TDR Targets

Basic information

Technical information

TDR Targets ID: 1238200
Name: (4-dimethylaminophenyl)-[1-(4-methylphenyl)-1 ,3,4,9-tetrahydropyrido[3,4-b]indol-2-yl]meth anone
MW: 409.523 | Formula: C27H27N3O
H donors: 1 H acceptors: 1 LogP: 5.26 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: Cc1ccc(cc1)C1N(CCc2c1[nH]c1c2cccc1)C(=O)c1ccc(cc1)N(C)C
InChi: 1S/C27H27N3O/c1-18-8-10-19(11-9-18)26-25-23(22-6-4-5-7-24(22)28-25)16-17-30(26)27(31)20-12-14-21(15-13-20)29(2)3/h4-15,26,28H,16-17H2,1-3H3
InChiKey: JJOVQVWOTSPFDG-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

(4-dimethylaminophenyl)-[1-(4-methylphenyl)-1,3,4,9-tetrahydro-$b-carbolin-2-yl]methanone
G811-0284
NCGC00134567-01

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Escherichia coli	penicillin-binding protein	Starlite/ChEMBL	No references
Homo sapiens	glucagon-like peptide 1 receptor	Starlite/ChEMBL	No references
Homo sapiens	tumor protein p53	Starlite/ChEMBL	No references
Homo sapiens	SMAD family member 2	Starlite/ChEMBL	No references
Homo sapiens	bromodomain adjacent to zinc finger domain, 2B	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	expressed protein	Get druggable targets OG5_131570	All targets in OG5_131570
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_131570	All targets in OG5_131570
Schistosoma japonicum	hypothetical protein	Get druggable targets OG5_131570	All targets in OG5_131570
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_131570	All targets in OG5_131570
Brugia malayi	Bromodomain containing protein	Get druggable targets OG5_131570	All targets in OG5_131570
Loa Loa (eye worm)	transcription factor SMAD2	Get druggable targets OG5_131716	All targets in OG5_131716
Loa Loa (eye worm)	MH2 domain-containing protein	Get druggable targets OG5_131716	All targets in OG5_131716
Schistosoma japonicum	Cleft lip and palate transmembrane protein 1-like protein, putative	Get druggable targets OG5_131570	All targets in OG5_131570
Echinococcus granulosus	tumor protein p63	Get druggable targets OG5_140038	All targets in OG5_140038
Schistosoma japonicum	Conserved hypothetical protein	Get druggable targets OG5_131570	All targets in OG5_131570
Mycobacterium tuberculosis	Possible penicillin-binding protein	Get druggable targets OG5_149948	All targets in OG5_149948
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_131570	All targets in OG5_131570
Brugia malayi	MH2 domain containing protein	Get druggable targets OG5_131716	All targets in OG5_131716
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_131570	All targets in OG5_131570
Echinococcus multilocularis	tumor protein p63	Get druggable targets OG5_140038	All targets in OG5_140038
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	Get druggable targets OG5_131570	All targets in OG5_131570
Schistosoma mansoni	bromodomain containing protein	Get druggable targets OG5_131570	All targets in OG5_131570
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	Get druggable targets OG5_131570	All targets in OG5_131570
Schistosoma japonicum	ko:K01549 ATP synthase [EC3.6.3.14], putative	Get druggable targets OG5_131570	All targets in OG5_131570

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	MH2 domain containing protein	SMAD family member 2	467 aa	405 aa	31.6 %
Loa Loa (eye worm)	pigment dispersing factor receptor c	glucagon-like peptide 1 receptor	463 aa	388 aa	25.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Entamoeba histolytica	hypothetical protein	0.0042	0.0586	1
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0038	0.049	0.0348
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0085	0.1687	0.1563
Entamoeba histolytica	hypothetical protein	0.0042	0.0586	1
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0038	0.049	0.0348
Trypanosoma brucei	DNA polymerase beta thumb, putative	0.0043	0.0609	0.0647
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0043	0.0609	0.0647
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0085	0.1687	0.1563
Loa Loa (eye worm)	hypothetical protein	0.0096	0.1978	0.2148
Plasmodium falciparum	ataxin-2 like protein, putative	0.0029	0.0266	0.5234
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0041	0.0564	0.0423
Schistosoma mansoni	hypothetical protein	0.0038	0.049	0.0391
Schistosoma mansoni	hypothetical protein	0.0356	0.8669	0.9717
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0633	0.057
Brugia malayi	Importin beta-1 subunit	0.0033	0.0374	0.057
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0356	0.8669	1
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0038	0.049	0.0348
Trichomonas vaginalis	D-aminoacylase, putative	0.0043	0.0633	0.0759
Brugia malayi	RNA, U transporter 1	0.0095	0.1954	0.2982
Brugia malayi	DnaJ domain containing protein	0.0061	0.1093	0.1668
Brugia malayi	MH2 domain containing protein	0.0144	0.322	0.4913
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0043	0.0633	0.0493
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0266	0.0139
Echinococcus multilocularis	methyl CpG binding domain protein 2	0.004	0.0547	0.0405
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0143	0.3196	0.4267
Brugia malayi	beta-lactamase family protein	0.0043	0.0633	0.0966
Loa Loa (eye worm)	PHD-finger family protein	0.0049	0.0763	0.0723
Loa Loa (eye worm)	MH2 domain-containing protein	0.0144	0.322	0.3606
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0633	0.057
Loa Loa (eye worm)	DnaJ domain-containing protein	0.0061	0.1093	0.111
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0027	0.0211	0.01
Schistosoma mansoni	cpg binding protein	0.0038	0.0481	0.0381
Trichomonas vaginalis	penicillin-binding protein, putative	0.0043	0.0633	0.0759
Toxoplasma gondii	LsmAD domain-containing protein	0.0029	0.0266	0.1145
Loa Loa (eye worm)	glutaminase 2	0.0274	0.6554	0.7518
Trypanosoma cruzi	hypothetical protein, conserved	0.0043	0.0633	0.068
Schistosoma mansoni	zinc finger protein	0.0036	0.0441	0.0335
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.012	0.2593	0.3956
Trypanosoma brucei	PAB1-binding protein , putative	0.0029	0.0266	0.0166
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0564	0.0489
Trichomonas vaginalis	glutaminase, putative	0.0274	0.6554	1
Toxoplasma gondii	hypothetical protein	0.0049	0.077	0.6022
Loa Loa (eye worm)	hypothetical protein	0.006	0.1051	0.106
Trypanosoma brucei	ISWI complex protein	0.0036	0.0441	0.0411
Schistosoma mansoni	hypothetical protein	0.0036	0.0441	0.0335
Leishmania major	mitochondrial DNA polymerase beta	0.0303	0.7292	1
Loa Loa (eye worm)	hypothetical protein	0.012	0.2593	0.287
Plasmodium vivax	ataxin-2 like protein, putative	0.0029	0.0266	0.2437
Plasmodium vivax	hypothetical protein, conserved	0.0043	0.0633	1
Schistosoma mansoni	hypothetical protein	0.0038	0.049	0.0391
Brugia malayi	latrophilin 2 splice variant baaae	0.0082	0.1619	0.2471
Echinococcus multilocularis	zinc finger protein	0.0048	0.0745	0.0607
Plasmodium falciparum	ataxin-2 like protein, putative	0.0029	0.0266	0.5234
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0065	0.1182	1
Plasmodium falciparum	importin beta, putative	0.0033	0.0374	1
Trypanosoma brucei	importin beta-1 subunit, putative	0.0033	0.0374	0.0317
Echinococcus multilocularis	snurportin 1	0.0356	0.8669	0.8649
Schistosoma mansoni	importin beta-1	0.0033	0.0374	0.0258
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0043	0.0633	0.0554
Onchocerca volvulus		0.0043	0.0633	0.4288
Echinococcus multilocularis	geminin	0.0366	0.8917	0.8901
Schistosoma mansoni	methyl-cpg binding protein mbd	0.004	0.0547	0.0455
Mycobacterium ulcerans	hypothetical protein	0.0159	0.3612	0.5031
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0142	0.317	0.3067
Trypanosoma cruzi	PAB1-binding protein , putative	0.0029	0.0266	0.0166
Onchocerca volvulus		0.0043	0.0633	0.4288
Echinococcus granulosus	beta LACTamase domain containing family member	0.0043	0.0633	0.0493
Brugia malayi	Calcitonin receptor-like protein seb-1	0.012	0.2593	0.3956
Echinococcus granulosus	GPCR family 2	0.0038	0.049	0.0348
Leishmania major	hypothetical protein, conserved	0.0036	0.0441	0.0411
Trichomonas vaginalis	protein kinase inhibitor, putative	0.0061	0.1093	0.1477
Schistosoma mansoni	hypothetical protein	0.0042	0.0586	0.05
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0278	0.6653	1
Schistosoma mansoni	hypothetical protein	0.0049	0.0763	0.0702
Trichomonas vaginalis	D-aminoacylase, putative	0.0043	0.0633	0.0759
Plasmodium vivax	importin-beta 2, putative	0.0033	0.0374	0.4657
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0043	0.0633	0.0554
Loa Loa (eye worm)	transcription factor SMAD2	0.0144	0.322	0.3606
Schistosoma mansoni	methyl-cpg binding protein mbd	0.004	0.0547	0.0455
Leishmania major	hypothetical protein, conserved	0.0043	0.0633	0.068
Echinococcus multilocularis	GPCR, family 2	0.0038	0.049	0.0348
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0633	0.057
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0066	0.1221	0.1224
Echinococcus granulosus	methyl CpG binding domain protein 2	0.004	0.0547	0.0405
Loa Loa (eye worm)	hypothetical protein	0.009	0.1835	0.198
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0052	0.0849	0.0982
Toxoplasma gondii	ABC1 family protein	0.0043	0.0633	0.4698
Echinococcus granulosus	dnaJ subfamily C 6	0.0061	0.1093	0.096
Trichomonas vaginalis	importin beta-1, putative	0.0027	0.0211	0.01
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0159	0.3612	0.4948
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0043	0.0609	0.0647
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0038	0.049	0.0348
Trichomonas vaginalis	penicillin-binding protein, putative	0.0043	0.0633	0.0759
Brugia malayi	CXXC zinc finger family protein	0.0031	0.032	0.0488
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0055	0.0924	0.0886
Loa Loa (eye worm)	beta-lactamase	0.0043	0.0633	0.057
Loa Loa (eye worm)	hypothetical protein	0.0102	0.2139	0.2337
Mycobacterium ulcerans	glutaminase	0.0274	0.6554	1
Echinococcus granulosus	snurportin 1	0.0356	0.8669	0.8649
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0042	0.0586	0.0445
Loa Loa (eye worm)	glutaminase	0.0274	0.6554	0.7518
Brugia malayi	Latrophilin receptor protein 2	0.0038	0.049	0.0747
Schistosoma mansoni	hypothetical protein	0.0038	0.049	0.0391
Onchocerca volvulus		0.006	0.1051	1
Echinococcus multilocularis	tumor protein p63	0.0408	1	1
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0027	0.0211	0.01
Mycobacterium leprae	Probable lipase LipE	0.0043	0.0633	0.5
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0041	0.0564	0.0476
Echinococcus multilocularis	dnaJ subfamily C 6	0.0061	0.1093	0.096
Echinococcus granulosus	histone lysine methyltransferase setb	0.0041	0.0564	0.0423
Schistosoma mansoni	hypothetical protein	0.0366	0.8917	1
Brugia malayi	beta-lactamase family protein	0.0043	0.0633	0.0966
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0038	0.049	0.0402
Schistosoma mansoni	cpg binding protein	0.0038	0.0481	0.0381
Trichomonas vaginalis	D-aminoacylase, putative	0.0043	0.0633	0.0759
Trypanosoma cruzi	ISWI complex protein	0.0036	0.0441	0.0411
Entamoeba histolytica	hypothetical protein	0.0027	0.0211	0.1464
Loa Loa (eye worm)	hypothetical protein	0.0166	0.379	0.4274
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0043	0.0633	0.0966
Brugia malayi	beta-lactamase	0.0043	0.0633	0.0966
Echinococcus granulosus	fetal alzheimer antigen falz	0.0055	0.0924	0.0789
Echinococcus granulosus	geminin	0.0366	0.8917	0.8901
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0027	0.0211	0.009
Trypanosoma cruzi	hypothetical protein, conserved	0.0043	0.0633	0.068
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0031	0.032	0.0203
Schistosoma mansoni	hypothetical protein	0.0038	0.049	0.0391
Brugia malayi	Bromodomain containing protein	0.0178	0.4094	0.6246
Echinococcus multilocularis	cpg binding protein	0.0038	0.0481	0.0339
Trypanosoma brucei	hypothetical protein, conserved	0.0043	0.0633	0.068
Trypanosoma cruzi	ISWI complex protein	0.0036	0.0441	0.0411
Schistosoma mansoni	cellular tumor antigen P53	0.006	0.1051	0.103
Brugia malayi	hypothetical protein	0.0029	0.0266	0.0405
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.0143	0.3196	0.4267
Schistosoma mansoni	bromodomain containing protein	0.0151	0.3386	0.3693
Brugia malayi	Bromodomain containing protein	0.009	0.183	0.2793
Echinococcus multilocularis	importin subunit beta 1	0.0033	0.0374	0.023
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0303	0.7292	1
Entamoeba histolytica	hypothetical protein	0.0042	0.0586	1
Echinococcus granulosus	importin subunit beta 1	0.0033	0.0374	0.023
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0038	0.049	0.0747
Loa Loa (eye worm)	hypothetical protein	0.0082	0.1619	0.1728
Echinococcus granulosus	zinc finger protein	0.0048	0.0745	0.0607
Entamoeba histolytica	hypothetical protein	0.0042	0.0586	1
Schistosoma mansoni	zinc finger protein	0.0048	0.0745	0.0682
Mycobacterium leprae	conserved hypothetical protein	0.0043	0.0633	0.5
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0142	0.317	0.3067
Schistosoma mansoni	glutaminase	0.0274	0.6554	0.7305
Onchocerca volvulus		0.0043	0.0633	0.4288
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0303	0.7292	1
Loa Loa (eye worm)	hypothetical protein	0.0038	0.049	0.0402
Trypanosoma brucei	importin beta-1 subunit, putative	0.0033	0.0374	0.0317
Schistosoma mansoni	cpg binding protein	0.0031	0.032	0.0197
Brugia malayi	glutaminase DH11.1	0.0274	0.6554	1
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0025	0.0147	0.0225
Brugia malayi	PHD-finger family protein	0.006	0.1067	0.1628
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0043	0.0633	0.057
Schistosoma mansoni	transcription factor LCR-F1	0.0042	0.0586	0.05
Trichomonas vaginalis	esterase, putative	0.0043	0.0633	0.0759
Loa Loa (eye worm)	bromodomain containing protein	0.0042	0.0584	0.0512
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0633	0.057
Leishmania major	hypothetical protein, conserved	0.0029	0.0266	0.0166
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0633	0.057
Echinococcus granulosus	cpg binding protein	0.0038	0.0481	0.0339
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0055	0.0924	0.0789
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.012	0.2593	0.287
Toxoplasma gondii	HEAT repeat-containing protein	0.0033	0.0374	0.2188
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	0.0025	0.0147	0.5
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.0143	0.3196	0.4267
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0043	0.0609	0.0647
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0374	0.0266
Trypanosoma cruzi	PAB1-binding protein , putative	0.0029	0.0266	0.0166
Brugia malayi	hypothetical protein	0.0042	0.0586	0.0894
Leishmania major	importin beta-1 subunit, putative	0.0027	0.0211	0.009
Schistosoma mansoni	hypothetical protein	0.0366	0.8917	1
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0042	0.0586	0.0445
Schistosoma mansoni	hypothetical protein	0.0082	0.1619	0.1679
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0041	0.0564	0.0476
Schistosoma mansoni	hypothetical protein	0.0061	0.1093	0.1079
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0633	0.057
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.0303	0.7292	1

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	= 0.7079 um	PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))]	ChEMBL.	No reference
Potency (functional)	= 3.9811 um	PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Permissive Temperature. (Class of assay: confirmatory) [Related pubchem assays: 902 ]	ChEMBL.	No reference
Potency (functional)	10 uM	PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	11.2202 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249]	ChEMBL.	No reference
Potency (functional)	= 12.5893 um	PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53 Null Cells at the Nonpermissive Temperature. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 12.5893 um	PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53 Null Cells at the Permissive Temperature. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	12.5893 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391]	ChEMBL.	No reference
Potency (functional)	12.5893 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860]	ChEMBL.	No reference
Potency (functional)	22.3872 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404]	ChEMBL.	No reference
Potency (functional)	= 31.6228 um	PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Nonpermissive Temperature. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	31.6228 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402]	ChEMBL.	No reference
Potency (functional)	= 39.8107 um	PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1318029

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1238200