Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | polymerase (DNA directed) iota | Starlite/ChEMBL | No references |
Streptococcus pyogenes serotype M1 | Streptokinase A | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | basic transcription factor 3a, putative | 0.0042 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0042 | 1 | 1 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0023 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 1 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0023 | 0 | 0.5 |
Trypanosoma brucei | transcription factor BTF3, putative | 0.0042 | 1 | 1 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0023 | 0 | 0.5 |
Echinococcus multilocularis | transcription factor btf3 | 0.0042 | 1 | 1 |
Trypanosoma cruzi | transcription factor btf3, putative | 0.0042 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0042 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0042 | 1 | 1 |
Schistosoma mansoni | transcription factor btf3 | 0.0042 | 1 | 1 |
Entamoeba histolytica | transcription factor BTF3, putative | 0.0042 | 1 | 1 |
Toxoplasma gondii | NAC domain-containing protein | 0.0042 | 1 | 0.5 |
Trypanosoma cruzi | transcription factor btf3, putative | 0.0042 | 1 | 1 |
Plasmodium vivax | basic transcription factor 3b, putative | 0.0042 | 1 | 0.5 |
Plasmodium falciparum | basic transcription factor 3b, putative | 0.0042 | 1 | 0.5 |
Giardia lamblia | DINP protein human, muc B family | 0.0023 | 0 | 0.5 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0023 | 0 | 0.5 |
Loa Loa (eye worm) | ICD-1 protein | 0.0042 | 1 | 1 |
Echinococcus granulosus | transcription factor btf3 | 0.0042 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 0.119 um | PUBCHEM_BIOASSAY: Luminescence Microorganism-Based Dose Confirmation HTS to Identify Inhibitors of Streptokinase Promotor Activity. (Class of assay: confirmatory) [Related pubchem assays: 1677 (Project Summary), 1662 (Primary HTS)] | ChEMBL. | No reference |
Potency (functional) | 5.6234 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 10 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.