TDR Targets

Basic information

Technical information

TDR Targets ID: 1237505
Name: G883-0042
MW: 338.4 | Formula: C20H22N2O3
H donors: 1 H acceptors: 2 LogP: 2.42 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: CCOc1ccccc1C(=O)NCc1ccc2c(c1)CCN2C(=O)C
InChi: 1S/C20H22N2O3/c1-3-25-19-7-5-4-6-17(19)20(24)21-13-15-8-9-18-16(12-15)10-11-22(18)14(2)23/h4-9,12H,3,10-11,13H2,1-2H3,(H,21,24)
InChiKey: CYGATYKBDGZHLB-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-[(1-acetyl-2,3-dihydroindol-5-yl)methyl]-2-ethoxybenzamide
N-[(1-acetylindolin-5-yl)methyl]-2-ethoxy-benzamide
N-[(1-acetyl-5-indolinyl)methyl]-2-ethoxybenzamide
N-[(1-ethanoyl-2,3-dihydroindol-5-yl)methyl]-2-ethoxy-benzamide
NCGC00137731-01

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	ubiquitin specific peptidase 1	Starlite/ChEMBL	No references
Homo sapiens	apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G	Starlite/ChEMBL	No references
Homo sapiens	lamin A/C	Starlite/ChEMBL	No references
Homo sapiens	TAR DNA binding protein	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	TAR DNA-binding protein 43, putative	Get druggable targets OG5_132461	All targets in OG5_132461
Onchocerca volvulus		Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	Get druggable targets OG5_132461	All targets in OG5_132461
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus multilocularis	cytoplasmic intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma japonicum	expressed protein	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Brugia malayi	intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma mansoni	intermediate filament proteins	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma japonicum	TAR DNA-binding protein 43, putative	Get druggable targets OG5_132461	All targets in OG5_132461
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus granulosus	tar DNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Brugia malayi	RNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Brugia malayi	TAR-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Echinococcus multilocularis	lamin dm0	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma mansoni	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Brugia malayi	RNA recognition motif domain containing protein	Get druggable targets OG5_132461	All targets in OG5_132461
Echinococcus granulosus	intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus granulosus	cytoplasmic intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma japonicum	ko:K07611 lamin, putative	Get druggable targets OG5_128723	All targets in OG5_128723
Brugia malayi	Intermediate filament tail domain containing protein	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus multilocularis	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus granulosus	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus multilocularis	musashi	Get druggable targets OG5_128723	All targets in OG5_128723
Onchocerca volvulus		Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma japonicum	Lamin-C, putative	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	RNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma japonicum	expressed protein	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	TAR-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Echinococcus multilocularis	tar DNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Echinococcus granulosus	lamin dm0	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma japonicum	Intermediate filament protein ifa-1, putative	Get druggable targets OG5_128723	All targets in OG5_128723

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	CHD4 protein	0.0015	0.0176	0.027
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0034	0.0925	0.1397
Echinococcus granulosus	chromodomain helicase DNA binding protein 1	0.0013	0.0107	0.0155
Echinococcus multilocularis	dna polymerase kappa	0.0021	0.043	0.0645
Schistosoma mansoni	DNA polymerase eta	0.0021	0.043	0.0498
Mycobacterium tuberculosis	Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase)	0.012	0.414	0.3877
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0021	0.043	0.0645
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.005	0.1527	0.2311
Schistosoma mansoni	chromobox protein	0.0077	0.2549	0.3766
Loa Loa (eye worm)	hypothetical protein	0.0043	0.1266	0.1937
Loa Loa (eye worm)	6-phosphofructokinase	0.012	0.414	0.6353
Onchocerca volvulus		0.0043	0.1252	0.1787
Trichomonas vaginalis	phosphofructokinase, putative	0.0032	0.0847	0.1837
Echinococcus multilocularis	6 phosphofructokinase	0.012	0.414	0.6277
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0043	0.1252	0.0859
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.043	0.0628
Echinococcus multilocularis	geminin	0.0185	0.6593	1
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.2515	0.3713
Echinococcus multilocularis	inositol monophosphatase 1	0.0044	0.1294	0.1957
Plasmodium falciparum	ATP-dependent 6-phosphofructokinase	0.0032	0.0847	1
Trichomonas vaginalis	phosphofructokinase, putative	0.012	0.414	1
Trypanosoma brucei	DNA polymerase IV, putative	0.0021	0.043	0.0628
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0044	0.1294	0.2943
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0032	0.0845	0.129
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0043	0.1252	0.1766
Trichomonas vaginalis	phosphofructokinase, putative	0.0032	0.0847	0.1837
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.2515	0.3713
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.005	0.1527	0.219
Trichomonas vaginalis	conserved hypothetical protein	0.0017	0.0254	0.0367
Mycobacterium ulcerans	beta-lactamase	0.0043	0.1252	0.2216
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0044	0.1294	0.2329
Echinococcus multilocularis	Chromo domain	0.0013	0.0107	0.0155
Trypanosoma brucei	DNA polymerase IV, putative	0.0021	0.043	0.0628
Trichomonas vaginalis	D-aminoacylase, putative	0.0043	0.1252	0.2839
Plasmodium vivax	hypothetical protein, conserved	0.0043	0.1252	1
Trypanosoma brucei	DNA polymerase IV, putative	0.0021	0.043	0.0628
Loa Loa (eye worm)	hypothetical protein	0.0043	0.1252	0.1916
Brugia malayi	beta-lactamase family protein	0.0043	0.1252	0.1922
Echinococcus multilocularis	tar DNA binding protein	0.0076	0.2515	0.381
Schistosoma mansoni	intermediate filament proteins	0.0033	0.0857	0.1158
Brugia malayi	TAR-binding protein	0.0076	0.2515	0.3861
Brugia malayi	hypothetical protein	0.0013	0.0107	0.0164
Echinococcus granulosus	inositol monophosphatase 1	0.0044	0.1294	0.1957
Mycobacterium leprae	conserved hypothetical protein	0.0043	0.1252	0.0439
Echinococcus granulosus	Chromo domain	0.0013	0.0107	0.0155
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0107	0.0156
Treponema pallidum	diphosphate--fructose-6-phosphate 1-phosphotransferase	0.012	0.414	1
Trichomonas vaginalis	chromobox protein, putative	0.0077	0.2549	0.6056
Brugia malayi	ImpB/MucB/SamB family protein	0.0021	0.043	0.0659
Echinococcus multilocularis	chromobox protein 1	0.0077	0.2549	0.3862
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.005	0.1527	0.2344
Trichomonas vaginalis	penicillin-binding protein, putative	0.0043	0.1252	0.2839
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.0044	0.1294	0.2329
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.043	0.0628
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.002	0.0382	0.0683
Brugia malayi	intermediate filament protein	0.0033	0.0857	0.1316
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0043	0.1252	0.2216
Brugia malayi	Associated with TFs and helicases family protein	0.0013	0.0107	0.0164
Brugia malayi	CXXC zinc finger family protein	0.0032	0.0845	0.1297
Schistosoma mansoni	cpg binding protein	0.0034	0.0914	0.1245
Schistosoma mansoni	hypothetical protein	0.0034	0.0925	0.1262
Loa Loa (eye worm)	hypothetical protein	0.0043	0.1252	0.1916
Entamoeba histolytica	phosphofructokinase, putative	0.012	0.414	1
Entamoeba histolytica	pyrophosphate-dependent phosphofructokinase	0.0032	0.0847	0.1837
Brugia malayi	SET domain containing protein	0.0013	0.0133	0.0204
Brugia malayi	latrophilin 2 splice variant baaae	0.0074	0.243	0.373
Trypanosoma brucei	hypothetical protein, conserved	0.0043	0.1252	0.2705
Brugia malayi	beta-lactamase family protein	0.0043	0.1252	0.1922
Trichomonas vaginalis	phosphofructokinase, putative	0.0032	0.0847	0.1837
Onchocerca volvulus		0.0182	0.6514	1
Brugia malayi	6-phosphofructokinase	0.012	0.414	0.6356
Trichomonas vaginalis	phosphofructokinase, putative	0.0032	0.0847	0.1837
Schistosoma mansoni	hypothetical protein	0.0034	0.0925	0.1262
Entamoeba histolytica	phosphofructokinase, putative	0.012	0.414	1
Echinococcus granulosus	chromobox protein 1	0.0077	0.2549	0.3862
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0021	0.043	0.0498
Mycobacterium ulcerans	esterase/lipase LipP	0.0043	0.1252	0.2216
Brugia malayi	RNA recognition motif domain containing protein	0.0076	0.2515	0.3861
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.005	0.1527	0.219
Echinococcus granulosus	cpg binding protein	0.0034	0.0914	0.138
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.002	0.0382	0.0683
Trichomonas vaginalis	chromobox protein, putative	0.0077	0.2549	0.6056
Trichomonas vaginalis	phosphofructokinase, putative	0.012	0.414	1
Schistosoma mansoni	lamin	0.0033	0.0857	0.1158
Loa Loa (eye worm)	helicase	0.0013	0.0107	0.0156
Echinococcus multilocularis	chromobox protein 2	0.0013	0.0107	0.0155
Onchocerca volvulus		0.0034	0.0912	0.1257
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.043	0.0628
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.2515	0.3713
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0044	0.1294	0.2329
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0017	0.0254	0.0367
Schistosoma mansoni	cpg binding protein	0.0032	0.0845	0.1138
Mycobacterium ulcerans	6-phosphofructokinase	0.012	0.414	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0043	0.1252	0.2839
Entamoeba histolytica	deoxycytidyl transferase, putative	0.0021	0.043	0.0801
Trichomonas vaginalis	phosphofructokinase, putative	0.0032	0.0847	0.1837
Toxoplasma gondii	phosphofructokinase PFKII	0.0032	0.0847	0.4057
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0109	0.3726	0.572
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0016	0.0222	0.0329
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0199	0.0299
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0107	0.0156
Onchocerca volvulus		0.0033	0.0857	0.1172
Brugia malayi	Valyl-tRNA synthetase	0.0013	0.0107	0.0164
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0912	0.1394
Brugia malayi	Heterochromatin protein 1	0.0077	0.2549	0.3914
Schistosoma mansoni	lamin	0.0033	0.0857	0.1158
Echinococcus multilocularis	dna polymerase eta	0.0021	0.043	0.0645
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0043	0.1252	0.1922
Echinococcus granulosus	chromobox protein 1	0.0077	0.2549	0.3862
Loa Loa (eye worm)	hypothetical protein	0.0021	0.043	0.0653
Mycobacterium ulcerans	hypothetical protein	0.0043	0.1252	0.2216
Loa Loa (eye worm)	RNA binding protein	0.0076	0.2515	0.3856
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0021	0.043	0.0645
Mycobacterium tuberculosis	Probable lipase LipD	0.0043	0.1252	0.0859
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.005	0.1527	0.2311
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0044	0.1294	0.2943
Trichomonas vaginalis	esterase, putative	0.0043	0.1252	0.2839
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0021	0.043	0.0801
Mycobacterium tuberculosis	Conserved protein	0.0043	0.1252	0.0859
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.002	0.0382	0.0683
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0043	0.1252	0.0859
Loa Loa (eye worm)	hypothetical protein	0.0074	0.243	0.3725
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.043	0.0628
Trichomonas vaginalis	DNA polymerase eta, putative	0.0021	0.043	0.0801
Trypanosoma cruzi	hypothetical protein, conserved	0.0043	0.1252	0.2216
Brugia malayi	Latrophilin receptor protein 2	0.0034	0.0925	0.142
Trichomonas vaginalis	6-phosphofructokinase, putative	0.0032	0.0847	0.1837
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.043	0.0628
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.2515	0.3713
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0788	0.1689
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0199	0.0299
Brugia malayi	RNA binding protein	0.0076	0.2515	0.3861
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0043	0.1252	0.1893
Schistosoma mansoni	cpg binding protein	0.0034	0.0914	0.1245
Entamoeba histolytica	phosphofructokinase, putative	0.012	0.414	1
Echinococcus granulosus	chromobox protein 2	0.0013	0.0107	0.0155
Echinococcus granulosus	dna polymerase eta	0.0021	0.043	0.0645
Schistosoma mansoni	hypothetical protein	0.0074	0.243	0.3582
Trichomonas vaginalis	chromobox protein, putative	0.0047	0.139	0.3182
Mycobacterium leprae	PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE)	0.012	0.414	1
Chlamydia trachomatis	fructose-6-phosphate phosphotransferase	0.0032	0.0847	0.5
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.002	0.0382	0.0683
Schistosoma mansoni	inositol monophosphatase	0.0044	0.1294	0.183
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0034	0.0925	0.1397
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0788	0.1689
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0034	0.0925	0.142
Echinococcus multilocularis	chromodomain helicase DNA binding protein 1	0.0013	0.0107	0.0155
Echinococcus granulosus	tar DNA binding protein	0.0076	0.2515	0.381
Echinococcus multilocularis	cpg binding protein	0.0034	0.0914	0.138
Loa Loa (eye worm)	TAR-binding protein	0.0076	0.2515	0.3856
Echinococcus multilocularis	Chromobox protein 3	0.0013	0.0107	0.0155
Schistosoma mansoni	6-phosphofructokinase	0.012	0.414	0.6219
Brugia malayi	hypothetical protein	0.0182	0.6514	1
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0021	0.043	0.0498
Echinococcus granulosus	GPCR family 2	0.0034	0.0925	0.1397
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0044	0.1294	0.6502
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0107	0.0156
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.002	0.0382	0.0683
Mycobacterium tuberculosis	Inositol-1-monophosphatase SuhB	0.004	0.1119	0.0721
Onchocerca volvulus		0.0043	0.1252	0.1787
Brugia malayi	6-phosphofructokinase	0.012	0.414	0.6356
Trichomonas vaginalis	penicillin-binding protein, putative	0.0043	0.1252	0.2839
Echinococcus granulosus	lamin	0.0033	0.0857	0.1294
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0016	0.0222	0.0329
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0034	0.0925	0.1414
Brugia malayi	Type III restriction enzyme, res subunit family protein	0.0013	0.0107	0.0164
Echinococcus multilocularis	lamin dm0	0.0033	0.0857	0.1294
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0061	0.1933	1
Echinococcus multilocularis	musashi	0.0033	0.0857	0.1294
Schistosoma mansoni	inositol monophosphatase	0.0044	0.1294	0.183
Mycobacterium tuberculosis	Probable esterase LipL	0.0043	0.1252	0.0859
Loa Loa (eye worm)	inositol-1	0.0044	0.1294	0.198
Trichomonas vaginalis	conserved hypothetical protein	0.0043	0.1266	0.2874
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0925	0.1414
Giardia lamblia	Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit	0.0032	0.0847	1
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0016	0.0234	0.0317
Echinococcus multilocularis	chromobox protein 1	0.0077	0.2549	0.3862
Onchocerca volvulus		0.0043	0.1252	0.1787
Brugia malayi	cytoplasmic intermediate filament protein	0.0017	0.0287	0.044
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0109	0.3726	0.572
Trypanosoma brucei	DNA polymerase eta, putative	0.0021	0.043	0.0628
Loa Loa (eye worm)	beta-lactamase	0.0043	0.1252	0.1916
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0021	0.043	0.0653
Brugia malayi	Inositol-1	0.0044	0.1294	0.1986
Echinococcus granulosus	dna polymerase kappa	0.0021	0.043	0.0645
Schistosoma mansoni	hypothetical protein	0.0185	0.6593	1
Echinococcus multilocularis	chromodomain helicase DNA binding protein 4	0.0015	0.0176	0.026
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.0044	0.1294	0.5
Schistosoma mansoni	chromobox protein	0.0077	0.2549	0.3766
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.005	0.1527	0.2311
Trichomonas vaginalis	conserved hypothetical protein	0.0043	0.1266	0.2874
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0107	0.0156
Loa Loa (eye worm)	CHromoDomain protein family member	0.0015	0.0176	0.0263
Toxoplasma gondii	ABC1 family protein	0.0043	0.1252	0.6272
Trypanosoma brucei	ATP-dependent 6-phosphofructokinase, glycosomal	0.012	0.414	1
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0076	0.2515	0.3856
Brugia malayi	M-phase phosphoprotein, mpp8	0.0013	0.0107	0.0164
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0068	0.2208	0.324
Echinococcus granulosus	Chromobox protein 3	0.0013	0.0107	0.0155
Trichomonas vaginalis	inositol monophosphatase, putative	0.0044	0.1294	0.2943
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0044	0.1294	0.2943
Mycobacterium tuberculosis	Probable hydrolase	0.0043	0.1252	0.0859
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0107	0.0156
Mycobacterium tuberculosis	Conserved protein	0.0043	0.1252	0.0859
Brugia malayi	chromobox protein homolog 3	0.0043	0.1266	0.1943
Echinococcus granulosus	6 phosphofructokinase	0.012	0.414	0.6277
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.043	0.0628
Loa Loa (eye worm)	hypothetical protein	0.0043	0.1252	0.1916
Trypanosoma brucei	unspecified product	0.0021	0.043	0.0628
Loa Loa (eye worm)	heterochromatin protein 1	0.0077	0.2549	0.3909
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0109	0.3726	0.5717
Mycobacterium leprae	Probable lipase LipE	0.0043	0.1252	0.0439
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0013	0.0133	0.0041
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0044	0.1294	0.2811
Loa Loa (eye worm)	hypothetical protein	0.0043	0.1252	0.1916
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0043	0.1252	0.1766
Echinococcus granulosus	geminin	0.0185	0.6593	1
Brugia malayi	Intermediate filament tail domain containing protein	0.0033	0.0857	0.1316
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.005	0.1527	0.2311
Echinococcus granulosus	intermediate filament protein	0.0033	0.0857	0.1294
Onchocerca volvulus		0.0033	0.0857	0.1172
Onchocerca volvulus		0.0032	0.0845	0.1152
Echinococcus granulosus	lamin dm0	0.0033	0.0857	0.1294
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0107	0.0156
Schistosoma mansoni	hypothetical protein	0.0034	0.0925	0.1262
Loa Loa (eye worm)	intermediate filament protein	0.0033	0.0857	0.131
Toxoplasma gondii	phosphofructokinase domain-containing protein	0.0032	0.0847	0.4057
Trypanosoma cruzi	ATP-dependent 6-phosphofructokinase, glycosomal	0.012	0.414	1
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.2515	0.3713
Toxoplasma gondii	6-phosphofructokinase	0.0032	0.0847	0.4057
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.043	0.0628
Loa Loa (eye worm)	hypothetical protein	0.0182	0.6514	1
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0047	0.139	0.2003
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0043	0.1266	0.1809
Plasmodium vivax	6-phosphofructokinase, putative	0.0032	0.0847	0.6469
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.043	0.0628
Trichomonas vaginalis	phosphofructokinase, putative	0.012	0.414	1
Echinococcus multilocularis	GPCR, family 2	0.0034	0.0925	0.1397
Leishmania major	ATP-dependent phosphofructokinase	0.012	0.414	1
Loa Loa (eye worm)	6-phosphofructokinase	0.012	0.414	0.6353
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0034	0.0925	0.1397
Plasmodium vivax	6-phosphofructokinase, putative	0.0032	0.0847	0.6469
Trichomonas vaginalis	chromobox protein, putative	0.0047	0.139	0.3182
Schistosoma mansoni	hypothetical protein	0.0034	0.0925	0.1262
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0034	0.0925	0.1397
Echinococcus granulosus	chromodomain helicase DNA binding protein 4	0.0015	0.0176	0.026
Loa Loa (eye worm)	hypothetical protein	0.0043	0.1252	0.1916
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0044	0.1294	0.2329
Mycobacterium tuberculosis	Probable lipase LipE	0.0043	0.1252	0.0859
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0107	0.0156
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.043	0.0628
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.043	0.0628
Brugia malayi	Protein cec-1.	0.0013	0.0107	0.0164
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0043	0.1252	0.0859
Loa Loa (eye worm)	phosphofructokinase	0.012	0.414	0.6353
Brugia malayi	beta-lactamase	0.0043	0.1252	0.1922
Loa Loa (eye worm)	hypothetical protein	0.0043	0.1252	0.1916
Trichomonas vaginalis	phosphofructokinase, putative	0.0032	0.0847	0.1837
Trichomonas vaginalis	phosphofructokinase, putative	0.012	0.414	1
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.002	0.0382	0.0683
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0017	0.0287	0.0433
Schistosoma mansoni	hypothetical protein	0.0185	0.6593	1
Plasmodium falciparum	ATP-dependent 6-phosphofructokinase	0.0032	0.0847	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0043	0.1252	0.2216
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.002	0.0382	0.0683
Brugia malayi	phosphofructokinase	0.012	0.414	0.6356
Mycobacterium ulcerans	lipase LipD	0.0043	0.1252	0.2216
Trichomonas vaginalis	D-aminoacylase, putative	0.0043	0.1252	0.2839
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0835	0.1275
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.002	0.0382	0.0683
Echinococcus granulosus	beta LACTamase domain containing family member	0.0043	0.1252	0.1893
Leishmania major	hypothetical protein, conserved	0.0043	0.1252	0.2216
Loa Loa (eye worm)	hypothetical protein	0.0109	0.3726	0.5717
Echinococcus multilocularis	lamin	0.0033	0.0857	0.1294
Brugia malayi	ImpB/MucB/SamB family protein	0.0021	0.043	0.0659
Onchocerca volvulus		0.0013	0.0133	0.0041
Chlamydia trachomatis	fructose-6-phosphate phosphotransferase	0.0032	0.0847	0.5
Schistosoma mansoni	6-phosphofructokinase	0.012	0.414	0.6219
Schistosoma mansoni	chromodomain helicase DNA binding protein	0.0015	0.0176	0.0107
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0033	0.0857	0.131
Mycobacterium tuberculosis	Conserved protein	0.0043	0.1252	0.0859
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.005	0.1527	0.219
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.005	0.1527	0.2339
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0222	0.0333
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0043	0.1252	0.1916
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0857	0.131

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	0.3548 uM	PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 1.5849 um	PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	2.2387 uM	PubChem BioAssay. qHTS for Inhibitors of Vif-A3G Interactions: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	12.5893 uM	PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1318585

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1237505