Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | hydroxysteroid (17-beta) dehydrogenase 10 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium falciparum | 3-oxoacyl-[acyl-carrier-protein] reductase | hydroxysteroid (17-beta) dehydrogenase 10 | 252 aa | 251 aa | 24.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.031 | 0.8278 | 0.7154 |
Echinococcus granulosus | carboxylesterase 5A | 0.031 | 0.8278 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.031 | 0.8278 | 0.8278 |
Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0069 | 0 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.031 | 0.8278 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.036 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.031 | 0.8278 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.031 | 0.8278 | 1 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.036 | 1 | 0.5 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.036 | 1 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.031 | 0.8278 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.031 | 0.8278 | 0.7154 |
Leishmania major | C-8 sterol isomerase-like protein | 0.036 | 1 | 1 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0069 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.031 | 0.8278 | 0.7154 |
Loa Loa (eye worm) | carboxylesterase | 0.031 | 0.8278 | 0.7154 |
Brugia malayi | Carboxylesterase family protein | 0.031 | 0.8278 | 0.8278 |
Echinococcus multilocularis | carboxylesterase 5A | 0.031 | 0.8278 | 1 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0069 | 0 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.031 | 0.8278 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 3.1623 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 15.8489 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (binding) | 25.1189 uM | PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 56.2341 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.