Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | lamin A/C | Starlite/ChEMBL | No references |
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Homo sapiens | parathyroid hormone 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.1324 | 0.0478 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0062 | 0.3473 | 0.3473 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0075 | 0.4426 | 0.4426 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.3473 | 0.7073 |
Schistosoma mansoni | hypothetical protein | 0.0075 | 0.4426 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0109 | 0.71 | 0.71 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.006 | 0.3273 | 0.9133 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 1 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0045 | 0.2133 | 0.2133 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.2133 | 0.296 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0035 | 0.1324 | 0.0675 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.006 | 0.3273 | 0.646 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 0.9796 | 0.9796 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0035 | 0.1324 | 0.1324 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.1984 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.2133 | 0.296 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.2133 | 0.296 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0043 | 0.1984 | 0.3538 |
Onchocerca volvulus | Huntingtin homolog | 0.0147 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.1984 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.1324 | 0.0478 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.2133 | 0.4185 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.1123 | 0.1123 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.1984 | 0.2503 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.2133 | 0.4185 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.006 | 0.3273 | 0.9133 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.4426 | 0.4426 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.006 | 0.3273 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.1984 | 0.5 |
Echinococcus granulosus | tar DNA binding protein | 0.0062 | 0.3473 | 1 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0035 | 0.1324 | 0.0675 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0.3273 | 0.5 |
Echinococcus multilocularis | GPCR, family 2 | 0.0035 | 0.1324 | 0.0675 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.006 | 0.3273 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 0.1984 | 0.2503 |
Loa Loa (eye worm) | RNA binding protein | 0.0062 | 0.3473 | 0.3473 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0043 | 0.1984 | 0.3538 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 0.1169 | 0.1169 |
Echinococcus multilocularis | tar DNA binding protein | 0.0062 | 0.3473 | 1 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 0.1169 | 0.1169 |
Loa Loa (eye worm) | TAR-binding protein | 0.0062 | 0.3473 | 0.3473 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0035 | 0.1324 | 0.1324 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.1324 | 0.1324 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.3473 | 0.7073 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0045 | 0.2133 | 0.2133 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0.3273 | 0.5 |
Brugia malayi | intermediate filament protein | 0.0033 | 0.1169 | 0.1169 |
Brugia malayi | hypothetical protein | 0.0043 | 0.1984 | 0.1984 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0109 | 0.71 | 0.71 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0035 | 0.1324 | 0.1324 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.1984 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.1169 | 0.1169 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.3473 | 0.7073 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.006 | 0.3273 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.71 | 0.71 |
Brugia malayi | MH2 domain containing protein | 0.0144 | 0.9796 | 0.9796 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 0.9796 | 0.9796 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 1 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0109 | 0.71 | 0.71 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0035 | 0.1324 | 0.0675 |
Echinococcus granulosus | GPCR family 2 | 0.0035 | 0.1324 | 0.0675 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0.3273 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0062 | 0.3473 | 0.3473 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0035 | 0.1324 | 0.0675 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.3473 | 0.7073 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0062 | 0.3473 | 0.3473 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.1324 | 0.0478 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.3473 | 0.7073 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.1324 | 0.0478 |
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 0.1169 | 0.1169 |
Onchocerca volvulus | Huntingtin homolog | 0.0147 | 1 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.2133 | 0.4185 |
Brugia malayi | RNA binding protein | 0.0062 | 0.3473 | 0.3473 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.2133 | 0.4185 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.006 | 0.3273 | 0.646 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 0.1778 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 3.1623 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 8.9125 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 56.2341 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 112.2018 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.