Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Matrixin family protein | 0.0057 | 0.3228 | 0.3228 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0052 | 0.269 | 1 |
Brugia malayi | Hemopexin family protein | 0.0033 | 0.0538 | 0.0538 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.3768 | 1 |
Brugia malayi | RNA binding protein | 0.0061 | 0.3768 | 0.3768 |
Mycobacterium ulcerans | hydrolase | 0.0029 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.3768 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0116 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.3768 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.3768 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0061 | 0.3768 | 0.3768 |
Mycobacterium leprae | PROBABLE HYDROLASE | 0.0029 | 0 | 0.5 |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.0085 | 0.6504 | 1 |
Loa Loa (eye worm) | matrixin family protein | 0.0057 | 0.3228 | 0.3228 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0061 | 0.3768 | 0.3768 |
Mycobacterium tuberculosis | Probable peptidoglycan hydrolase | 0.0029 | 0 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0061 | 0.3768 | 0.3768 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0116 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.3768 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0061 | 0.3768 | 0.3768 |
Loa Loa (eye worm) | TAR-binding protein | 0.0061 | 0.3768 | 0.3768 |
Loa Loa (eye worm) | matrixin family protein | 0.0052 | 0.269 | 0.269 |
Onchocerca volvulus | Matrilysin homolog | 0.0052 | 0.269 | 1 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0085 | 0.6504 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 7.9433 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 31.6228 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Potency (functional) | = 89.1251 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.