Detailed information for compound 1235148

Basic information

Technical information
  • TDR Targets ID: 1235148
  • Name: 2-ethylamino-6-(1-methylindol-3-yl)-8-[[(2R)- oxolan-2-yl]methyl]pteridin-7-one
  • MW: 404.465 | Formula: C22H24N6O2
  • H donors: 1 H acceptors: 3 LogP: 2.32 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCNc1ncc2c(n1)n(C[C@H]1CCCO1)c(=O)c(n2)c1cn(c2c1cccc2)C
  • InChi: 1S/C22H24N6O2/c1-3-23-22-24-11-17-20(26-22)28(12-14-7-6-10-30-14)21(29)19(25-17)16-13-27(2)18-9-5-4-8-15(16)18/h4-5,8-9,11,13-14H,3,6-7,10,12H2,1-2H3,(H,23,24,26)/t14-/m1/s1
  • InChiKey: HUAVUIOONQIXBD-CQSZACIVSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-ethylamino-6-(1-methylindol-3-yl)-8-[[(2R)-tetrahydrofuran-2-yl]methyl]pteridin-7-one
  • 2-ethylamino-6-(1-methyl-3-indolyl)-8-[[(2R)-2-tetrahydrofuranyl]methyl]-7-pteridinone
  • 2-ethylamino-6-(1-methylindol-3-yl)-8-(tetrahydrofurfuryl)pteridin-7-one
  • NCGC00010051
  • PCOP-20192

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens mitogen-activated protein kinase 1 Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 1, subfamily A, polypeptide 2 Starlite/ChEMBL No references
Homo sapiens multiple endocrine neoplasia I No references
Homo sapiens ubiquitin specific peptidase 2 Starlite/ChEMBL No references
Homo sapiens caspase 1, apoptosis-related cysteine peptidase Starlite/ChEMBL No references
Homo sapiens hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 3, subfamily A, polypeptide 4 Starlite/ChEMBL No references
Bacillus anthracis Anthrax lethal factor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Giardia lamblia Kinase, CMGC MAPK Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Schistosoma japonicum IPR001394,Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2,domain-containing Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania braziliensis mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania infantum cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania braziliensis mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440,map kinase Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania mexicana ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Cryptosporidium hominis ubiquitin specific protease 66 Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma congolense ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma congolense tyrosine protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Cryptosporidium parvum ubiquitin C-terminal hydrolase of the cysteine proteinase fold Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Trypanosoma congolense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania braziliensis cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Trypanosoma cruzi mitogen activated protein kinase 2, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Candida albicans cytochrome P450 56 Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma brucei mitogen activated protein kinase 4, putative Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) CYP4Cod1 Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131074 All targets in OG5_131074
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus granulosus ubiquitin specific protease 41 Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania donovani ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma brucei gambiense mitogen-activated protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum Ubiquitin carboxyl-terminal hydrolase 8, putative Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania donovani mitogen activated protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum ko:K04371 extracellular signal-regulated kinase 1/2, putative Get druggable targets OG5_126781 All targets in OG5_126781
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum ko:K01072 ubiquitin thiolesterase [EC3.1.2.15], putative Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma brucei gambiense protein kinase, putative,tyrosine protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase Get druggable targets OG5_127431 All targets in OG5_127431
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania infantum mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 Get druggable targets OG5_126781 All targets in OG5_126781
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans Serine/threonine protein kinase of MAP kinase family Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania donovani cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 Get druggable targets OG5_127431 All targets in OG5_127431
Brugia malayi hypoxia-induced factor 1 Get druggable targets OG5_131074 All targets in OG5_131074
Candida albicans MAP kinase implicated in PKC1-controlled signalling pathway Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum Ubiquitin carboxyl-terminal hydrolase 8, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum expressed protein Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum Mitogen-activated protein kinase 3, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania mexicana mitogen-activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi mitogen activated protein kinase 4, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum IPR015063,Domain of unknown function DUF1873,domain-containing Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) hypoxia-induced factor 1 Get druggable targets OG5_131074 All targets in OG5_131074
Leishmania braziliensis ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Echinococcus granulosus mitogen activated protein kinase 3 Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans MAP kinase-like orf Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania donovani mitogen-activated protein kinase 4 Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 Get druggable targets OG5_127431 All targets in OG5_127431
Brugia malayi MAP kinase sur-1 Get druggable targets OG5_126781 All targets in OG5_126781
Cryptosporidium hominis MAPK Get druggable targets OG5_126781 All targets in OG5_126781
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis mitogen activated protein kinase 3 Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania infantum mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 Get druggable targets OG5_126781 All targets in OG5_126781
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans ubiquitin-specific protease Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma brucei gambiense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi mitogen-activated protein kinase 11, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania infantum ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma brucei gambiense ubiquitin carboxyl-terminal hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Echinococcus multilocularis mitogen activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase Get druggable targets OG5_127431 All targets in OG5_127431
Candida albicans cytochrome P450 556 Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans closely related to C.maltosa N-alkane-inducible cytochrome P-450, alkane hydroxylating monooxygenase CYP52A3-b aka P450Alk1A (BA Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus multilocularis ubiquitin specific protease 41 Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum Mitogen-activated protein kinase 3, putative Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans MAP kinase-like orf Get druggable targets OG5_126781 All targets in OG5_126781
Cryptosporidium parvum MAPK, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi mitogen-activated protein kinase 11, putative Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania mexicana cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus granulosus mitogen activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania mexicana mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania major mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania major cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Brugia malayi hypothetical protein Get druggable targets OG5_131074 All targets in OG5_131074
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans Serine/threonine protein kinase of MAP kinase family Get druggable targets OG5_126781 All targets in OG5_126781
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei mitogen-activated protein kinase 5 mitogen-activated protein kinase 1 360 aa 361 aa 33.2 %
Brugia malayi Cytochrome P450 family protein cytochrome P450, family 1, subfamily A, polypeptide 2 516 aa 470 aa 26.2 %
Echinococcus granulosus caspase 8 caspase 1, apoptosis-related cysteine peptidase 383 aa 312 aa 26.6 %
Brugia malayi cytochrome P450 cytochrome P450, family 3, subfamily A, polypeptide 4 502 aa 492 aa 24.2 %
Plasmodium falciparum ubiquitin specific protease, putative ubiquitin specific peptidase 2 362 aa 378 aa 25.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica steroid 5-alpha reductase, putative 0.0044 0.0693 0.1831
Trypanosoma brucei NADH-dependent fumarate reductase 0.0022 0.0228 0.054
Echinococcus multilocularis BC026374 protein (S09 family) 0.004 0.0606 0.0606
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0114 0.0114
Plasmodium falciparum protein farnesyltransferase subunit alpha 0.0157 0.303 0.8021
Echinococcus multilocularis sterol regulatory element binding protein 0.0055 0.0909 0.0909
Loa Loa (eye worm) hypothetical protein 0.0045 0.0702 0.1821
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0191 0.3736 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.1138 0.5141
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.017 0.0383
Echinococcus multilocularis geranylgeranyl transferase type 2 subunit alpha 0.0041 0.0621 0.0621
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0152 0.2918 0.2899
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0041 0.0621 0.16
Brugia malayi Carboxylesterase family protein 0.004 0.0606 0.151
Loa Loa (eye worm) hypothetical protein 0.004 0.0606 0.1571
Echinococcus granulosus acetylcholinesterase 0.0152 0.2918 0.2918
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.0247 0.059
Leishmania major cytochrome p450-like protein 0.0023 0.0247 0.059
Plasmodium vivax hypothetical protein, conserved 0.0073 0.1292 0.3147
Trypanosoma brucei NADH-cytochrome b5 reductase, putative 0.0022 0.0228 0.054
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0045 0.0702 0.0702
Echinococcus multilocularis NADPH dependent diflavin oxidoreductase 1 0.0191 0.3736 0.3736
Echinococcus granulosus carboxylesterase 5A 0.0152 0.2918 0.2918
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0044 0.0693 0.1795
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.0247 0.059
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0062 0.1051 0.276
Entamoeba histolytica Rab geranylgeranyltransferase alpha subunit, putative 0.0041 0.0621 0.1578
Schistosoma mansoni patched 1 0.0055 0.0909 0.0884
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.022 0.0347
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0028 0.0357 0.0859
Schistosoma mansoni hypothetical protein 0.0171 0.3307 0.3288
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0045 0.0702 0.167
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0702 0.1819
Echinococcus multilocularis protein dispatched 1 0.0055 0.0909 0.0909
Schistosoma mansoni cpg binding protein 0.0037 0.0537 0.051
Echinococcus granulosus geranylgeranyl transferase type 2 subunit alpha 0.0041 0.0621 0.0621
Treponema pallidum flavodoxin 0.0073 0.1292 1
Leishmania major NADH-dependent fumarate reductase, putative 0.0022 0.0228 0.054
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0044 0.0693 0.1646
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0157 0.303 0.7841
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0044 0.0693 0.1646
Brugia malayi Cell death protein 3 precursor 0.0071 0.125 0.3192
Brugia malayi hypothetical protein 0.004 0.0606 0.151
Loa Loa (eye worm) hypothetical protein 0.0044 0.0693 0.1798
Toxoplasma gondii flavodoxin domain-containing protein 0.0095 0.1742 0.7939
Trichomonas vaginalis spcc417.12 protein, putative 0.004 0.0606 0.1406
Echinococcus multilocularis carbonic anhydrase 0.0028 0.0357 0.0357
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.0022 0.0228 0.054
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0044 0.0693 0.3083
Trypanosoma brucei cytochrome P450, putative 0.0023 0.0247 0.059
Schistosoma mansoni cpg binding protein 0.0037 0.0537 0.051
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0062 0.1067 0.2672
Trypanosoma brucei Metacaspase-4 0.0021 0.022 0.0519
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0062 0.1051 0.276
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.017 0.0208
Brugia malayi flavodoxin family protein 0.0191 0.3736 0.9685
Entamoeba histolytica trans-2,3-enoyl-CoA reductase, putative 0.0044 0.0693 0.1831
Trypanosoma brucei NADH-dependent fumarate reductase 0.0022 0.0228 0.054
Schistosoma mansoni carbonic anhydrase-related 0.0028 0.0357 0.033
Schistosoma mansoni synaptic glycoprotein sc2 related 0.0044 0.0693 0.0667
Schistosoma mansoni carbonic anhydrase-related 0.0028 0.0357 0.033
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0621 0.16
Plasmodium falciparum geranylgeranyl transferase type-2 subunit alpha, putative 0.0041 0.0621 0.1266
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0062 0.1051 0.276
Leishmania major NADH-cytochrome b5 reductase, putative 0.0022 0.0228 0.054
Echinococcus granulosus mitogen activated protein kinase 3 0.0062 0.1051 0.1051
Loa Loa (eye worm) FAD binding domain-containing protein 0.0191 0.3736 0.9687
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0073 0.1292 0.3289
Brugia malayi Carboxylesterase family protein 0.004 0.0606 0.151
Trypanosoma brucei metacaspase 0.0021 0.022 0.0519
Trypanosoma cruzi metacaspase, putative 0.0021 0.022 0.0519
Schistosoma mansoni acetylcholinesterase 0.004 0.0606 0.058
Brugia malayi CXXC zinc finger family protein 0.0035 0.0496 0.1222
Giardia lamblia Hypothetical protein 0.017 0.3286 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0021 0.022 0.0347
Onchocerca volvulus 0.0022 0.0228 0.1159
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0021 0.022 0.0347
Echinococcus multilocularis acetylcholinesterase 0.0152 0.2918 0.2918
Schistosoma mansoni synaptic glycoprotein sc2 related 0.0044 0.0693 0.0667
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.017 0.5
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0045 0.0702 0.1819
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.1051 0.2629
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0752 0.0752
Echinococcus granulosus cytochrome b5 reductase 4 0.0022 0.0228 0.0228
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.004 0.0606 0.058
Onchocerca volvulus 0.0044 0.0693 0.5186
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.13 0.1276
Loa Loa (eye worm) hypothetical protein 0.0035 0.0503 0.1305
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.1051 0.2629
Plasmodium falciparum NADH-cytochrome b5 reductase, putative 0.0022 0.0228 0.0163
Brugia malayi Cytochrome P450 family protein 0.0023 0.0247 0.0572
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.0022 0.0228 0.054
Echinococcus granulosus single minded 2 0.0043 0.0678 0.0678
Trypanosoma brucei NADH-dependent fumarate reductase, putative 0.0022 0.0228 0.054
Chlamydia trachomatis Na(+)-translocating NADH-quinone reductase subunit F 0.0022 0.0228 0.063
Echinococcus multilocularis carboxylesterase 5A 0.0152 0.2918 0.2918
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0016 0.0105 0.0209
Trypanosoma brucei metacaspase MCA3 0.0021 0.022 0.0519
Echinococcus granulosus cytochrome P450 2K1 0.0012 0.0028 0.0028
Echinococcus granulosus synaptic glycoprotein sc2 0.0044 0.0693 0.0693
Plasmodium falciparum polyprenol reductase, putative 0.0044 0.0693 0.1468
Loa Loa (eye worm) cytochrome b5 reductase 4 0.0022 0.0228 0.0591
Leishmania major 3-oxo-5-alpha-steroid 4-dehydrogenase-like protein 0.0044 0.0693 0.1795
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0157 0.303 0.8062
Schistosoma mansoni hydroxymethylglutaryl-CoA reductase (NADPH) 0.0133 0.2526 0.2505
Schistosoma mansoni diflavin oxidoreductase 0.0095 0.1742 0.1719
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0157 0.303 0.8062
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0041 0.0621 0.0595
Leishmania major protein farnesyltransferase alpha subunit, putative 0.0041 0.0621 0.16
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0021 0.022 0.022
Echinococcus granulosus family S9 non peptidase ue S09 family 0.004 0.0606 0.0606
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0114 0.0114
Schistosoma mansoni carbonic anhydrase 0.0028 0.0357 0.033
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0062 0.1051 0.276
Schistosoma mansoni single-minded 0.0059 0.0994 0.0969
Leishmania major p450 reductase, putative 0.0191 0.3736 1
Plasmodium falciparum carbonic anhydrase 0.0028 0.0357 0.0525
Chlamydia trachomatis sulfite reductase 0.0118 0.2222 1
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0062 0.1051 0.4741
Leishmania major cytochrome-b5 reductase, putative 0.0022 0.0228 0.054
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0752 0.0752
Echinococcus granulosus neuroligin 0.004 0.0606 0.0606
Schistosoma mansoni carbonic anhydrase-related 0.0028 0.0357 0.033
Trypanosoma brucei hypothetical protein, conserved 0.0041 0.0621 0.16
Echinococcus multilocularis carbonic anhydrase 0.0028 0.0357 0.0357
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0123 0.2316 0.6172
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0044 0.0693 0.3083
Entamoeba histolytica type A flavoprotein, putative 0.0073 0.1292 0.3924
Onchocerca volvulus Cell death protein 3 homolog 0.0071 0.125 1
Echinococcus granulosus geminin 0.0171 0.3307 0.3307
Trichomonas vaginalis NADPH fad oxidoreductase, putative 0.017 0.3286 0.8765
Plasmodium falciparum S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative 0.0073 0.1292 0.3147
Echinococcus granulosus mitogen activated protein kinase 0.0062 0.1051 0.1051
Brugia malayi hypoxia-induced factor 1 0.0182 0.3541 0.9175
Loa Loa (eye worm) hypothetical protein 0.004 0.0606 0.1571
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0028 0.0357 0.0859
Plasmodium vivax protein prenyltransferase alpha subunit, putative 0.0041 0.0621 0.1266
Loa Loa (eye worm) hypothetical protein 0.005 0.0808 0.2094
Echinococcus multilocularis protein patched 0.0055 0.0909 0.0909
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0752 0.1891
Echinococcus multilocularis mitogen activated protein kinase 0.0062 0.1051 0.1051
Trypanosoma cruzi p450 reductase, putative 0.0022 0.0228 0.054
Mycobacterium ulcerans hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase 0.0133 0.2526 0.6737
Echinococcus granulosus apoptotic protease activating factor 1 0.005 0.0808 0.0808
Plasmodium vivax metacaspase 1, putative 0.0021 0.022 0.0142
Echinococcus multilocularis caspase 8 0.0021 0.022 0.022
Loa Loa (eye worm) hypoxia-induced factor 1 0.0182 0.3541 0.9181
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0045 0.0702 0.0676
Mycobacterium tuberculosis Hypothetical oxidoreductase 0.0022 0.0228 0.0596
Giardia lamblia Flavohemoprotein lateral transfer candidate 0.0022 0.0228 0.0187
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0044 0.0693 0.1646
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0702 0.1819
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0062 0.1067 0.2672
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0693 0.1646
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.0022 0.0228 0.054
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.004 0.0606 0.1721
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.004 0.0606 0.0606
Onchocerca volvulus 0.004 0.0606 0.443
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.0022 0.0228 0.054
Echinococcus granulosus caspase 0.0021 0.022 0.022
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0496 0.1285
Trypanosoma cruzi Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative 0.0073 0.1292 0.3409
Loa Loa (eye worm) FAD binding domain-containing protein 0.0118 0.2222 0.5761
Echinococcus multilocularis protein prenyltransferase alpha subunit 0.0041 0.0621 0.0621
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0062 0.1051 0.276
Echinococcus multilocularis NADPH cytochrome P450 reductase 0.0191 0.3736 0.3736
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0045 0.0702 0.1709
Leishmania major NADH-dependent fumarate reductase-like protein 0.0022 0.0228 0.054
Trypanosoma cruzi metacaspase 5, putative 0.0021 0.022 0.0519
Leishmania major metacaspase, putative 0.0021 0.022 0.0519
Mycobacterium ulcerans oxidoreductase 0.0022 0.0228 0.054
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.1051 0.2629
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.017 0.0383
Onchocerca volvulus 0.004 0.0606 0.443
Entamoeba histolytica hypothetical protein 0.0044 0.0693 0.1831
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.022 0.0347
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.017 0.0383
Giardia lamblia Kinase, CMGC MAPK 0.0062 0.1051 0.2829
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0021 0.022 0.0891
Brugia malayi flavodoxin family protein 0.0073 0.1292 0.3302
Trypanosoma cruzi p450 reductase, putative 0.0191 0.3736 1
Trypanosoma brucei oxidoreductase-protein, putative 0.0022 0.0228 0.054
Brugia malayi bHLH-PAS transcription factor 0.0043 0.0678 0.1698
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0752 0.0726
Trypanosoma cruzi metacaspase, putative 0.0021 0.022 0.0519
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.004 0.0606 0.1721
Schistosoma mansoni hypothetical protein 0.0016 0.0114 0.0086
Schistosoma mansoni neuroligin 3 (S09 family) 0.004 0.0606 0.058
Schistosoma mansoni hypothetical protein 0.0016 0.0114 0.0086
Loa Loa (eye worm) hypothetical protein 0.0051 0.0839 0.2176
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0021 0.022 0.0502
Trypanosoma cruzi metacaspase 5, putative 0.0021 0.022 0.0519
Mycobacterium ulcerans putative regulatory protein 0.0043 0.0678 0.1753
Loa Loa (eye worm) carboxylesterase 0.0152 0.2918 0.7567
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.004 0.0606 0.058
Loa Loa (eye worm) cytochrome P450 family protein 0.0012 0.0028 0.0072
Schistosoma mansoni hypothetical protein 0.0016 0.0114 0.0086
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0023 0.0247 0.059
Trypanosoma cruzi Protein prenyltransferase alpha subunit repeat, putative 0.0041 0.0621 0.16
Echinococcus multilocularis Niemann Pick C1 protein 0.0055 0.0909 0.0909
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0015 0.0094 0.0243
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0015 0.0094 0.0178
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0028 0.0357 0.0859
Brugia malayi Cytochrome P450 family protein 0.0023 0.0247 0.0572
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0157 0.303 0.7857
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.017 0.0383
Trypanosoma brucei NADH-cytochrome b5 reductase, putative 0.0022 0.0228 0.054
Plasmodium falciparum 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0044 0.0693 0.1468
Trypanosoma brucei NADPH-dependent diflavin oxidoreductase 1 0.0191 0.3736 1
Trypanosoma cruzi cytochrome-b5 reductase, putative 0.0022 0.0228 0.054
Loa Loa (eye worm) hypothetical protein 0.0152 0.2918 0.7567
Mycobacterium ulcerans flavodoxin reductase Hmp 0.0022 0.0228 0.054
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.022 0.0347
Plasmodium vivax NADPH-cytochrome p450 reductase, putative 0.0191 0.3736 1
Leishmania major protein kinase, putative 0.0016 0.0105 0.0209
Trypanosoma brucei metacaspase MCA2 0.0021 0.022 0.0519
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.017 0.017
Echinococcus granulosus acetylcholinesterase 0.0152 0.2918 0.2918
Echinococcus granulosus carbonic anhydrase 0.0028 0.0357 0.0357
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0752 0.0726
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0044 0.0693 0.3083
Brugia malayi Cytochrome b5-like Heme/Steroid binding domain containing protein 0.0022 0.0228 0.0523
Brugia malayi MAP kinase sur-1 0.0062 0.1051 0.2673
Schistosoma mansoni hypothetical protein 0.0016 0.0114 0.0086
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0055 0.0909 0.2358
Plasmodium vivax oxidoreductase NAD-binding domain containing protein 0.0022 0.0228 0.0163
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0114 0.0225
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0062 0.1067 0.2672
Brugia malayi hypothetical protein 0.005 0.0808 0.2037
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0839 0.2176
Echinococcus multilocularis caspase 0.0021 0.022 0.022
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0021 0.022 0.0347
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0621 0.16
Loa Loa (eye worm) hypothetical protein 0.0021 0.022 0.0571
Echinococcus granulosus Niemann Pick C1 protein 0.0055 0.0909 0.0909
Mycobacterium tuberculosis Possible oxygenase 0.0022 0.0228 0.0596
Schistosoma mansoni hypothetical protein 0.0171 0.3307 0.3288
Trypanosoma brucei NADH-cytochrome b5 reductase, putative 0.0022 0.0228 0.054
Schistosoma mansoni serine/threonine protein kinase 0.0062 0.1051 0.1026
Giardia lamblia Nitric oxide synthase, inducible 0.017 0.3286 1
Brugia malayi Synaptic glycoprotein SC2 0.0044 0.0693 0.1738
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.017 0.0383
Onchocerca volvulus 0.0043 0.0678 0.5051
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.0022 0.0228 0.054
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0073 0.1292 0.3289
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0114 0.0225
Echinococcus multilocularis carbonic anhydrase 0.0028 0.0357 0.0357
Leishmania major oxidoreductase-like protein 0.0022 0.0228 0.054
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0114 0.0114
Mycobacterium tuberculosis Probable oxidoreductase 0.0022 0.0228 0.0596
Mycobacterium leprae Possible regulatory protein 0.0015 0.0094 1
Loa Loa (eye worm) hypothetical protein 0.0197 0.3857 1
Echinococcus granulosus protein farnesyltransferase alpha subunit 0.0157 0.303 0.303
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0021 0.022 0.0891
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.004 0.0606 0.1406
Mycobacterium ulcerans carboxylesterase, LipT 0.0174 0.3387 0.906
Plasmodium vivax ferredoxin--NADP reductase, putative 0.0022 0.0228 0.0163
Echinococcus granulosus aryl hydrocarbon receptor 0.0015 0.0094 0.0094
Trypanosoma brucei NADH-cytochrome b5 reductase-like protein 0.0022 0.0228 0.054
Loa Loa (eye worm) hypothetical protein 0.0028 0.0357 0.0925
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0045 0.0702 0.167
Trichomonas vaginalis sulfite reductase, putative 0.0191 0.3736 1
Loa Loa (eye worm) hypothetical protein 0.0191 0.3736 0.9687
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0062 0.1051 0.2726
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0021 0.022 0.0347
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0055 0.0909 0.0884
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0191 0.3736 1
Loa Loa (eye worm) hypothetical protein 0.0157 0.303 0.7857
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.0022 0.0228 0.054
Loa Loa (eye worm) hypothetical protein 0.0133 0.2526 0.6549
Mycobacterium ulcerans hypothetical protein 0.0044 0.0693 0.1795
Brugia malayi PAS domain containing protein 0.0059 0.0994 0.2523
Trypanosoma cruzi oxidoreductase-protein, putative 0.0022 0.0228 0.054
Trypanosoma cruzi Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative 0.0073 0.1292 0.3409
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0016 0.0105 0.0209
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0503 0.1242
Plasmodium vivax 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0044 0.0693 0.1468
Trypanosoma brucei NADH-cytochrome b5 reductase, putative 0.0022 0.0228 0.054
Echinococcus multilocularis transfer RNA-Lys 0.0043 0.0678 0.0678
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0123 0.2316 0.6006
Loa Loa (eye worm) hypothetical protein 0.004 0.0606 0.1571
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0028 0.0357 0.0925
Onchocerca volvulus 0.0041 0.0621 0.4561
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0041 0.0621 0.155
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0015 0.0094 0.0094
Loa Loa (eye worm) CYP4Cod1 0.0023 0.0247 0.064
Plasmodium vivax flavodoxin domain containing protein 0.017 0.3286 0.8738
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0752 0.1949
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0044 0.0693 0.1646
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.017 0.044
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0021 0.022 0.0347
Loa Loa (eye worm) hypothetical protein 0.004 0.0606 0.1571
Mycobacterium ulcerans oxygenase 0.0022 0.0228 0.054
Schistosoma mansoni hypothetical protein 0.0028 0.0357 0.033
Loa Loa (eye worm) flavodoxin family protein 0.0073 0.1292 0.335
Leishmania major cytochrome P450 reductase, putative 0.017 0.3286 0.8787
Trypanosoma brucei NADH-dependent fumarate reductase, putative 0.0022 0.0228 0.054
Schistosoma mansoni ap endonuclease 0.0019 0.017 0.0142
Echinococcus granulosus carbonic anhydrase 0.0028 0.0357 0.0357
Echinococcus multilocularis para nitrobenzyl esterase 0.004 0.0606 0.0606
Echinococcus multilocularis GPCR, family 2 0.0016 0.0114 0.0114
Leishmania major carbonic anhydrase-like protein 0.0123 0.2316 0.6172
Echinococcus granulosus hydroxymethylglutaryl coenzyme A reductase 0.0133 0.2526 0.2526
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0114 0.0114
Echinococcus granulosus carbonic anhydrase 0.0028 0.0357 0.0357
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0247 0.064
Trypanosoma cruzi metacaspase, putative 0.0021 0.022 0.0519
Loa Loa (eye worm) hypothetical protein 0.004 0.0606 0.1571
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0062 0.1051 0.276
Entamoeba histolytica type A flavoprotein, putative 0.0073 0.1292 0.3924
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0045 0.0702 0.1761
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0016 0.0105 0.0209
Brugia malayi Carboxylesterase family protein 0.0152 0.2918 0.7549
Entamoeba histolytica 3-oxo-5-alpha-steroid 4-dehydrogenase domain-containing protein 0.0044 0.0693 0.1831
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0021 0.022 0.0347
Mycobacterium tuberculosis Possible electron transfer protein FdxB 0.0022 0.0228 0.0596
Plasmodium vivax polyprenol reductase, putative 0.0044 0.0693 0.1468
Loa Loa (eye worm) hypothetical protein 0.0015 0.0094 0.0243
Schistosoma mansoni NADH-cytochrome B5 reductase 0.0022 0.0228 0.0201
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0247 0.064
Loa Loa (eye worm) carboxylesterase 0.004 0.0606 0.1571
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.0022 0.0228 0.054
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0015 0.0094 0.0178
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0044 0.0693 0.1646
Loa Loa (eye worm) diaphorase 0.0022 0.0228 0.0591
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0702 0.167
Echinococcus multilocularis aryl hydrocarbon receptor 0.0015 0.0094 0.0094
Trypanosoma brucei S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative 0.0073 0.1292 0.3409
Plasmodium falciparum nitric oxide synthase, putative 0.0191 0.3736 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0606 0.1571
Leishmania major NADH-cytochrome b5 reductase, putative 0.0022 0.0228 0.054
Trypanosoma brucei 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.0133 0.2526 0.6737
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.0022 0.0228 0.054
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0022 0.0228 0.054
Echinococcus multilocularis 0.0012 0.0028 0.0028
Schistosoma mansoni cytochrome B5 0.0022 0.0228 0.0201
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0015 0.0094 0.0178
Toxoplasma gondii NADH-cytochrome b5 reductase 1, putative 0.0022 0.0228 0.0927
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0021 0.022 0.0891
Echinococcus granulosus caspase 8 0.0021 0.022 0.022
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0702 0.1819
Echinococcus granulosus methionine synthase reductase 0.0118 0.2222 0.2222
Schistosoma mansoni hypothetical protein 0.0494 1 1
Brugia malayi Carboxylesterase family protein 0.0152 0.2918 0.7549
Mycobacterium tuberculosis Probable monooxygenase 0.0022 0.0228 0.0596
Schistosoma mansoni protein farnesyltransferase alpha subunit 0.0157 0.303 0.3011
Trypanosoma brucei carbonic anhydrase-like protein 0.0123 0.2316 0.6172
Loa Loa (eye worm) hypothetical protein 0.0028 0.0357 0.0925
Echinococcus multilocularis NADH cytochrome b5 reductase 3 0.0022 0.0228 0.0228
Leishmania major NADPH-cytochrome p450 reductase-like protein 0.0191 0.3736 1
Echinococcus granulosus 3 oxo 5 alpha steroid 4 dehydrogenase C terminal 0.0044 0.0693 0.0693
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0073 0.1292 0.3289
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0044 0.0693 0.1646
Loa Loa (eye worm) hypothetical protein 0.0071 0.125 0.3241
Loa Loa (eye worm) carbonic anhydrase 3 0.0123 0.2316 0.6006
Leishmania major cytochrome-b5 reductase, putative 0.0022 0.0228 0.054
Onchocerca volvulus 0.004 0.0606 0.443
Entamoeba histolytica type A flavoprotein, putative 0.0073 0.1292 0.3924
Trypanosoma cruzi metacaspase, putative 0.0021 0.022 0.0519
Echinococcus granulosus para nitrobenzyl esterase 0.004 0.0606 0.0606
Echinococcus granulosus carbonic anhydrase II 0.0123 0.2316 0.2316
Leishmania major protein kinase, putative 0.0016 0.0105 0.0209
Echinococcus multilocularis caspase 2 0.0071 0.125 0.125
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0114 0.0295
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0839 0.2119
Entamoeba histolytica protein farnesyltransferase alpha subunit, putative 0.0157 0.303 1
Mycobacterium ulcerans electron transfer protein FdxB 0.0022 0.0228 0.054
Trypanosoma brucei nitrate reductase, putative 0.0022 0.0228 0.054
Leishmania major 3-hydroxy-3-methylglutaryl-CoA reductase 0.0133 0.2526 0.6737
Mycobacterium ulcerans formate dehydrogenase H FdhF 0.0191 0.3736 1
Leishmania major NADH-cytochrome b5 reductase, putative 0.0022 0.0228 0.054
Plasmodium falciparum metacaspase 1 0.0021 0.022 0.0142
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0045 0.0702 0.0702
Brugia malayi Carboxylesterase family protein 0.004 0.0606 0.151
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0045 0.0702 0.0702
Echinococcus granulosus BC026374 protein S09 family 0.004 0.0606 0.0606
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0021 0.022 0.022
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.0022 0.0228 0.054
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0044 0.0693 0.1795
Echinococcus multilocularis carbonic anhydrase II 0.0123 0.2316 0.2316
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0123 0.2316 0.2295
Loa Loa (eye worm) hypothetical protein 0.0152 0.2918 0.7567
Trypanosoma brucei protein farnesyltransferase alpha subunit, putative 0.0041 0.0621 0.16
Echinococcus granulosus caspase 2 0.0071 0.125 0.125
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.0022 0.0228 0.054
Loa Loa (eye worm) cytochrome P450 0.0012 0.0028 0.0072
Brugia malayi Carboxylesterase family protein 0.004 0.0606 0.151
Echinococcus multilocularis apoptotic protease activating factor 1 0.005 0.0808 0.0808
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0839 0.2119
Brugia malayi hypothetical protein 0.0197 0.3857 1
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0028 0.0357 0.0859
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.017 0.0371
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.017 0.017
Loa Loa (eye worm) hypothetical protein 0.0055 0.0909 0.2358
Toxoplasma gondii exonuclease III APE 0.0019 0.017 0.0657
Echinococcus multilocularis methionine synthase reductase 0.0118 0.2222 0.2222
Toxoplasma gondii ferredoxin NADP+ oxidoreductase FNR 0.0022 0.0228 0.0927
Echinococcus granulosus NADPH dependent diflavin oxidoreductase 1 0.0191 0.3736 0.3736
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0021 0.022 0.0193
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase 0.0133 0.2526 0.6737
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0909 0.2239
Plasmodium vivax hypothetical protein, conserved 0.0021 0.022 0.0142
Echinococcus granulosus sterol regulatory element binding protein 0.0055 0.0909 0.0909
Brugia malayi FAD binding domain containing protein 0.0191 0.3736 0.9685
Schistosoma mansoni ap endonuclease 0.0019 0.017 0.0142
Echinococcus multilocularis protein farnesyltransferase alpha subunit 0.0157 0.303 0.303
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0045 0.0702 0.1862
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.0133 0.2526 0.6737
Echinococcus granulosus NADPH cytochrome P450 reductase 0.0191 0.3736 0.3736
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0752 0.0752
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0191 0.3736 1
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.0022 0.0228 0.054
Schistosoma mansoni NADPH flavin oxidoreductase 0.0096 0.1772 0.1749
Echinococcus granulosus Protein patched homolog 1 0.0055 0.0909 0.0909
Plasmodium falciparum metacaspase-like protein 0.0021 0.022 0.0142
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.004 0.0606 0.058
Trypanosoma cruzi nitrate reductase, putative 0.0022 0.0228 0.054
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0021 0.022 0.0347
Mycobacterium tuberculosis Carboxylesterase LipT 0.0174 0.3387 1
Plasmodium falciparum NADPH--cytochrome P450 reductase, putative 0.0073 0.1292 0.3147
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0073 0.1292 0.3289
Loa Loa (eye worm) hypothetical protein 0.0028 0.0357 0.0925
Brugia malayi 3-oxo-5-alpha-steroid 4-dehydrogenase 1 0.0044 0.0693 0.1738
Echinococcus multilocularis 3 oxo 5 alpha steroid 4 dehydrogenase, C terminal 0.0044 0.0693 0.0693
Loa Loa (eye worm) hypothetical protein 0.004 0.0606 0.1571
Echinococcus multilocularis mitogen activated protein kinase 3 0.0062 0.1051 0.1051
Onchocerca volvulus 0.004 0.0606 0.443
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0752 0.0752
Echinococcus multilocularis neuroligin 0.004 0.0606 0.0606
Echinococcus granulosus cpg binding protein 0.0037 0.0537 0.0537
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0044 0.0693 0.1795
Trypanosoma brucei NADH-cytochrome b5 reductase, putative 0.0022 0.0228 0.054
Entamoeba histolytica type A flavoprotein, putative 0.0073 0.1292 0.3924
Echinococcus granulosus ubiquitin specific protease 41 0.0045 0.0702 0.0702
Echinococcus multilocularis dnaJ subfamily B 0.0494 1 1
Schistosoma mansoni cpg binding protein 0.0035 0.0496 0.0469
Echinococcus multilocularis synaptic glycoprotein sc2 0.0044 0.0693 0.0693
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0041 0.0621 0.16
Trypanosoma cruzi NADPH-dependent FMN/FAD containing oxidoreductase, putative 0.0191 0.3736 1
Mycobacterium ulcerans flavodoxin oxidoreductase 0.0022 0.0228 0.054
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.022 0.0347
Schistosoma mansoni caspase-3 (C14 family) 0.0021 0.022 0.0193
Schistosoma mansoni hypothetical protein 0.005 0.0808 0.0782
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0041 0.0621 0.16
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0693 0.1646
Onchocerca volvulus 0.005 0.0808 0.6174
Echinococcus multilocularis geminin 0.0171 0.3307 0.3307
Schistosoma mansoni caspase-7 (C14 family) 0.0021 0.022 0.0193
Leishmania major hypothetical protein, conserved 0.0073 0.1292 0.3409
Trypanosoma brucei metacaspase 5, putative 0.0021 0.022 0.0519
Trypanosoma cruzi NADPH--cytochrome P450 reductase, putative 0.0073 0.1292 0.3409
Echinococcus multilocularis hydroxymethylglutaryl coenzyme A reductase 0.0133 0.2526 0.2526
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.0022 0.0228 0.054
Trypanosoma cruzi cytochrome-b5 reductase, putative 0.0022 0.0228 0.054
Giardia lamblia 3-hydroxy-3-methylglutaryl-coenzyme A reductase 0.0062 0.1067 0.288
Schistosoma mansoni cytochrome P450 reductase 0.0191 0.3736 0.3718
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0028 0.0357 0.0859
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0021 0.022 0.0347
Echinococcus multilocularis ubiquitin specific protease 41 0.0045 0.0702 0.0702
Entamoeba histolytica type A flavoprotein, putative 0.0073 0.1292 0.3924
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0157 0.303 0.8062
Echinococcus granulosus protein prenyltransferase alpha subunit 0.0041 0.0621 0.0621
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative 0.0044 0.0693 0.1795
Schistosoma mansoni aryl hydrocarbon receptor 0.0059 0.0994 0.0969
Toxoplasma gondii hypothetical protein 0.0028 0.0357 0.1523
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0123 0.2316 0.6172
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0015 0.0094 0.0094
Brugia malayi Hydroxymethylglutaryl-coenzyme A reductase family protein 0.0133 0.2526 0.6524
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0752 0.0726
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0044 0.0693 0.1795
Mycobacterium ulcerans monooxygenase 0.0022 0.0228 0.054
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0191 0.3736 1
Treponema pallidum ferredoxin-NADP(+) reductase subunit alpha 0.0022 0.0228 0.0519
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0041 0.0621 0.161
Schistosoma mansoni BC026374 protein (S09 family) 0.004 0.0606 0.058
Brugia malayi CHE-14 protein 0.0055 0.0909 0.2302
Trypanosoma brucei protein kinase, putative 0.0062 0.1051 0.276
Giardia lamblia Rab geranylgeranyltransferase 0.0157 0.303 0.9179
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0045 0.0702 0.0702
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.1051 0.2629
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0021 0.022 0.0347
Toxoplasma gondii flavodoxin domain-containing protein 0.0095 0.1742 0.7939
Trypanosoma brucei NADPH-cytochrome p450 reductase, putative 0.0191 0.3736 1
Plasmodium falciparum ferredoxin--NADP reductase 0.0022 0.0228 0.0163
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.017 0.0208
Giardia lamblia Rab geranylgeranyltransferase 0.0041 0.0621 0.1449
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.022 0.0347
Echinococcus granulosus NADH cytochrome b5 reductase 3 0.0022 0.0228 0.0228
Brugia malayi FAD binding domain containing protein 0.0118 0.2222 0.5731
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0044 0.0693 0.1646
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0123 0.2316 0.5977
Brugia malayi diaphorase 0.0022 0.0228 0.0523
Echinococcus granulosus GPCR family 2 0.0016 0.0114 0.0114
Loa Loa (eye worm) acetylcholinesterase 1 0.0152 0.2918 0.7567
Onchocerca volvulus 0.0035 0.0496 0.3476
Onchocerca volvulus 0.004 0.0606 0.443
Leishmania major reductase, putative 0.0022 0.0228 0.054
Giardia lamblia Synaptic glycoprotein SC2 0.0044 0.0693 0.1681
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0016 0.0105 0.0209
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0116 0.2187 0.5747
Schistosoma mansoni gliotactin 0.004 0.0606 0.058
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.017 0.0422
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0045 0.0702 0.0676
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0123 0.2316 0.5977
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0062 0.1051 0.276
Echinococcus multilocularis acetylcholinesterase 0.0152 0.2918 0.2918
Plasmodium vivax prenyltransferase alpha subunit, putative 0.0157 0.303 0.8021
Trypanosoma brucei NADH-cytochrome b5 reductase, putative 0.0022 0.0228 0.054
Toxoplasma gondii hypothetical protein 0.0041 0.0621 0.2748
Toxoplasma gondii hypothetical protein 0.0116 0.2187 1
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0123 0.2316 0.2295
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0041 0.0621 0.16
Loa Loa (eye worm) carboxylesterase 0.004 0.0606 0.1571
Schistosoma mansoni 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase 0.0118 0.2222 0.22
Loa Loa (eye worm) hypothetical protein 0.0044 0.0693 0.1798
Loa Loa (eye worm) hypothetical protein 0.0044 0.0693 0.1798
Echinococcus granulosus cytochrome b5 reductase 4 0.0022 0.0228 0.0228
Leishmania major nitrate reductase, putative 0.0022 0.0228 0.054
Echinococcus multilocularis cpg binding protein 0.0037 0.0537 0.0537
Echinococcus multilocularis cytochrome b5 reductase 4 0.0022 0.0228 0.0228
Schistosoma mansoni caspase-7 (C14 family) 0.0071 0.125 0.1225
Schistosoma mansoni hypothetical protein 0.0035 0.0503 0.0477
Trypanosoma cruzi reductase, putative 0.0022 0.0228 0.054
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0041 0.0621 0.1447
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.022 0.0347
Loa Loa (eye worm) hypothetical protein 0.0016 0.0114 0.0295

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2d6 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c19 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c9 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 7.943282347 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp3a4 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 10 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp1a2 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
Potency (functional) = 3.1623 um PUBCHEM_BIOASSAY: qHTS Assay for Anthrax Lethal Toxin Internalization. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.9811 um PUBCHEM_BIOASSAY: qHTS Assay for Allosteric/Competitive Inhibitors of Caspase-1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 5.0119 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Small Molecule Agonists for Hypoxia Response Element Signaling Pathway. (Class of assay: confirmatory) [Related pubchem assays: 915 ] ChEMBL. No reference
Potency (functional) = 5.0119 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Small Molecule Antagonists for Hypoxia Response Element Signaling Pathway. (Class of assay: confirmatory) [Related pubchem assays: 914 ] ChEMBL. No reference
Potency (functional) = 7.9433 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (ADMET) = 7.9433 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Cytochrome P450 3A4. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference
Potency (ADMET) = 7.9433 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference
Potency (functional) = 8.9125 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Fluorescein Labeled MLL-derived Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Ubiquitin-specific Protease USP2a. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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