Detailed information for compound 1236624

Basic information

Technical information
  • TDR Targets ID: 1236624
  • Name: 3,4-diethoxy-N-[2-(3H-imidazol-4-yl)ethyl]ben zamide
  • MW: 303.356 | Formula: C16H21N3O3
  • H donors: 2 H acceptors: 2 LogP: 2.01 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1cc(ccc1OCC)C(=O)NCCc1c[nH]cn1
  • InChi: 1S/C16H21N3O3/c1-3-21-14-6-5-12(9-15(14)22-4-2)16(20)18-8-7-13-10-17-11-19-13/h5-6,9-11H,3-4,7-8H2,1-2H3,(H,17,19)(H,18,20)
  • InChiKey: TWMVTFFARRROHP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens ataxin 2 Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0158 0.9716 1
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0084 0.483 0.4972
Mycobacterium ulcerans hypothetical protein 0.002 0.0646 0.5103
Loa Loa (eye worm) hypothetical protein 0.0084 0.483 0.4972
Loa Loa (eye worm) hypothetical protein 0.0075 0.4245 0.4368
Mycobacterium ulcerans transmembrane transport protein 0.002 0.0646 0.5103
Brugia malayi nuclear receptor NHR-67 0.0075 0.4245 0.4368
Brugia malayi ecdysone receptor 0.0075 0.4245 0.4368
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0018 0.0555 0.0571
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0158 0.9716 1
Schistosoma mansoni neuropathy target esterase/swiss cheese-related protein 0.002 0.0646 0.0646
Brugia malayi Cytochrome P450 family protein 0.0028 0.1209 0.1245
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0075 0.4245 0.4245
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0018 0.0555 0.0571
Trypanosoma cruzi protein kinase A regulatory subunit 0.002 0.0646 0.4777
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0158 0.9716 0.9716
Loa Loa (eye worm) hypothetical protein 0.0075 0.4245 0.4368
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0158 0.9716 0.9716
Mycobacterium ulcerans hypothetical protein 0.002 0.0646 0.5103
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0018 0.0555 0.0571
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0084 0.483 0.483
Loa Loa (eye worm) hypothetical protein 0.0018 0.0555 0.0571
Brugia malayi Nuclear hormone receptor-like 1 0.0084 0.483 0.4972
Leishmania major cytochrome p450-like protein 0.0011 0.0058 0.0432
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.001 0.0003 0.0003
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0018 0.0555 0.0571
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0646 1
Loa Loa (eye worm) hypothetical protein 0.0075 0.4245 0.4368
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0158 0.9716 1
Schistosoma mansoni cpg binding protein 0.0037 0.1759 0.1759
Onchocerca volvulus 0.0035 0.163 0.1677
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0158 0.9716 1
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0018 0.0555 0.0571
Echinococcus multilocularis voltage gated potassium channel 0.0043 0.2182 0.2246
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.1352 1
Brugia malayi CXXC zinc finger family protein 0.0035 0.163 0.1677
Echinococcus granulosus glycine receptor subunit alpha 1 0.0018 0.0555 0.0571
Echinococcus granulosus voltage gated potassium channel 0.0043 0.2182 0.2246
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.1352 1
Echinococcus multilocularis cGMP dependent protein kinase 1 0.002 0.0646 0.0665
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.1352 1
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0018 0.0555 0.0571
Treponema pallidum cyclic nucleotide binding protein 0.002 0.0646 0.5
Treponema pallidum cyclic nucleotide binding protein 0.002 0.0646 0.5
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0158 0.9716 1
Echinococcus granulosus FTZ F1 alpha 0.0158 0.9716 1
Echinococcus granulosus hyperpolarization activated cyclic 0.0029 0.1287 0.1325
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0149 0.9105 0.9371
Schistosoma mansoni voltage-gated potassium channel 0.0023 0.0895 0.0895
Schistosoma mansoni thyroid hormone receptor 0.0158 0.9716 0.9716
Brugia malayi nuclear hormone receptor 0.0075 0.4245 0.4368
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0029 0.1287 0.1258
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0018 0.0555 0.0555
Schistosoma mansoni camp-dependent protein kinase regulatory chain 0.002 0.0646 0.0646
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.2976 0.3063
Brugia malayi nuclear receptor NHR-88 0.0158 0.9716 1
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0018 0.0555 0.0571
Brugia malayi Nuclear hormone receptor-like 1 0.0158 0.9716 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0158 0.9716 1
Brugia malayi cytochrome P450 0.0011 0.0058 0.006
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.2976 0.3063
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0149 0.9105 0.9371
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0029 0.1287 0.1287
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.2976 0.2976
Leishmania major cytochrome p450-like protein 0.0011 0.0058 0.0432
Brugia malayi hypothetical protein 0.0075 0.4245 0.4368
Loa Loa (eye worm) hypothetical protein 0.002 0.0646 0.0665
Echinococcus granulosus cAMP dependent protein kinase regulatory 0.002 0.0646 0.0665
Onchocerca volvulus 0.0075 0.4245 0.4368
Brugia malayi hypothetical protein 0.0084 0.483 0.4972
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0075 0.4245 0.4245
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0014 0.0253 0.026
Toxoplasma gondii protein kinase G AGC kinase family member PKG 0.002 0.0646 0.1764
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.0003
Schistosoma mansoni hypothetical protein 0.0014 0.0254 0.0254
Mycobacterium tuberculosis Conserved protein 0.002 0.0646 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0028 0.1209 0.1245
Schistosoma mansoni hypothetical protein 0.002 0.0646 0.0646
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0018 0.0555 0.0571
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0158 0.9716 0.9716
Brugia malayi Nuclear hormone receptor E75 0.0075 0.4245 0.4368
Schistosoma mansoni hypothetical protein 0.0014 0.0253 0.0253
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0075 0.4245 0.4368
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0075 0.4245 0.4368
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0158 0.9716 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0029 0.1287 0.1258
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0018 0.0555 0.0571
Loa Loa (eye worm) hypothetical protein 0.0018 0.0555 0.0571
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0061 0.0063
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.001 0.0003 0.0003
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0646 1
Brugia malayi Cation transporter family protein 0.0018 0.0555 0.0571
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0018 0.0555 0.0571
Leishmania major regulatory subunit of protein kinase a-like protein 0.002 0.0646 0.4777
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.002 0.0646 0.0646
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0029 0.1287 0.1325
Schistosoma mansoni voltage-gated potassium channel 0.0163 1 1
Schistosoma mansoni camp-dependent protein kinase type II-alpha regulatory subunit 0.002 0.0646 0.0646
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0075 0.4245 0.4368
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.002 0.0646 0.0665
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0646 0.0477
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0158 0.9716 1
Leishmania major cyclic nucleotide-binding protein-like protein 0.002 0.0646 0.4777
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.0003
Schistosoma mansoni nuclear receptor 0.0075 0.4245 0.4245
Schistosoma mansoni nuclear receptor nhr-48 0.0075 0.4245 0.4245
Echinococcus multilocularis cGMP dependent protein kinase 1 0.002 0.0646 0.0665
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.1352 0.3693
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0646 0.0646
Loa Loa (eye worm) cytochrome P450 0.0011 0.0058 0.006
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.002 0.0646 0.0477
Loa Loa (eye worm) hypothetical protein 0.0075 0.4245 0.4368
Echinococcus granulosus Nuclear hormone receptor HR96 0.0075 0.4245 0.4368
Echinococcus multilocularis nAChR subunit 0.001 0.0003 0.0003
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0158 0.9716 0.9716
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.163 0.1677
Trypanosoma cruzi cytochrome P450, putative 0.0028 0.1209 0.8946
Trypanosoma cruzi Flagellar Member 6 0.002 0.0646 0.4777
Trypanosoma brucei cyclic nucleotide-binding domain containing protein, putative 0.002 0.0646 0.4777
Loa Loa (eye worm) GABA receptor subunit 0.001 0.0003 0.0003
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0158 0.9716 1
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0018 0.0555 0.0555
Leishmania major hypothetical protein, conserved 0.003 0.1352 1
Trypanosoma cruzi regulatory subunit of protein kinase a-like protein, putative 0.002 0.0646 0.4777
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0061 0.0063
Loa Loa (eye worm) cytochrome P450 family protein 0.003 0.1324 0.1363
Brugia malayi nuclear hormone receptor family member odr-7 0.0075 0.4245 0.4368
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0018 0.0555 0.0555
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0158 0.9716 1
Schistosoma mansoni camp-dependent protein kinase type I-beta regulatory subunit 0.002 0.0646 0.0646
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0018 0.0555 0.0555
Loa Loa (eye worm) hypothetical protein 0.0158 0.9716 1
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0011 0.0058 0.0432
Mycobacterium ulcerans transcriptional regulatory protein 0.002 0.0646 0.5103
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0075 0.4245 0.4368
Echinococcus multilocularis cpg binding protein 0.0037 0.1759 0.1811
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.002 0.0646 0.1764
Brugia malayi Cytochrome P450 family protein 0.0011 0.0058 0.006
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0061 0.0063
Onchocerca volvulus 0.0018 0.0555 0.0571
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0158 0.9716 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0028 0.1209 0.1245
Schistosoma mansoni voltage-gated potassium channel 0.0029 0.1287 0.1287
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.0003
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0018 0.0555 0.0571
Schistosoma mansoni cyclic nucleotide-gated ion channel 0.002 0.0646 0.0646
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0158 0.9716 1
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0075 0.4245 0.4368
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0043 0.2182 0.2246
Onchocerca volvulus 0.0018 0.0555 0.0571
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0158 0.9716 1
Onchocerca volvulus 0.002 0.0646 0.0665
Onchocerca volvulus 0.0018 0.0555 0.0571
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0029 0.1287 0.1287
Loa Loa (eye worm) hypothetical protein 0.0018 0.0555 0.0571
Onchocerca volvulus 0.0158 0.9716 1
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0018 0.0555 0.0555
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0149 0.9105 0.9371
Loa Loa (eye worm) hypothetical protein 0.0158 0.9716 1
Brugia malayi Cytochrome P450 family protein 0.003 0.1324 0.1363
Loa Loa (eye worm) hypothetical protein 0.0018 0.0555 0.0571
Chlamydia trachomatis cAMP-dependent protein kinase regulatory subunit 0.002 0.0646 0.5
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0084 0.483 0.4972
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.2976 0.3063
Schistosoma mansoni nAChR subunit 0.0018 0.0555 0.0555
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0029 0.1287 0.1287
Loa Loa (eye worm) hypothetical protein 0.0018 0.0555 0.0571
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0043 0.2182 0.2246
Trypanosoma brucei cyclic nucleotide-binding domain containing protein, putative 0.002 0.0646 0.4777
Schistosoma mansoni nuclear hormone receptor 0.0158 0.9716 0.9716
Loa Loa (eye worm) nuclear receptor NHR-67 0.0075 0.4245 0.4368
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0158 0.9716 1
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.001 0.0003 0.0003
Mycobacterium ulcerans hypothetical protein 0.002 0.0646 0.5103
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0018 0.0555 0.0555
Brugia malayi photoreceptor-specific nuclear receptor 0.0158 0.9716 1
Brugia malayi aryl hydrocarbon receptor nuclear translocator protein, putative 0.0014 0.0254 0.0261
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0158 0.9716 1
Echinococcus granulosus nAChR subunit 0.0018 0.0555 0.0571
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0029 0.1287 0.1325
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0043 0.2182 0.2246
Brugia malayi Nuclear hormone receptor-like 1 0.0084 0.483 0.4972
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0018 0.0555 0.0571
Mycobacterium ulcerans regulatory protein 0.002 0.0646 0.5103
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0011 0.0058 0.0432
Trichomonas vaginalis cAMP-dependent protein kinase type I-beta regulatory subunit, putative 0.002 0.0646 0.0477
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0018 0.0555 0.0571
Echinococcus granulosus glycine receptor subunit beta 0.0018 0.0555 0.0571
Brugia malayi orphan nuclear receptor NR2E1 0.0075 0.4245 0.4368
Loa Loa (eye worm) hypothetical protein 0.0075 0.4245 0.4368
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.0003
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0158 0.9716 1
Loa Loa (eye worm) hypothetical protein 0.003 0.1352 0.1391
Echinococcus granulosus Nuclear hormone receptor HR96 0.0075 0.4245 0.4368
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0646 0.0646
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.0003
Schistosoma mansoni nAChR subunit 0.0018 0.0555 0.0555
Loa Loa (eye worm) hypothetical protein 0.0043 0.2182 0.2246
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.002 0.0646 0.1764
Entamoeba histolytica hypothetical protein 0.001 0.0003 0.5
Echinococcus granulosus cytochrome P450 2K1 0.0011 0.0058 0.006
Schistosoma mansoni cpg binding protein 0.0037 0.1759 0.1759
Echinococcus multilocularis cAMP dependent protein kinase type I beta 0.002 0.0646 0.0665
Loa Loa (eye worm) hypothetical protein 0.0158 0.9716 1
Schistosoma mansoni cpg binding protein 0.0035 0.163 0.163
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0139 0.8463 1
Echinococcus granulosus glycine receptor subunit alpha 1 0.0018 0.0555 0.0571
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0075 0.4245 0.4368
Loa Loa (eye worm) hypothetical protein 0.0018 0.0555 0.0571
Loa Loa (eye worm) hypothetical protein 0.0084 0.483 0.4972
Schistosoma mansoni nuclear hormone receptor 0.0075 0.4245 0.4245
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0018 0.0555 0.0571
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.4176 0.4176
Trypanosoma brucei STE group serine/threonine-protein kinase, putative 0.0014 0.0254 0.1879
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0029 0.1287 0.1325
Brugia malayi cAMP-dependent protein kinase regulatory chain, putative 0.002 0.0646 0.0665
Brugia malayi Cation transporter family protein 0.0018 0.0555 0.0571
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0158 0.9716 1
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0075 0.4245 0.4368
Mycobacterium tuberculosis Probable glutamine-transport ATP-binding protein ABC transporter GlnQ 0.002 0.0646 1
Schistosoma mansoni RAR-like nuclear receptor 0.0158 0.9716 0.9716
Loa Loa (eye worm) ACC-1 protein 0.0018 0.0555 0.0571
Brugia malayi Cytochrome P450 family protein 0.0028 0.1209 0.1245
Brugia malayi tailless protein 0.0075 0.4245 0.4368
Echinococcus granulosus cGMP dependent protein kinase 1 0.002 0.0646 0.0665
Loa Loa (eye worm) hypothetical protein 0.0018 0.0555 0.0571
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0018 0.0555 0.0571
Brugia malayi Egg laying defective protein 4 0.002 0.0646 0.0665
Trypanosoma brucei cAMP response protein 1, putative 0.002 0.0646 0.4777
Loa Loa (eye worm) hypothetical protein 0.0084 0.483 0.4972
Loa Loa (eye worm) ACC-1 protein 0.0018 0.0555 0.0571
Trypanosoma cruzi cytochrome P450, putative 0.0028 0.1209 0.8946
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0158 0.9716 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0646 0.0665
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0084 0.483 0.4972
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0158 0.9716 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0555 0.0571
Echinococcus multilocularis ecdysone induced protein 78C 0.0158 0.9716 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0075 0.4245 0.4368
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0646 0.0646
Schistosoma mansoni hypothetical protein 0.0011 0.0058 0.0058
Brugia malayi N-terminal motif family protein 0.002 0.0646 0.0665
Loa Loa (eye worm) hypothetical protein 0.0075 0.4245 0.4368
Schistosoma mansoni nAChR subunit 0.0018 0.0555 0.0555
Schistosoma mansoni coup transcription factor 0.0158 0.9716 0.9716
Brugia malayi Cyclic-nucleotide gated cation channel, C. elegans tax-4 ortholog 0.002 0.0646 0.0665
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0555 0.0571
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.001 0.0003 0.0003
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0158 0.9716 1
Leishmania major protein kinase, putative 0.002 0.0646 0.4777
Loa Loa (eye worm) hypothetical protein 0.0018 0.0555 0.0571
Toxoplasma gondii cAMP-dependent protein kinase regulatory subunit 0.002 0.0646 0.1764
Trypanosoma cruzi cAMP response protein 1 0.002 0.0646 0.4777
Echinococcus multilocularis FTZ F1 alpha 0.0158 0.9716 1
Brugia malayi nuclear hormone receptor family member nhr-6 0.0075 0.4245 0.4368
Brugia malayi Nuclear hormone receptor E75 0.0075 0.4245 0.4368
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0052 0.0054
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0029 0.1287 0.1325
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0158 0.9716 1
Loa Loa (eye worm) steroid hormone receptor 0.0158 0.9716 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.2976 0.3063
Loa Loa (eye worm) hypothetical protein 0.0158 0.9716 1
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0029 0.1287 0.1325
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0158 0.9716 1
Schistosoma mansoni nAChR subunit 0.0018 0.0555 0.0555
Toxoplasma gondii cytochrome p450 superfamily protein 0.0011 0.0058 0.0159
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0028 0.1209 1
Trypanosoma brucei Flagellar Member 6 0.002 0.0646 0.4777
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0018 0.0555 0.0571
Echinococcus granulosus nuclear receptor nhr 48 0.0075 0.4245 0.4368
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0158 0.9716 1
Loa Loa (eye worm) LGC-31 protein 0.0018 0.0555 0.0571
Brugia malayi excitatory GABA receptor EXP-1A 0.0018 0.0555 0.0571
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0158 0.9716 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.2976 0.2976
Trichomonas vaginalis cAMP-dependent protein kinase regulatory subunit, putative 0.002 0.0646 0.0477
Schistosoma mansoni camp-dependent protein kinase type I-beta regulatory subunit 0.002 0.0646 0.0646
Schistosoma mansoni steroid hormone receptor ad4bp 0.0158 0.9716 0.9716
Loa Loa (eye worm) hypothetical protein 0.0018 0.051 0.0525
Loa Loa (eye worm) hypothetical protein 0.0158 0.9716 1
Schistosoma mansoni voltage-gated potassium channel 0.0043 0.2182 0.2182
Mycobacterium ulcerans hypothetical protein 0.002 0.0646 0.5103
Trypanosoma cruzi cAMP response protein 1, putative 0.002 0.0646 0.4777
Mycobacterium leprae Conserved hypothetical protein 0.002 0.0646 1
Echinococcus multilocularis nuclear receptor nhr 48 0.0075 0.4245 0.4368
Echinococcus multilocularis nAChR subunit 0.0018 0.0555 0.0571
Loa Loa (eye worm) CYP4Cod1 0.0028 0.1209 0.1245
Brugia malayi ecdysteroid receptor 0.0158 0.9716 1
Mycobacterium tuberculosis Probable conserved transmembrane transport protein 0.002 0.0646 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0555 0.0571
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0018 0.0555 0.0571
Brugia malayi hypothetical protein 0.0084 0.483 0.4972
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0029 0.1287 0.1325
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0158 0.9716 1
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0014 0.0253 0.026
Echinococcus multilocularis glycine receptor subunit beta 0.0018 0.0555 0.0571
Brugia malayi conserved hypotetical protein 0.0075 0.4245 0.4368
Trypanosoma cruzi cyclic nucleotide-binding domain containing protein, putative 0.002 0.0646 0.4777
Schistosoma mansoni camp-dependent rap1 guanine-nucleotide exchange factor 0.002 0.0646 0.0646
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0029 0.1287 0.1325
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0029 0.1287 0.1287
Loa Loa (eye worm) hypothetical protein 0.0018 0.0555 0.0571
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0158 0.9716 0.9716
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0018 0.0555 0.0571
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0646 0.4777
Onchocerca volvulus 0.002 0.0646 0.0665
Trypanosoma cruzi cAMP binding protein, putative 0.002 0.0646 0.4777
Schistosoma mansoni voltage-gated potassium channel 0.0043 0.2182 0.2182
Onchocerca volvulus 0.001 0.0003 0.0003
Echinococcus multilocularis cAMP dependent protein kinase type II regulatory 0.002 0.0646 0.0665
Treponema pallidum catabolite gene activator (Crp) 0.002 0.0646 0.5
Onchocerca volvulus 0.001 0.0003 0.0003
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.2976 0.3063
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.1352 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0158 0.9716 0.9716
Mycobacterium tuberculosis Probable conserved transmembrane protein 0.002 0.0646 1
Giardia lamblia CAMP-dependent protein kinase regulatory chain 0.002 0.0646 0.5
Echinococcus multilocularis expressed conserved protein 0.002 0.0646 0.0665
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0075 0.4245 0.4368
Schistosoma mansoni thyroid hormone receptor 0.0158 0.9716 0.9716
Echinococcus multilocularis patatin phospholipase domain containing protein 0.002 0.0646 0.0665
Onchocerca volvulus 0.0018 0.0555 0.0571
Loa Loa (eye worm) hypothetical protein 0.0018 0.0555 0.0571
Loa Loa (eye worm) DR-78 0.0075 0.4245 0.4368
Echinococcus granulosus ecdysone induced protein 78C 0.0158 0.9716 1
Leishmania major hypothetical protein, conserved 0.002 0.0646 0.4777
Schistosoma mansoni nAChR subunit 0.0018 0.0555 0.0555
Schistosoma mansoni nuclear hormone receptor 0.0075 0.4245 0.4245
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0018 0.0555 0.0571
Loa Loa (eye worm) hypothetical protein 0.0018 0.0555 0.0571
Loa Loa (eye worm) hypothetical protein 0.0018 0.0555 0.0571
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.001 0.0003 0.0003
Echinococcus multilocularis glycine receptor subunit beta 0.0018 0.0555 0.0571
Trypanosoma brucei protein kinase A regulatory subunit 0.002 0.0646 0.4777
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0158 0.9716 1
Echinococcus granulosus cGMP dependent protein kinase 0.002 0.0646 0.0665
Loa Loa (eye worm) hypothetical protein 0.0084 0.483 0.4972
Onchocerca volvulus 0.0018 0.0555 0.0571
Echinococcus granulosus cyclic nucleotide gated cation channel 0.002 0.0646 0.0665
Echinococcus granulosus thyroid hormone receptor alpha 0.0075 0.4245 0.4368
Schistosoma mansoni neuropathy target esterase/swiss cheese-related protein 0.002 0.0646 0.0646
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.001 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0075 0.4245 0.4368
Leishmania major protein kinase, putative 0.002 0.0646 0.4777
Schistosoma mansoni cytochrome P450 0.0011 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.0018 0.0555 0.0571
Loa Loa (eye worm) nuclear hormone receptor 0.0075 0.4245 0.4368
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0158 0.9716 1
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0029 0.1287 0.1325
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0018 0.0555 0.0571
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.002 0.0646 0.0646
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0018 0.0555 0.0571
Leishmania major hypothetical protein, conserved 0.002 0.0646 0.4777
Schistosoma mansoni nuclear receptor 0.0075 0.4245 0.4245
Brugia malayi nuclear receptor NHR-88 0.0075 0.4245 0.4368
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0029 0.1287 0.1325
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0555 0.0571
Loa Loa (eye worm) cAMP-dependent protein kinase regulatory subunit 0.002 0.0646 0.0665
Mycobacterium tuberculosis Probable transcriptional regulatory protein Cmr 0.002 0.0646 1
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0018 0.0555 0.0571
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.2976 0.2976
Leishmania major protein kinase A regulatory subunit, putative 0.002 0.0646 0.4777
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0018 0.0555 0.0571
Schistosoma mansoni similar to Protein C20orf152 homolog 0.002 0.0646 0.0646
Loa Loa (eye worm) hypothetical protein 0.0029 0.1287 0.1325
Onchocerca volvulus 0.0018 0.0555 0.0571
Schistosoma mansoni nAChR subunit 0.0018 0.0555 0.0555
Echinococcus granulosus glycine receptor subunit alpha 1 0.0018 0.0555 0.0571
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0158 0.9716 1
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0018 0.0555 0.0571
Leishmania major hypothetical protein, unknown function 0.002 0.0646 0.4777
Onchocerca volvulus Protein ultraspiracle homolog 0.0158 0.9716 1
Echinococcus multilocularis cAMP dependent protein kinase regulatory 0.002 0.0646 0.0665
Schistosoma mansoni retinoic acid receptor RXR 0.0158 0.9716 0.9716
Echinococcus granulosus nAChR subunit 0.001 0.0003 0.0003
Schistosoma mansoni camp-dependent protein kinase type II regulatory subunit 0.002 0.0646 0.0646
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.002 0.0646 0.0665
Loa Loa (eye worm) hypothetical protein 0.0018 0.0555 0.0571
Schistosoma mansoni zinc finger protein 0.0075 0.4245 0.4245
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0011 0.0058 0.0432
Brugia malayi nuclear hormone receptor 0.0158 0.9716 1
Echinococcus granulosus cAMP dependent protein kinase type II regulatory 0.002 0.0646 0.0665
Loa Loa (eye worm) hypothetical protein 0.0075 0.4245 0.4368
Brugia malayi steroid hormone receptor 0.0158 0.9716 1
Echinococcus granulosus hyperpolarization activated cyclic 0.0029 0.1287 0.1325
Loa Loa (eye worm) hypothetical protein 0.0075 0.4245 0.4368
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0018 0.0555 0.0571
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0158 0.9716 1
Trypanosoma brucei cytochrome P450, putative 0.0028 0.1209 0.8946
Loa Loa (eye worm) hypothetical protein 0.0158 0.9716 1
Echinococcus multilocularis hyperpolarization activated cyclic 0.0029 0.1287 0.1325
Brugia malayi nuclear receptor RXR 0.0084 0.483 0.4972
Echinococcus granulosus glycine receptor subunit beta 0.0018 0.0555 0.0571
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0018 0.0555 0.0571
Schistosoma mansoni neurotransmitter gated ion channel 0.001 0.0003 0.0003
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0018 0.0555 0.0571
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0018 0.0555 0.0571
Mycobacterium leprae Possible transporter protein 0.0014 0.0254 0.3331
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0158 0.9716 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0555 0.0571
Brugia malayi Hypothetical UPF0028 protein ZK370.4 in chromosome III, putative 0.002 0.0646 0.0665
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0018 0.0555 0.0571
Loa Loa (eye worm) hypothetical protein 0.0129 0.7818 0.8046
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.002 0.0646 0.1764
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.1352 1
Echinococcus multilocularis hyperpolarization activated cyclic 0.0029 0.1287 0.1325
Loa Loa (eye worm) hypothetical protein 0.0075 0.4245 0.4368
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0555 0.0571
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0158 0.9716 1
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0018 0.0555 0.0571
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0158 0.9716 1
Echinococcus granulosus patatin phospholipase domain containing protein 0.002 0.0646 0.0665
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0018 0.0555 0.0571
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0075 0.4245 0.4368
Loa Loa (eye worm) hypothetical protein 0.0084 0.483 0.4972
Loa Loa (eye worm) hypothetical protein 0.0018 0.0555 0.0571
Loa Loa (eye worm) AGC/PKG protein kinase 0.002 0.0646 0.0665
Echinococcus granulosus single minded 2 0.0014 0.0254 0.0261
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0029 0.1287 0.1287
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0075 0.4245 0.4368
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0018 0.0555 0.0571
Loa Loa (eye worm) hypothetical protein 0.0075 0.4245 0.4368
Leishmania major hypothetical protein, conserved 0.002 0.0646 0.4777
Brugia malayi hypothetical protein 0.0075 0.4245 0.4368
Leishmania major cytochrome p450-like protein 0.0028 0.1209 0.8946
Onchocerca volvulus 0.0075 0.4245 0.4368
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.0003
Echinococcus multilocularis thyroid hormone receptor alpha 0.0158 0.9716 1
Echinococcus granulosus cpg binding protein 0.0037 0.1759 0.1811
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0018 0.0555 0.0571
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0158 0.9716 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0139 0.8463 1
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.002 0.0646 0.1764
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0011 0.0058 0.0432
Brugia malayi nuclear receptor RXR 0.0075 0.4245 0.4368
Brugia malayi Cation transporter family protein 0.0018 0.0555 0.0571
Brugia malayi hypothetical protein 0.002 0.0645 0.0664
Loa Loa (eye worm) hypothetical protein 0.0018 0.0555 0.0571
Trypanosoma cruzi regulatory subunit of protein kinase a-like protein, putative 0.002 0.0646 0.4777
Loa Loa (eye worm) hypothetical protein 0.0158 0.9716 1
Brugia malayi Steroid receptor seven-up type 2 0.0158 0.9716 1
Onchocerca volvulus Bile acid receptor homolog 0.0158 0.9716 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0158 0.9716 1
Schistosoma mansoni 60S ribosomal protein L21 0.0023 0.0895 0.0895
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0018 0.0555 0.0571
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0018 0.0555 0.0571
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0075 0.4245 0.4368
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0149 0.9105 0.9371
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.002 0.0646 0.0665
Schistosoma mansoni nAChR subunit 0.0018 0.0555 0.0555
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.002 0.0646 0.0477
Trypanosoma brucei cAMP binding protein, putative 0.002 0.0646 0.4777
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.1352 1
Echinococcus granulosus cAMP dependent protein kinase type I beta 0.002 0.0646 0.0665
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0011 0.0058 0.0432
Loa Loa (eye worm) hypothetical protein 0.0018 0.0555 0.0571
Loa Loa (eye worm) hypothetical protein 0.0075 0.4245 0.4368
Brugia malayi hypothetical protein 0.003 0.1352 0.1391
Echinococcus granulosus cGMP dependent protein kinase 1 0.002 0.0646 0.0665
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.3661 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.2976 0.3063
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0018 0.0555 0.0571
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0084 0.483 0.483
Loa Loa (eye worm) hypothetical protein 0.0158 0.9716 1
Onchocerca volvulus Putative nachr subunit 0.0018 0.0555 0.0571
Treponema pallidum catabolite gene activator 0.002 0.0646 0.5
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.0003
Echinococcus multilocularis 0.0011 0.0058 0.006
Brugia malayi Cyclic-nucleotide gated cation channel 0.0029 0.1287 0.1325

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 2.2387 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 7.9433 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 31.6228 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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