Detailed information for compound 1236399

Basic information

Technical information
  • TDR Targets ID: 1236399
  • Name: (Z)-3-[3-(4-methoxy-3-nitrophenyl)-1-phenylpy razol-4-yl]-1-morpholin-4-ylprop-2-en-1-one
  • MW: 434.445 | Formula: C23H22N4O5
  • H donors: 0 H acceptors: 4 LogP: 2.87 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1[N+](=O)[O-])c1nn(cc1/C=C\C(=O)N1CCOCC1)c1ccccc1
  • InChi: 1S/C23H22N4O5/c1-31-21-9-7-17(15-20(21)27(29)30)23-18(8-10-22(28)25-11-13-32-14-12-25)16-26(24-23)19-5-3-2-4-6-19/h2-10,15-16H,11-14H2,1H3/b10-8-
  • InChiKey: VLZKCKGIQFYCNP-NTMALXAHSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (Z)-3-[3-(4-methoxy-3-nitro-phenyl)-1-phenyl-pyrazol-4-yl]-1-morpholino-prop-2-en-1-one
  • (Z)-3-[3-(4-methoxy-3-nitrophenyl)-1-phenyl-4-pyrazolyl]-1-morpholinoprop-2-en-1-one
  • (Z)-3-[3-(4-methoxy-3-nitro-phenyl)-1-phenyl-pyrazol-4-yl]-1-morpholin-4-yl-prop-2-en-1-one
  • SMR000271995
  • 4-{3-[3-(4-methoxy-3-nitrophenyl)-1-phenyl-1H-pyrazol-4-yl]acryloyl}morpholine
  • MLS000676261

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens lamin A/C Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens huntingtin Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi hypothetical protein 0.0753 0.351 0.351
Loa Loa (eye worm) hypothetical protein 0.0068 0.0228 0.0228
Plasmodium vivax pyruvate kinase, putative 0.0026 0.0026 0.0164
Schistosoma mansoni neuropeptide F-like receptor 0.0068 0.0228 0.0228
Echinococcus granulosus 7tm_1 domain containing protein 0.0068 0.0228 0.0228
Trypanosoma cruzi pyruvate kinase 2, putative 0.0026 0.0026 0.0834
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0358 0.1616 0.1616
Loa Loa (eye worm) hypothetical protein 0.0068 0.0228 0.0228
Schistosoma mansoni biogenic amine receptor 0.0068 0.0228 0.0228
Loa Loa (eye worm) animal heme peroxidase 0.0753 0.351 0.351
Loa Loa (eye worm) hypothetical protein 0.0032 0.0054 0.0054
Schistosoma mansoni hypothetical protein 0.0068 0.0228 0.0228
Brugia malayi hypothetical protein 0.0068 0.0228 0.0228
Loa Loa (eye worm) hypothetical protein 0.0068 0.0228 0.0228
Echinococcus granulosus neuropeptide s receptor 0.0068 0.0228 0.0228
Loa Loa (eye worm) hypothetical protein 0.0068 0.0228 0.0228
Loa Loa (eye worm) solute carrier family 6 member 4 0.2109 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0068 0.0228 0.0228
Plasmodium falciparum amino acid transporter, putative 0.0358 0.1616 1
Loa Loa (eye worm) pyruvate kinase 0.0026 0.0026 0.0026
Brugia malayi Dopamine receptor protein 2 0.0068 0.0228 0.0228
Brugia malayi Animal haem peroxidase family protein 0.0753 0.351 0.351
Onchocerca volvulus 0.0068 0.0228 0.0228
Loa Loa (eye worm) hypothetical protein 0.0753 0.351 0.351
Echinococcus multilocularis sodium and chloride dependent glycine 0.0358 0.1616 0.1616
Echinococcus multilocularis neuropeptide Y receptor 0.0068 0.0228 0.0228
Echinococcus granulosus neuropeptide Y receptor 0.0068 0.0228 0.0228
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0358 0.1616 0.1616
Brugia malayi GnHR receptor homolog 0.0068 0.0228 0.0228
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0068 0.0228 0.0228
Echinococcus multilocularis neuropeptide FF receptor 2 0.0068 0.0228 0.0228
Brugia malayi Serotonin receptor 0.0068 0.0228 0.0228
Loa Loa (eye worm) hypothetical protein 0.0068 0.0228 0.0228
Echinococcus granulosus peroxidasin 0.0753 0.351 0.351
Loa Loa (eye worm) hypothetical protein 0.0033 0.0057 0.0057
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0358 0.1616 0.1616
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0068 0.0228 0.0228
Echinococcus granulosus hypothetical protein 0.1549 0.7322 0.7322
Echinococcus granulosus rhodopsin orphan GPCR 0.0068 0.0228 0.0228
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0068 0.0228 0.0228
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0358 0.1616 0.1616
Loa Loa (eye worm) hypothetical protein 0.0068 0.0228 0.0228
Loa Loa (eye worm) hypothetical protein 0.0374 0.1691 0.1691
Echinococcus multilocularis peroxidasin 0.0753 0.351 0.351
Schistosoma mansoni opsin-like receptor 0.0068 0.0228 0.0228
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0358 0.1616 0.1616
Brugia malayi hypothetical protein 0.0148 0.061 0.061
Echinococcus granulosus g-protein coupled receptor 0.0068 0.0228 0.0228
Loa Loa (eye worm) TYRA-2 protein 0.0068 0.0228 0.0228
Echinococcus granulosus neuropeptides capa receptor 0.0068 0.0228 0.0228
Leishmania major pyruvate kinase 0.0026 0.0026 0.0834
Echinococcus granulosus biogenic amine 5HT receptor 0.0455 0.2082 0.2082
Loa Loa (eye worm) hypothetical protein 0.0358 0.1616 0.1616
Loa Loa (eye worm) hypothetical protein 0.0068 0.0228 0.0228
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0068 0.0228 0.0228
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0068 0.0228 0.0228
Onchocerca volvulus Pyruvate kinase homolog 0.0026 0.0026 0.0026
Schistosoma mansoni neuropeptide receptor 0.0068 0.0228 0.0228
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0358 0.1616 1
Brugia malayi follicle stimulating hormone receptor 0.0068 0.0228 0.0228
Trichomonas vaginalis pyruvate kinase, putative 0.0026 0.0026 0.5
Loa Loa (eye worm) hypothetical protein 0.0753 0.351 0.351
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0358 0.1616 0.1616
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.0087 0.0317 1
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0068 0.0228 0.0228
Onchocerca volvulus 0.0753 0.351 0.351
Schistosoma mansoni amine GPCR 0.0233 0.1019 0.1019
Brugia malayi putative neuropeptide receptor NPR1 0.0068 0.0228 0.0228
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0068 0.0228 0.0228
Schistosoma mansoni hypothetical protein 0.0068 0.0228 0.0228
Loa Loa (eye worm) hypothetical protein 0.0068 0.0228 0.0228
Leishmania major polypeptide deformylase-like protein, putative 0.0087 0.0317 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0068 0.0228 0.0228
Loa Loa (eye worm) serotonin transporter b 0.2109 1 1
Echinococcus granulosus alpha 1A adrenergic receptor 0.0068 0.0228 0.0228
Onchocerca volvulus 0.0068 0.0228 0.0228
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0068 0.0228 0.0228
Schistosoma mansoni biogenic amine (5HT) receptor 0.0068 0.0228 0.0228
Brugia malayi G protein-coupled receptor F59B2.13 0.0068 0.0228 0.0228
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0068 0.0228 0.0228
Echinococcus granulosus pyruvate kinase 0.0026 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0068 0.0228 0.0228
Loa Loa (eye worm) hypothetical protein 0.2109 1 1
Loa Loa (eye worm) hypothetical protein 0.0358 0.1616 0.1616
Echinococcus multilocularis musashi 0.0033 0.0057 0.0057
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0068 0.0228 0.0228
Brugia malayi larval opioid receptor 0.0068 0.0228 0.0228
Onchocerca volvulus Peroxidasin homolog 0.0753 0.351 0.351
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0358 0.1616 1
Loa Loa (eye worm) hypothetical protein 0.0455 0.2082 0.2082
Schistosoma mansoni neuropeptide F-like receptor 0.0068 0.0228 0.0228
Brugia malayi G-protein coupled receptor 0.0068 0.0228 0.0228
Onchocerca volvulus 0.0068 0.0228 0.0228
Echinococcus granulosus neuropeptide receptor A26 0.0068 0.0228 0.0228
Brugia malayi Blistered cuticle protein 3 0.0753 0.351 0.351
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0068 0.0228 0.0228
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0068 0.0228 0.0228
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0358 0.1616 0.1616
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0068 0.0228 0.0228
Loa Loa (eye worm) hypothetical protein 0.0068 0.0228 0.0228
Schistosoma mansoni neuropeptide receptor 0.0068 0.0228 0.0228
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0068 0.0228 0.0228
Loa Loa (eye worm) animal heme peroxidase 0.0753 0.351 0.351
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.1107 0.5201 0.5201
Loa Loa (eye worm) animal heme peroxidase 0.0753 0.351 0.351
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0374 0.1691 0.1691
Schistosoma mansoni sodium/chloride dependent transporter 0.0358 0.1616 0.1616
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0358 0.1616 0.1616
Echinococcus granulosus serotonin receptor 0.0068 0.0228 0.0228
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0068 0.0228 0.0228
Loa Loa (eye worm) animal heme peroxidase 0.0753 0.351 0.351
Brugia malayi hypothetical protein 0.0068 0.0228 0.0228
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0068 0.0228 0.0228
Schistosoma mansoni biogenic amine receptor 0.0068 0.0228 0.0228
Brugia malayi hypothetical protein 0.0068 0.0228 0.0228
Echinococcus multilocularis neuropeptide s receptor 0.0068 0.0228 0.0228
Brugia malayi hypothetical protein 0.0068 0.0228 0.0228
Loa Loa (eye worm) hypothetical protein 0.0148 0.061 0.061
Echinococcus granulosus tachykinin peptides receptor 99D 0.0068 0.0228 0.0228
Echinococcus granulosus orexin receptor type 2 0.0068 0.0228 0.0228
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.4591 0.4591
Onchocerca volvulus Neuropeptide F receptor homolog 0.0068 0.0228 0.0228
Echinococcus multilocularis sodium and chloride dependent glycine 0.0358 0.1616 0.1616
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0358 0.1616 0.1616
Echinococcus multilocularis pyruvate kinase 0.0026 0.0026 0.0026
Echinococcus granulosus G protein coupled receptor 139 0.0068 0.0228 0.0228
Schistosoma mansoni amine GPCR 0.0068 0.0228 0.0228
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0358 0.1616 0.1616
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0358 0.1616 0.1616
Onchocerca volvulus 0.0068 0.0228 0.0228
Echinococcus granulosus sex peptide receptor 0.0068 0.0228 0.0228
Trypanosoma cruzi Peptide deformylase 2, putative 0.0087 0.0317 1
Echinococcus multilocularis serotonin receptor 0.0455 0.2082 0.2082
Onchocerca volvulus Dual oxidase homolog 0.0753 0.351 0.351
Brugia malayi hypothetical protein 0.0068 0.0228 0.0228
Brugia malayi G-protein coupled receptor 0.0068 0.0228 0.0228
Echinococcus multilocularis somatostatin receptor 0.0068 0.0228 0.0228
Onchocerca volvulus 0.0033 0.0057 0.0057
Brugia malayi Dopamine receptor 0.0068 0.0228 0.0228
Brugia malayi neuropeptide F receptor 0.0068 0.0228 0.0228
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0057 0.0057
Loa Loa (eye worm) G-protein coupled receptor 0.0068 0.0228 0.0228
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0068 0.0228 0.0228
Schistosoma mansoni amine GPCR 0.0068 0.0228 0.0228
Loa Loa (eye worm) melatonin receptor type 1A 0.0068 0.0228 0.0228
Loa Loa (eye worm) hypothetical protein 0.0068 0.0228 0.0228
Brugia malayi ORL1-like opioid receptor 0.0068 0.0228 0.0228
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0068 0.0228 0.0228
Echinococcus multilocularis orexin receptor type 2 0.0068 0.0228 0.0228
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0068 0.0228 0.0228
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0358 0.1616 0.1616
Schistosoma mansoni histamine h1 receptor 0.0068 0.0228 0.0228
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.0272 0.1204 1
Loa Loa (eye worm) hypothetical protein 0.0068 0.0228 0.0228
Onchocerca volvulus 0.0753 0.351 0.351
Brugia malayi Serotonin receptor 0.156 0.7373 0.7373
Loa Loa (eye worm) hypothetical protein 0.0068 0.0228 0.0228
Onchocerca volvulus 0.0068 0.0228 0.0228
Echinococcus multilocularis fmrfamide receptor 0.0068 0.0228 0.0228
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0068 0.0228 0.0228
Loa Loa (eye worm) hypothetical protein 0.0358 0.1616 0.1616
Loa Loa (eye worm) hypothetical protein 0.0068 0.0228 0.0228
Loa Loa (eye worm) blistered cuticle protein 3 0.0753 0.351 0.351
Schistosoma mansoni neuropeptide receptor 0.0068 0.0228 0.0228
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0068 0.0228 0.0228
Loa Loa (eye worm) pyruvate kinase 0.0026 0.0026 0.0026
Echinococcus granulosus rhodopsin orphan GPCR 0.0068 0.0228 0.0228
Onchocerca volvulus Pyruvate kinase homolog 0.0026 0.0026 0.0026
Brugia malayi Peroxidasin 0.0753 0.351 0.351
Echinococcus granulosus neuropeptide FF receptor 2 0.0068 0.0228 0.0228
Echinococcus multilocularis g protein coupled receptor 0.0068 0.0228 0.0228
Echinococcus multilocularis neuropeptide receptor 0.0068 0.0228 0.0228
Toxoplasma gondii hypothetical protein 0.0228 0.0991 0.6134
Brugia malayi G protein-coupled receptor 0.0068 0.0228 0.0228
Onchocerca volvulus 0.0068 0.0228 0.0228
Loa Loa (eye worm) hypothetical protein 0.0068 0.0228 0.0228
Brugia malayi hypothetical protein 0.0068 0.0228 0.0228
Echinococcus multilocularis serotonin transporter 0.2109 1 1
Schistosoma mansoni neuropeptide receptor 0.0068 0.0228 0.0228
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0068 0.0228 0.0228
Brugia malayi hypothetical protein 0.0068 0.0228 0.0228
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0068 0.0228 0.0228
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0293 0.1303 1
Echinococcus granulosus g protein coupled receptor 0.0068 0.0228 0.0228
Onchocerca volvulus Peroxidase homolog 0.0753 0.351 0.351
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0026 0.0026 0.022
Schistosoma mansoni amine GPCR 0.0068 0.0228 0.0228
Loa Loa (eye worm) hypothetical protein 0.0068 0.0228 0.0228
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0068 0.0228 0.0228
Trypanosoma cruzi Peptide deformylase 2, putative 0.0087 0.0317 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0068 0.0228 0.0228
Schistosoma mansoni amine GPCR 0.0068 0.0228 0.0228
Mycobacterium leprae Probable pyruvate kinase PykA 0.0026 0.0026 0.0267
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0358 0.1616 0.1616
Onchocerca volvulus 0.0068 0.0228 0.0228
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0068 0.0228 0.0228
Echinococcus multilocularis serotonin receptor 0.0455 0.2082 0.2082
Toxoplasma gondii pyruvate kinase PyK1 0.0026 0.0026 0.0164
Loa Loa (eye worm) hypothetical protein 0.0026 0.0026 0.0026
Schistosoma mansoni biogenic amine receptor 0.0068 0.0228 0.0228
Onchocerca volvulus 0.0068 0.0228 0.0228
Loa Loa (eye worm) hypothetical protein 0.0068 0.0228 0.0228
Loa Loa (eye worm) hypothetical protein 0.0068 0.0228 0.0228
Brugia malayi Animal haem peroxidase family protein 0.0753 0.351 0.351
Onchocerca volvulus 0.0358 0.1616 0.1616
Brugia malayi hypothetical protein 0.0068 0.0228 0.0228
Echinococcus granulosus pyruvate kinase 0.0026 0.0026 0.0026
Brugia malayi Tachykinin-like peptides receptor 99D 0.0068 0.0228 0.0228
Loa Loa (eye worm) hypothetical protein 0.0068 0.0228 0.0228
Loa Loa (eye worm) G-protein coupled receptor 0.0068 0.0228 0.0228
Loa Loa (eye worm) hypothetical protein 0.0068 0.0228 0.0228
Loa Loa (eye worm) hypothetical protein 0.0753 0.351 0.351
Loa Loa (eye worm) hypothetical protein 0.0068 0.0228 0.0228
Loa Loa (eye worm) hypothetical protein 0.0753 0.351 0.351
Echinococcus granulosus allatostatin A receptor 0.0068 0.0228 0.0228
Schistosoma mansoni intermediate filament proteins 0.0033 0.0057 0.0057
Brugia malayi RE15519p 0.0068 0.0228 0.0228
Echinococcus multilocularis g-protein coupled receptor 0.0068 0.0228 0.0228
Onchocerca volvulus 0.0068 0.0228 0.0228
Loa Loa (eye worm) hypothetical protein 0.0753 0.351 0.351
Brugia malayi hypothetical protein 0.0068 0.0228 0.0228
Plasmodium vivax amine transporter, putative 0.0358 0.1616 1
Echinococcus multilocularis g protein coupled receptor 0.0068 0.0228 0.0228
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0068 0.0228 0.0228
Loa Loa (eye worm) hypothetical protein 0.0374 0.1691 0.1691
Brugia malayi hypothetical protein 0.0068 0.0228 0.0228
Leishmania major pyruvate kinase 0.0026 0.0026 0.0834
Loa Loa (eye worm) hypothetical protein 0.0068 0.0228 0.0228
Echinococcus granulosus somatostatin receptor 0.0068 0.0228 0.0228
Loa Loa (eye worm) hypothetical protein 0.2109 1 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0068 0.0228 0.0228
Onchocerca volvulus 0.0068 0.0228 0.0228
Loa Loa (eye worm) hypothetical protein 0.0753 0.351 0.351
Loa Loa (eye worm) hypothetical protein 0.0148 0.061 0.061
Onchocerca volvulus 0.0068 0.0228 0.0228
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0068 0.0228 0.0228
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0374 0.1691 0.1691
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0068 0.0228 0.0228
Loa Loa (eye worm) hypothetical protein 0.0753 0.351 0.351
Echinococcus granulosus fmrfamide receptor 0.0068 0.0228 0.0228
Echinococcus multilocularis sex peptide receptor 0.0068 0.0228 0.0228
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0068 0.0228 0.0228
Loa Loa (eye worm) neuropeptide F receptor 0.0068 0.0228 0.0228
Echinococcus multilocularis rhodopsin orphan GPCR 0.0068 0.0228 0.0228
Echinococcus multilocularis neuropeptide receptor A26 0.0068 0.0228 0.0228
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0358 0.1616 0.1616
Loa Loa (eye worm) hypothetical protein 0.2109 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0068 0.0228 0.0228
Wolbachia endosymbiont of Brugia malayi peptide deformylase 0.0228 0.0991 0.5
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0068 0.0228 0.0228
Brugia malayi Pyruvate kinase, muscle isozyme 0.0026 0.0026 0.0026
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0057 0.0057
Onchocerca volvulus Peroxidasin homolog 0.0753 0.351 0.351
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0068 0.0228 0.0228
Trypanosoma brucei Peptide deformylase 2 0.0087 0.0317 1
Echinococcus multilocularis neuropeptides capa receptor 0.0068 0.0228 0.0228
Schistosoma mansoni lamin 0.0033 0.0057 0.0057
Echinococcus granulosus g protein coupled receptor 0.0068 0.0228 0.0228
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0068 0.0228 0.0228
Echinococcus granulosus peptide allatostatin:somatostatin 0.0068 0.0228 0.0228
Brugia malayi putative neuropeptide receptor 0.0068 0.0228 0.0228
Schistosoma mansoni hypothetical protein 0.0068 0.0228 0.0228
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0068 0.0228 0.0228
Echinococcus granulosus rhodopsin orphan GPCR 0.0068 0.0228 0.0228
Echinococcus granulosus tm gpcr rhodopsin 0.0068 0.0228 0.0228
Plasmodium falciparum pyruvate kinase 0.0026 0.0026 0.0164
Mycobacterium ulcerans pyruvate kinase 0.0026 0.0026 0.0203
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0068 0.0228 0.0228
Echinococcus multilocularis pyruvate kinase 0.0026 0.0026 0.0026
Onchocerca volvulus 0.0358 0.1616 0.1616
Mycobacterium ulcerans peptide deformylase 0.0228 0.0991 0.7606
Loa Loa (eye worm) hypothetical protein 0.0068 0.0228 0.0228
Loa Loa (eye worm) hypothetical protein 0.0753 0.351 0.351
Loa Loa (eye worm) hypothetical protein 0.0753 0.351 0.351
Loa Loa (eye worm) hypothetical protein 0.0358 0.1616 0.1616
Plasmodium vivax peptide deformylase, putative 0.0228 0.0991 0.6134
Brugia malayi Animal haem peroxidase family protein 0.0753 0.351 0.351
Brugia malayi neuropeptide F receptor 0.0068 0.0228 0.0228
Onchocerca volvulus Chorion peroxidase homolog 0.0753 0.351 0.351
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0068 0.0228 0.0228
Toxoplasma gondii hypothetical protein 0.0358 0.1616 1
Loa Loa (eye worm) hypothetical protein 0.0068 0.0228 0.0228
Onchocerca volvulus Huntingtin homolog 0.0148 0.061 0.061
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0358 0.1616 0.1616
Echinococcus multilocularis rhodopsin orphan GPCR 0.0068 0.0228 0.0228
Echinococcus multilocularis neuropeptide Y receptor 0.0068 0.0228 0.0228
Schistosoma mansoni sodium/chloride dependent transporter 0.0358 0.1616 0.1616
Loa Loa (eye worm) hypothetical protein 0.0753 0.351 0.351
Loa Loa (eye worm) hypothetical protein 0.0068 0.0228 0.0228
Loa Loa (eye worm) hypothetical protein 0.0068 0.0228 0.0228
Echinococcus multilocularis dro:myosuppressin receptor 0.0068 0.0228 0.0228
Schistosoma mansoni pyruvate kinase 0.0026 0.0026 0.0026
Echinococcus multilocularis neuropeptide receptor 0.0068 0.0228 0.0228
Echinococcus granulosus lamin 0.0033 0.0057 0.0057
Echinococcus granulosus dro:myosuppressin receptor 0.0068 0.0228 0.0228
Echinococcus multilocularis neuropeptides capa receptor 0.0068 0.0228 0.0228
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0358 0.1616 1
Onchocerca volvulus Huntingtin homolog 0.0148 0.061 0.061
Onchocerca volvulus Peroxidase homolog 0.0753 0.351 0.351
Loa Loa (eye worm) hypothetical protein 0.0753 0.351 0.351
Loa Loa (eye worm) hypothetical protein 0.0753 0.351 0.351
Chlamydia trachomatis peptide deformylase 0.0228 0.0991 0.6134
Onchocerca volvulus 0.0068 0.0228 0.0228
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0358 0.1616 0.1616
Schistosoma mansoni peroxidasin 0.0753 0.351 0.351
Schistosoma mansoni neuropeptide f receptor 76f 0.0068 0.0228 0.0228
Schistosoma mansoni myosin xvIII 0.0068 0.0228 0.0228
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0358 0.1616 0.1616
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.0087 0.0317 1
Brugia malayi Animal haem peroxidase family protein 0.0753 0.351 0.351
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0358 0.1616 0.1616
Loa Loa (eye worm) hypothetical protein 0.0068 0.0228 0.0228
Echinococcus granulosus neuropeptide receptor 0.0068 0.0228 0.0228
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0068 0.0228 0.0228
Onchocerca volvulus 0.0068 0.0228 0.0228
Brugia malayi hypothetical protein 0.0358 0.1616 0.1616
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0068 0.0228 0.0228
Echinococcus granulosus lamin dm0 0.0033 0.0057 0.0057
Onchocerca volvulus 0.0068 0.0228 0.0228
Echinococcus multilocularis rhodopsin orphan GPCR 0.0068 0.0228 0.0228
Mycobacterium tuberculosis Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) 0.0228 0.0991 0.823
Toxoplasma gondii hypothetical protein 0.0358 0.1616 1
Echinococcus granulosus tm gpcr rhodopsin 0.1107 0.5201 0.5201
Loa Loa (eye worm) hypothetical protein 0.0068 0.0228 0.0228
Schistosoma mansoni lamin 0.0033 0.0057 0.0057
Schistosoma mansoni sodium-dependent amino acid transporter 0.0358 0.1616 0.1616
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0068 0.0228 0.0228
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0068 0.0228 0.0228
Onchocerca volvulus Pyruvate kinase homolog 0.0026 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0068 0.0228 0.0228
Chlamydia trachomatis pyruvate kinase 0.0026 0.0026 0.0164
Loa Loa (eye worm) hypothetical protein 0.0068 0.0228 0.0228
Schistosoma mansoni alpha-1 adrenergic receptor 0.0068 0.0228 0.0228
Echinococcus granulosus 7TM GPCR rhodopsin 0.0068 0.0228 0.0228
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.2109 1 1
Brugia malayi Dopamine receptor protein 1 0.0068 0.0228 0.0228
Onchocerca volvulus 0.0033 0.0057 0.0057
Echinococcus multilocularis lamin dm0 0.0033 0.0057 0.0057
Loa Loa (eye worm) hypothetical protein 0.0068 0.0228 0.0228
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0057 0.0057
Echinococcus granulosus neuropeptide receptor 0.0068 0.0228 0.0228
Brugia malayi Melatonin receptor type 1A 0.0068 0.0228 0.0228
Loa Loa (eye worm) hypothetical protein 0.0068 0.0228 0.0228
Schistosoma mansoni growth hormone secretagogue receptor 0.0068 0.0228 0.0228
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0068 0.0228 0.0228
Loa Loa (eye worm) hypothetical protein 0.0455 0.2082 0.2082
Onchocerca volvulus 0.0358 0.1616 0.1616
Echinococcus granulosus tm gpcr rhodopsin 0.0068 0.0228 0.0228
Loa Loa (eye worm) pyruvate kinase 0.0026 0.0026 0.0026
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0358 0.1616 1
Echinococcus multilocularis pyruvate kinase 0.0021 0.0000076947 0.0000076947
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0068 0.0228 0.0228
Echinococcus granulosus rhodopsin orphan GPCR 0.0068 0.0228 0.0228
Echinococcus granulosus intermediate filament protein 0.0033 0.0057 0.0057
Schistosoma mansoni adenoreceptor 0.0068 0.0228 0.0228
Schistosoma mansoni pyruvate kinase 0.0026 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0068 0.0228 0.0228
Loa Loa (eye worm) hypothetical protein 0.0068 0.0228 0.0228
Brugia malayi AKH receptor 0.0068 0.0228 0.0228
Giardia lamblia Pyruvate kinase 0.0026 0.0026 0.5
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0068 0.0228 0.0228
Schistosoma mansoni opsin-like receptor 0.0068 0.0228 0.0228
Brugia malayi sulfakinin receptor protein 0.0068 0.0228 0.0228
Echinococcus multilocularis G protein coupled receptor 139 0.0068 0.0228 0.0228
Echinococcus granulosus sodium and chloride dependent glycine 0.0358 0.1616 0.1616
Loa Loa (eye worm) hypothetical protein 0.0068 0.0228 0.0228
Trypanosoma cruzi pyruvate kinase 2, putative 0.0026 0.0026 0.0834
Loa Loa (eye worm) hypothetical protein 0.0753 0.351 0.351
Echinococcus multilocularis rhodopsin orphan GPCR 0.0068 0.0228 0.0228
Loa Loa (eye worm) hypothetical protein 0.0068 0.0228 0.0228
Plasmodium falciparum transporter, putative 0.0358 0.1616 1
Onchocerca volvulus 0.0068 0.0228 0.0228
Echinococcus granulosus serotonin transporter 0.2109 1 1
Schistosoma mansoni hypothetical protein 0.0068 0.0228 0.0228
Loa Loa (eye worm) hypothetical protein 0.0753 0.351 0.351
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0068 0.0228 0.0228
Loa Loa (eye worm) hypothetical protein 0.0358 0.1616 0.1616
Loa Loa (eye worm) neuropeptide F receptor 0.0068 0.0228 0.0228
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0068 0.0228 0.0228
Echinococcus granulosus neuropeptides capa receptor 0.0068 0.0228 0.0228
Echinococcus multilocularis fmrfamide receptor 0.0068 0.0228 0.0228
Mycobacterium leprae PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) 0.0228 0.0991 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0455 0.2082 0.2082
Echinococcus granulosus biogenic amine 5HT receptor 0.0068 0.0228 0.0228
Loa Loa (eye worm) hypothetical protein 0.0358 0.1616 0.1616
Echinococcus granulosus neuropeptide Y receptor 0.0068 0.0228 0.0228
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0068 0.0228 0.0228
Echinococcus multilocularis lamin 0.0033 0.0057 0.0057
Echinococcus multilocularis conserved hypothetical protein 0.1481 0.6996 0.6996
Treponema pallidum sodium- and chloride- dependent transporter 0.2109 1 1
Loa Loa (eye worm) hypothetical protein 0.0068 0.0228 0.0228
Plasmodium vivax hypothetical protein, conserved 0.0358 0.1616 1
Brugia malayi Pyruvate kinase, M2 isozyme 0.0026 0.0026 0.0026
Brugia malayi Animal haem peroxidase family protein 0.0753 0.351 0.351
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0068 0.0228 0.0228
Loa Loa (eye worm) hypothetical protein 0.0068 0.0228 0.0228
Echinococcus granulosus rhodopsin orphan GPCR 0.0068 0.0228 0.0228
Echinococcus granulosus sodium and chloride dependent glycine 0.0358 0.1616 0.1616
Onchocerca volvulus 0.2109 1 1
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0293 0.1303 1
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0358 0.1616 0.1616
Echinococcus multilocularis G-protein coupled receptor, putative 0.0068 0.0228 0.0228
Plasmodium falciparum peptide deformylase 0.0228 0.0991 0.6134
Brugia malayi intermediate filament protein 0.0033 0.0057 0.0057
Onchocerca volvulus 0.0068 0.0228 0.0228
Schistosoma mansoni opsin-like receptor 0.0068 0.0228 0.0228
Schistosoma mansoni peroxidasin 0.0753 0.351 0.351
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0358 0.1616 0.1616
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0358 0.1616 0.1616
Schistosoma mansoni sodium/chloride dependent transporter 0.2109 1 1
Loa Loa (eye worm) hypothetical protein 0.0068 0.0228 0.0228
Loa Loa (eye worm) hypothetical protein 0.0358 0.1616 0.1616
Echinococcus multilocularis g protein coupled receptor 0.0068 0.0228 0.0228
Trypanosoma brucei Polypeptide deformylase 1 0.0087 0.0317 1
Loa Loa (eye worm) hypothetical protein 0.0068 0.0228 0.0228
Loa Loa (eye worm) hypothetical protein 0.0068 0.0228 0.0228
Echinococcus multilocularis allatostatin A receptor 0.0068 0.0228 0.0228
Echinococcus multilocularis rhodopsin orphan GPCR 0.0068 0.0228 0.0228
Echinococcus multilocularis rhodopsin orphan GPCR 0.0068 0.0228 0.0228
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0068 0.0228 0.0228
Onchocerca volvulus 0.0068 0.0228 0.0228
Echinococcus granulosus g protein coupled receptor 0.0068 0.0228 0.0228
Onchocerca volvulus 0.0753 0.351 0.351
Echinococcus granulosus rhodopsin orphan GPCR 0.0068 0.0228 0.0228
Loa Loa (eye worm) norepinephrine transporter 0.2109 1 1
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0068 0.0228 0.0228
Trichomonas vaginalis pyruvate kinase, putative 0.0026 0.0026 0.5

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.2818 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 0.5623 um PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] ChEMBL. No reference
Potency (functional) 1.1175 uM PubChem BioAssay. qHTS screen for small molecules that inhibit ELG1-dependent DNA repair: Hit Confirmation with 5FU Viability. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.4068 uM PubChem BioAssay. HTS assay for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1: Hit Confirmation. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.0787 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 2.31 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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