvulus Cathepsin F homolog 0.073 0.6933 1
Entamoeba histolytica cysteine protease, putative 0.0388 0.303 0.4054
Loa Loa (eye worm) hypothetical protein 0.0497 0.4272 0.4272
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.073 0.6933 1
Brugia malayi Papain family cysteine protease containing protein 0.0156 0.037 0.037
Echinococcus multilocularis cysteine protease 0.073 0.6933 0.6933
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0388 0.303 0.2763
Trypanosoma cruzi cysteine peptidase, putative 0.0388 0.303 0.2763
Loa Loa (eye worm) hypothetical protein 0.0497 0.4272 0.4272
Loa Loa (eye worm) hypothetical protein 0.0998 1 1
Onchocerca volvulus 0.073 0.6933 1
Echinococcus multilocularis voltage gated potassium channel 0.0181 0.0656 0.0656
Entamoeba histolytica cysteine protease, putative 0.0388 0.303 0.4054
Brugia malayi cathepsin F-like cysteine proteinase 0.0233 0.1247 0.1247
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.073 0.6933 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0156 0.037 0.0533
Entamoeba histolytica cysteine protease, putative 0.073 0.6933 1
Loa Loa (eye worm) hypothetical protein 0.0156 0.037 0.037
Trypanosoma cruzi cysteine peptidase, putative 0.073 0.6933 0.6815
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.073 0.6933 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.073 0.6933 1
Trichomonas vaginalis conserved hypothetical protein 0.0156 0.037 0.0533
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.073 0.6933 1
Brugia malayi Cathepsin L-like precursor 0.073 0.6933 0.6933
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.073 0.6933 1
Onchocerca volvulus 0.073 0.6933 1
Schistosoma mansoni cathepsin S (C01 family) 0.0156 0.037 0.037
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0998 1 1
Loa Loa (eye worm) hypothetical protein 0.073 0.6933 0.6933
Echinococcus granulosus cathepsin b 0.0998 1 1
Loa Loa (eye worm) hypothetical protein 0.0156 0.037 0.037
Entamoeba histolytica cysteine protease, putative 0.0388 0.303 0.4054
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0233 0.1247 0.1247
Plasmodium vivax vivapain-2 0.073 0.6933 1
Loa Loa (eye worm) hypothetical protein 0.0233 0.1247 0.1247
Entamoeba histolytica cysteine protease, putative 0.0388 0.303 0.4054
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.073 0.6933 0.6933
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0181 0.0656 0.0656
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0388 0.303 0.303
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0998 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0416 0.3348 0.4829
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.073 0.6933 1
Entamoeba histolytica cysteine proteinase, putative 0.0388 0.303 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0156 0.037 0.0533
Loa Loa (eye worm) hypothetical protein 0.0233 0.1247 0.1247
Plasmodium vivax vivapain-3 0.0388 0.303 0.4054
Plasmodium falciparum cysteine proteinase falcipain 2a 0.073 0.6933 1
Leishmania major cathepsin L-like protease 0.073 0.6933 1
Schistosoma mansoni voltage-gated potassium channel 0.0682 0.6388 0.6388
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.073 0.6933 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0156 0.037 0.0533
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.073 0.6933 1
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0156 0.037 0.037
Brugia malayi cathepsin F-like cysteine proteinase 0.0156 0.037 0.037
Trichomonas vaginalis conserved hypothetical protein 0.0156 0.037 0.0533
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0625 0.5731 0.5731
Onchocerca volvulus 0.0497 0.4272 0.5946
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0156 0.037 0.037
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.073 0.6933 1
Entamoeba histolytica cysteine proteinase, putative 0.0388 0.303 0.4054
Schistosoma mansoni cathepsin F (C01 family) 0.073 0.6933 0.6933
Plasmodium vivax vivapain-2 0.073 0.6933 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.073 0.6933 1
Entamoeba histolytica cysteine proteinase, putative 0.073 0.6933 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0998 1 1
Echinococcus granulosus cathepsin l1 0.0497 0.4272 0.4272
Giardia lamblia Cathepsin B precursor 0.0416 0.3348 1
Brugia malayi Papain family cysteine protease containing protein 0.0388 0.303 0.303
Giardia lamblia Cathepsin B precursor 0.0416 0.3348 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.073 0.6933 0.6933
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.073 0.6933 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.073 0.6933 1
Leishmania major cathepsin L-like protease 0.073 0.6933 1
Giardia lamblia Cathepsin B precursor 0.0416 0.3348 1
Leishmania major cathepsin L-like protease 0.073 0.6933 1
Entamoeba histolytica cysteine proteinase 1, putative 0.0388 0.303 0.4054
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0583 0.5261 0.7589
Onchocerca volvulus 0.073 0.6933 1
Trypanosoma cruzi cysteine peptidase, putative 0.073 0.6933 0.6815
Echinococcus multilocularis cathepsin L cysteine protease 0.073 0.6933 0.6933
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0181 0.0656 0.0656
Loa Loa (eye worm) hypothetical protein 0.0181 0.0656 0.0656
Entamoeba histolytica cysteine protease, putative 0.0388 0.303 0.4054
Trypanosoma cruzi cysteine proteinase, putative 0.0388 0.303 0.2763
Toxoplasma gondii cathepsin CPL 0.073 0.6933 1
Brugia malayi Papain family cysteine protease containing protein 0.073 0.6933 0.6933
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.073 0.6933 1
Schistosoma mansoni cathepsin C 0.0156 0.037 0.037
Schistosoma mansoni voltage-gated potassium channel 0.0682 0.6388 0.6388
Schistosoma mansoni cathepsin B (C01 family) 0.0156 0.037 0.037
Entamoeba histolytica cysteine protease, putative 0.0388 0.303 0.4054
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0156 0.037 0.037
Brugia malayi Cathepsin L-like precursor 0.073 0.6933 0.6933
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.073 0.6933 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0156 0.037 0.0533
Entamoeba histolytica cysteine proteinase, putative 0.0388 0.303 0.4054
Leishmania major cathepsin L-like protease 0.073 0.6933 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0156 0.037 0.0533
Schistosoma mansoni cathepsin F (C01 family) 0.073 0.6933 0.6933
Loa Loa (eye worm) hypothetical protein 0.0156 0.037 0.037
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0181 0.0656 0.0656
Brugia malayi Papain family cysteine protease containing protein 0.0388 0.303 0.303
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0156 0.037 0.0533
Echinococcus multilocularis cathepsin b 0.0998 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.073 0.6933 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.073 0.6933 1
Echinococcus granulosus voltage gated potassium channel 0.0181 0.0656 0.0656
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.073 0.6933 1
Trypanosoma cruzi cysteine proteinase, putative 0.0388 0.303 0.2763
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0156 0.037 0.0533
Loa Loa (eye worm) hypothetical protein 0.0542 0.4788 0.4788
Entamoeba histolytica cysteine protease, putative 0.0388 0.303 0.4054
Trypanosoma brucei cysteine peptidase C (CPC) 0.0416 0.3348 0.0814
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0497 0.4272 0.6162
Brugia malayi Cathepsin L-like precursor 0.0233 0.1247 0.1247
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0156 0.037 0.0533
Loa Loa (eye worm) fibroinase 0.073 0.6933 0.6933
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0625 0.5731 0.5731
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0156 0.037 0.037
Loa Loa (eye worm) cysteine protease 0.073 0.6933 0.6933
Echinococcus multilocularis cysteine protease 0.073 0.6933 0.6933
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0156 0.037 0.0533
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0497 0.4272 0.4052
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0998 1 1
Schistosoma mansoni cathepsin F (C01 family) 0.0497 0.4272 0.4272
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0156 0.037 0.037
Loa Loa (eye worm) hypothetical protein 0.0156 0.037 0.037
Onchocerca volvulus 0.073 0.6933 1
Schistosoma mansoni voltage-gated potassium channel 0.0181 0.0656 0.0656
Trypanosoma cruzi cruzipain precursor, putative 0.0233 0.1247 0.0911
Echinococcus granulosus cathepsin L cysteine proteinase 0.073 0.6933 0.6933
Entamoeba histolytica cysteine protease, putative 0.0388 0.303 0.4054
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0416 0.3348 0.3348
Echinococcus multilocularis cathepsin l cysteine peptidase 0.073 0.6933 0.6933
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0625 0.5731 0.5731
Brugia malayi Cathepsin L-like cysteine proteinase 0.0497 0.4272 0.4272
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0156 0.037 0.0533
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0156 0.037 0.037
Loa Loa (eye worm) hypothetical protein 0.0156 0.037 0.037
Plasmodium falciparum cysteine proteinase falcipain 1 0.0388 0.303 0.4054
Entamoeba histolytica cysteine proteinase, putative 0.0497 0.4272 0.5946
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0388 0.303 0.4371
Echinococcus multilocularis cathepsin L 0.0156 0.037 0.037
Loa Loa (eye worm) hypothetical protein 0.0156 0.037 0.037
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0583 0.5261 0.7589
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.073 0.6933 1
Leishmania major cathepsin L-like protease 0.073 0.6933 1
Plasmodium falciparum cysteine proteinase falcipain 2b 0.073 0.6933 1
Brugia malayi cathepsin Z-like cysteine proteinase 0.0156 0.037 0.037
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0416 0.3348 0.3093
Toxoplasma gondii cathepsin B 0.0416 0.3348 0.4538
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0156 0.037 0.037
Entamoeba histolytica cysteine protease, putative 0.0388 0.303 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.073 0.6933 1
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0233 0.1247 0.1247
Schistosoma mansoni cathepsin s 0.0233 0.1247 0.1247
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0156 0.037 0.037
Trypanosoma cruzi cysteine peptidase, putative 0.073 0.6933 0.6815
Onchocerca volvulus 0.073 0.6933 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.073 0.6933 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0156 0.037 0.0533
Entamoeba histolytica cysteine protease, putative 0.0388 0.303 0.4054
Entamoeba histolytica cysteine proteinase, putative 0.073 0.6933 1
Loa Loa (eye worm) hypothetical protein 0.0497 0.4272 0.4272

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 8.9125 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 20.5962 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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