Detailed information for compound 1236334

Basic information

Technical information
  • TDR Targets ID: 1236334
  • Name: N-(2-morpholin-4-ylphenyl)-2-oxo-1H-quinoline -4-carboxamide
  • MW: 349.383 | Formula: C20H19N3O3
  • H donors: 2 H acceptors: 3 LogP: 2.75 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Oc1nc2ccccc2c(c1)C(=O)Nc1ccccc1N1CCOCC1
  • InChi: 1S/C20H19N3O3/c24-19-13-15(14-5-1-2-6-16(14)21-19)20(25)22-17-7-3-4-8-18(17)23-9-11-26-12-10-23/h1-8,13H,9-12H2,(H,21,24)(H,22,25)
  • InChiKey: CFLVUJKRJMLDKT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-(2-morpholinophenyl)-2-oxo-1H-quinoline-4-carboxamide
  • 2-keto-N-(2-morpholinophenyl)-1H-quinoline-4-carboxamide
  • T5357494
  • ZINC05268760

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0187 0.6448 1
Loa Loa (eye worm) RNA binding protein 0.0065 0.1733 0.2687
Loa Loa (eye worm) hypothetical protein 0.0088 0.2612 0.4051
Loa Loa (eye worm) hypothetical protein 0.0043 0.088 0.1364
Brugia malayi Cytochrome P450 family protein 0.003 0.0365 0.0566
Schistosoma mansoni tar DNA-binding protein 0.0065 0.1733 0.2687
Onchocerca volvulus 0.0043 0.088 0.1364
Giardia lamblia CAMP-dependent protein kinase regulatory chain 0.0021 0 0.5
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0031 0.0405 0.082
Echinococcus granulosus hyperpolarization activated cyclic 0.0031 0.0405 0.0628
Loa Loa (eye worm) hypothetical protein 0.0031 0.0405 0.0628
Brugia malayi hypothetical protein 0.0099 0.3023 0.4688
Echinococcus multilocularis FTZ F1 alpha 0.0187 0.6448 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0187 0.6448 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.088 0.1364
Echinococcus multilocularis nuclear receptor nhr 48 0.0088 0.2612 0.4051
Loa Loa (eye worm) hypothetical protein 0.0046 0.097 0.1505
Loa Loa (eye worm) hypothetical protein 0.0043 0.088 0.1364
Brugia malayi Steroid receptor seven-up type 2 0.0187 0.6448 1
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.003 0.0365 0.4146
Loa Loa (eye worm) hypothetical protein 0.0043 0.088 0.1364
Trichomonas vaginalis esterase, putative 0.0043 0.088 0.1782
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.088 0.1364
Onchocerca volvulus 0.0187 0.6448 1
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.088 1
Brugia malayi Nuclear hormone receptor-like 1 0.0187 0.6448 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.0088 0.2612 0.4051
Loa Loa (eye worm) DR-78 0.0088 0.2612 0.4051
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.088 1
Brugia malayi TAR-binding protein 0.0065 0.1733 0.2687
Onchocerca volvulus 0.0088 0.2612 0.4051
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0088 0.2612 0.4051
Echinococcus multilocularis ecdysone induced protein 78C 0.0187 0.6448 1
Schistosoma mansoni tar DNA-binding protein 0.0065 0.1733 0.2687
Schistosoma mansoni nuclear receptor 0.0088 0.2612 0.4051
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0031 0.0405 0.0628
Loa Loa (eye worm) hypothetical protein 0.0043 0.088 0.1364
Brugia malayi orphan nuclear receptor NR2E1 0.0088 0.2612 0.4051
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0031 0.0405 0.0628
Schistosoma mansoni nuclear receptor nhr-48 0.0088 0.2612 0.4051
Loa Loa (eye worm) hypothetical protein 0.0043 0.088 0.1364
Loa Loa (eye worm) hypothetical protein 0.0088 0.2612 0.4051
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0187 0.6448 1
Brugia malayi nuclear receptor RXR 0.0099 0.3023 0.4688
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0088 0.2612 0.4051
Schistosoma mansoni RAR-like nuclear receptor 0.0187 0.6448 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.088 0.088
Schistosoma mansoni thyroid hormone receptor 0.0187 0.6448 1
Brugia malayi beta-lactamase family protein 0.0043 0.088 0.1364
Schistosoma mansoni coup transcription factor 0.0187 0.6448 1
Brugia malayi hypothetical protein 0.0088 0.2612 0.4051
Plasmodium vivax hypothetical protein, conserved 0.0043 0.088 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.088 0.1364
Loa Loa (eye worm) beta-lactamase 0.0043 0.088 0.1364
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0187 0.6448 1
Echinococcus granulosus nuclear receptor nhr 48 0.0088 0.2612 0.4051
Loa Loa (eye worm) hypothetical protein 0.0187 0.6448 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0187 0.6448 1
Treponema pallidum cyclic nucleotide binding protein 0.0021 0 0.5
Brugia malayi Nuclear hormone receptor-like 1 0.0099 0.3023 0.4688
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0187 0.6448 1
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0088 0.2612 0.4051
Onchocerca volvulus 0.0088 0.2612 0.4051
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.088 0.1364
Brugia malayi Nuclear hormone receptor-like 1 0.0099 0.3023 0.4688
Schistosoma mansoni nuclear hormone receptor 0.0187 0.6448 1
Loa Loa (eye worm) hypothetical protein 0.0088 0.2612 0.4051
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0088 0.2612 0.4051
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.088 0.088
Plasmodium falciparum cGMP-dependent protein kinase 0.0021 0 0.5
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0031 0.0405 0.0628
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.088 1
Brugia malayi conserved hypotetical protein 0.0088 0.2612 0.4051
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0187 0.6448 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0187 0.6448 1
Loa Loa (eye worm) nuclear hormone receptor 0.0088 0.2612 0.4051
Loa Loa (eye worm) hypothetical protein 0.0099 0.3023 0.4688
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0187 0.6448 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0187 0.6448 1
Loa Loa (eye worm) hypothetical protein 0.0088 0.2612 0.4051
Loa Loa (eye worm) hypothetical protein 0.0088 0.2612 0.4051
Brugia malayi nuclear receptor NHR-88 0.0187 0.6448 1
Mycobacterium tuberculosis Conserved protein 0.0043 0.088 0.088
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0187 0.6448 1
Echinococcus multilocularis tar DNA binding protein 0.0065 0.1733 0.2687
Brugia malayi hypothetical protein 0.0088 0.2612 0.4051
Loa Loa (eye worm) hypothetical protein 0.0187 0.6448 1
Brugia malayi nuclear hormone receptor family member nhr-6 0.0088 0.2612 0.4051
Loa Loa (eye worm) hypothetical protein 0.0187 0.6448 1
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.088 0.088
Brugia malayi nuclear hormone receptor 0.0088 0.2612 0.4051
Onchocerca volvulus Protein ultraspiracle homolog 0.0187 0.6448 1
Echinococcus granulosus ecdysone induced protein 78C 0.0187 0.6448 1
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0088 0.2612 0.4051
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0187 0.6448 1
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0158 0.5342 0.8284
Brugia malayi RNA recognition motif domain containing protein 0.0065 0.1733 0.2687
Mycobacterium tuberculosis Conserved protein 0.0043 0.088 0.088
Schistosoma mansoni tar DNA-binding protein 0.0065 0.1733 0.2687
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0031 0.0405 0.0628
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.088 0.1364
Trypanosoma cruzi cytochrome P450, putative 0.003 0.0365 0.4146
Trypanosoma cruzi cytochrome P450, putative 0.003 0.0365 0.4146
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0187 0.6448 1
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0046 0.097 0.1505
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0088 0.2612 0.4051
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0187 0.6448 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0187 0.6448 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0187 0.6448 1
Brugia malayi ecdysone receptor 0.0088 0.2612 0.4051
Loa Loa (eye worm) hypothetical protein 0.0187 0.6448 1
Mycobacterium ulcerans hypothetical protein 0.0043 0.088 1
Loa Loa (eye worm) hypothetical protein 0.0088 0.2612 0.4051
Schistosoma mansoni tar DNA-binding protein 0.0065 0.1733 0.2687
Schistosoma mansoni voltage-gated potassium channel 0.0025 0.0158 0.0244
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0088 0.2612 0.4051
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0088 0.2612 0.4051
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0187 0.6448 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0088 0.2612 0.4051
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0148 0.4937 1
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.088 0.088
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0031 0.0405 0.0628
Echinococcus granulosus voltage gated potassium channel 0.0046 0.097 0.1505
Loa Loa (eye worm) hypothetical protein 0.0187 0.6448 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0099 0.3023 0.4688
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.088 0.1782
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.088 0.1782
Echinococcus granulosus thyroid hormone receptor alpha 0.0088 0.2612 0.4051
Schistosoma mansoni nuclear hormone receptor 0.0088 0.2612 0.4051
Loa Loa (eye worm) hypothetical protein 0.0088 0.2612 0.4051
Brugia malayi hypothetical protein 0.0099 0.3023 0.4688
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.088 0.1782
Brugia malayi Cytochrome P450 family protein 0.0032 0.0438 0.068
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.088 0.088
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0031 0.0405 0.082
Schistosoma mansoni thyroid hormone receptor 0.0187 0.6448 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0187 0.6448 1
Schistosoma mansoni nuclear receptor 0.0088 0.2612 0.4051
Schistosoma mansoni voltage-gated potassium channel 0.0046 0.097 0.1505
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0148 0.4937 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0187 0.6448 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0187 0.6448 1
Loa Loa (eye worm) hypothetical protein 0.0088 0.2612 0.4051
Schistosoma mansoni voltage-gated potassium channel 0.0031 0.0405 0.0628
Schistosoma mansoni nuclear hormone receptor 0.0088 0.2612 0.4051
Echinococcus multilocularis hyperpolarization activated cyclic 0.0031 0.0405 0.0628
Brugia malayi Cyclic-nucleotide gated cation channel 0.0031 0.0405 0.0628
Loa Loa (eye worm) cytochrome P450 family protein 0.003 0.0365 0.0566
Loa Loa (eye worm) CYP4Cod1 0.003 0.0365 0.0566
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0187 0.6448 1
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0099 0.3023 0.4688
Brugia malayi ecdysteroid receptor 0.0187 0.6448 1
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0187 0.6448 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0187 0.6448 1
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0158 0.5342 0.8284
Loa Loa (eye worm) hypothetical protein 0.0137 0.4529 0.7024
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0158 0.5342 0.8284
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0187 0.6448 1
Mycobacterium tuberculosis Conserved protein 0.0043 0.088 0.088
Brugia malayi Nuclear hormone receptor E75 0.0088 0.2612 0.4051
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.088 1
Loa Loa (eye worm) hypothetical protein 0.0088 0.2612 0.4051
Loa Loa (eye worm) hypothetical protein 0.0187 0.6448 1
Echinococcus granulosus tar DNA binding protein 0.0065 0.1733 0.2687
Echinococcus granulosus hyperpolarization activated cyclic 0.0031 0.0405 0.0628
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.088 0.088
Brugia malayi Cytochrome P450 family protein 0.003 0.0365 0.0566
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0187 0.6448 1
Mycobacterium ulcerans beta-lactamase 0.0043 0.088 1
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0099 0.3023 0.4688
Brugia malayi nuclear receptor NHR-88 0.0088 0.2612 0.4051
Mycobacterium leprae conserved hypothetical protein 0.0043 0.088 1
Loa Loa (eye worm) hypothetical protein 0.0088 0.2612 0.4051
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0187 0.6448 1
Schistosoma mansoni zinc finger protein 0.0088 0.2612 0.4051
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.088 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0187 0.6448 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0187 0.6448 1
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0046 0.097 0.1505
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.088 0.1782
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0031 0.0405 0.0628
Brugia malayi tailless protein 0.0088 0.2612 0.4051
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0031 0.0405 0.0628
Loa Loa (eye worm) hypothetical protein 0.0088 0.2612 0.4051
Mycobacterium ulcerans lipase LipD 0.0043 0.088 1
Mycobacterium leprae Probable lipase LipE 0.0043 0.088 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0187 0.6448 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0187 0.6448 1
Loa Loa (eye worm) TAR-binding protein 0.0065 0.1733 0.2687
Loa Loa (eye worm) hypothetical protein 0.0099 0.3023 0.4688
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.088 0.088
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0031 0.0405 0.0628
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0088 0.2612 0.4051
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0031 0.0405 0.0628
Brugia malayi photoreceptor-specific nuclear receptor 0.0187 0.6448 1
Loa Loa (eye worm) nuclear receptor NHR-67 0.0088 0.2612 0.4051
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0031 0.0405 0.0628
Schistosoma mansoni 60S ribosomal protein L21 0.0025 0.0158 0.0244
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0187 0.6448 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0187 0.6448 1
Loa Loa (eye worm) hypothetical protein 0.0088 0.2612 0.4051
Chlamydia trachomatis cAMP-dependent protein kinase regulatory subunit 0.0021 0 0.5
Brugia malayi nuclear hormone receptor 0.0187 0.6448 1
Brugia malayi Nuclear hormone receptor E75 0.0088 0.2612 0.4051
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.088 0.1782
Treponema pallidum catabolite gene activator (Crp) 0.0021 0 0.5
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0088 0.2612 0.4051
Brugia malayi beta-lactamase family protein 0.0043 0.088 0.1364
Onchocerca volvulus 0.0043 0.088 0.1364
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0088 0.2612 0.4051
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0187 0.6448 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0032 0.0438 0.068
Brugia malayi nuclear hormone receptor family member odr-7 0.0088 0.2612 0.4051
Loa Loa (eye worm) hypothetical protein 0.0099 0.3023 0.4688
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0187 0.6448 1
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0099 0.3023 0.4688
Schistosoma mansoni tar DNA-binding protein 0.0065 0.1733 0.2687
Loa Loa (eye worm) hypothetical protein 0.0187 0.6448 1
Treponema pallidum cyclic nucleotide binding protein 0.0021 0 0.5
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0187 0.6448 1
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0031 0.0405 0.0628
Echinococcus granulosus Nuclear hormone receptor HR96 0.0088 0.2612 0.4051
Schistosoma mansoni voltage-gated potassium channel 0.0046 0.097 0.1505
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0031 0.0405 0.0628
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0187 0.6448 1
Schistosoma mansoni voltage-gated potassium channel 0.0173 0.5907 0.9161
Brugia malayi beta-lactamase 0.0043 0.088 0.1364
Schistosoma mansoni voltage-gated potassium channel 0.0173 0.5907 0.9161
Echinococcus multilocularis voltage gated potassium channel 0.0046 0.097 0.1505
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0187 0.6448 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0187 0.6448 1
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0158 0.5342 0.8284
Leishmania major hypothetical protein, conserved 0.0043 0.088 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0187 0.6448 1
Brugia malayi RNA binding protein 0.0065 0.1733 0.2687
Onchocerca volvulus Bile acid receptor homolog 0.0187 0.6448 1
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0088 0.2612 0.4051
Echinococcus granulosus FTZ F1 alpha 0.0187 0.6448 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.088 0.1364
Loa Loa (eye worm) hypothetical protein 0.0099 0.3023 0.4688
Loa Loa (eye worm) steroid hormone receptor 0.0187 0.6448 1
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0031 0.0405 0.0628
Brugia malayi steroid hormone receptor 0.0187 0.6448 1
Schistosoma mansoni retinoic acid receptor RXR 0.0187 0.6448 1
Echinococcus multilocularis hyperpolarization activated cyclic 0.0031 0.0405 0.0628
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0099 0.3023 0.4688
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0046 0.097 0.1505
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0187 0.6448 1
Onchocerca volvulus 0.0043 0.088 0.1364
Trypanosoma brucei cytochrome P450, putative 0.003 0.0365 0.4146
Loa Loa (eye worm) hypothetical protein 0.0187 0.6448 1
Loa Loa (eye worm) hypothetical protein 0.0088 0.2612 0.4051
Toxoplasma gondii ABC1 family protein 0.0043 0.088 1
Loa Loa (eye worm) hypothetical protein 0.0099 0.3023 0.4688
Brugia malayi nuclear receptor NHR-67 0.0088 0.2612 0.4051
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0187 0.6448 1
Leishmania major cytochrome p450-like protein 0.003 0.0365 0.4146
Treponema pallidum catabolite gene activator 0.0021 0 0.5
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0031 0.0405 0.0628
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0065 0.1733 0.2687
Schistosoma mansoni steroid hormone receptor ad4bp 0.0187 0.6448 1
Loa Loa (eye worm) cytochrome P450 family protein 0.003 0.0365 0.0566
Brugia malayi nuclear receptor RXR 0.0088 0.2612 0.4051
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.088 0.1364
Plasmodium falciparum cAMP-dependent protein kinase regulatory subunit 0.0021 0 0.5

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.7079 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.