Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Homo sapiens | lamin A/C | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Mus musculus | RAR-related orphan receptor gamma | Starlite/ChEMBL | No references |
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.0356 | 0.0356 |
Brugia malayi | RNA binding protein | 0.0076 | 0.3341 | 0.4872 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.2236 | 0.3261 |
Echinococcus multilocularis | lamin | 0.0033 | 0.1058 | 0.1058 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.0356 | 0.0356 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.3341 | 0.4872 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0356 | 0.0356 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.1504 | 0.1504 |
Brugia malayi | intermediate filament protein | 0.0033 | 0.1058 | 0.1543 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.2236 | 0.2236 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0019 | 0.0356 | 0.0519 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0016 | 0.0182 | 0.0182 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.2236 | 0.2236 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0016 | 0.0182 | 0.0182 |
Echinococcus granulosus | intermediate filament protein | 0.0033 | 0.1058 | 0.1058 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.2494 | 0.3637 |
Schistosoma mansoni | intermediate filament proteins | 0.0033 | 0.1058 | 0.1058 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.1058 | 0.1543 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 0.1058 | 0.1543 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.1504 | 0.2194 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.3341 | 0.3341 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.2236 | 0.2236 |
Echinococcus granulosus | GPCR family 2 | 0.0019 | 0.0356 | 0.0356 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 0.1058 | 0.1543 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0019 | 0.0356 | 0.0519 |
Echinococcus multilocularis | lamin dm0 | 0.0033 | 0.1058 | 0.1058 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0356 | 0.0356 |
Echinococcus multilocularis | geminin | 0.0205 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0356 | 0.0519 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 0.6858 | 1 |
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 0.1058 | 0.1543 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.1027 | 0.1498 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.2236 | 0.2236 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3341 | 0.3341 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.1504 | 0.2194 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0356 | 0.0356 |
Echinococcus granulosus | lamin | 0.0033 | 0.1058 | 0.1058 |
Schistosoma mansoni | lamin | 0.0033 | 0.1058 | 0.1058 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.3341 | 0.4872 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0017 | 0.0272 | 0.0397 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.3341 | 0.4872 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.2236 | 0.2236 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3341 | 0.3341 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 1 | 1 |
Onchocerca volvulus | 0.0033 | 0.1058 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.2494 | 0.3637 |
Echinococcus granulosus | lamin dm0 | 0.0033 | 0.1058 | 0.1058 |
Onchocerca volvulus | 0.0033 | 0.1058 | 1 | |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.3341 | 0.3341 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.2494 | 0.3637 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0356 | 0.0356 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0019 | 0.0356 | 0.0519 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.3341 | 0.4872 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0182 | 0.0266 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0017 | 0.0272 | 0.0397 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.2236 | 0.2236 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.2236 | 0.2236 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3341 | 0.3341 |
Brugia malayi | MH2 domain containing protein | 0.0144 | 0.6858 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3341 | 0.3341 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3341 | 0.3341 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 0.6858 | 1 |
Echinococcus multilocularis | GPCR, family 2 | 0.0019 | 0.0356 | 0.0356 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0152 | 0.0221 |
Echinococcus multilocularis | musashi | 0.0033 | 0.1058 | 0.1058 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.2494 | 0.3637 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0152 | 0.0221 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.0356 | 0.0356 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.0356 | 0.0356 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.3341 | 0.4872 |
Schistosoma mansoni | lamin | 0.0033 | 0.1058 | 0.1058 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.2236 | 0.3261 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 3.5481 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 7.0795 um | PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 11.2202 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 18.3564 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 19.9526 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 19.9526 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 31.6228 um | PUBCHEM_BIOASSAY: Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. This assay monitors tau fibrillation by fluorescence polarization (FP) of Alexa 594-labeled K18 P301L, which does not fibrillize readily but incorporates into growing filaments of unlabeled tau. (Class of assay: confirmatory) [Related pubchem assays: 596 ] | ChEMBL. | No reference |
Potency (functional) | = 35.4813 um | PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Potency (functional) | 125.8925 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.