Detailed information for compound 1233997

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 344.448 | Formula: C18H16O3S2
  • H donors: 0 H acceptors: 1 LogP: 4.94 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)c1c(sc2c1cc(OC)cc2)c1ccc(cc1)SC
  • InChi: 1S/C18H16O3S2/c1-20-12-6-9-15-14(10-12)16(18(19)21-2)17(23-15)11-4-7-13(22-3)8-5-11/h4-10H,1-3H3
  • InChiKey: YMDDDGJIPJHXNM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens Rap guanine nucleotide exchange factor (GEF) 4 Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens tumor protein p53 Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens _UBC13, UbcH-ben, UbcH13 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania donovani ubiquitin-conjugating enzyme E2, putative Get druggable targets OG5_127739 All targets in OG5_127739
Theileria parva ubiquitin-protein ligase, putative Get druggable targets OG5_127739 All targets in OG5_127739
Schistosoma japonicum ko:K10580 ubiquitin-conjugating enzyme E2 N, putative Get druggable targets OG5_127739 All targets in OG5_127739
Cryptosporidium hominis ubiquitin-conjugating enzyme Get druggable targets OG5_127739 All targets in OG5_127739
Entamoeba histolytica ubiquitin-conjugating enzyme family protein Get druggable targets OG5_127739 All targets in OG5_127739
Brugia malayi N-terminal motif family protein Get druggable targets OG5_131726 All targets in OG5_131726
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative Get druggable targets OG5_127739 All targets in OG5_127739
Brugia malayi Ubiquitin conjugating enzyme protein 13 Get druggable targets OG5_127739 All targets in OG5_127739
Candida albicans post-replication repair Get druggable targets OG5_127739 All targets in OG5_127739
Echinococcus granulosus ubiquitin conjugating enzyme E2 N Get druggable targets OG5_127739 All targets in OG5_127739
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog Get druggable targets OG5_131726 All targets in OG5_131726
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 Get druggable targets OG5_127739 All targets in OG5_127739
Echinococcus granulosus tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Plasmodium falciparum ubiquitin-conjugating enzyme E2 N, putative Get druggable targets OG5_127739 All targets in OG5_127739
Plasmodium knowlesi ubiquitin-conjugating enzyme E2 N, putative Get druggable targets OG5_127739 All targets in OG5_127739
Candida albicans ubiquitin-conjugating enzyme Get druggable targets OG5_127739 All targets in OG5_127739
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 Get druggable targets OG5_127739 All targets in OG5_127739
Babesia bovis ubiquitin-conjugating enzyme E2, putative Get druggable targets OG5_127739 All targets in OG5_127739
Trypanosoma congolense ubiquitin-protein ligase, putative Get druggable targets OG5_127739 All targets in OG5_127739
Cryptosporidium parvum ubiquitin-conjugating enzyme Get druggable targets OG5_127739 All targets in OG5_127739
Brugia malayi ubiquitin conjugating enzyme protein 13 Get druggable targets OG5_127739 All targets in OG5_127739
Trypanosoma brucei gambiense ubiquitin-conjugating enzyme e2, putative,ubiquitin carrier protein, putative,ubiquitin-protein ligase, putative Get druggable targets OG5_127739 All targets in OG5_127739
Leishmania major ubiquitin-conjugating enzyme e2, putative Get druggable targets OG5_127739 All targets in OG5_127739
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131726 All targets in OG5_131726
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative Get druggable targets OG5_127739 All targets in OG5_127739
Leishmania braziliensis ubiquitin-conjugating enzyme e2, putative Get druggable targets OG5_127739 All targets in OG5_127739
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative Get druggable targets OG5_127739 All targets in OG5_127739
Echinococcus multilocularis ubiquitin conjugating enzyme E2 N Get druggable targets OG5_127739 All targets in OG5_127739
Plasmodium vivax ubiquitin-conjugating enzyme E2 N, putative Get druggable targets OG5_127739 All targets in OG5_127739
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative Get druggable targets OG5_127739 All targets in OG5_127739
Schistosoma mansoni ubiquitin conjugating enzyme 13 Get druggable targets OG5_127739 All targets in OG5_127739
Echinococcus multilocularis tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Toxoplasma gondii ubiquitin-conjugating enzyme subfamily protein Get druggable targets OG5_127739 All targets in OG5_127739
Leishmania infantum ubiquitin-conjugating enzyme e2, putative Get druggable targets OG5_127739 All targets in OG5_127739
Candida albicans ubiquitin conjugating enzyme Get druggable targets OG5_127739 All targets in OG5_127739
Trypanosoma brucei ubiquitin-protein ligase, putative Get druggable targets OG5_127739 All targets in OG5_127739
Leishmania mexicana ubiquitin-conjugating enzyme e2, putative Get druggable targets OG5_127739 All targets in OG5_127739
Neospora caninum Ubiquitin carrier protein (EC 6.3.2.-), related Get druggable targets OG5_127739 All targets in OG5_127739
Plasmodium berghei ubiquitin-conjugating enzyme E2 N, putative Get druggable targets OG5_127739 All targets in OG5_127739
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Plasmodium falciparum ubiquitin-conjugating enzyme E2, putative _UBC13, UbcH-ben, UbcH13 152 aa 153 aa 32.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.1045 0.6062 0.6061
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0055 0.0261 0.0264
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0055 0.0261 0.0264
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0059 0.0286 0.0473
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0059 0.0286 0.0438
Onchocerca volvulus 0.0059 0.0286 0.0469
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.1045 0.6062 0.6061
Echinococcus multilocularis histone acetyltransferase MYST2 0.0043 0.019 0.0188
Trichomonas vaginalis aldo-keto reductase, putative 0.0303 0.1713 0.2808
Echinococcus granulosus aldo keto reductase 0.1045 0.6062 0.6061
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0157 0.0862 0.1418
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0092 0.0481 0.076
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0055 0.0261 0.0431
Loa Loa (eye worm) hypothetical protein 0.0035 0.0148 0.0148
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0055 0.0261 0.0259
Brugia malayi tailless protein 0.0026 0.0091 0.0151
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0025 0.0086 0.0135
Loa Loa (eye worm) hypothetical protein 0.0155 0.085 0.0865
Loa Loa (eye worm) hypothetical protein 0.0155 0.085 0.0865
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0244 0.0399
Echinococcus multilocularis geminin 0.039 0.2223 0.2221
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0046 0.0208 0.0205
Loa Loa (eye worm) oxidoreductase 0.1045 0.6062 0.619
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0014 0.0022 0.0029
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0013 0.0015 0.0012
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0043 0.019 0.0314
Mycobacterium ulcerans beta-lactamase 0.0059 0.0286 0.0438
Brugia malayi Fz domain containing protein 0.0035 0.0148 0.0243
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0055 0.0261 0.0431
Brugia malayi NADH-dependent xylose reductase 0.0303 0.1713 0.2826
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0203 0.1132 0.1867
Plasmodium vivax hypothetical protein, conserved 0.0014 0.0024 0.0015
Schistosoma mansoni hypothetical protein 0.0042 0.0185 0.0301
Trichomonas vaginalis aldo-keto reductase, putative 0.1045 0.6062 1
Echinococcus granulosus secreted frizzled protein 0.0035 0.0148 0.0145
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0026 0.0091 0.0089
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0025 0.0086 0.0142
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0014 0.0022 0.0036
Loa Loa (eye worm) hypothetical protein 0.0035 0.0148 0.0148
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0013 0.0015 0.002
Loa Loa (eye worm) beta-lactamase 0.0059 0.0286 0.029
Trichomonas vaginalis aldo-keto reductase, putative 0.1045 0.6062 1
Entamoeba histolytica hypothetical protein 0.0043 0.0194 0.018
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0026 0.0091 0.0151
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0055 0.0261 0.0427
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0059 0.0286 0.029
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0014 0.0022 0.0029
Schistosoma mansoni metabotropic glutamate receptor 0.0091 0.0475 0.078
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0157 0.0862 0.086
Echinococcus multilocularis frizzled 5 0.0077 0.0393 0.0391
Loa Loa (eye worm) hypothetical protein 0.0026 0.0091 0.0091
Echinococcus multilocularis SAM and MBT domain containing protein 0.0038 0.016 0.0157
Trypanosoma cruzi hypothetical protein, conserved 0.0059 0.0286 0.0438
Brugia malayi Muscleblind-like protein 0.0155 0.085 0.1401
Loa Loa (eye worm) hypothetical protein 0.0055 0.0261 0.0264
Loa Loa (eye worm) steroid hormone receptor 0.0055 0.0261 0.0264
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.0244 0.0242
Schistosoma mansoni aldo-keto reductase 0.1045 0.6062 1
Loa Loa (eye worm) nuclear receptor NHR-67 0.0026 0.0091 0.0091
Mycobacterium ulcerans esterase/lipase LipP 0.0059 0.0286 0.0438
Plasmodium vivax ubiquitin-conjugating enzyme E2 N, putative 0.0046 0.021 0.111
Loa Loa (eye worm) frizzled/Smoothened family membrane region containing protein 0.0042 0.0185 0.0187
Echinococcus multilocularis hyperpolarization activated cyclic 0.0013 0.0015 0.0012
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0055 0.0261 0.0427
Loa Loa (eye worm) hypothetical protein 0.0055 0.0261 0.0264
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.1045 0.6062 0.6061
Brugia malayi nuclear receptor NHR-67 0.0026 0.0091 0.0151
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.1045 0.6062 1
Trichomonas vaginalis glucosylceramidase, putative 0.0203 0.1132 0.1847
Echinococcus multilocularis secreted frizzled protein 0.0035 0.0148 0.0145
Toxoplasma gondii aldo/keto reductase family oxidoreductase 0.0303 0.1713 0.2823
Schistosoma mansoni nuclear receptor 0.0026 0.0091 0.0147
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0026 0.0091 0.0089
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0014 0.0019 0.0017
Brugia malayi regulator of G-protein signaling egl-10 0.0011 0.0002 0.0004
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0055 0.0261 0.0431
Schistosoma mansoni voltage-gated potassium channel 0.005 0.023 0.0375
Onchocerca volvulus Bile acid receptor homolog 0.0055 0.0261 0.0427
Toxoplasma gondii oxidoreductase, aldo/keto reductase family protein 0.0303 0.1713 0.2823
Loa Loa (eye worm) hypothetical protein 0.0059 0.0286 0.029
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0055 0.0261 0.0431
Echinococcus granulosus cGMP dependent protein kinase 1 0.0011 0.0004 0.0002
Trichomonas vaginalis glucosylceramidase, putative 0.0203 0.1132 0.1847
Trichomonas vaginalis glucosylceramidase, putative 0.0203 0.1132 0.1847
Loa Loa (eye worm) hypothetical protein 0.0029 0.0109 0.0109
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0046 0.021 0.0311
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0059 0.0286 0.0438
Loa Loa (eye worm) hypothetical protein 0.0042 0.0185 0.0187
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0055 0.0261 0.0259
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0013 0.0015 0.002
Onchocerca volvulus Protein ultraspiracle homolog 0.0055 0.0261 0.0427
Plasmodium falciparum CDGSH iron-sulfur domain-containing protein, putative 0.0014 0.0024 0.0117
Schistosoma mansoni voltage-gated potassium channel 0.0013 0.0015 0.002
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0013 0.0015 0.0012
Loa Loa (eye worm) AGC/PKG protein kinase 0.0011 0.0004 0.0002
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0148 0.0807 0.0805
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0055 0.0261 0.0259
Onchocerca volvulus 0.0059 0.0286 0.0469
Mycobacterium tuberculosis Conserved protein 0.0303 0.1713 0.28
Entamoeba histolytica alcohol dehydrogenase, putative 0.0303 0.1713 0.2722
Brugia malayi mbt repeat family protein 0.0038 0.016 0.0264
Loa Loa (eye worm) glutamate receptor 0.0011 0.0004 0.0002
Trichomonas vaginalis aldo-keto reductase, putative 0.1045 0.6062 1
Trypanosoma cruzi hypothetical protein, conserved 0.0059 0.0286 0.0438
Toxoplasma gondii NADPH-glutathione reductase 0.0014 0.0022 0.0032
Mycobacterium tuberculosis Conserved protein 0.0059 0.0286 0.0438
Plasmodium falciparum CDGSH iron-sulfur domain-containing protein, putative 0.0014 0.0024 0.0117
Trichomonas vaginalis aldo-keto reductase, putative 0.1045 0.6062 1
Brugia malayi ubiquitin conjugating enzyme protein 13 0.0046 0.021 0.0346
Echinococcus multilocularis muscleblind protein 0.0155 0.085 0.0847
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0046 0.0208 0.0343
Trichomonas vaginalis glutathione reductase, putative 0.0014 0.0022 0.0012
Trichomonas vaginalis aldo-keto reductase, putative 0.0303 0.1713 0.2808
Echinococcus granulosus frizzled 0.0077 0.0393 0.0391
Toxoplasma gondii aldose reductase, putative 0.1045 0.6062 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0109 0.0109
Echinococcus multilocularis aldo keto reductase 0.1045 0.6062 0.6061
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0011 0.0004 0.0002
Echinococcus multilocularis frizzled 0.0077 0.0393 0.0391
Echinococcus multilocularis frizzled 4 0.0077 0.0393 0.0391
Loa Loa (eye worm) hypothetical protein 0.0055 0.0261 0.0264
Schistosoma mansoni zinc finger protein 0.0026 0.0091 0.0147
Trichomonas vaginalis glucosylceramidase, putative 0.0133 0.0722 0.1169
Leishmania major ubiquitin-conjugating enzyme e2, putative 0.0046 0.021 0.0339
Echinococcus granulosus cdgsh iron sulfur domain containing protein 0.024 0.1344 0.1342
Loa Loa (eye worm) hypothetical protein 0.0026 0.0091 0.0091
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0013 0.0015 0.0012
Trichomonas vaginalis aldo-keto reductase, putative 0.1045 0.6062 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0055 0.0261 0.0264
Schistosoma mansoni frizzled-like receptor 0.0042 0.0185 0.0301
Mycobacterium tuberculosis Probable lipase LipD 0.0059 0.0286 0.0438
Schistosoma mansoni RAR-like nuclear receptor 0.0055 0.0261 0.0427
Trichomonas vaginalis mercuric reductase, putative 0.0014 0.0022 0.0012
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0025 0.0086 0.0118
Onchocerca volvulus 0.1045 0.6062 1
Schistosoma mansoni aldo-keto reductase 0.1045 0.6062 1
Loa Loa (eye worm) frizzled/Smoothened family membrane region containing protein 0.0077 0.0393 0.0399
Trichomonas vaginalis glucosylceramidase, putative 0.0141 0.0764 0.1239
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0055 0.0261 0.0259
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0194 0.0192
Giardia lamblia Aldose reductase 0.1045 0.6062 1
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0014 0.0022 0.5
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0055 0.0261 0.0259
Echinococcus multilocularis expressed conserved protein 0.0011 0.0004 0.0002
Loa Loa (eye worm) hypothetical protein 0.0013 0.0015 0.0013
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0014 0.0022 0.0103
Brugia malayi nuclear hormone receptor 0.0055 0.0261 0.0431
Brugia malayi RE40412p 0.0014 0.0024 0.004
Echinococcus multilocularis voltage gated potassium channel 0.0017 0.0037 0.0034
Schistosoma mansoni myelin transcription factor 1 myt1 0.0043 0.019 0.031
Echinococcus granulosus aldo keto reductase family 1 member B4 0.1045 0.6062 0.6061
Echinococcus granulosus cGMP dependent protein kinase 1 0.0011 0.0004 0.0002
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0013 0.0015 0.0012
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0025 0.0086 0.0138
Echinococcus granulosus ubiquitin specific protease 41 0.0025 0.0086 0.0084
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0026 0.0091 0.0147
Trichomonas vaginalis aldo-keto reductase, putative 0.1045 0.6062 1
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0055 0.0261 0.0427
Loa Loa (eye worm) thioredoxin reductase 0.004 0.0177 0.0178
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.1045 0.6062 1
Schistosoma mansoni nuclear hormone receptor 0.0026 0.0091 0.0147
Brugia malayi nuclear hormone receptor 0.0026 0.0091 0.0151
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0115 0.0615 0.1011
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0055 0.0261 0.0259
Brugia malayi Frizzled/Smoothened family membrane region containing protein 0.0042 0.0185 0.0305
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0026 0.0091 0.0089
Trichomonas vaginalis glucosylceramidase, putative 0.0133 0.0722 0.1169
Loa Loa (eye worm) hypothetical protein 0.0026 0.0091 0.0091
Schistosoma mansoni serine/threonine protein kinase 0.0157 0.0862 0.1418
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0103 0.0541 0.086
Loa Loa (eye worm) hypothetical protein 0.0026 0.0091 0.0091
Onchocerca volvulus 0.0035 0.0148 0.0239
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0059 0.0286 0.0438
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0052 0.0244 0.0247
Loa Loa (eye worm) hypothetical protein 0.0026 0.0091 0.0091
Entamoeba histolytica alcohol dehydrogenase, putative 0.0303 0.1713 0.2722
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0038 0.016 0.026
Echinococcus multilocularis aldo keto reductase 0.1045 0.6062 0.6061
Loa Loa (eye worm) MBCTL1 0.0043 0.019 0.0192
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0059 0.0286 0.0438
Brugia malayi GnHR receptor homolog 0.0201 0.1118 0.1845
Schistosoma mansoni pol-related 0.1045 0.6062 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.0244 0.0242
Leishmania major hypothetical protein, unknown function 0.0014 0.0024 0.0033
Loa Loa (eye worm) hypothetical protein 0.0042 0.0185 0.0187
Echinococcus granulosus aldo keto reductase family 1 member B4 0.1045 0.6062 0.6061
Brugia malayi conserved hypotetical protein 0.0026 0.0091 0.0151
Echinococcus granulosus Nuclear hormone receptor HR96 0.0026 0.0091 0.0089
Giardia lamblia Aldose reductase 0.1045 0.6062 1
Schistosoma mansoni hypothetical protein 0.0014 0.0024 0.0036
Loa Loa (eye worm) hypothetical protein 0.0025 0.0086 0.0086
Brugia malayi nuclear receptor RXR 0.0026 0.0091 0.0151
Onchocerca volvulus 0.0014 0.0024 0.0036
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0025 0.0086 0.0138
Brugia malayi Thioredoxin reductase 0.004 0.0177 0.0292
Trichomonas vaginalis glucosylceramidase, putative 0.0133 0.0722 0.1169
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0014 0.0022 0.0019
Brugia malayi DIX domain containing protein 0.0011 0.0002 0.0004
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0011 0.0004 0.0003
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0092 0.0481 0.0336
Mycobacterium tuberculosis Probable lipase LipE 0.0059 0.0286 0.0438
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0194 0.0192
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0157 0.0862 0.086
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0013 0.0015 0.002
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0046 0.0208 0.0205
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0013 0.0015 0.0013
Trypanosoma brucei ubiquitin-protein ligase, putative 0.0046 0.021 0.0311
Trichomonas vaginalis aldo-keto reductase, putative 0.1045 0.6062 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0055 0.0261 0.0259
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0046 0.021 0.0322
Echinococcus granulosus voltage gated potassium channel 0.0017 0.0037 0.0034
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0025 0.0086 0.0107
Trichomonas vaginalis glucosylceramidase, putative 0.0133 0.0722 0.1169
Loa Loa (eye worm) oxidoreductase 0.1045 0.6062 0.619
Loa Loa (eye worm) hypothetical protein 0.0036 0.0148 0.0149
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.1045 0.6062 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0091 0.0091
Plasmodium falciparum glutathione reductase 0.004 0.0177 0.101
Loa Loa (eye worm) hypothetical protein 0.0059 0.0286 0.029
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0092 0.0481 0.076
Onchocerca volvulus 0.0026 0.0091 0.0147
Echinococcus granulosus Nuclear hormone receptor HR96 0.0026 0.0091 0.0089
Brugia malayi steroid hormone receptor 0.0055 0.0261 0.0431
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0055 0.0261 0.0259
Trichomonas vaginalis aldo-keto reductase, putative 0.1045 0.6062 1
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0025 0.0086 0.0084
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0014 0.0022 0.0029
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0025 0.0086 0.0084
Loa Loa (eye worm) transcription factor SMAD2 0.0123 0.0659 0.067
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0055 0.0261 0.0431
Brugia malayi nuclear receptor RXR 0.0029 0.0109 0.0181
Mycobacterium tuberculosis Conserved protein 0.0059 0.0286 0.0438
Brugia malayi hypothetical protein 0.0029 0.0109 0.0181
Brugia malayi Steroid receptor seven-up type 2 0.0055 0.0261 0.0431
Echinococcus granulosus beta LACTamase domain containing family member 0.0059 0.0286 0.0284
Echinococcus granulosus aldo keto reductase family 1 member B4 0.1045 0.6062 0.6061
Echinococcus multilocularis frizzled 10 0.0077 0.0393 0.0391
Brugia malayi mbt repeat family protein 0.0038 0.016 0.0264
Plasmodium vivax glutathione reductase, putative 0.004 0.0177 0.0917
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0026 0.0091 0.0089
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0013 0.0015 0.0012
Brugia malayi hypothetical protein 0.0026 0.0091 0.0151
Brugia malayi N-terminal motif family protein 0.0223 0.1249 0.206
Toxoplasma gondii zinc finger cdgsh type protein 0.0014 0.0024 0.0036
Brugia malayi metabotropic glutamate receptor type 2 0.0014 0.0019 0.0032
Loa Loa (eye worm) hypothetical protein 0.0026 0.0091 0.0091
Trypanosoma brucei aldo-keto reductase, putative 0.1045 0.6062 1
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0043 0.019 0.0188
Toxoplasma gondii ABC1 family protein 0.0059 0.0286 0.0469
Echinococcus granulosus conserved hypothetical protein 0.0014 0.0024 0.0022
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0026 0.0091 0.0147
Loa Loa (eye worm) hypothetical protein 0.0026 0.0091 0.0091
Loa Loa (eye worm) hypothetical protein 0.0223 0.1249 0.1273
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0026 0.0091 0.0147
Echinococcus granulosus voltage gated potassium channel subunit 0.0303 0.1713 0.1711
Echinococcus granulosus frizzled 0.0077 0.0393 0.0391
Plasmodium vivax hypothetical protein, conserved 0.0059 0.0286 0.1565
Trichomonas vaginalis glucosylceramidase, putative 0.0203 0.1132 0.1847
Plasmodium vivax thioredoxin reductase, putative 0.004 0.0177 0.0917
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0055 0.0261 0.0431
Echinococcus multilocularis FTZ F1 alpha 0.0055 0.0261 0.0259
Schistosoma mansoni camp-dependent rap1 guanine-nucleotide exchange factor 0.0013 0.0014 0.0019
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.1045 0.6062 0.6061
Schistosoma mansoni serine/threonine protein kinase 0.0011 0.0004 0.0003
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0013 0.0015 0.0012
Echinococcus multilocularis frizzled 0.0077 0.0393 0.0391
Trypanosoma cruzi trypanothione reductase, putative 0.004 0.0177 0.0257
Trichomonas vaginalis penicillin-binding protein, putative 0.0059 0.0286 0.0449
Schistosoma mansoni secreted frizzled-related protein 0.0035 0.0148 0.0239
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0157 0.0862 0.0878
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0055 0.0261 0.0264
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0055 0.0261 0.0427
Brugia malayi Nuclear hormone receptor-like 1 0.0029 0.0109 0.0181
Schistosoma mansoni serine/threonine protein kinase 0.0011 0.0004 0.0003
Onchocerca volvulus 0.0026 0.0091 0.0147
Schistosoma mansoni thyroid hormone receptor 0.0055 0.0261 0.0427
Plasmodium vivax oxidoreductase, aldo/keto reductase domain containing protein 0.0303 0.1713 1
Echinococcus granulosus geminin 0.039 0.2223 0.2221
Schistosoma mansoni hypothetical protein 0.0228 0.1278 0.2105
Trypanosoma cruzi aldo/keto reductase, putative 0.0303 0.1713 0.28
Plasmodium falciparum CDGSH iron-sulfur domain-containing protein, putative 0.0014 0.0024 0.0117
Toxoplasma gondii ubiquitin-conjugating enzyme subfamily protein 0.0046 0.021 0.0342
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0055 0.0261 0.0427
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.1045 0.6062 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0055 0.0261 0.0259
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0055 0.0261 0.0431
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0046 0.0208 0.021
Loa Loa (eye worm) oxidoreductase 0.1045 0.6062 0.619
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0244 0.0399
Loa Loa (eye worm) glutamate-cysteine ligase modifier subunit 0.0303 0.1713 0.1747
Mycobacterium tuberculosis Probable hydrolase 0.0059 0.0286 0.0438
Mycobacterium ulcerans oxidoreductase 0.1045 0.6062 1
Schistosoma mansoni hypothetical protein 0.0254 0.1429 0.2354
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.1045 0.6062 0.6061
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0223 0.1249 0.2057
Onchocerca volvulus 0.0102 0.0537 0.0882
Entamoeba histolytica aldose reductase, putative 0.1045 0.6062 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.019 0.0192
Brugia malayi hypothetical protein 0.0029 0.0109 0.0181
Loa Loa (eye worm) hypothetical protein 0.0026 0.0091 0.0091
Loa Loa (eye worm) hypothetical protein 0.0102 0.0537 0.0546
Onchocerca volvulus Glucosylceramidase homolog 0.0133 0.0722 0.1187
Brugia malayi Frizzled/Smoothened family membrane region containing protein 0.0077 0.0393 0.0648
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.1045 0.6062 1
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0014 0.0022 0.5
Onchocerca volvulus 0.0038 0.016 0.026
Loa Loa (eye worm) hypothetical protein 0.0042 0.0185 0.0187
Trichomonas vaginalis aldo-keto reductase, putative 0.1045 0.6062 1
Entamoeba histolytica hypothetical protein 0.0043 0.0194 0.018
Echinococcus granulosus metabotropic glutamate receptor 5 0.0014 0.0019 0.0017
Schistosoma mansoni frizzled-like receptor 0.0077 0.0393 0.0645
Brugia malayi photoreceptor-specific nuclear receptor 0.0055 0.0261 0.0431
Brugia malayi nuclear receptor NHR-88 0.0055 0.0261 0.0431
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0029 0.0109 0.0177
Brugia malayi nuclear receptor NHR-88 0.0026 0.0091 0.0151
Schistosoma mansoni frizzled 0.0077 0.0393 0.0645
Mycobacterium leprae Conserved hypothetical protein 0.0742 0.4289 0.693
Schistosoma mansoni wnt inhibitor frzb2 0.0035 0.0148 0.0239
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0055 0.0261 0.0431
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0303 0.1713 0.2808
Trichomonas vaginalis D-aminoacylase, putative 0.0059 0.0286 0.0449
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0013 0.0015 0.0013
Loa Loa (eye worm) hypothetical protein 0.0059 0.0286 0.029
Echinococcus granulosus aldo keto reductase family 1, member B4 0.0303 0.1713 0.1711
Echinococcus multilocularis conserved hypothetical protein 0.0014 0.0024 0.0022
Plasmodium falciparum aldehyde reductase, putative 0.0303 0.1713 1
Brugia malayi hypothetical protein 0.0011 0.0002 0.0004
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0103 0.0541 0.086
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.1045 0.6062 1
Echinococcus granulosus aldo keto reductase 0.1045 0.6062 0.6061
Loa Loa (eye worm) hypothetical protein 0.0055 0.0261 0.0264
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0025 0.0086 0.0107
Brugia malayi Nuclear hormone receptor-like 1 0.0029 0.0109 0.0181
Schistosoma mansoni CDGSH-type Zn finger-containing protein-like protein 0.0254 0.1429 0.2354
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0025 0.0086 0.0084
Schistosoma mansoni cellular tumor antigen P53 0.006 0.029 0.0474
Echinococcus multilocularis tumor protein p63 0.0408 0.233 0.2328
Schistosoma mansoni nuclear hormone receptor 0.0026 0.0091 0.0147
Loa Loa (eye worm) hypothetical protein 0.1682 0.9792 1
Echinococcus multilocularis secreted frizzled protein 5 0.0035 0.0148 0.0145
Echinococcus multilocularis secreted frizzled protein 0.0035 0.0148 0.0145
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0014 0.0022 0.0029
Brugia malayi glutathione reductase 0.004 0.0177 0.0292
Schistosoma mansoni serine/threonine protein kinase 0.0011 0.0004 0.0003
Schistosoma mansoni hypothetical protein 0.0043 0.0194 0.0316
Loa Loa (eye worm) DR-78 0.0026 0.0091 0.0091
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0017 0.0037 0.0034
Entamoeba histolytica ubiquitin-conjugating enzyme family protein 0.0046 0.021 0.0206
Trypanosoma cruzi aldo-keto reductase 0.1045 0.6062 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.1045 0.6062 0.6061
Entamoeba histolytica hypothetical protein 0.0043 0.0194 0.018
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0014 0.0022 0.0032
Onchocerca volvulus 0.1045 0.6062 1
Trichomonas vaginalis aldo/keto reductase, putative 0.1045 0.6062 1
Brugia malayi hypothetical protein 0.0043 0.0194 0.032
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0055 0.0261 0.0431
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0013 0.0015 0.002
Loa Loa (eye worm) hypothetical protein 0.0017 0.0037 0.0035
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.004 0.0177 0.0257
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0038 0.016 0.026
Loa Loa (eye worm) hypothetical protein 0.0059 0.0286 0.029
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0014 0.0022 0.0019
Leishmania major trypanothione reductase 0.004 0.0177 0.0285
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0025 0.0086 0.0107
Echinococcus multilocularis ubiquitin conjugating enzyme E2 N 0.0046 0.021 0.0207
Plasmodium falciparum thioredoxin reductase 0.0014 0.0022 0.0103
Schistosoma mansoni sex comb on midleg homolog 0.0038 0.016 0.026
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0055 0.0261 0.0431
Loa Loa (eye worm) oxidoreductase 0.1045 0.6062 0.619
Echinococcus granulosus frizzled 5 0.0077 0.0393 0.0391
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0017 0.0037 0.0061
Onchocerca volvulus 0.1045 0.6062 1
Onchocerca volvulus 0.0303 0.1713 0.2823
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0026 0.0091 0.0089
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0046 0.021 0.0211
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0055 0.0261 0.0431
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0025 0.0086 0.0118
Leishmania major aldo-keto reductase-like protein 0.1045 0.6062 1
Echinococcus multilocularis ubiquitin specific protease 41 0.0025 0.0086 0.0084
Echinococcus multilocularis aldehyde reductase 0.0742 0.4289 0.4288
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0046 0.021 0.0322
Trichomonas vaginalis aldo-keto reductase, putative 0.1045 0.6062 1
Treponema pallidum NADH oxidase 0.0014 0.0022 0.5
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0014 0.0022 0.0032
Trichomonas vaginalis esterase, putative 0.0059 0.0286 0.0449
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0026 0.0091 0.0147
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0059 0.0286 0.0469
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0194 0.0316
Mycobacterium leprae Possible oxidoreductase 0.0303 0.1713 0.247
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0157 0.0862 0.1422
Echinococcus granulosus frizzled 4 0.0077 0.0393 0.0391
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0025 0.0086 0.0107
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0026 0.0091 0.0089
Brugia malayi Egg laying defective protein 4 0.0011 0.0004 0.0007
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0026 0.0091 0.0091
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0055 0.0261 0.0259
Mycobacterium tuberculosis Probable reductase 0.0092 0.0481 0.076
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.1045 0.6062 0.6061
Trichomonas vaginalis D-aminoacylase, putative 0.0059 0.0286 0.0449
Echinococcus granulosus hyperpolarization activated cyclic 0.0013 0.0015 0.0012
Echinococcus multilocularis aldo keto reductase 0.1045 0.6062 0.6061
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0043 0.0192 0.0293
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0046 0.021 0.0311
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0026 0.0091 0.0089
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0055 0.0261 0.0427
Schistosoma mansoni hypothetical protein 0.0042 0.0185 0.0301
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0244 0.0399
Trypanosoma brucei aldo/keto reductase, putative 0.0303 0.1713 0.28
Brugia malayi RE40412p 0.0014 0.0024 0.004
Echinococcus granulosus aldehyde reductase 0.0742 0.4289 0.4288
Mycobacterium ulcerans lipase LipD 0.0059 0.0286 0.0438
Echinococcus granulosus thioredoxin glutathione reductase 0.004 0.0177 0.0174
Schistosoma mansoni thyroid hormone receptor 0.0055 0.0261 0.0427
Plasmodium falciparum ubiquitin-conjugating enzyme E2 N, putative 0.0046 0.021 0.1201
Onchocerca volvulus 0.0059 0.0286 0.0469
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0055 0.0261 0.0427
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0017 0.0037 0.0034
Plasmodium vivax hypothetical protein, conserved 0.0014 0.0024 0.0015
Schistosoma mansoni ubiquitin conjugating enzyme 13 0.0046 0.021 0.0342
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0055 0.0261 0.0264
Plasmodium falciparum glutathione reductase 0.0014 0.0022 0.0103
Onchocerca volvulus 0.0055 0.0261 0.0427
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0157 0.0862 0.0878
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0029 0.0109 0.0109
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0029 0.0109 0.0107
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0046 0.021 0.0211
Loa Loa (eye worm) hypothetical protein 0.006 0.029 0.0293
Echinococcus granulosus aldo keto reductase family 1 member B4 0.1045 0.6062 0.6061
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0014 0.0022 0.0103
Loa Loa (eye worm) hypothetical protein 0.1045 0.6062 0.619
Trypanosoma brucei prostaglandin f synthase 0.1045 0.6062 1
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0148 0.0807 0.0805
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0011 0.0002 0.0004
Leishmania major hypothetical protein, conserved 0.0059 0.0286 0.0466
Trichomonas vaginalis conserved hypothetical protein 0.0303 0.1713 0.2808
Brugia malayi Fz domain containing protein 0.0035 0.0148 0.0243
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0011 0.0002 0.0004
Loa Loa (eye worm) nuclear hormone receptor 0.0026 0.0091 0.0091
Onchocerca volvulus 0.1045 0.6062 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0123 0.0659 0.067
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.1045 0.6062 0.6061
Toxoplasma gondii PfMNL-2 CISD1 family iron-sulfur protein, putative 0.0014 0.0024 0.0036
Trypanosoma brucei trypanothione reductase 0.004 0.0177 0.0257
Mycobacterium ulcerans hypothetical protein 0.0059 0.0286 0.0438
Echinococcus granulosus cGMP dependent protein kinase 0.0011 0.0004 0.0002
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) 0.0634 0.3654 0.6025
Echinococcus granulosus FTZ F1 alpha 0.0055 0.0261 0.0259
Mycobacterium tuberculosis Probable esterase LipL 0.0059 0.0286 0.0438
Schistosoma mansoni sex comb on midleg homolog 0.0038 0.016 0.026
Echinococcus granulosus secreted frizzled protein 5 0.0035 0.0148 0.0145
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0043 0.019 0.0188
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.1045 0.6062 0.6061
Trichomonas vaginalis aldo-keto reductase, putative 0.1045 0.6062 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0378 0.2156 0.3532
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0055 0.0261 0.0264
Loa Loa (eye worm) hypothetical protein 0.0055 0.0261 0.0264
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.1045 0.6062 1
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0029 0.0109 0.0177
Echinococcus granulosus ecdysone induced protein 78C 0.0055 0.0261 0.0259
Echinococcus granulosus hyperpolarization activated cyclic 0.0013 0.0015 0.0012
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0025 0.0086 0.0084
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0055 0.0261 0.0264
Echinococcus multilocularis polycomb protein SCMH1 0.0038 0.016 0.0157
Toxoplasma gondii protein kinase G AGC kinase family member PKG 0.0011 0.0004 0.0003
Brugia malayi glutamate-cysteine ligase modifier subunit 0.0303 0.1713 0.2826
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0052 0.0244 0.0403
Echinococcus granulosus histone acetyltransferase MYST2 0.0043 0.019 0.0188
Loa Loa (eye worm) hypothetical protein 0.0026 0.0091 0.0091
Brugia malayi Nuclear hormone receptor-like 1 0.0055 0.0261 0.0431
Trichomonas vaginalis aldo/keto reductase, putative 0.1045 0.6062 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0055 0.0261 0.0259
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.1045 0.6062 1
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0014 0.0022 0.5
Schistosoma mansoni frizzled-like receptor 0.0042 0.0185 0.0301
Brugia malayi Frizzled/Smoothened family membrane region containing protein 0.0077 0.0393 0.0648
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.5677 0.5676
Echinococcus multilocularis muscleblind protein 1 0.0155 0.085 0.0847
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0086 0.0118
Brugia malayi beta-lactamase 0.0059 0.0286 0.0473
Echinococcus granulosus polycomb protein SCMH1 0.0038 0.016 0.0157
Echinococcus granulosus thyroid hormone receptor alpha 0.0026 0.0091 0.0089
Schistosoma mansoni steroid hormone receptor ad4bp 0.0055 0.0261 0.0427
Schistosoma mansoni hypothetical protein 0.039 0.2223 0.3664
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0011 0.0004 0.0002
Trichomonas vaginalis glucosylceramidase, putative 0.0133 0.0722 0.1169
Schistosoma mansoni retinoic acid receptor RXR 0.0055 0.0261 0.0427
Trichomonas vaginalis aldo-keto reductase, putative 0.1045 0.6062 1
Brugia malayi Protein kinase domain containing protein 0.0157 0.0862 0.1422
Onchocerca volvulus 0.006 0.029 0.0474
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0029 0.0109 0.0107
Echinococcus granulosus aldo keto reductase family 1 member B4 0.1045 0.6062 0.6061
Loa Loa (eye worm) hypothetical protein 0.0055 0.0261 0.0264
Echinococcus granulosus tumor protein p63 0.0408 0.233 0.2328
Echinococcus granulosus SAM and MBT domain containing protein 0.0038 0.016 0.0157
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0055 0.0261 0.0259
Loa Loa (eye worm) hypothetical protein 0.0029 0.0109 0.0109
Echinococcus multilocularis beta LACTamase domain containing family member 0.0059 0.0286 0.0284
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0203 0.1132 0.1154
Schistosoma mansoni potassium channel beta 0.0303 0.1713 0.2823
Echinococcus granulosus aldo keto reductase family 1 member B4 0.1045 0.6062 0.6061
Brugia malayi Nuclear hormone receptor E75 0.0026 0.0091 0.0151
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0043 0.0192 0.0293
Brugia malayi orphan nuclear receptor NR2E1 0.0026 0.0091 0.0151
Loa Loa (eye worm) hypothetical protein 0.0059 0.0286 0.029
Schistosoma mansoni nuclear receptor 0.0026 0.0091 0.0147
Brugia malayi ecdysteroid receptor 0.0055 0.0261 0.0431
Toxoplasma gondii aldo-keto reductase 0.0303 0.1713 0.2823
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.1045 0.6062 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0059 0.0286 0.0469
Toxoplasma gondii zinc finger CDGSH-type domain-containing protein 0.0014 0.0024 0.0036
Echinococcus multilocularis aldo keto reductase 0.1045 0.6062 0.6061
Brugia malayi Ubiquitin conjugating enzyme protein 13 0.0046 0.021 0.0346
Entamoeba histolytica aldose reductase, putative 0.1045 0.6062 1
Schistosoma mansoni voltage-gated potassium channel 0.0017 0.0037 0.0057
Loa Loa (eye worm) hypothetical protein 0.0014 0.0024 0.0022
Mycobacterium tuberculosis Probable dehydrogenase 0.0092 0.0481 0.076
Trichomonas vaginalis penicillin-binding protein, putative 0.0059 0.0286 0.0449
Brugia malayi Cyclic-nucleotide gated cation channel 0.0013 0.0015 0.0024
Toxoplasma gondii thioredoxin reductase 0.004 0.0177 0.0288
Plasmodium vivax hypothetical protein, conserved 0.0014 0.0024 0.0015
Echinococcus granulosus muscleblind protein 0.0155 0.085 0.0847
Schistosoma mansoni voltage-gated potassium channel 0.005 0.023 0.0375
Echinococcus granulosus aldo keto reductase 0.1045 0.6062 0.6061
Brugia malayi hypothetical protein 0.0026 0.0091 0.0151
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.1045 0.6062 0.6061
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0103 0.0541 0.0441
Loa Loa (eye worm) hypothetical protein 0.0014 0.0019 0.0017
Trichomonas vaginalis aldo-keto reductase, putative 0.0303 0.1713 0.2808
Brugia malayi ecdysone receptor 0.0026 0.0091 0.0151
Brugia malayi Nuclear hormone receptor E75 0.0026 0.0091 0.0151
Schistosoma mansoni hypothetical protein 0.0042 0.0185 0.0301
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.1045 0.6062 0.6061
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0055 0.0261 0.0431
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0092 0.0481 0.076
Brugia malayi beta-lactamase family protein 0.0059 0.0286 0.0473
Loa Loa (eye worm) hypothetical protein 0.0055 0.0261 0.0264
Echinococcus multilocularis thioredoxin glutathione reductase 0.004 0.0177 0.0174
Loa Loa (eye worm) oxidoreductase 0.1045 0.6062 0.619
Entamoeba histolytica hypothetical protein 0.0043 0.0194 0.018
Trichomonas vaginalis glucosylceramidase, putative 0.0203 0.1132 0.1847
Loa Loa (eye worm) hypothetical protein 0.0029 0.0109 0.0109
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0013 0.0015 0.002
Plasmodium vivax aldehyde reductase, putative 0.0303 0.1713 1
Echinococcus granulosus ubiquitin conjugating enzyme E2 N 0.0046 0.021 0.0207
Mycobacterium tuberculosis Conserved protein 0.0059 0.0286 0.0438
Echinococcus multilocularis ecdysone induced protein 78C 0.0055 0.0261 0.0259
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.1045 0.6062 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0109 0.0109
Brugia malayi nuclear hormone receptor family member nhr-6 0.0026 0.0091 0.0151
Leishmania major aldo/keto reductase, putative,aldo/keto reductase family-like protein 0.0303 0.1713 0.2821
Echinococcus multilocularis voltage gated potassium channel subunit 0.0303 0.1713 0.1711
Schistosoma mansoni coup transcription factor 0.0055 0.0261 0.0427
Trypanosoma brucei hypothetical protein, conserved 0.0059 0.0286 0.0438
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0013 0.0015 0.0012
Loa Loa (eye worm) mbt repeat family protein 0.0038 0.016 0.0161
Loa Loa (eye worm) hypothetical protein 0.0014 0.0024 0.0022
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.0244 0.0242
Loa Loa (eye worm) hypothetical protein 0.0059 0.0286 0.029
Plasmodium falciparum aldo-keto reductase, putative 0.0303 0.1713 1
Echinococcus granulosus frizzled 0.0077 0.0393 0.0391
Echinococcus multilocularis smoothened 0.1717 1 1
Schistosoma mansoni nuclear hormone receptor 0.0055 0.0261 0.0427
Trichomonas vaginalis D-aminoacylase, putative 0.0059 0.0286 0.0449
Trichomonas vaginalis glucosylceramidase, putative 0.0203 0.1132 0.1847
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0055 0.0261 0.0431
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0055 0.0261 0.0259
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0092 0.0481 0.076
Trichomonas vaginalis aldo/keto reductase, putative 0.1045 0.6062 1
Echinococcus granulosus hypothetical protein 0.1045 0.6062 0.6061
Onchocerca volvulus 0.1045 0.6062 1
Loa Loa (eye worm) frizzled/Smoothened family membrane region containing protein 0.0077 0.0393 0.0399
Schistosoma mansoni frizzled-like receptor 0.0077 0.0393 0.0645
Echinococcus granulosus aldo keto reductase family 1 member B4 0.1045 0.6062 0.6061
Trypanosoma cruzi aldo/keto reductase, putative 0.1045 0.6062 1
Echinococcus multilocularis nuclear receptor nhr 48 0.0026 0.0091 0.0089
Trichomonas vaginalis glucosylceramidase, putative 0.0133 0.0722 0.1169
Leishmania major prostaglandin f synthase, putative 0.1045 0.6062 1
Schistosoma mansoni nuclear receptor nhr-48 0.0026 0.0091 0.0147
Loa Loa (eye worm) hypothetical protein 0.0026 0.0091 0.0091
Trichomonas vaginalis glucosylceramidase, putative 0.0141 0.0764 0.1239
Mycobacterium tuberculosis Probable oxidoreductase 0.1045 0.6062 1
Brugia malayi nuclear hormone receptor family member odr-7 0.0026 0.0091 0.0151
Trichomonas vaginalis glucosylceramidase, putative 0.0133 0.0722 0.1169
Loa Loa (eye worm) sfrp2 0.0035 0.0148 0.0148
Mycobacterium ulcerans hypothetical protein 0.0303 0.1713 0.28
Loa Loa (eye worm) hypothetical protein 0.0055 0.0261 0.0264
Onchocerca volvulus 0.1045 0.6062 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.1045 0.6062 0.6061
Entamoeba histolytica aldose reductase, putative 0.1045 0.6062 1
Echinococcus multilocularis cdgsh iron sulfur domain containing protein 0.024 0.1344 0.1342
Echinococcus multilocularis hyperpolarization activated cyclic 0.0013 0.0015 0.0012
Brugia malayi beta-lactamase family protein 0.0059 0.0286 0.0473
Loa Loa (eye worm) hypothetical protein 0.0038 0.016 0.0161
Onchocerca volvulus 0.0014 0.0024 0.0036
Echinococcus granulosus nuclear receptor nhr 48 0.0026 0.0091 0.0089
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.0244 0.0242
Mycobacterium tuberculosis Probable oxidoreductase 0.0103 0.0541 0.086
Echinococcus granulosus aldo keto reductase family 1 member B4 0.1045 0.6062 0.6061
Loa Loa (eye worm) hypothetical protein 0.0026 0.0091 0.0091
Loa Loa (eye worm) hypothetical protein 0.0026 0.0091 0.0091
Brugia malayi MH2 domain containing protein 0.0123 0.0659 0.1087
Schistosoma mansoni hypothetical protein 0.039 0.2223 0.3664
Brugia malayi hypothetical protein 0.0011 0.0002 0.0004
Plasmodium falciparum thioredoxin reductase 0.004 0.0177 0.101
Loa Loa (eye worm) glutathione reductase 0.004 0.0177 0.0178
Echinococcus multilocularis thyroid hormone receptor alpha 0.0055 0.0261 0.0259
Brugia malayi Uncharacterized hematopoietic stem/progenitor cells protein MDS029 0.0102 0.0537 0.0886
Schistosoma mansoni voltage-gated potassium channel 0.0017 0.0037 0.0057

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 18.903 uM PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS for the identification of UBC13 Polyubiquitin Inhibitors via a TR-FRET Assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID485273, AID485343, AID493182] ChEMBL. No reference
IC50 (functional) > 20 uM PUBCHEM_BIOASSAY: Dose Response confirmation of UBC13 Polyubiquitin Inhibitors using a Bfl-1 counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID485273, AID485343] ChEMBL. No reference
IC50 (functional) > 20 uM PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS for the identification of UBC13 Polyubiquitin Inhibitors via a TR-FRET Assay reconfirm. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID485273, AID485343, AID493155] ChEMBL. No reference
Potency (functional) 0.7308 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.0596 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.5481 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2): primary screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.0119 uM PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] ChEMBL. No reference
Potency (functional) 7.3048 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143] ChEMBL. No reference
Potency (functional) 7.3048 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 10.3225 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS Assay to Identify Small Molecule Activators of BRCA1 Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 56.2341 uM PubChem BioAssay. qHTS Assay for Inhibitors of the HIV-1 protein Vpr. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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