Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | thyroid hormone receptor, beta | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | photoreceptor-specific nuclear receptor | thyroid hormone receptor, beta | 461 aa | 414 aa | 24.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | acetylcholinesterase | 0.0339 | 1 | 1 |
Onchocerca volvulus | 0.0057 | 0 | 0.5 | |
Echinococcus multilocularis | acetylcholinesterase | 0.0339 | 1 | 1 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0057 | 0 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0339 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0339 | 1 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0164 | 0.3792 | 0.3792 |
Schistosoma mansoni | hypothetical protein | 0.0152 | 0.3359 | 0.3359 |
Onchocerca volvulus | 0.0057 | 0 | 0.5 | |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0057 | 0 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0164 | 0.3792 | 0.3792 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0057 | 0 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0339 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0339 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0057 | 0 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0339 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0339 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0339 | 1 | 1 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0152 | 0.3359 | 0.3359 |
Echinococcus granulosus | carboxylesterase 5A | 0.0339 | 1 | 1 |
Onchocerca volvulus | 0.0057 | 0 | 0.5 | |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0057 | 0 | 0.5 |
Onchocerca volvulus | 0.0057 | 0 | 0.5 | |
Onchocerca volvulus | 0.0057 | 0 | 0.5 | |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0339 | 1 | 1 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0152 | 0.3359 | 0.3359 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0164 | 0.3792 | 0.3792 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0057 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0339 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 3 um | PUBCHEM_BIOASSAY: Secondary Confirmation Assay for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2, Texas Red Fluoroprobe. (Class of assay: confirmatory) [Related pubchem assays: 1573, 1469, 1570, 1479, 1571, 1572 ] | ChEMBL. | No reference |
Potency (functional) | = 12.6 um | PUBCHEM_BIOASSAY: Gene Reporter Secondary Assay for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2 in a Thyroid Receptor Assay. (Class of assay: confirmatory) [Related pubchem assays: 1573, 1485, 1469, 1570, 1479, 1571, 1572 ] | ChEMBL. | No reference |
Potency (functional) | = 19.9 um | PUBCHEM_BIOASSAY: Cell Viability Secondary Assay for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2. (Class of assay: confirmatory) [Related pubchem assays: 1479, 1573, 1571, 1485, 1469, 1572, 1570 ] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.