Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.2345 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0397 | 0.1389 | 0.1389 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0396 | 0.1386 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0396 | 0.1386 | 0.1386 |
Loa Loa (eye worm) | hypothetical protein | 0.0396 | 0.1386 | 0.1386 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0396 | 0.1386 | 0.1093 |
Loa Loa (eye worm) | carboxylesterase | 0.2345 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0396 | 0.1386 | 0.1386 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.027 | 0.0828 | 0.0516 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0396 | 0.1386 | 0.5 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0396 | 0.1386 | 0.0608 |
Loa Loa (eye worm) | hypothetical protein | 0.0396 | 0.1386 | 0.1386 |
Loa Loa (eye worm) | glutamate receptor | 0.0127 | 0.0195 | 0.0195 |
Echinococcus granulosus | acetylcholinesterase | 0.2345 | 1 | 1 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0396 | 0.1386 | 0.0608 |
Echinococcus multilocularis | carboxylesterase 5A | 0.2345 | 1 | 1 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0396 | 0.1386 | 0.0608 |
Loa Loa (eye worm) | hypothetical protein | 0.0396 | 0.1386 | 0.1386 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0396 | 0.1386 | 0.1093 |
Brugia malayi | Carboxylesterase family protein | 0.0396 | 0.1386 | 0.1386 |
Echinococcus granulosus | acetylcholinesterase | 0.2345 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.2345 | 1 | 1 |
Echinococcus granulosus | neuroligin | 0.0396 | 0.1386 | 0.0608 |
Brugia malayi | metabotropic glutamate receptor type 2 | 0.0157 | 0.0329 | 0.0329 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0367 | 0.1255 | 0.0957 |
Schistosoma mansoni | acetylcholinesterase | 0.0396 | 0.1386 | 0.1093 |
Echinococcus granulosus | carboxylesterase 5A | 0.2345 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.2345 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.2345 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0396 | 0.1386 | 0.1093 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.2345 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0396 | 0.1386 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.2345 | 1 | 1 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0396 | 0.1386 | 0.0608 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0396 | 0.1386 | 0.5 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.0397 | 0.1389 | 0.0611 |
Onchocerca volvulus | 0.0396 | 0.1386 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0396 | 0.1386 | 0.1386 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0396 | 0.1386 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0396 | 0.1386 | 0.1386 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0396 | 0.1386 | 0.5 |
Onchocerca volvulus | 0.0396 | 0.1386 | 0.5 | |
Loa Loa (eye worm) | carboxylesterase | 0.0396 | 0.1386 | 0.1386 |
Onchocerca volvulus | 0.0396 | 0.1386 | 0.5 | |
Onchocerca volvulus | 0.0396 | 0.1386 | 0.5 | |
Loa Loa (eye worm) | glutamate receptor | 0.0322 | 0.106 | 0.106 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0396 | 0.1386 | 0.0608 |
Onchocerca volvulus | 0.0396 | 0.1386 | 0.5 | |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0396 | 0.1386 | 0.1093 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0322 | 0.106 | 0.106 |
Loa Loa (eye worm) | hypothetical protein | 0.0396 | 0.1386 | 0.1386 |
Loa Loa (eye worm) | hypothetical protein | 0.0396 | 0.1386 | 0.1386 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0396 | 0.1386 | 0.0608 |
Brugia malayi | Carboxylesterase family protein | 0.0396 | 0.1386 | 0.1386 |
Loa Loa (eye worm) | hypothetical protein | 0.0396 | 0.1386 | 0.1386 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0396 | 0.1386 | 0.1093 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.0292 | 0.0926 | 0.0926 |
Brugia malayi | hypothetical protein | 0.0396 | 0.1386 | 0.1386 |
Schistosoma mansoni | gliotactin | 0.0396 | 0.1386 | 0.1093 |
Echinococcus multilocularis | neuroligin | 0.0396 | 0.1386 | 0.0608 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.0397 | 0.1389 | 0.0611 |
Echinococcus multilocularis | acetylcholinesterase | 0.2345 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.