Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Homo sapiens | lamin A/C | Starlite/ChEMBL | No references |
Homo sapiens | vitamin D (1,25- dihydroxyvitamin D3) receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | steroid hormone receptor | vitamin D (1,25- dihydroxyvitamin D3) receptor | 427 aa | 416 aa | 24.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | lamin | 0.0033 | 0.2842 | 0.2772 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.2745 | 0.2745 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 0.2842 | 0.2561 |
Echinococcus multilocularis | musashi | 0.0033 | 0.2842 | 0.2772 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 1 | 1 |
Onchocerca volvulus | 0.0033 | 0.2842 | 0.5 | |
Echinococcus granulosus | lamin | 0.0033 | 0.2842 | 0.2772 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0097 | 0.0097 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 1 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 1 | 1 |
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 0.2842 | 0.2842 |
Brugia malayi | intermediate filament protein | 0.0033 | 0.2842 | 0.2561 |
Onchocerca volvulus | 0.0033 | 0.2842 | 0.5 | |
Echinococcus granulosus | lamin dm0 | 0.0033 | 0.2842 | 0.2772 |
Echinococcus multilocularis | lamin dm0 | 0.0033 | 0.2842 | 0.2772 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 0.2842 | 0.2842 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 1 | 1 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0017 | 0.0379 | 0.0379 |
Echinococcus granulosus | intermediate filament protein | 0.0033 | 0.2842 | 0.2772 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 1 | 1 |
Brugia malayi | TAR-binding protein | 0.0076 | 1 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.2842 | 0.2842 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 0.0355 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 8.9125 uM | PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] | ChEMBL. | No reference |
Potency (functional) | 19.9526 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.