Detailed information for compound 1238046

Basic information

Technical information
  • TDR Targets ID: 1238046
  • Name: 2-(4-methoxyphenyl)-4-(4-methylphenyl)sulfony l-N-(phenylmethyl)-1,3-oxazol-5-amine
  • MW: 434.507 | Formula: C24H22N2O4S
  • H donors: 1 H acceptors: 3 LogP: 5.83 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)c1oc(c(n1)S(=O)(=O)c1ccc(cc1)C)NCc1ccccc1
  • InChi: 1S/C24H22N2O4S/c1-17-8-14-21(15-9-17)31(27,28)24-23(25-16-18-6-4-3-5-7-18)30-22(26-24)19-10-12-20(29-2)13-11-19/h3-15,25H,16H2,1-2H3
  • InChiKey: DVJRHQOHLBWHKT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(4-methoxyphenyl)-4-(4-methylphenyl)sulfonyl-N-(phenylmethyl)oxazol-5-amine
  • 2-(4-methoxyphenyl)-4-(4-methylphenyl)sulfonyl-N-(phenylmethyl)-5-oxazolamine
  • benzyl-[2-(4-methoxyphenyl)-4-(4-methylphenyl)sulfonyl-oxazol-5-yl]amine
  • T0503-7760
  • NCGC00100846-01
  • Oprea1_170046

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Schistosoma mansoni Thioredoxin glutathione reductase Starlite/ChEMBL No references
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium berghei thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum MGC84926 protein, related Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium hominis thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania braziliensis trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi Thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Theileria parva thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium parvum thioredoxin reductase 1 Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania mexicana trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium yoelii glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Leishmania donovani trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium yoelii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma congolense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum Glutathione reductase, related Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Trypanosoma cruzi trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania infantum trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Toxoplasma gondii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei gambiense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Babesia bovis thiodoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.5 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.2 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast Thioredoxin reductase 1, cytoplasmic   499 aa 506 aa 23.7 %
Leishmania donovani dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Leishmania major acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 462 aa 25.8 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Leishmania braziliensis acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 22.8 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.3 %
Toxoplasma gondii NADPH-glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 529 aa 31.8 %
Plasmodium berghei dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 539 aa 22.3 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.6 %
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 454 aa 25.3 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 519 aa 23.7 %
Plasmodium berghei dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 26.9 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Leishmania mexicana 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 452 aa 25.7 %
Plasmodium falciparum thioredoxin reductase Thioredoxin reductase 1, cytoplasmic   499 aa 511 aa 45.2 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.3 %
Leishmania infantum dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Leishmania braziliensis dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 488 aa 21.9 %
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 460 aa 25.4 %
Trypanosoma brucei dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.4 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Leishmania infantum acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.2 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, point mutation,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.3 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Leishmania braziliensis 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 450 aa 25.6 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.9 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.5 %
Neospora caninum glutathione reductase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 32.7 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.5 %
Plasmodium falciparum glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 500 aa 32.2 %
Onchocerca volvulus Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 57.3 %
Neospora caninum Dihydrolipoyl dehydrogenase (EC 1.8.1.4), related Thioredoxin reductase 1, cytoplasmic   499 aa 464 aa 24.8 %
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 518 aa 24.9 %
Leishmania donovani acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Neospora caninum hypothetical protein Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.0 %
Leishmania mexicana acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 24.4 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 540 aa 23.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0521 0.1928
Giardia lamblia NADH oxidase lateral transfer candidate 0.0036 0.0529 0.1753
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0038 0.0602 0.0658
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0036 0.0529 0.1074
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0036 0.0529 0.0534
Trichomonas vaginalis ran, putative 0.0021 0.0051 0.0059
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0639 0.0644
Brugia malayi hypothetical protein 0.0242 0.7211 0.9606
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0059 0.1287 0.1406
Loa Loa (eye worm) hypothetical protein 0.0059 0.1287 0.1406
Echinococcus multilocularis baculoviral IAP repeat containing protein 0.019 0.5537 0.6046
Schistosoma mansoni hypothetical protein 0.005 0.1002 0.1002
Loa Loa (eye worm) hypothetical protein 0.0242 0.7211 0.7875
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0036 0.0529 0.1958
Mycobacterium tuberculosis Conserved protein 0.0035 0.0521 0.0667
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0602 0.0698
Leishmania major mitochondrial DNA polymerase beta 0.0326 0.9916 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0529 0.0534
Loa Loa (eye worm) intermediate filament protein 0.0059 0.1287 0.1406
Plasmodium falciparum thioredoxin reductase 0.0036 0.0529 0.1958
Loa Loa (eye worm) hypothetical protein 0.0035 0.0521 0.0569
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0026 0.0223 0.0297
Echinococcus multilocularis caspase 2 0.005 0.1002 0.1094
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein 0.0036 0.053 0.0534
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0036 0.053 0.0579
Trypanosoma cruzi DNA polymerase eta, putative 0.0039 0.0639 0.0644
Echinococcus granulosus lamin 0.0059 0.1287 0.1406
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0521 0.0667
Onchocerca volvulus Cell death protein 3 homolog 0.005 0.1002 0.0593
Treponema pallidum NADH oxidase 0.0036 0.0529 1
Echinococcus granulosus dna polymerase kappa 0.0039 0.0639 0.0698
Echinococcus multilocularis inhibitor of apoptosis protein 0.019 0.5537 0.6046
Brugia malayi Intermediate filament tail domain containing protein 0.0059 0.1287 0.1715
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0639 0.0644
Schistosoma mansoni ran 0.0021 0.0051 0.0051
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0639 0.0644
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0036 0.0529 0.0534
Mycobacterium tuberculosis Probable reductase 0.0234 0.6961 0.8916
Mycobacterium ulcerans hypothetical protein 0.0035 0.0521 0.1057
Brugia malayi Augmenter of liver regeneration 0.0036 0.053 0.0706
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.0544 0.0595
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0247 0.0249
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0113 0.3018 0.3043
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0543 0.0543
Trypanosoma cruzi polo-like protein kinase, putative 0.0113 0.3018 0.3043
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0051 0.0056
Echinococcus granulosus caspase 2 0.005 0.1002 0.1094
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0036 0.0529 0.0529
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0639 0.0644
Onchocerca volvulus 0.0059 0.1287 0.0945
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0036 0.0529 0.0534
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0543 0.201
Schistosoma mansoni inhibitor of apoptosis (iap) domain family member 0.019 0.5537 0.5537
Loa Loa (eye worm) beta-lactamase 0.0035 0.0521 0.0569
Echinococcus multilocularis lamin 0.0059 0.1287 0.1406
Loa Loa (eye worm) hypothetical protein 0.005 0.1002 0.1094
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0056 0.1183 0.1193
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0036 0.053 0.0534
Plasmodium vivax glutathione reductase, putative 0.0103 0.2702 1
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0036 0.0529 0.0534
Trichomonas vaginalis CAMK family protein kinase 0.0113 0.3018 0.3497
Plasmodium falciparum thioredoxin reductase 0.0103 0.2702 1
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0521 0.0604
Plasmodium vivax thioredoxin reductase, putative 0.0103 0.2702 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0521 0.0569
Toxoplasma gondii Erv1 / Alr family protein 0.0036 0.053 0.1962
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.1179 0.1366
Loa Loa (eye worm) hypothetical protein 0.019 0.5537 0.6046
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.019 0.5537 0.7375
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0036 0.0529 0.1074
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0544 0.0631
Brugia malayi intermediate filament protein 0.0059 0.1287 0.1715
Trypanosoma brucei unspecified product 0.0027 0.0247 0.0249
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0639 0.0644
Trichomonas vaginalis CAMK family protein kinase 0.0113 0.3018 0.3497
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0639 0.0644
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0639 0.0644
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0326 0.9916 1
Onchocerca volvulus 0.005 0.1002 0.0593
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0521 0.0521
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.139 0.1517
Brugia malayi ImpB/MucB/SamB family protein 0.0039 0.0639 0.0851
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0039 0.0639 0.0698
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0544 0.1804
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0639 0.0644
Schistosoma mansoni terminal deoxycytidyl transferase 0.0039 0.0639 0.0639
Entamoeba histolytica deoxycytidyl transferase, putative 0.0039 0.0639 0.2117
Loa Loa (eye worm) hypothetical protein 0.005 0.1002 0.1094
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0544 0.0631
Echinococcus granulosus thioredoxin glutathione reductase 0.0103 0.2722 0.2972
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0302 0.9157 1
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0038 0.0602 0.1995
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0154 0.4365 0.4402
Mycobacterium tuberculosis Conserved protein 0.0035 0.0521 0.0667
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0261 0.7808 1
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0051 0.0189
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0521 0.0667
Echinococcus multilocularis dna polymerase kappa 0.0039 0.0639 0.0698
Brugia malayi glutathione reductase 0.0103 0.2702 0.3599
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0039 0.0639 0.0644
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0039 0.0639 0.0818
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0261 0.7808 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0226 0.6685 0.8563
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0234 0.6961 0.8916
Loa Loa (eye worm) hypothetical protein 0.0036 0.0543 0.0593
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0639 0.0644
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0544 0.0549
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0708 0.0943
Echinococcus granulosus dna polymerase eta 0.0039 0.0639 0.0698
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0036 0.0529 0.1958
Echinococcus multilocularis lamin dm0 0.0059 0.1287 0.1406
Loa Loa (eye worm) TAR-binding protein 0.0062 0.139 0.1517
Schistosoma mansoni tar DNA-binding protein 0.0062 0.139 0.139
Mycobacterium tuberculosis Conserved protein 0.0035 0.0521 0.0667
Trichomonas vaginalis CAMK family protein kinase 0.0113 0.3018 0.3497
Brugia malayi beta-lactamase 0.0035 0.0521 0.0694
Mycobacterium ulcerans DNA polymerase IV 0.0039 0.0639 0.1296
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0051 0.017
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0039 0.0639 0.074
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein 0.0036 0.053 0.0534
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0036 0.0529 0.0534
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0051 0.0068
Onchocerca volvulus 0.0049 0.0975 0.056
Leishmania major trypanothione reductase 0.0103 0.2702 0.2725
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0639 0.0644
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0543 0.0543
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0038 0.0602 0.0658
Loa Loa (eye worm) hypothetical protein 0.0041 0.0708 0.0773
Schistosoma mansoni tar DNA-binding protein 0.0062 0.139 0.139
Loa Loa (eye worm) thioredoxin reductase 0.0103 0.2702 0.295
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0521 0.0604
Brugia malayi RNA binding protein 0.0062 0.139 0.1851
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0036 0.0529 0.0534
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0544 0.0631
Loa Loa (eye worm) hypothetical protein 0.019 0.5537 0.6046
Schistosoma mansoni hypothetical protein 0.0049 0.0975 0.0975
Echinococcus granulosus baculoviral IAP repeat containing protein 0.019 0.5537 0.6046
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative 0.0036 0.053 0.1962
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0026 0.0223 0.0297
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0326 0.9916 1
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0038 0.0602 0.0802
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.012 0.0139
Brugia malayi RNA, U transporter 1 0.0081 0.1982 0.264
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0521 0.0667
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0036 0.0529 0.1074
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0036 0.0529 1
Loa Loa (eye worm) RNA binding protein 0.0062 0.139 0.1517
Trichomonas vaginalis CAMK family protein kinase 0.0113 0.3018 0.3497
Entamoeba histolytica hypothetical protein 0.0023 0.012 0.0397
Mycobacterium ulcerans hypothetical protein 0.0172 0.4928 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0103 0.2722 0.2972
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0529 0.0534
Leishmania major alpha glucosidase II subunit, putative 0.0036 0.0544 0.0549
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0544 0.1804
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0154 0.4365 0.4402
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0521 0.0667
Brugia malayi beta-lactamase family protein 0.0035 0.0521 0.0694
Loa Loa (eye worm) hypothetical protein 0.0027 0.0264 0.0288
Onchocerca volvulus Deterin homolog 0.019 0.5537 0.6185
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0051 0.0189
Schistosoma mansoni kinase 0.0057 0.1227 0.1227
Schistosoma mansoni lamin 0.0059 0.1287 0.1287
Echinococcus granulosus lysosomal alpha glucosidase 0.0163 0.4638 0.5065
Loa Loa (eye worm) hypothetical protein 0.0035 0.0521 0.0569
Toxoplasma gondii NADPH-glutathione reductase 0.0036 0.0529 0.1958
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0602 0.0698
Schistosoma mansoni alpha-glucosidase 0.014 0.3906 0.3906
Trichomonas vaginalis glutathione reductase, putative 0.0036 0.0529 0.0613
Loa Loa (eye worm) hypothetical protein 0.0028 0.0299 0.0326
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0293 0.032
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0234 0.6961 0.8916
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0529 0.0534
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0521 0.0521
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0039 0.0639 0.0639
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0639 0.0644
Onchocerca volvulus 0.0286 0.863 1
Brugia malayi Thioredoxin reductase 0.0103 0.2702 0.3599
Trichomonas vaginalis CAMK family protein kinase 0.0113 0.3018 0.3497
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0051 0.0052
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0038 0.0602 0.0602
Leishmania major DNA polymerase kappa, putative 0.0039 0.0639 0.0644
Plasmodium falciparum glutathione reductase 0.0103 0.2702 1
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0036 0.0529 0.1958
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0521 0.0604
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0046 0.0859 0.0866
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0154 0.4365 0.4402
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.0544 0.0595
Mycobacterium tuberculosis Conserved hypothetical protein 0.0039 0.0639 0.0818
Loa Loa (eye worm) hypothetical protein 0.0035 0.0521 0.0569
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0038 0.0602 0.0607
Schistosoma mansoni hypothetical protein 0.0302 0.9157 0.9157
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0234 0.6961 0.8916
Schistosoma mansoni ran 0.0021 0.0051 0.0051
Trypanosoma cruzi trypanothione reductase, putative 0.0036 0.0529 0.0534
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0113 0.3018 0.3296
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0036 0.0544 0.2015
Echinococcus multilocularis tar DNA binding protein 0.0062 0.139 0.1517
Trichomonas vaginalis DNA polymerase eta, putative 0.0039 0.0639 0.074
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0602 0.0607
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0051 0.0056
Brugia malayi TAR-binding protein 0.0062 0.139 0.1851
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.7507 0.8198
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0639 0.0644
Echinococcus granulosus apoptotic protease activating factor 1 0.005 0.1002 0.1094
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0046 0.0859 0.0866
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.012 0.0121
Leishmania major importin beta-1 subunit, putative 0.0023 0.012 0.0121
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0036 0.053 0.0579
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0529 0.0534
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0521 0.0525
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0521 0.0667
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0544 0.0631
Brugia malayi ImpB/MucB/SamB family protein 0.0039 0.0639 0.0851
Schistosoma mansoni hypothetical protein 0.019 0.5537 0.5537
Trypanosoma brucei DNA polymerase eta, putative 0.0039 0.0639 0.0644
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0293 0.1085
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0032 0.04 0.0437
Trichomonas vaginalis maltase-glucoamylase, putative 0.0036 0.0544 0.0631
Onchocerca volvulus 0.019 0.5537 0.6185
Loa Loa (eye worm) hypothetical protein 0.0058 0.1252 0.1368
Mycobacterium ulcerans lipase LipD 0.0035 0.0521 0.1057
Loa Loa (eye worm) hypothetical protein 0.0035 0.0521 0.0569
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0051 0.0052
Echinococcus granulosus lamin dm0 0.0059 0.1287 0.1406
Trichomonas vaginalis mercuric reductase, putative 0.0036 0.0529 0.0613
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0163 0.4638 0.5065
Echinococcus granulosus intermediate filament protein 0.0059 0.1287 0.1406
Toxoplasma gondii Erv1 / Alr family protein 0.0036 0.053 0.1962
Plasmodium falciparum importin beta, putative 0.0028 0.0293 0.1085
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0521 0.0694
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0543 0.0593
Echinococcus granulosus tar DNA binding protein 0.0062 0.139 0.1517
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.0544 0.0725
Brugia malayi beta-lactamase family protein 0.0035 0.0521 0.0694
Onchocerca volvulus 0.0094 0.242 0.2342
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0521 0.0569
Trypanosoma brucei polo-like protein kinase 0.0113 0.3018 0.3043
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0602 0.0607
Schistosoma mansoni serine/threonine protein kinase 0.0113 0.3018 0.3018
Trichomonas vaginalis importin beta-1, putative 0.0023 0.012 0.0139
Echinococcus multilocularis apoptotic protease activating factor 1 0.005 0.1002 0.1094
Plasmodium falciparum glutathione reductase 0.0036 0.0529 0.1958
Brugia malayi hypothetical protein 0.005 0.1002 0.1335
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0039 0.0639 0.0698
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0046 0.0859 0.0866
Schistosoma mansoni lamin 0.0059 0.1287 0.1287
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0521 0.0525
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0051 0.0189
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0544 0.0631
Echinococcus granulosus importin subunit beta 1 0.0028 0.0293 0.032
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0046 0.0859 0.0866
Toxoplasma gondii hypothetical protein 0.0053 0.1077 0.3986
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0529 0.0534
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0113 0.3018 0.3296
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0521 0.0569
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0521 0.0569
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0544 0.0631
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0051 0.0052
Echinococcus granulosus ubiquitin specific protease 41 0.0038 0.0602 0.0658
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0261 0.7808 1
Mycobacterium ulcerans DNA polymerase IV 0.0039 0.0639 0.1296
Mycobacterium tuberculosis Conserved hypothetical protein 0.0172 0.4928 0.6312
Echinococcus multilocularis survival motor neuron protein 1 0.0242 0.7211 0.7875
Echinococcus granulosus snurportin 1 0.0302 0.9157 1
Echinococcus multilocularis ubiquitin specific protease 41 0.0038 0.0602 0.0658
Trypanosoma brucei glucosidase, putative 0.0036 0.0544 0.0549
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0036 0.0529 1
Schistosoma mansoni DNA polymerase eta 0.0039 0.0639 0.0639
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0113 0.3018 0.3296
Loa Loa (eye worm) hypothetical protein 0.0028 0.0293 0.032
Giardia lamblia Kinase, PLK 0.0113 0.3018 1
Loa Loa (eye worm) hypothetical protein 0.006 0.1324 0.1446
Leishmania major hypothetical protein, conserved 0.0036 0.053 0.0534
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0036 0.0529 0.0534
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0639 0.0644
Brugia malayi Pre-SET motif family protein 0.0251 0.7507 1
Schistosoma mansoni inhibitor of apoptosis protein 0.019 0.5537 0.5537
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0028 0.0299 0.0326
Trypanosoma cruzi trypanothione reductase, putative 0.0103 0.2702 0.2725
Plasmodium vivax SET domain protein, putative 0.0036 0.0543 0.201
Trypanosoma cruzi polo-like protein kinase, putative 0.0113 0.3018 0.3043
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0036 0.0529 0.5
Brugia malayi cytoplasmic intermediate filament protein 0.0032 0.04 0.0533
Schistosoma mansoni hypothetical protein 0.0041 0.0708 0.0708
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0521 0.1057
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.05 0.0546
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.1324 0.1446
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0544 0.0631
Schistosoma mansoni importin beta-1 0.0028 0.0293 0.0293
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0602 0.0607
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0234 0.6961 0.8916
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.019 0.5537 0.7375
Trypanosoma brucei unspecified product 0.0039 0.0639 0.0644
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0028 0.0299 0.0326
Loa Loa (eye worm) hypothetical protein 0.0039 0.0639 0.0698
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0639 0.0644
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0036 0.0529 0.0705
Brugia malayi Pre-SET motif family protein 0.0036 0.0543 0.0723
Mycobacterium ulcerans beta-lactamase 0.0035 0.0521 0.1057
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0036 0.0529 0.0534
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0543 0.0543
Brugia malayi Importin beta-1 subunit 0.0028 0.0293 0.039
Loa Loa (eye worm) glutathione reductase 0.0103 0.2702 0.295
Onchocerca volvulus 0.0059 0.1287 0.0945
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0036 0.053 0.0534
Brugia malayi Cell death protein 3 precursor 0.005 0.1002 0.1335
Trichomonas vaginalis sucrase-isomaltase, putative 0.0036 0.0544 0.0631
Schistosoma mansoni tar DNA-binding protein 0.0062 0.139 0.139
Leishmania major hypothetical protein, conserved 0.0035 0.0521 0.0525
Schistosoma mansoni intermediate filament proteins 0.0059 0.1287 0.1287
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.1324 0.1764
Entamoeba histolytica Ran family GTPase 0.0021 0.0051 0.017
Loa Loa (eye worm) hypothetical protein 0.0038 0.0602 0.0658
Schistosoma mansoni alpha-glucosidase 0.014 0.3906 0.3906
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0039 0.0639 0.0698
Entamoeba histolytica serine/threonine protein kinase, putative 0.0113 0.3018 1
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.1179 0.1366
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0036 0.0529 0.0678
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0103 0.2702 0.346
Brugia malayi Glycosyl hydrolases family 31 protein 0.0163 0.4638 0.6179
Trichomonas vaginalis set domain proteins, putative 0.0286 0.863 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0036 0.0529 0.0534
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0036 0.0529 0.0534
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0544 0.0549
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0051 0.0056
Onchocerca volvulus 0.0036 0.0543 0.0027
Toxoplasma gondii thioredoxin reductase 0.0103 0.2702 1
Schistosoma mansoni tar DNA-binding protein 0.0062 0.139 0.139
Trypanosoma brucei unspecified product 0.0027 0.0247 0.0249
Plasmodium vivax importin-beta 2, putative 0.0028 0.0293 0.1085
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0543 0.0593
Echinococcus multilocularis lysosomal alpha glucosidase 0.0163 0.4638 0.5065
Brugia malayi serine/threonine-protein kinase plk-2 0.0113 0.3018 0.402
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0543 0.0593
Echinococcus multilocularis dna polymerase eta 0.0039 0.0639 0.0698
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0975 0.1299
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0521 0.0667
Giardia lamblia DINP protein human, muc B family 0.0039 0.0639 0.2117
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative 0.0036 0.053 0.1962
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0038 0.0602 0.1995
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0521 0.0525
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0521 0.0604
Echinococcus multilocularis snurportin 1 0.0302 0.9157 1
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.139 0.1851
Loa Loa (eye worm) hypothetical protein 0.0035 0.0521 0.0569
Leishmania major DNA polymerase eta, putative 0.0039 0.0639 0.0644
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0639 0.0644
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0038 0.0602 0.0602
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0521 0.0667
Toxoplasma gondii ABC1 family protein 0.0035 0.0521 0.1928
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.0544 0.0595
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0036 0.0529 0.1958
Schistosoma mansoni alpha glucosidase 0.0036 0.0544 0.0544
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0639 0.0644
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0036 0.0529 0.1958
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0293 0.0296
Mycobacterium tuberculosis Probable dehydrogenase 0.0234 0.6961 0.8916
Leishmania major GTP-binding protein, putative 0.0021 0.0051 0.0052
Trichomonas vaginalis esterase, putative 0.0035 0.0521 0.0604
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0036 0.0529 0.0578
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0543 0.0543
Echinococcus granulosus inhibitor of apoptosis protein 0.019 0.5537 0.6046
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0521 0.0604
Onchocerca volvulus Serine\/threonine kinase homolog 0.0113 0.3018 0.3079
Schistosoma mansoni caspase-7 (C14 family) 0.005 0.1002 0.1002
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0038 0.0602 0.0658
Mycobacterium tuberculosis Probable oxidoreductase 0.0261 0.7808 1
Echinococcus multilocularis musashi 0.0059 0.1287 0.1406
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0036 0.0529 0.0534
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0234 0.6961 0.8839
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.1324 0.1764
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0602 0.0698
Schistosoma mansoni tar DNA-binding protein 0.0062 0.139 0.139
Loa Loa (eye worm) hepatopoietin HPO2 0.0036 0.053 0.0579
Trichomonas vaginalis CAMK family protein kinase 0.0113 0.3018 0.3497
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0326 0.9916 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0264 0.0288
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0247 0.0249
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0521 0.1057
Trypanosoma brucei trypanothione reductase 0.0103 0.2702 0.2725
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0293 0.0296
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0036 0.0529 0.0578
Echinococcus granulosus survival motor neuron protein 1 0.0242 0.7211 0.7875
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0247 0.0249
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.012 0.0139
Trichomonas vaginalis CAMK family protein kinase 0.0113 0.3018 0.3497
Echinococcus multilocularis lysosomal alpha glucosidase 0.0163 0.4638 0.5065
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0038 0.0602 0.0658
Schistosoma mansoni survival motor neuron protein 0.0049 0.0975 0.0975
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0639 0.0644

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 5.6234 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 11.2202 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 17.7828 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (binding) = 31.6228 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1476 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent))] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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