Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Equus caballus | Ferritin light chain | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus multilocularis | expressed protein | Ferritin light chain | 175 aa | 146 aa | 30.1 % |
Schistosoma mansoni | ferritin | Ferritin light chain | 175 aa | 171 aa | 44.4 % |
Schistosoma mansoni | ferritin | Ferritin light chain | 175 aa | 171 aa | 43.9 % |
Schistosoma mansoni | apoferritin-2 | Ferritin light chain | 175 aa | 146 aa | 28.8 % |
Schistosoma mansoni | apoferritin-2 | Ferritin light chain | 175 aa | 142 aa | 29.6 % |
Schistosoma japonicum | Ferritin, putative | Ferritin light chain | 175 aa | 144 aa | 24.3 % |
Echinococcus granulosus | expressed protein | Ferritin light chain | 175 aa | 146 aa | 28.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.1324 | 0.5 |
Echinococcus granulosus | geminin | 0.0164 | 0.7187 | 1 |
Treponema pallidum | bacterioferrin (TpF1) | 0.001 | 0 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.1708 | 0.2377 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.1708 | 0.2377 |
Brugia malayi | RNA binding protein | 0.0065 | 0.2551 | 0.1414 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 0.7187 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.2551 | 0.3549 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 0.7187 | 1 |
Brugia malayi | hypothetical protein | 0.012 | 0.5163 | 0.4425 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.2551 | 0.3549 |
Brugia malayi | MH2 domain containing protein | 0.012 | 0.5135 | 0.4393 |
Trichomonas vaginalis | ferritin, putative | 0.001 | 0 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0039 | 0.1324 | 0.1842 |
Mycobacterium ulcerans | bacterioferritin BfrA | 0.001 | 0 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0065 | 0.2551 | 0.1414 |
Mycobacterium ulcerans | bacterioferritin BfrB | 0.001 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.5163 | 0.4167 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.1324 | 0.5 |
Mycobacterium tuberculosis | Probable bacterioferritin BfrA | 0.001 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.2551 | 0.3549 |
Mycobacterium leprae | PROBABLE BACTERIOFERRITIN BFRA | 0.001 | 0 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.1708 | 0.2377 |
Echinococcus granulosus | tar DNA binding protein | 0.0065 | 0.2551 | 0.3549 |
Wolbachia endosymbiont of Brugia malayi | bacterioferritin/cytochrome b1 | 0.001 | 0 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0065 | 0.2551 | 0.1414 |
Loa Loa (eye worm) | TAR-binding protein | 0.0065 | 0.2551 | 0.1016 |
Echinococcus multilocularis | geminin | 0.0164 | 0.7187 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0039 | 0.1324 | 0.1842 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0065 | 0.2551 | 0.1016 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.1324 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.2551 | 0.3549 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.5163 | 0.4167 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.1324 | 0.1842 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.1708 | 0.2377 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 0.2551 | 0.3549 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0224 | 1 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.012 | 0.5135 | 0.4133 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.1708 | 0.2377 |
Onchocerca volvulus | Huntingtin homolog | 0.012 | 0.5163 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0065 | 0.2551 | 0.1016 |
Echinococcus multilocularis | tar DNA binding protein | 0.0065 | 0.2551 | 0.3549 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.1324 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.012 | 0.5135 | 0.4133 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0047 | 0.1708 | 0.0443 |
Onchocerca volvulus | Huntingtin homolog | 0.012 | 0.5163 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.1708 | 0.2377 |
Mycobacterium tuberculosis | Bacterioferritin BfrB | 0.001 | 0 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.1708 | 0.2377 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0039 | 0.1324 | 0.1842 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (binding) | = 4.4668 um | PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] | ChEMBL. | No reference |
Potency (functional) | 44.6684 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of mutant isocitrate dehydrogenase 1 (IDH1): qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.