Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Inositol monophosphatase 1 | Starlite/ChEMBL | No references |
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | inositol monophosphatase 1 | 0.0045 | 0.0165 | 0.0337 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0045 | 0.0165 | 0.5 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0045 | 0.0165 | 0.5 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0096 | 0.279 | 0.5709 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.0106 | 0.0242 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0045 | 0.0165 | 0.5 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0138 | 0.4887 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0128 | 0.4379 | 1 |
Entamoeba histolytica | Niemann-Pick C1 protein, putative | 0.0096 | 0.279 | 1 |
Echinococcus multilocularis | protein dispatched 1 | 0.0047 | 0.0296 | 0.0606 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0045 | 0.0165 | 0.5 |
Brugia malayi | Niemann-Pick C1 protein precursor | 0.0096 | 0.279 | 0.6372 |
Echinococcus granulosus | expressed conserved protein | 0.0091 | 0.2494 | 0.5102 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0096 | 0.279 | 0.5709 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0045 | 0.0165 | 1 |
Echinococcus multilocularis | expressed conserved protein | 0.0091 | 0.2494 | 0.5102 |
Echinococcus granulosus | tar DNA binding protein | 0.0128 | 0.4379 | 0.8959 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0472 | 0.1078 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0045 | 0.0165 | 0.5 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0045 | 0.0165 | 1 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0045 | 0.0165 | 1 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0045 | 0.0165 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0043 | 0.0106 | 0.0217 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0138 | 0.4887 | 1 |
Brugia malayi | TAR-binding protein | 0.0128 | 0.4379 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0128 | 0.4379 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0128 | 0.4379 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0128 | 0.4379 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0128 | 0.4379 | 1 |
Schistosoma mansoni | inositol monophosphatase | 0.0045 | 0.0165 | 0.0376 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0045 | 0.0165 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.279 | 0.6372 |
Schistosoma mansoni | inositol monophosphatase | 0.0045 | 0.0165 | 0.0376 |
Schistosoma mansoni | tar DNA-binding protein | 0.0128 | 0.4379 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 0.0106 | 0.0242 |
Brugia malayi | Inositol-1 | 0.0045 | 0.0165 | 0.0376 |
Brugia malayi | RNA binding protein | 0.0128 | 0.4379 | 1 |
Brugia malayi | hypothetical protein | 0.0043 | 0.0106 | 0.0242 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0043 | 0.0106 | 0.0217 |
Loa Loa (eye worm) | inositol-1 | 0.0045 | 0.0165 | 0.0376 |
Schistosoma mansoni | tar DNA-binding protein | 0.0128 | 0.4379 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0128 | 0.4379 | 1 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0045 | 0.0165 | 0.0337 |
Echinococcus multilocularis | tar DNA binding protein | 0.0128 | 0.4379 | 0.8959 |
Loa Loa (eye worm) | TAR-binding protein | 0.0128 | 0.4379 | 1 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0045 | 0.0165 | 0.0219 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0098 | 0.2866 | 0.6544 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.0052 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | = 0.5012 um | PUBCHEM_BIOASSAY: qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors: Potentiation with Lithium. (Class of assay: confirmatory) [Related pubchem assays: 901 ] | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.