Detailed information for compound 1238081

Basic information

Technical information
  • TDR Targets ID: 1238081
  • Name: SMR000363533
  • MW: 226.234 | Formula: C12H10N4O
  • H donors: 3 H acceptors: 1 LogP: 1.1 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: NC(=O)NNC1=Nc2c3c1cccc3ccc2
  • InChi: 1S/C12H10N4O/c13-12(17)16-15-11-8-5-1-3-7-4-2-6-9(14-11)10(7)8/h1-6H,(H,14,15)(H3,13,16,17)
  • InChiKey: OTJFYCKFLJWCOH-UHFFFAOYSA-N  

Network

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Synonyms

  • T0517-4226
  • ZINC03306820
  • MLS001032966

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glutaminase Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium ulcerans glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Trichomonas vaginalis glutaminase, putative Get druggable targets OG5_129245 All targets in OG5_129245
Loa Loa (eye worm) glutaminase 2 Get druggable targets OG5_129245 All targets in OG5_129245
Loa Loa (eye worm) glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Schistosoma mansoni glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Brugia malayi glutaminase DH11.1 Get druggable targets OG5_129245 All targets in OG5_129245

By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0157 0.014
Trypanosoma cruzi T-complex protein 1, beta subunit, putative 0.0026 0.0079 0.044
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.007 0.0381 0.0532
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.015 0.0133
Trichomonas vaginalis chromobox protein, putative 0.0212 0.1369 0.1354
Schistosoma mansoni amine GPCR 0.0017 0.0013 0.0018
Echinococcus granulosus puromycin sensitive aminopeptidase 0.005 0.0243 0.0336
Trichomonas vaginalis Heterochromatin protein, putative 0.0057 0.0295 0.0279
Onchocerca volvulus Deterin homolog 0.0447 0.3006 0.3006
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0047 0.0223 0.0318
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0039 0.0036
Echinococcus granulosus bloom syndrome protein 0.0024 0.006 0.0075
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0353 0.2353 0.2681
Loa Loa (eye worm) hypothetical protein 0.0146 0.091 0.103
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0006
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0359 0.2178
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0006
Plasmodium vivax hypothetical protein, conserved 0.0147 0.0918 0.7788
Trypanosoma cruzi cruzipain precursor, putative 0.0067 0.0359 0.2178
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0023 0.0054 0.1418
Schistosoma mansoni hypothetical protein 0.0112 0.0673 0.0958
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0017 0.0013 0.0007
Plasmodium falciparum phd finger protein, putative 0.0147 0.0918 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.0013 0.0007
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0017 0.0013 0.0007
Echinococcus granulosus serotonin receptor 0.0017 0.0013 0.0007
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0006
Echinococcus granulosus puromycin sensitive aminopeptidase 0.005 0.0243 0.0336
Schistosoma mansoni biogenic amine receptor 0.0017 0.0013 0.0018
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.005 0.0243 0.2019
Echinococcus multilocularis chromobox protein 2 0.0057 0.0295 0.041
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.005 0.0243 0.0336
Echinococcus granulosus chromobox protein 1 0.0351 0.2339 0.3321
Echinococcus multilocularis G protein coupled receptor 139 0.0017 0.0013 0.0007
Schistosoma mansoni chromobox protein 0.0351 0.2339 0.3328
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0295 0.0279
Brugia malayi Importin beta-1 subunit 0.0028 0.009 0.0103
Plasmodium vivax heterochromatin protein 1, putative 0.0057 0.0295 0.2467
Echinococcus multilocularis bloom syndrome protein 0.0024 0.006 0.0075
Echinococcus multilocularis cysteine protease 0.0017 0.0017 0.0014
Schistosoma mansoni biogenic amine receptor 0.0017 0.0013 0.0018
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0006
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.009 0.0724
Echinococcus granulosus puromycin sensitive aminopeptidase 0.005 0.0243 0.0336
Loa Loa (eye worm) PHD-finger family protein 0.004 0.0174 0.019
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0241 0.1577 0.2243
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0359 0.2178
Toxoplasma gondii aminopeptidase N, putative 0.005 0.0243 0.2027
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0027 0.0084 0.011
Brugia malayi hypothetical protein 0.0017 0.0013 0.0014
Brugia malayi hypothetical protein 0.005 0.0243 0.0277
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.005 0.0243 0.0336
Loa Loa (eye worm) hypothetical protein 0.0079 0.0448 0.0503
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0081 0.0457 0.0521
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0039 0.0045
Echinococcus granulosus neuropeptide FF receptor 2 0.0017 0.0013 0.0007
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.005 0.0243 0.1458
Brugia malayi hypoxia-induced factor 1 0.0155 0.0972 0.1108
Onchocerca volvulus 0.0017 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0006
Brugia malayi Dopamine receptor protein 2 0.0017 0.0013 0.0014
Loa Loa (eye worm) jmjC domain-containing protein 0.0079 0.0448 0.0503
Echinococcus multilocularis neuropeptides capa receptor 0.0017 0.0013 0.0007
Loa Loa (eye worm) jmjC domain-containing protein 0.0079 0.0448 0.0503
Schistosoma mansoni cpg binding protein 0.0058 0.0298 0.0425
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0017 0.0013 0.0007
Loa Loa (eye worm) hypothetical protein 0.0037 0.015 0.0163
Brugia malayi hypothetical protein 0.0017 0.0012 0.0014
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0013 0.0018
Brugia malayi chromobox protein homolog 3 0.0197 0.1265 0.1442
Brugia malayi Tachykinin-like peptides receptor 99D 0.0017 0.0013 0.0014
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0071 0.0387 0.037
Loa Loa (eye worm) RecQ helicase 0.0024 0.006 0.006
Brugia malayi Melatonin receptor type 1A 0.0017 0.0013 0.0014
Brugia malayi jmjC domain containing protein 0.0079 0.0448 0.0511
Trypanosoma cruzi squalene synthase, putative 0.0248 0.1623 1
Schistosoma mansoni chromobox protein 0.0351 0.2339 0.3328
Leishmania major squalene synthase, putative 0.0248 0.1623 1
Loa Loa (eye worm) hypothetical protein 0.0168 0.1062 0.1203
Echinococcus granulosus GPCR family 2 0.0112 0.0673 0.0948
Plasmodium falciparum M1-family alanyl aminopeptidase 0.005 0.0243 0.2588
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0023 0.0054 0.0155
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0017 0.0013 0.0014
Loa Loa (eye worm) hypothetical protein 0.0027 0.0084 0.0088
Brugia malayi hypothetical protein 0.0432 0.2902 0.3308
Loa Loa (eye worm) hypothetical protein 0.0074 0.0414 0.0464
Echinococcus granulosus lamin 0.0056 0.0287 0.0398
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0026 0.0079 0.0112
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.006 0.0043
Onchocerca volvulus 0.0037 0.015 0.015
Schistosoma mansoni jumonji/arid domain-containing protein 0.0304 0.2016 0.2868
Echinococcus granulosus phd:f box containing protein 0.0079 0.0448 0.0628
Brugia malayi Bloom's syndrome protein homolog 0.0024 0.006 0.0069
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0112 0.0673 0.0948
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.005 0.0243 0.0226
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0006
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.003 0.014
Brugia malayi hypothetical protein 0.0026 0.0076 0.0086
Loa Loa (eye worm) hypothetical protein 0.0037 0.015 0.0163
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0017 0.0017 0.0011
Mycobacterium tuberculosis Conserved protein 0.0037 0.015 0.0481
Brugia malayi G protein-coupled receptor F59B2.13 0.0017 0.0013 0.0014
Brugia malayi intermediate filament protein 0.0056 0.0287 0.0327
Brugia malayi Bromodomain containing protein 0.0151 0.095 0.1083
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0353 0.2353 0.2675
Echinococcus granulosus peregrin 0.0151 0.095 0.1342
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.015 0.0481
Onchocerca volvulus 0.0017 0.0017 0.0017
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0017 0.0025
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0039 0.0195
Echinococcus granulosus g protein coupled receptor 0.0017 0.0013 0.0007
Leishmania major protein kinase, putative 0.0017 0.0013 0.0036
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0217 0.1407 0.2002
Onchocerca volvulus 0.0057 0.0295 0.0295
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.015 0.0133
Echinococcus granulosus survival motor neuron protein 1 0.0229 0.1493 0.2116
Brugia malayi neuropeptide F receptor 0.0017 0.0013 0.0014
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0006
Loa Loa (eye worm) glutaminase 2 0.033 0.2195 0.2495
Loa Loa (eye worm) hypothetical protein 0.005 0.0243 0.0269
Schistosoma mansoni opsin-like receptor 0.0017 0.0013 0.0018
Echinococcus granulosus somatostatin receptor 0.0017 0.0013 0.0007
Echinococcus granulosus dro:myosuppressin receptor 0.0017 0.0013 0.0007
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.0013 0.0007
Schistosoma mansoni importin beta-1 0.0028 0.009 0.0129
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0026 0.0079 0.0112
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0295 0.0279
Leishmania major cathepsin L-like protease 0.0067 0.0359 0.2178
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.015 0.0204
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0013 0.0018
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0217 0.1407 0.1994
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0006
Echinococcus granulosus leukotriene A 4 hydrolase 0.0939 0.6435 0.9156
Schistosoma mansoni aldehyde dehydrogenase 0.0181 0.1157 0.1647
Loa Loa (eye worm) hypothetical protein 0.0147 0.0918 0.1039
Schistosoma mansoni apoferritin-2 0.0043 0.0196 0.0278
Brugia malayi Cathepsin L-like precursor 0.0017 0.0017 0.002
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0442 0.2977 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.015 0.0163
Brugia malayi hypothetical protein 0.005 0.0243 0.0277
Schistosoma mansoni ran 0.0021 0.0039 0.0055
Onchocerca volvulus 0.0241 0.1577 0.1577
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0057 0.0295 0.045
Onchocerca volvulus 0.0017 0.0017 0.0017
Schistosoma mansoni inhibitor of apoptosis (iap) domain family member 0.0447 0.3006 0.4277
Echinococcus granulosus chromobox protein 2 0.0057 0.0295 0.041
Echinococcus granulosus lamin dm0 0.0056 0.0287 0.0398
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.015 0.0214
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.015 0.0481
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.003 0.0034
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.015 0.0481
Loa Loa (eye worm) hypothetical protein 0.0037 0.015 0.0163
Schistosoma mansoni amine GPCR 0.0017 0.0013 0.0018
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0006
Mycobacterium ulcerans aminopeptidase N PepN 0.005 0.0243 0.0723
Brugia malayi hypothetical protein 0.0146 0.091 0.1037
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.005 0.0243 0.0226
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0017 0.0014
Brugia malayi CXXC zinc finger family protein 0.0058 0.0298 0.034
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.003 0.0013
Echinococcus multilocularis jumonji domain containing 1A 0.0079 0.0448 0.0628
Toxoplasma gondii ABC1 family protein 0.0037 0.015 0.1236
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0299 0.1975 0.2244
Echinococcus multilocularis importin subunit beta 1 0.0028 0.009 0.0118
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0034 0.013 0.026
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0017 0.0013 0.0018
Loa Loa (eye worm) hypothetical protein 0.0026 0.0077 0.008
Trypanosoma cruzi major cysteine proteinase, putative 0.0052 0.026 0.1564
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0017 0.0013 0.0007
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0017 0.0013 0.0014
Trichomonas vaginalis chromobox protein, putative 0.0351 0.2339 0.2325
Schistosoma mansoni inhibitor of apoptosis protein 0.0447 0.3006 0.4277
Schistosoma mansoni transient receptor potential channel 0.0099 0.0582 0.0829
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0359 0.2178
Toxoplasma gondii PHD-finger domain-containing protein 0.0147 0.0918 0.779
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0079 0.0448 0.2726
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0017 0.0013 0.0018
Leishmania major cathepsin L-like protease 0.0017 0.0017 0.0062
Echinococcus multilocularis chromobox protein 1 0.0351 0.2339 0.3321
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0017 0.0013 0.0007
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0147 0.0918 0.1306
Schistosoma mansoni hypothetical protein 0.0147 0.0918 0.1306
Echinococcus granulosus inhibitor of apoptosis protein 0.0447 0.3006 0.4271
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0184 0.1177 1
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0064 0.0344 0.048
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0038 0.0157 0.0431
Echinococcus granulosus chromobox protein 1 0.0351 0.2339 0.3321
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.005 0.0243 0.0336
Schistosoma mansoni phosphatidylserine receptor 0.0079 0.0448 0.0638
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0017 0.0013 0.0007
Mycobacterium leprae conserved hypothetical protein 0.0037 0.015 0.0331
Schistosoma mansoni neuropeptide F-like receptor 0.0017 0.0013 0.0018
Loa Loa (eye worm) TYRA-2 protein 0.0017 0.0013 0.0006
Echinococcus granulosus ferritin 0.0043 0.0196 0.0268
Brugia malayi Peptidase family M1 containing protein 0.005 0.0243 0.0277
Echinococcus multilocularis dnaJ subfamily B 0.0824 0.5632 0.8011
Echinococcus granulosus rhodopsin orphan GPCR 0.0017 0.0013 0.0007
Loa Loa (eye worm) hypothetical protein 0.0057 0.0295 0.0329
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0006
Brugia malayi putative neuropeptide receptor 0.0017 0.0013 0.0014
Schistosoma mansoni cpg binding protein 0.0065 0.0347 0.0494
Trichomonas vaginalis esterase, putative 0.0037 0.015 0.0133
Schistosoma mansoni opsin-like receptor 0.0017 0.0013 0.0018
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.005 0.0243 0.2588
Loa Loa (eye worm) G-protein coupled receptor 0.0017 0.0013 0.0006
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0197 0.1265 0.1265
Echinococcus granulosus zinc finger protein 0.0041 0.0183 0.025
Echinococcus granulosus mixed lineage leukemia protein mll 0.0021 0.0042 0.005
Loa Loa (eye worm) helicase 0.0057 0.0295 0.0329
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0064 0.0344 0.048
Entamoeba histolytica Ran family GTPase 0.0021 0.0039 0.0035
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0023 0.0054 0.5
Schistosoma mansoni alpha-1 adrenergic receptor 0.0017 0.0013 0.0018
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0007 0.0011
Schistosoma mansoni hypothetical protein 0.0048 0.023 0.0327
Leishmania major cysteine peptidase A (CPA) 0.0017 0.0017 0.0062
Echinococcus granulosus chaperonin containing TCP1 subunit 2 beta 0.0026 0.0079 0.0101
Trypanosoma cruzi Aminopeptidase M1, putative 0.005 0.0243 0.1458
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.007 0.0381 0.0532
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0017 0.0013 0.0006
Giardia lamblia PHD finger protein 15 0.0147 0.0918 0.1438
Loa Loa (eye worm) hypothetical protein 0.0037 0.0151 0.0164
Echinococcus granulosus snurportin 1 0.0299 0.1975 0.2802
Loa Loa (eye worm) hypothetical protein 0.0057 0.0295 0.0329
Onchocerca volvulus 0.0037 0.015 0.015
Echinococcus granulosus 7tm_1 domain containing protein 0.0017 0.0013 0.0007
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.015 0.0133
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0051 0.0254 0.2712
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0006
Echinococcus multilocularis baculoviral IAP repeat containing protein 0.0447 0.3006 0.4271
Echinococcus multilocularis neuropeptide s receptor 0.0017 0.0013 0.0007
Onchocerca volvulus 0.0056 0.0287 0.0287
Echinococcus granulosus neuropeptide Y receptor 0.0017 0.0013 0.0007
Schistosoma mansoni amine GPCR 0.0017 0.0013 0.0018
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.005 0.0243 0.1458
Echinococcus multilocularis dro:myosuppressin receptor 0.0017 0.0013 0.0007
Loa Loa (eye worm) hypothetical protein 0.0284 0.1871 0.2125
Schistosoma mansoni aryl hydrocarbon receptor 0.005 0.0243 0.0346
Schistosoma mansoni hypothetical protein 0.0241 0.1575 0.2241
Entamoeba histolytica hypothetical protein 0.0023 0.0054 0.0058
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.005 0.0243 0.1458
Onchocerca volvulus 0.0017 0.0013 0.0013
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0017 0.0013 0.0007
Schistosoma mansoni ap endonuclease 0.0019 0.003 0.0043
Echinococcus granulosus biogenic amine 5HT receptor 0.0017 0.0013 0.0007
Loa Loa (eye worm) PHD-finger family protein 0.0147 0.0918 0.1039
Mycobacterium ulcerans hypothetical protein 0.0037 0.015 0.0408
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.003 0.0021
Loa Loa (eye worm) hypothetical protein 0.0197 0.1265 0.1434
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0017 0.0013 0.0007
Toxoplasma gondii PHD-finger domain-containing protein 0.0147 0.0918 0.779
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0939 0.6435 0.7332
Loa Loa (eye worm) beta-lactamase 0.0037 0.015 0.0163
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.015 0.0133
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0054 0.0399
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0057 0.0295 0.045
Brugia malayi isocitrate dehydrogenase 0.0016 0.0007 0.0008
Echinococcus multilocularis musashi 0.0056 0.0287 0.0398
Brugia malayi Valyl-tRNA synthetase 0.0057 0.0295 0.0337
Echinococcus multilocularis Chromobox protein 3 0.0057 0.0295 0.041
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.004 0.0361
Schistosoma mansoni microtubule-associated protein tau 0.0669 0.4556 0.6483
Schistosoma mansoni neuropeptide receptor 0.0017 0.0013 0.0018
Loa Loa (eye worm) hypothetical protein 0.0447 0.3006 0.342
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0013 0.0018
Leishmania major importin beta-1 subunit, putative 0.0023 0.0054 0.0285
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.003 0.0198
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0026 0.0079 0.0112
Onchocerca volvulus 0.0037 0.0153 0.0153
Trichomonas vaginalis conserved hypothetical protein 0.0139 0.0865 0.0849
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0442 0.2977 1
Echinococcus granulosus aminopeptidase N 0.005 0.0243 0.0336
Brugia malayi hypothetical protein 0.0057 0.0295 0.0337
Leishmania major hypothetical protein, conserved 0.003 0.0102 0.0587
Schistosoma mansoni intermediate filament proteins 0.0056 0.0287 0.0408
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0057 0.0295 0.042
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0006
Schistosoma mansoni glutaminase 0.033 0.2195 0.3123
Echinococcus granulosus allatostatin A receptor 0.0017 0.0013 0.0007
Schistosoma mansoni lamin 0.0056 0.0287 0.0408
Onchocerca volvulus 0.0017 0.0013 0.0013
Brugia malayi hypothetical protein 0.0017 0.0013 0.0014
Echinococcus granulosus neuropeptide Y receptor 0.0017 0.0013 0.0007
Mycobacterium ulcerans glutaminase 0.033 0.2195 0.7347
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0295 0.0279
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.005 0.0243 0.1458
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0054 0.0285
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0013 0.0018
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0017 0.0013 0.0018
Onchocerca volvulus Cathepsin F homolog 0.0017 0.0017 0.0017
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0057 0.0295 0.0337
Schistosoma mansoni ferritin 0.0043 0.0196 0.0278
Echinococcus granulosus rhodopsin orphan GPCR 0.0017 0.0013 0.0007
Loa Loa (eye worm) G-protein coupled receptor 0.0017 0.0013 0.0006
Trypanosoma brucei Aminopeptidase M1, putative 0.005 0.0243 0.1458
Loa Loa (eye worm) TATA binding protein associated factor 0.005 0.0243 0.0269
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0359 0.2178
Onchocerca volvulus 0.0017 0.0017 0.0017
Schistosoma mansoni jumonji/arid domain-containing protein 0.0304 0.2016 0.2868
Brugia malayi jmjC domain containing protein 0.0079 0.0448 0.0511
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.015 0.0214
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.005 0.0243 0.0346
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0017 0.0013 0.0013
Onchocerca volvulus 0.0154 0.0969 0.0969
Brugia malayi jmjC domain containing protein 0.0304 0.2016 0.2297
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0295 0.0279
Onchocerca volvulus 0.0017 0.0013 0.0013
Toxoplasma gondii aminopeptidase N protein 0.005 0.0243 0.2027
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0054 0.0036
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0006
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0038 0.0157 0.7664
Brugia malayi G protein-coupled receptor 0.0017 0.0013 0.0014
Trichomonas vaginalis chromobox protein, putative 0.0057 0.0295 0.0279
Echinococcus granulosus biogenic amine 5HT receptor 0.0017 0.0013 0.0007
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0076 0.0599
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0906 0.6203 0.6196
Brugia malayi PHD-finger family protein 0.0055 0.0279 0.0317
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0157 0.0925
Echinococcus multilocularis serotonin receptor 0.0017 0.0013 0.0007
Schistosoma mansoni lamin 0.0056 0.0287 0.0408
Brugia malayi Pre-SET motif family protein 0.1275 0.8775 1
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0039 0.0044
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0054 0.0286
Schistosoma mansoni blooms syndrome DNA helicase 0.0019 0.0026 0.0036
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0006
Schistosoma mansoni neuropeptide receptor 0.0017 0.0013 0.0018
Schistosoma mansoni hypothetical protein 0.0017 0.0013 0.0018
Plasmodium vivax vivapain-2 0.0017 0.0017 0.0089
Schistosoma mansoni ferritin 0.0043 0.0196 0.0278
Loa Loa (eye worm) hypothetical protein 0.0062 0.0327 0.0364
Brugia malayi beta-lactamase family protein 0.0037 0.015 0.0171
Loa Loa (eye worm) hypothetical protein 0.0447 0.3006 0.342
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.005 0.0243 0.0336
Loa Loa (eye worm) hypothetical protein 0.0081 0.0457 0.0513
Onchocerca volvulus 0.0047 0.0221 0.0221
Echinococcus multilocularis phd:f box containing protein 0.0079 0.0448 0.0628
Leishmania major phosphopantetheinyl transferase-like protein 0.0023 0.0054 0.0286
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.0013 0.0007
Trichomonas vaginalis inositol monophosphatase, putative 0.0038 0.0157 0.014
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0021 0.0042 0.005
Loa Loa (eye worm) neuropeptide F receptor 0.0017 0.0013 0.0006
Schistosoma mansoni survival motor neuron protein 0.0047 0.0221 0.0315
Echinococcus granulosus alpha 1A adrenergic receptor 0.0017 0.0013 0.0007
Schistosoma mansoni hypothetical protein 0.0017 0.0013 0.0018
Onchocerca volvulus 0.0017 0.0017 0.0017
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0057 0.0295 0.042
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0079 0.0448 0.2726
Echinococcus granulosus importin subunit beta 1 0.0028 0.009 0.0118
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0181 0.1157 0.1638
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.015 0.0133
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0017 0.0013 0.0018
Trichomonas vaginalis ran, putative 0.0021 0.0039 0.0022
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0017 0.0013 0.0007
Onchocerca volvulus 0.0017 0.0013 0.0013
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.015 0.0885
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0076 0.0423
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0017 0.0013 0.0006
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0017 0.0013 0.0018
Echinococcus multilocularis fmrfamide receptor 0.0017 0.0013 0.0007
Schistosoma mansoni inositol monophosphatase 0.0038 0.0157 0.0223
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0039 0.0195
Echinococcus multilocularis survival motor neuron protein 1 0.0229 0.1493 0.2116
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0023 0.0054 0.0038
Echinococcus multilocularis g protein coupled receptor 0.0017 0.0013 0.0007
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0071 0.0387 0.037
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0601 0.4078 0.5798
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0906 0.6203 0.6196
Loa Loa (eye worm) peptidase family M1 containing protein 0.005 0.0243 0.0269
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0359 0.2178
Onchocerca volvulus 0.0017 0.0017 0.0017
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0017 0.0014
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0006
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0017 0.0017 0.0011
Echinococcus multilocularis cpg binding protein 0.0065 0.0347 0.0484
Echinococcus multilocularis GPCR, family 2 0.0112 0.0673 0.0948
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0006
Schistosoma mansoni methyl-cpg binding protein mbd 0.0033 0.0126 0.0179
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0039 0.0195
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0038 0.0157 0.1292
Echinococcus multilocularis neuropeptide receptor A26 0.0017 0.0013 0.0007
Onchocerca volvulus 0.0017 0.0013 0.0013
Brugia malayi SET domain containing protein 0.0065 0.0351 0.04
Plasmodium vivax SET domain protein, putative 0.0184 0.1177 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0006
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.015 0.0885
Schistosoma mansoni hypothetical protein 0.003 0.0102 0.0146
Loa Loa (eye worm) hypothetical protein 0.0026 0.0077 0.008
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0006
Trichomonas vaginalis glutaminase, putative 0.033 0.2195 0.2181
Echinococcus multilocularis JmjC domain containing protein 4 0.0079 0.0448 0.0628
Echinococcus granulosus Squalene phytoene synthase 0.0077 0.0434 0.0608
Echinococcus granulosus G protein coupled receptor 139 0.0017 0.0013 0.0007
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0006
Brugia malayi Serotonin receptor 0.0017 0.0013 0.0014
Trypanosoma cruzi ISWI complex protein 0.003 0.0102 0.0587
Schistosoma mansoni aminopeptidase A (M01 family) 0.005 0.0243 0.0346
Echinococcus multilocularis serotonin receptor 0.0017 0.0013 0.0007
Loa Loa (eye worm) T-complex protein 1 0.0026 0.0079 0.0081
Toxoplasma gondii aldehyde dehydrogenase 0.0181 0.1157 0.9834
Onchocerca volvulus 0.005 0.0243 0.0243
Echinococcus multilocularis apoptotic protease activating factor 1 0.0146 0.091 0.1286
Echinococcus multilocularis inhibitor of apoptosis protein 0.0447 0.3006 0.4271
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0007 0.0004
Brugia malayi F/Y-rich N-terminus family protein 0.0076 0.0425 0.0485
Brugia malayi hypothetical protein 0.0017 0.0013 0.0014
Schistosoma mansoni transient receptor potential channel 0.0065 0.035 0.0498
Echinococcus multilocularis L aminoadipate semialdehyde 0.0081 0.0457 0.0641
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.0013 0.0007
Brugia malayi jmjC domain containing protein 0.0601 0.4078 0.4647
Schistosoma mansoni myosin xvIII 0.0017 0.0013 0.0018
Echinococcus multilocularis ferritin 0.0043 0.0196 0.0268
Echinococcus multilocularis zinc finger protein 0.0041 0.0183 0.025
Loa Loa (eye worm) jmjC domain-containing protein 0.0079 0.0448 0.0503
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0017 0.0013 0.0007
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0906 0.6203 0.6196
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0119 0.0725 0.1022
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0184 0.1177 0.1674
Loa Loa (eye worm) latrophilin receptor protein 2 0.0112 0.0673 0.0759
Giardia lamblia TCP-1 chaperonin subunit beta 0.0026 0.0079 0.0078
Echinococcus granulosus neuropeptides capa receptor 0.0017 0.0013 0.0007
Echinococcus granulosus rhodopsin orphan GPCR 0.0017 0.0013 0.0007
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0221 0.0252
Loa Loa (eye worm) hypothetical protein 0.0057 0.0295 0.0329
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0056 0.0287 0.0319
Echinococcus multilocularis lamin dm0 0.0056 0.0287 0.0398
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0006
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.005 0.0243 0.1458
Trypanosoma cruzi cysteine peptidase, putative 0.0067 0.0359 0.2178
Echinococcus multilocularis lysine specific demethylase 5A 0.0297 0.1967 0.2791
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0447 0.3006 0.3425
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0112 0.0673 0.0948
Onchocerca volvulus 0.0146 0.091 0.091
Brugia malayi Cathepsin L-like precursor 0.0017 0.0017 0.002
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.003 0.0032
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0442 0.2977 1
Plasmodium falciparum JmjC domain-containing protein, putative 0.0079 0.0448 0.4839
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0006
Loa Loa (eye worm) hypothetical protein 0.0077 0.0434 0.0487
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0906 0.6203 0.6196
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0069 0.0377 0.0536
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0017 0.0017 0.0109
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0234 0.1523 0.5105
Brugia malayi Calcitonin receptor-like protein seb-1 0.0353 0.2353 0.2681
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0017 0.0013 0.0006
Entamoeba histolytica T-complex protein 1 beta subunit, putative 0.0026 0.0079 0.0099
Trichomonas vaginalis DNA helicase recq1, putative 0.0024 0.006 0.0043
Plasmodium vivax hypothetical protein, conserved 0.0051 0.0254 0.2115
Brugia malayi putative neuropeptide receptor NPR1 0.0017 0.0013 0.0014
Echinococcus granulosus transient receptor potential gamma protein 0.0099 0.0582 0.0819
Echinococcus multilocularis caspase 2 0.0146 0.091 0.1286
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0359 0.2178
Mycobacterium ulcerans putative regulatory protein 0.0037 0.0153 0.0417
Schistosoma mansoni histamine h1 receptor 0.0017 0.0013 0.0018
Echinococcus multilocularis neuropeptides capa receptor 0.0017 0.0013 0.0007
Echinococcus granulosus microtubule associated protein 2 0.0669 0.4556 0.6479
Loa Loa (eye worm) heterochromatin protein 1 0.0351 0.2339 0.2659
Onchocerca volvulus Huntingtin homolog 0.0128 0.0786 0.0786
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0447 0.3006 0.3425
Echinococcus granulosus transient receptor potential ion channel A 0.0095 0.0559 0.0786
Onchocerca volvulus 0.0017 0.0013 0.0013
Onchocerca volvulus 0.0037 0.015 0.015
Brugia malayi beta-lactamase 0.0037 0.015 0.0171
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0006
Plasmodium vivax importin-beta 2, putative 0.0028 0.009 0.0713
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0006
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0017 0.0025
Leishmania major GTP-binding protein, putative 0.0021 0.0039 0.0195
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0017 0.0013 0.0018
Brugia malayi ORL1-like opioid receptor 0.0017 0.0013 0.0014
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0043 0.0196 0.0634
Brugia malayi Associated with TFs and helicases family protein 0.0057 0.0295 0.0337
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0057 0.0295 0.3164
Brugia malayi hypothetical protein 0.0017 0.0013 0.0014
Brugia malayi Pre-SET motif family protein 0.0184 0.1177 0.1341
Echinococcus multilocularis snurportin 1 0.0299 0.1975 0.2802
Brugia malayi jmjC domain containing protein 0.0079 0.0448 0.0511
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0039 0.0274
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0017 0.0014
Trypanosoma cruzi squalene synthase, putative 0.0248 0.1623 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0304 0.2016 0.2291
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0157 0.014
Loa Loa (eye worm) hypothetical protein 0.0217 0.1407 0.1596
Mycobacterium ulcerans aldehyde dehydrogenase 0.0181 0.1157 0.3825
Trichomonas vaginalis conserved hypothetical protein 0.0197 0.1265 0.125
Schistosoma mansoni methyl-cpg binding protein mbd 0.0033 0.0126 0.0179
Echinococcus granulosus lysine specific demethylase 5A 0.0304 0.2016 0.2861
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0017 0.0013 0.0007
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0057 0.0295 0.0279
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.003 0.0026
Echinococcus multilocularis PHD finger protein rhinoceros 0.0147 0.0918 0.1297
Schistosoma mansoni chromobox protein 0.0057 0.0295 0.042
Brugia malayi G-protein coupled receptor 0.0017 0.0013 0.0014
Schistosoma mansoni hypothetical protein 0.0057 0.0295 0.042
Echinococcus multilocularis transfer RNA-Lys 0.0037 0.0153 0.0207
Echinococcus multilocularis Chromo domain 0.0057 0.0295 0.041
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0057 0.0295 0.2475
Leishmania major hypothetical protein, conserved 0.0026 0.0076 0.0423
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0054 0.0036
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0079 0.0448 0.0638
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0017 0.0013 0.0018
Onchocerca volvulus NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 homolog 0.0077 0.0434 0.0434
Schistosoma mansoni hypothetical protein 0.0047 0.0221 0.0315
Schistosoma mansoni biogenic amine receptor 0.0017 0.0013 0.0018
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0017 0.0013 0.0018
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0048 0.023 0.1376
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0064 0.0344 0.0328
Onchocerca volvulus 0.0017 0.0013 0.0013
Schistosoma mansoni hypothetical protein 0.0146 0.091 0.1295
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0157 0.0925
Echinococcus granulosus sex peptide receptor 0.0017 0.0013 0.0007
Echinococcus multilocularis jumonji domain containing protein 0.0204 0.1318 0.1867
Trichomonas vaginalis set domain proteins, putative 0.1451 1 1
Onchocerca volvulus 0.0017 0.0013 0.0013
Echinococcus granulosus g protein coupled receptor 0.0017 0.0013 0.0007
Mycobacterium tuberculosis Conserved protein 0.0037 0.015 0.0481
Echinococcus multilocularis short transient receptor potential channel 6 0.0065 0.035 0.0488
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0025 0.0067 0.0085
Echinococcus multilocularis G-protein coupled receptor, putative 0.0017 0.0013 0.0007
Brugia malayi T-complex protein 1, beta subunit 0.0026 0.0079 0.0089
Mycobacterium leprae Probable lipase LipE 0.0037 0.015 0.0331
Brugia malayi follicle stimulating hormone receptor 0.0017 0.0013 0.0014
Loa Loa (eye worm) ctsf protein 0.0017 0.0017 0.0011
Echinococcus multilocularis chromobox protein 1 0.0351 0.2339 0.3321
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.0013 0.0007
Brugia malayi hypothetical protein 0.0017 0.0013 0.0014
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0017 0.0017 0.0109
Loa Loa (eye worm) aminopeptidase N 0.005 0.0243 0.0269
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.005 0.0243 0.0336
Schistosoma mansoni chromobox protein 0.0057 0.0295 0.042
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0359 0.2178
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.005 0.0243 0.1458
Brugia malayi beta-lactamase family protein 0.0037 0.015 0.0171
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0017 0.0014
Echinococcus granulosus Chromo domain 0.0057 0.0295 0.041
Echinococcus granulosus apoptotic protease activating factor 1 0.0146 0.091 0.1286
Echinococcus multilocularis transient receptor potential gamma protein 0.0099 0.0582 0.0819
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0017 0.0013 0.0007
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0181 0.1157 0.7115
Loa Loa (eye worm) hypothetical protein 0.0026 0.0076 0.0078
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0006
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0006
Trichomonas vaginalis chromobox protein, putative 0.0057 0.0295 0.0279
Brugia malayi AF-10 protein 0.0048 0.023 0.0262
Leishmania major cathepsin L-like protease 0.0067 0.0359 0.2178
Trypanosoma cruzi cysteine peptidase, putative 0.0067 0.0359 0.2178
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0017 0.0013 0.0006
Echinococcus granulosus fmrfamide receptor 0.0017 0.0013 0.0007
Schistosoma mansoni zinc finger protein 0.0041 0.0183 0.026
Schistosoma mansoni growth hormone secretagogue receptor 0.0017 0.0013 0.0018
Onchocerca volvulus Neuropeptide F receptor homolog 0.0017 0.0013 0.0013
Echinococcus multilocularis lysine specific demethylase 6a 0.0079 0.0448 0.0628
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0007 0.0015
Echinococcus granulosus cathepsin l1 0.0017 0.0017 0.0014
Schistosoma mansoni amine GPCR 0.0017 0.0013 0.0018
Trypanosoma brucei ISWI complex protein 0.003 0.0102 0.0587
Brugia malayi hypothetical protein 0.0168 0.1062 0.1211
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0071 0.0387 0.037
Echinococcus multilocularis geminin 0.1024 0.7028 1
Loa Loa (eye worm) hypothetical protein 0.0181 0.1157 0.1311
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.005 0.0243 0.1458
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0048 0.023 0.1376
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0006
Mycobacterium ulcerans aldehyde dehydrogenase 0.0181 0.1157 0.3825
Loa Loa (eye worm) hypothetical protein 0.0137 0.0851 0.0962
Loa Loa (eye worm) hypothetical protein 0.0229 0.1493 0.1694
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0017 0.0013 0.0018
Brugia malayi bHLH-PAS transcription factor 0.0037 0.0153 0.0174
Plasmodium falciparum heterochromatin protein 1 0.0057 0.0295 0.3164
Entamoeba histolytica hypothetical protein 0.0057 0.0295 0.045
Schistosoma mansoni hypothetical protein 0.0299 0.1975 0.281
Echinococcus granulosus puromycin sensitive aminopeptidase 0.005 0.0243 0.0336
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0023 0.0054 0.008
Echinococcus multilocularis sex peptide receptor 0.0017 0.0013 0.0007
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0017 0.0013 0.0014
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0039 0.0285
Brugia malayi Cathepsin L-like precursor 0.0017 0.0017 0.002
Plasmodium falciparum importin beta, putative 0.0028 0.009 0.0911
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0006
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.003 0.014
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0006
Onchocerca volvulus Cathepsin L homolog 0.0017 0.0017 0.0017
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0057 0.0295 0.042
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.0013 0.0007
Echinococcus granulosus short transient receptor potential channel 6 0.0065 0.035 0.0488
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.005 0.0243 0.1458
Brugia malayi Bromodomain containing protein 0.0074 0.0413 0.0471
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.015 0.0481
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0017 0.0013 0.0014
Plasmodium vivax JmjC domain containing protein 0.0079 0.0448 0.3771
Echinococcus granulosus single minded 2 0.0037 0.0153 0.0207
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0043 0.0196 0.0486
Loa Loa (eye worm) inositol-1 0.0038 0.0157 0.0171
Plasmodium falciparum T-complex protein 1 subunit beta 0.0026 0.0079 0.0781
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.005 0.0243 0.0226
Echinococcus multilocularis microtubule associated protein 2 0.0669 0.4556 0.6479
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0295 0.0279
Schistosoma mansoni ferritin 0.0043 0.0196 0.0278
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0157 0.0925
Brugia malayi Inositol-1 0.0038 0.0157 0.0179
Echinococcus granulosus neuropeptide receptor 0.0017 0.0013 0.0007
Onchocerca volvulus 0.0056 0.0287 0.0287
Loa Loa (eye worm) intermediate filament protein 0.0056 0.0287 0.0319
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0295 0.0279
Brugia malayi Intermediate filament tail domain containing protein 0.0056 0.0287 0.0327
Brugia malayi hypothetical protein 0.0017 0.0013 0.0014
Echinococcus granulosus histone lysine methyltransferase setb 0.0217 0.1407 0.1994
Leishmania major cathepsin L-like protease 0.0017 0.0017 0.0062
Brugia malayi TATA binding protein associated factor 0.005 0.0243 0.0277
Schistosoma mansoni neuropeptide f receptor 76f 0.0017 0.0013 0.0018
Onchocerca volvulus 0.0017 0.0013 0.0013
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0071 0.0387 0.037
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.1275 0.8775 1
Echinococcus granulosus fetal alzheimer antigen falz 0.0047 0.0223 0.0307
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0048 0.023 0.1914
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0129 0.0797 0.1134
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0006
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.005 0.0243 0.0336
Echinococcus granulosus PHD finger protein rhinoceros 0.0147 0.0918 0.1297
Schistosoma mansoni opsin-like receptor 0.0017 0.0013 0.0018
Onchocerca volvulus 0.0017 0.0013 0.0013
Leishmania major cathepsin L-like protease 0.0067 0.0359 0.2178
Onchocerca volvulus 0.0017 0.0013 0.0013
Schistosoma mansoni bromodomain containing protein 0.0126 0.0773 0.1101
Schistosoma mansoni hypothetical protein 0.0447 0.3006 0.4277
Brugia malayi Peptidase family M1 containing protein 0.005 0.0243 0.0277
Loa Loa (eye worm) hypothetical protein 0.0128 0.0786 0.0888
Echinococcus multilocularis Squalene phytoene synthase 0.0077 0.0434 0.0608
Schistosoma mansoni biogenic amine (5HT) receptor 0.0017 0.0013 0.0018
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.005 0.0243 0.0346
Echinococcus granulosus 7TM GPCR rhodopsin 0.0017 0.0013 0.0007
Echinococcus multilocularis g protein coupled receptor 0.0017 0.0013 0.0007
Loa Loa (eye worm) hypothetical protein 0.0037 0.015 0.0163
Loa Loa (eye worm) CHromoDomain protein family member 0.0064 0.0344 0.0384
Loa Loa (eye worm) hypothetical protein 0.0057 0.0295 0.0329
Brugia malayi Cathepsin L-like precursor 0.0017 0.0017 0.002
Brugia malayi hypothetical protein 0.0017 0.0013 0.0014
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0006
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0079 0.0448 0.3778
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0295 0.0279
Onchocerca volvulus 0.0017 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0006
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0013 0.0018
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0061 0.0319 0.1929
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0017 0.0013 0.0018
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.005 0.0243 0.2019
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.003 0.0013
Onchocerca volvulus 0.0081 0.0457 0.0457
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0906 0.6203 0.6196
Schistosoma mansoni phd/f-box containing protein 0.0079 0.0448 0.0638
Mycobacterium ulcerans aminopeptidase N PepN 0.005 0.0243 0.0723
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0064 0.0344 0.049
Loa Loa (eye worm) bromodomain containing protein 0.0034 0.0134 0.0145
Trypanosoma brucei squalene synthase, putative 0.0248 0.1623 1
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0023 0.0054 0.0409
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0112 0.0673 0.0948
Echinococcus granulosus rhodopsin orphan GPCR 0.0017 0.0013 0.0007
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0086 0.0497 0.0697
Loa Loa (eye worm) hypothetical protein 0.0055 0.028 0.031
Onchocerca volvulus 0.0017 0.0013 0.0013
Brugia malayi RNA, U transporter 1 0.008 0.0449 0.0512
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0181 0.1157 0.1638
Echinococcus multilocularis chaperonin containing TCP1, subunit 2 (beta) 0.0026 0.0079 0.0101
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.015 0.0481
Echinococcus granulosus baculoviral IAP repeat containing protein 0.0447 0.3006 0.4271
Schistosoma mansoni aldehyde dehydrogenase 0.0181 0.1157 0.1647
Echinococcus multilocularis lamin 0.0056 0.0287 0.0398
Brugia malayi G-protein coupled receptor 0.0017 0.0013 0.0014
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0176 0.1121 0.1586
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0054 0.0507
Trichomonas vaginalis chromobox protein, putative 0.0351 0.2339 0.2325
Echinococcus granulosus caspase 2 0.0146 0.091 0.1286
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.003 0.0032
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0006
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.015 0.0163
Loa Loa (eye worm) hypothetical protein 0.0033 0.0128 0.0138
Brugia malayi Serotonin receptor 0.0017 0.0013 0.0014
Trypanosoma cruzi aminopeptidase, putative 0.005 0.0243 0.1458
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0006
Brugia malayi Cathepsin L-like precursor 0.0017 0.0017 0.002
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.005 0.0243 0.1458
Plasmodium vivax hypothetical protein, conserved 0.0057 0.0295 0.2467
Brugia malayi larval opioid receptor 0.0017 0.0013 0.0014
Echinococcus granulosus tm gpcr rhodopsin 0.0017 0.0013 0.0007
Echinococcus granulosus inositol monophosphatase 1 0.0038 0.0157 0.0213
Echinococcus granulosus cathepsin l cysteine peptidase 0.0017 0.0017 0.0014
Schistosoma mansoni hypothetical protein 0.0077 0.0434 0.0618
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0939 0.6435 0.9156
Loa Loa (eye worm) hypothetical protein 0.0057 0.0295 0.0329
Loa Loa (eye worm) hypothetical protein 0.0146 0.091 0.103
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0017 0.0013 0.0018
Loa Loa (eye worm) hypothetical protein 0.0154 0.0969 0.1097
Brugia malayi M-phase phosphoprotein, mpp8 0.0057 0.0295 0.0337
Echinococcus multilocularis neuropeptide Y receptor 0.0017 0.0013 0.0007
Trypanosoma brucei aminopeptidase, putative 0.005 0.0243 0.1458
Echinococcus multilocularis aminopeptidase N 0.005 0.0243 0.0336
Echinococcus multilocularis allatostatin A receptor 0.0017 0.0013 0.0007
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0071 0.0387 0.037
Onchocerca volvulus 0.0017 0.0013 0.0013
Trypanosoma cruzi ISWI complex protein 0.003 0.0102 0.0587
Echinococcus multilocularis cysteine protease 0.0017 0.0017 0.0014
Echinococcus granulosus jumonji domain containing 1A 0.0079 0.0448 0.0628
Loa Loa (eye worm) hypothetical protein 0.0353 0.2353 0.2675
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0181 0.1157 0.1157
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0017 0.0013 0.0014
Trichomonas vaginalis conserved hypothetical protein 0.0139 0.0865 0.0849
Brugia malayi sulfakinin receptor protein 0.0017 0.0013 0.0014
Echinococcus granulosus rhodopsin orphan GPCR 0.0017 0.0013 0.0007
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0007 0.0015
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.015 0.0885
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.015 0.0204
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0021 0.0042 0.005
Echinococcus granulosus jumonji domain containing protein 0.0204 0.1318 0.1867
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0017 0.0013 0.0006
Trichomonas vaginalis chaperonin-60kD, ch60, putative 0.0026 0.0079 0.0061
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0057 0.0295 0.2475
Brugia malayi Dopamine receptor 0.0017 0.0013 0.0014
Echinococcus granulosus methyl CpG binding domain protein 2 0.0033 0.0126 0.0169
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0079 0.0448 0.3778
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.009 0.0513
Mycobacterium ulcerans phytoene synthase, CrtB 0.0077 0.0434 0.1371
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.003 0.0105 0.0112
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.003 0.014
Mycobacterium ulcerans aldehyde dehydrogenase 0.0181 0.1157 0.3825
Brugia malayi GnHR receptor homolog 0.0017 0.0013 0.0014
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0057 0.0295 0.041
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0017 0.0013 0.0007
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0043 0.0196 0.0634
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.0197 0.1265 0.125
Onchocerca volvulus 0.0057 0.0295 0.0295
Schistosoma mansoni neuropeptide receptor 0.0017 0.0013 0.0018
Loa Loa (eye worm) hypothetical protein 0.0028 0.009 0.0095
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0013 0.0018
Onchocerca volvulus Cell death protein 3 homolog 0.0146 0.091 0.091
Onchocerca volvulus 0.0017 0.0013 0.0013
Loa Loa (eye worm) cysteine protease 0.0017 0.0017 0.0011
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.015 0.0408
Echinococcus granulosus puromycin sensitive aminopeptidase 0.005 0.0243 0.0336
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0017 0.0013 0.0007
Toxoplasma gondii aminopeptidase n, putative 0.005 0.0243 0.2027
Loa Loa (eye worm) hypothetical protein 0.0079 0.0448 0.0503
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0184 0.1177 0.1666
Trichomonas vaginalis hypothetical protein 0.0057 0.0295 0.0279
Schistosoma mansoni neuropeptide receptor 0.0017 0.0013 0.0018
Loa Loa (eye worm) hypothetical protein 0.0112 0.0673 0.0759
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0057 0.0295 0.2475
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0023 0.0054 0.0409
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0601 0.4078 0.5798
Giardia lamblia Fructose-bisphosphate aldolase 0.0906 0.6203 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0906 0.6203 0.6196
Schistosoma mansoni transient receptor potential channel 0.0065 0.035 0.0498
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.015 0.0408
Trypanosoma brucei T-complex protein 1, beta subunit, putative 0.0026 0.0079 0.044
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0071 0.0387 0.037
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.015 0.0171
Echinococcus granulosus expressed protein 0.0043 0.0196 0.0268
Leishmania major cathepsin L-like protease 0.0017 0.0017 0.0062
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0057 0.0295 0.0279
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0359 0.2178
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.0013 0.0007
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0217 0.1407 0.2002
Treponema pallidum bacterioferrin (TpF1) 0.0043 0.0196 0.0268
Leishmania major hypothetical protein, conserved 0.0077 0.0434 0.2641
Onchocerca volvulus 0.0017 0.0013 0.0013
Treponema pallidum fructose-bisphosphate aldolase 0.0906 0.6203 1
Plasmodium vivax T-complex protein 1 subunit beta, putative 0.0026 0.0079 0.0612
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0063 0.0338 0.0321
Schistosoma mansoni single-minded 0.005 0.0243 0.0346
Echinococcus granulosus g protein coupled receptor 0.0017 0.0013 0.0007
Entamoeba histolytica hypothetical protein 0.0057 0.0295 0.045
Echinococcus granulosus Chromobox protein 3 0.0057 0.0295 0.041
Entamoeba histolytica hypothetical protein 0.0057 0.0295 0.045
Schistosoma mansoni hypothetical protein 0.1024 0.7028 1
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0054 0.0036
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0081 0.0457 0.065
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0013 0.0018
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.015 0.0481
Schistosoma mansoni hypothetical protein 0.0112 0.0673 0.0958
Brugia malayi Bromodomain containing protein 0.0149 0.0932 0.1062
Leishmania major hypothetical protein, conserved 0.0037 0.015 0.0885
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0017 0.0013 0.0007
Plasmodium falciparum cysteine proteinase falcipain 3 0.0017 0.0017 0.0109
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0017 0.0013 0.0007
Plasmodium vivax hypothetical protein, conserved 0.0037 0.015 0.1226
Trichomonas vaginalis chromobox protein, putative 0.0212 0.1369 0.1354
Schistosoma mansoni ferritin light chain 0.0043 0.0196 0.0278
Echinococcus granulosus TRP transient receptor potential channel 0.0037 0.0151 0.0205
Echinococcus granulosus dnaJ subfamily B 0.0824 0.5632 0.8011
Schistosoma mansoni ran 0.0021 0.0039 0.0055
Brugia malayi CHD4 protein 0.0064 0.0344 0.0392
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0086 0.0497 0.0697
Brugia malayi Latrophilin receptor protein 2 0.0112 0.0673 0.0767
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0017 0.0013 0.0007
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.003 0.014
Schistosoma mansoni zinc finger protein 0.003 0.0102 0.0146
Echinococcus multilocularis g protein coupled receptor 0.0017 0.0013 0.0007
Echinococcus granulosus L aminoadipate semialdehyde 0.0081 0.0457 0.0641
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0939 0.6435 0.9157
Entamoeba histolytica hypothetical protein 0.0023 0.0054 0.0059
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0006
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0212 0.1369 0.1369
Echinococcus granulosus peptide allatostatin:somatostatin 0.0017 0.0013 0.0007
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0007 0.0008
Plasmodium vivax hypothetical protein, conserved 0.0057 0.0295 0.2467
Schistosoma mansoni jumonji domain containing protein 0.0502 0.339 0.4823
Loa Loa (eye worm) CXXC zinc finger family protein 0.0058 0.0298 0.0332
Brugia malayi jmjC domain containing protein 0.0079 0.0448 0.0511
Onchocerca volvulus 0.0017 0.0017 0.0017
Echinococcus granulosus neuropeptide s receptor 0.0017 0.0013 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.0064 0.0344 0.0328
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0906 0.6203 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0006
Brugia malayi Peptidase family M1 containing protein 0.005 0.0243 0.0277
Schistosoma mansoni transient receptor potential channel 4 0.0099 0.0582 0.0829
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0076 0.0423
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0006
Brugia malayi Cell death protein 3 precursor 0.0146 0.091 0.1037
Brugia malayi hypothetical protein 0.0017 0.0013 0.0014
Echinococcus multilocularis expressed protein 0.0043 0.0196 0.0268
Schistosoma mansoni biogenic amine (5HT) receptor 0.0017 0.0013 0.0018
Mycobacterium ulcerans bacterioferritin BfrB 0.0043 0.0196 0.0562
Brugia malayi PHD-finger family protein 0.0052 0.0255 0.0291
Toxoplasma gondii t-complex protein beta subunit 0.0026 0.0079 0.0622
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0157 0.0925
Brugia malayi Protein cec-1. 0.0057 0.0295 0.0337
Onchocerca volvulus Huntingtin homolog 0.0128 0.0786 0.0786
Toxoplasma gondii cathepsin CPL 0.0017 0.0017 0.01
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0295 0.0279
Echinococcus multilocularis neuropeptide Y receptor 0.0017 0.0013 0.0007
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0043 0.0196 1
Schistosoma mansoni hypothetical protein 0.0824 0.5632 0.8013
Toxoplasma gondii exonuclease III APE 0.0019 0.003 0.0209
Trichomonas vaginalis ferritin, putative 0.0043 0.0196 0.0179
Loa Loa (eye worm) hypothetical protein 0.005 0.0243 0.0269
Echinococcus granulosus JmjC domain containing protein 4 0.0079 0.0448 0.0628
Schistosoma mansoni hypothetical protein 0.0112 0.0673 0.0958
Leishmania major cathepsin L-like protease 0.0017 0.0017 0.0062
Mycobacterium tuberculosis Conserved protein 0.0037 0.015 0.0481
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0076 0.0423
Loa Loa (eye worm) hypothetical protein 0.005 0.0243 0.0269
Echinococcus multilocularis peregrin 0.0151 0.095 0.1342
Echinococcus multilocularis g-protein coupled receptor 0.0017 0.0013 0.0007
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0181 0.1157 0.3873
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0057 0.0295 0.045
Echinococcus granulosus short transient receptor potential channel 6 0.0065 0.035 0.0488
Echinococcus granulosus tachykinin peptides receptor 99D 0.0017 0.0013 0.0007
Schistosoma mansoni ap endonuclease 0.0019 0.003 0.0043
Echinococcus granulosus neuropeptides capa receptor 0.0017 0.0013 0.0007
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0359 0.2178
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0076 0.0751
Brugia malayi Dopamine receptor protein 1 0.0017 0.0013 0.0014
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0033 0.0126 0.0169
Brugia malayi hypothetical protein 0.0229 0.1493 0.1701
Loa Loa (eye worm) hypothetical protein 0.0056 0.0287 0.0319
Echinococcus multilocularis fmrfamide receptor 0.0017 0.0013 0.0007
Brugia malayi PAS domain containing protein 0.005 0.0243 0.0277
Echinococcus multilocularis transient receptor potential ion channel A 0.0095 0.0559 0.0786
Schistosoma mansoni inositol monophosphatase 0.0038 0.0157 0.0223
Loa Loa (eye worm) hypothetical protein 0.0037 0.015 0.0163
Schistosoma mansoni hypothetical protein 0.0017 0.0013 0.0018
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0006
Echinococcus granulosus neuropeptide receptor A26 0.0017 0.0013 0.0007
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0017 0.002
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0017 0.0013 0.0018
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0021 0.0042 0.005
Trypanosoma cruzi aminopeptidase, putative 0.005 0.0243 0.1458
Brugia malayi PHD-finger family protein 0.0147 0.0918 0.1046
Echinococcus multilocularis neuropeptide receptor 0.0017 0.0013 0.0007
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0039 0.0014
Echinococcus granulosus orexin receptor type 2 0.0017 0.0013 0.0007
Echinococcus granulosus neuropeptide receptor 0.0017 0.0013 0.0007
Schistosoma mansoni cpg binding protein 0.0065 0.0347 0.0494
Brugia malayi hypothetical protein 0.0128 0.0786 0.0896
Echinococcus granulosus geminin 0.1024 0.7028 1
Schistosoma mansoni amine GPCR 0.0017 0.0013 0.0018
Echinococcus multilocularis somatostatin receptor 0.0017 0.0013 0.0007
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0017 0.0013 0.0007
Schistosoma mansoni hypothetical protein 0.0017 0.0013 0.0018
Loa Loa (eye worm) glutaminase 0.033 0.2195 0.2495
Loa Loa (eye worm) fibroinase 0.0017 0.0017 0.0011
Leishmania major cathepsin L-like protease 0.0017 0.0017 0.0062
Echinococcus granulosus cathepsin L cysteine proteinase 0.0017 0.0017 0.0014
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0006
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0006
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.005 0.0243 0.0346
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0034 0.013 0.0411
Mycobacterium tuberculosis Probable phytoene synthase PhyA 0.0077 0.0434 0.1437
Brugia malayi Cathepsin L-like precursor 0.0017 0.0017 0.002
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0017 0.0013 0.0007
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0071 0.0387 0.037
Brugia malayi glutaminase DH11.1 0.033 0.2195 0.2501
Schistosoma mansoni neuropeptide F-like receptor 0.0017 0.0013 0.0018
Echinococcus granulosus tm gpcr rhodopsin 0.0017 0.0013 0.0007
Loa Loa (eye worm) hypothetical protein 0.0017 0.0017 0.0011
Trypanosoma cruzi phytoene synthase, putative 0.0077 0.0434 0.2641
Echinococcus multilocularis neuropeptide FF receptor 2 0.0017 0.0013 0.0007
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0013 0.0018
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0037 0.0151 0.0205
Brugia malayi N-terminal motif family protein 0.0181 0.1157 0.1318
Schistosoma mansoni ferritin light chain 0.0043 0.0196 0.0278
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0038 0.0157 0.0226
Plasmodium vivax vivapain-2 0.0017 0.0017 0.0089
Onchocerca volvulus 0.0447 0.3006 0.3006
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0039 0.0045
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0025 0.0067 0.0085
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0906 0.6203 0.6196
Brugia malayi Heterochromatin protein 1 0.0351 0.2339 0.2665
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0013 0.0018
Brugia malayi RE15519p 0.0017 0.0013 0.0014
Loa Loa (eye worm) hypothetical protein 0.0119 0.0724 0.0818
Loa Loa (eye worm) hypothetical protein 0.0079 0.0446 0.05
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.015 0.0481
Toxoplasma gondii histone lysine methyltransferase SET1 0.0121 0.0737 0.6249
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0039 0.0346
Brugia malayi neuropeptide F receptor 0.0017 0.0013 0.0014
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0079 0.0448 0.2726
Entamoeba histolytica aminopeptidase, putative 0.005 0.0243 0.0365
Echinococcus granulosus tm gpcr rhodopsin 0.0017 0.0013 0.0007
Loa Loa (eye worm) hypothetical protein 0.0055 0.0279 0.0309
Mycobacterium ulcerans lipase LipD 0.0037 0.015 0.0408
Echinococcus granulosus cpg binding protein 0.0065 0.0347 0.0484
Echinococcus granulosus puromycin sensitive aminopeptidase 0.005 0.0243 0.0336
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0023 0.0054 0.008
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0006
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.003 0.0249
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0057 0.0295 0.3164
Loa Loa (eye worm) hypothetical protein 0.0128 0.0786 0.0888
Schistosoma mansoni jumonji domain containing protein 0.0079 0.0448 0.0638
Onchocerca volvulus Cathepsin L homolog 0.0017 0.0017 0.0017
Trypanosoma cruzi cysteine peptidase, putative 0.0017 0.0017 0.0062
Brugia malayi latrophilin 2 splice variant baaae 0.0241 0.1575 0.1795
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0906 0.6203 1
Trichomonas vaginalis chromobox protein, putative 0.0057 0.0295 0.0279
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0047 0.0223 0.0307
Schistosoma mansoni caspase-7 (C14 family) 0.0146 0.091 0.1295
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0112 0.0673 0.0767
Onchocerca volvulus 0.0058 0.0298 0.0298
Toxoplasma gondii PHD-finger domain-containing protein 0.0048 0.023 0.1914
Brugia malayi Transient-receptor-potential like protein 0.0037 0.0151 0.0172
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0076 0.0589
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0017 0.0013 0.0007
Trypanosoma cruzi cysteine peptidase, putative 0.0067 0.0359 0.2178
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0906 0.6203 0.6196
Brugia malayi T-complex protein 1, beta subunit 0.0026 0.0079 0.0089
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0006
Loa Loa (eye worm) hypothetical protein 0.0086 0.0495 0.0556
Loa Loa (eye worm) jmjC domain-containing protein 0.0303 0.2006 0.228
Onchocerca volvulus 0.005 0.0243 0.0243
Brugia malayi AKH receptor 0.0017 0.0013 0.0014
Loa Loa (eye worm) hypoxia-induced factor 1 0.0155 0.0972 0.11
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0006
Schistosoma mansoni ferritin 0.0043 0.0196 0.0278
Echinococcus multilocularis orexin receptor type 2 0.0017 0.0013 0.0007
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0112 0.0673 0.0948
Schistosoma mansoni protein phosphatase 2C 0.0079 0.0448 0.0638
Echinococcus granulosus intermediate filament protein 0.0056 0.0287 0.0398
Leishmania major hypothetical protein, conserved 0.0079 0.0448 0.2726
Echinococcus multilocularis short transient receptor potential channel 6 0.0065 0.035 0.0488
Schistosoma mansoni hypothetical protein 0.1024 0.7028 1
Schistosoma mansoni hypothetical protein 0.004 0.0174 0.0248
Loa Loa (eye worm) hypothetical protein 0.0057 0.0295 0.0329
Brugia malayi cytoplasmic intermediate filament protein 0.003 0.0105 0.012
Echinococcus granulosus rhodopsin orphan GPCR 0.0017 0.0013 0.0007
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0027 0.0084 0.011
Loa Loa (eye worm) hypothetical protein 0.0099 0.0582 0.0656
Mycobacterium ulcerans bacterioferritin BfrA 0.0043 0.0196 0.0562
Loa Loa (eye worm) melatonin receptor type 1A 0.0017 0.0013 0.0006
Echinococcus granulosus hypothetical protein 0.0017 0.0013 0.0007
Schistosoma mansoni adenoreceptor 0.0017 0.0013 0.0018
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.0013 0.0007
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.005 0.0243 0.1458
Schistosoma mansoni hypothetical protein 0.0112 0.0673 0.0958
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0359 0.2178
Loa Loa (eye worm) neuropeptide F receptor 0.0017 0.0013 0.0006
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0057 0.0295 0.0279
Trypanosoma brucei Aminopeptidase M1, putative 0.005 0.0243 0.1458
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0057 0.0295 0.041
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0006
Onchocerca volvulus 0.005 0.0243 0.0243
Echinococcus granulosus rhodopsin orphan GPCR 0.0017 0.0013 0.0007
Echinococcus multilocularis inositol monophosphatase 1 0.0038 0.0157 0.0213
Loa Loa (eye worm) hypothetical protein 0.0057 0.0295 0.0329
Schistosoma mansoni apoferritin-2 0.0043 0.0196 0.0278
Loa Loa (eye worm) hypothetical protein 0.0241 0.1575 0.1788
Leishmania major T-complex protein 1, beta subunit, putative 0.0026 0.0079 0.044
Echinococcus granulosus g-protein coupled receptor 0.0017 0.0013 0.0007
Brugia malayi hypothetical protein 0.0017 0.0013 0.0014
Loa Loa (eye worm) hypothetical protein 0.0017 0.0013 0.0006
Echinococcus granulosus lysine specific demethylase 6a 0.0079 0.0448 0.0628
Onchocerca volvulus 0.0017 0.0013 0.0013
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0119 0.0725 0.1022
Echinococcus multilocularis neuropeptide receptor 0.0017 0.0013 0.0007
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0359 0.2178
Onchocerca volvulus Alhambra homolog 0.0147 0.0918 0.0918
Mycobacterium ulcerans beta-lactamase 0.0037 0.015 0.0408
Trichomonas vaginalis chaperonin, putative 0.0026 0.0079 0.0061
Loa Loa (eye worm) histone methyltransferase 0.0025 0.0067 0.0068
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.003 0.0076
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.009 0.0513
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0076 0.0751
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0017 0.0013 0.0018
Brugia malayi hypothetical protein 0.0017 0.0013 0.0014
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0071 0.0387 0.037

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 19.9526 uM PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase Cleavage of Glycogen. (Class of assay: confirmatory) [Related pubchem assays: 1473, 1466 ] ChEMBL. No reference
Potency (binding) = 25.1189 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 25.1189 uM PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 63.0957 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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