Detailed information for compound 1238689

Basic information

Technical information
  • TDR Targets ID: 1238689
  • Name: 2-methoxy-6-(2-phenylethyl)-8-(thiophen-2-ylm ethyl)pteridin-7-one
  • MW: 378.448 | Formula: C20H18N4O2S
  • H donors: 0 H acceptors: 3 LogP: 2.89 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ncc2c(n1)n(Cc1cccs1)c(=O)c(n2)CCc1ccccc1
  • InChi: 1S/C20H18N4O2S/c1-26-20-21-12-17-18(23-20)24(13-15-8-5-11-27-15)19(25)16(22-17)10-9-14-6-3-2-4-7-14/h2-8,11-12H,9-10,13H2,1H3
  • InChiKey: QGPIDTWBSVGMIY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-methoxy-6-(2-phenylethyl)-8-(2-thienylmethyl)pteridin-7-one
  • 2-methoxy-6-(2-phenylethyl)-8-(2-thienylmethyl)-7-pteridinone
  • NCGC00011540
  • PCOP-528224

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Bacillus anthracis Anthrax lethal factor Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 2, subfamily D, polypeptide 6 Starlite/ChEMBL No references
Bacillus subtilis 4'-phosphopantetheinyl transferase ffp Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 1, subfamily A, polypeptide 2 Starlite/ChEMBL No references
Homo sapiens thyroid stimulating hormone receptor Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 3, subfamily A, polypeptide 4 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase Get druggable targets OG5_129301 All targets in OG5_129301
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania infantum cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus multilocularis L aminoadipate semialdehyde Get druggable targets OG5_129301 All targets in OG5_129301
Echinococcus granulosus L aminoadipate semialdehyde Get druggable targets OG5_129301 All targets in OG5_129301
Schistosoma japonicum ko:K00142 aminoadipate-semialdehyde dehydrogenase [EC1.2.1.31], putative Get druggable targets OG5_129301 All targets in OG5_129301
Candida albicans cytochrome P450 556 Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania braziliensis cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Onchocerca volvulus Get druggable targets OG5_129301 All targets in OG5_129301
Trypanosoma brucei gambiense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129301 All targets in OG5_129301
Schistosoma japonicum expressed protein Get druggable targets OG5_129301 All targets in OG5_129301
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma brucei cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase Get druggable targets OG5_129301 All targets in OG5_129301
Loa Loa (eye worm) CYP4Cod1 Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma congolense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Brugia malayi follicle stimulating hormone receptor Get druggable targets OG5_130089 All targets in OG5_130089
Candida albicans closely related to C.maltosa N-alkane-inducible cytochrome P-450, alkane hydroxylating monooxygenase CYP52A3-b aka P450Alk1A (BA Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans cytochrome P450 56 Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania mexicana cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania major cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) follicle stimulating hormone receptor Get druggable targets OG5_130089 All targets in OG5_130089
Cryptosporidium hominis proteinx0005 Get druggable targets OG5_129301 All targets in OG5_129301
Cryptosporidium parvum phosphopantetheinyl transferase Get druggable targets OG5_129301 All targets in OG5_129301
Leishmania donovani cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Entamoeba histolytica hypothetical protein 4'-phosphopantetheinyl transferase ffp   224 aa 198 aa 28.3 %
Trichomonas vaginalis conserved hypothetical protein 4'-phosphopantetheinyl transferase ffp   224 aa 197 aa 22.3 %
Brugia malayi cytochrome P450 cytochrome P450, family 2, subfamily D, polypeptide 6 497 aa 425 aa 32.0 %
Onchocerca volvulus 4'-phosphopantetheinyl transferase ffp   224 aa 186 aa 26.3 %
Candida albicans aminoadipate-semialdehyde dehydrogenase small subunit 4'-phosphopantetheinyl transferase ffp   224 aa 183 aa 27.3 %
Brugia malayi Cytochrome P450 family protein cytochrome P450, family 1, subfamily A, polypeptide 2 516 aa 470 aa 26.2 %
Candida albicans aminoadipate-semialdehyde dehydrogenase small subunit 4'-phosphopantetheinyl transferase ffp   224 aa 183 aa 27.3 %
Brugia malayi cytochrome P450 cytochrome P450, family 3, subfamily A, polypeptide 4 502 aa 492 aa 24.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis dna polymerase eta 0.002 0.0099 0.0118
Loa Loa (eye worm) hypothetical protein 0.0077 0.1294 0.1479
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0061 0.0955 0.0864
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0638 0.0851
Schistosoma mansoni thyroid hormone receptor 0.0174 0.3311 0.5408
Brugia malayi Pre-SET motif family protein 0.0062 0.0986 0.1111
Schistosoma mansoni jumonji domain containing protein 0.0091 0.1587 0.2563
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0099 0.0703
Plasmodium falciparum importin beta, putative 0.0029 0.0286 0.1186
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0286 0.2742
Loa Loa (eye worm) hypothetical protein 0.0035 0.0417 0.0476
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0099 0.0703
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0023 0.0175 0.0558
Loa Loa (eye worm) PHD-finger family protein 0.0035 0.0417 0.0476
Plasmodium vivax heterochromatin protein 1, putative 0.0025 0.0209 0.0609
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0099 0.0703
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0085 0.1464 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0023 0.0157 0.0161
Schistosoma mansoni autophagin-1 (C54 family) 0.0061 0.0955 0.1519
Echinococcus granulosus dna polymerase kappa 0.002 0.0099 0.0118
Schistosoma mansoni methyl-cpg binding protein mbd 0.0019 0.0074 0.0066
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.0747 0.7743
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0048 0.0037
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.0175 0.1531
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0638 0.0851
Loa Loa (eye worm) hypothetical protein 0.0023 0.0157 0.0179
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0025 0.0209 0.0289
Plasmodium vivax SET domain protein, putative 0.0062 0.0986 0.6424
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0099 0.0095
Schistosoma mansoni hypothetical protein 0.014 0.2608 0.4248
Brugia malayi Calcitonin receptor-like protein seb-1 0.0205 0.396 0.4516
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0099 0.0703
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0023 0.0157 0.0179
Schistosoma mansoni zinc finger protein 0.0021 0.0131 0.016
Loa Loa (eye worm) CHromoDomain protein family member 0.0027 0.0253 0.0289
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0025 0.0209 0.0268
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0032 0.0362 0.0414
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0099 0.0703
Schistosoma mansoni hypothetical protein 0.0025 0.0209 0.0289
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0023 0.0157 0.0203
Loa Loa (eye worm) hypothetical protein 0.0029 0.0286 0.0327
Loa Loa (eye worm) hypothetical protein 0.0054 0.081 0.0926
Loa Loa (eye worm) PHD-finger family protein 0.0022 0.0155 0.0178
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.069 0.0772
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0175 0.02
Echinococcus granulosus TGF beta signal transducer SmadC 0.0017 0.004 0.0038
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0062 0.0986 0.1324
Brugia malayi nuclear receptor NHR-88 0.0023 0.0157 0.0161
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0019 0.0074 0.0084
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0173 0.0075
Brugia malayi Muscleblind-like protein 0.0163 0.3082 0.351
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.01 0.1783 0.2887
Echinococcus multilocularis chromobox protein 2 0.0025 0.0209 0.0268
Schistosoma mansoni steroid hormone receptor ad4bp 0.0023 0.0157 0.0203
Loa Loa (eye worm) hypothetical protein 0.006 0.0938 0.1073
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0025 0.0209 0.0609
Echinococcus multilocularis muscleblind protein 0.0163 0.3082 0.4174
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0061 0.0955 0.0864
Loa Loa (eye worm) CYP4Cod1 0.0023 0.0175 0.02
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0039 0.0503 0.0667
Entamoeba histolytica hypothetical protein 0.0037 0.046 0.4221
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0099 0.0703
Schistosoma mansoni thyroid hormone receptor 0.0174 0.3311 0.5408
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0048 0.0055
Trypanosoma brucei unspecified product 0.002 0.0099 0.0703
Echinococcus granulosus mitogen activated protein kinase 3 0.0051 0.0747 0.0999
Echinococcus granulosus mothers against decapentaplegic 5 0.0017 0.004 0.0038
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0222 0.4316 0.5852
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0099 0.0113
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0128 0.0157
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0434 0.8748 1
Brugia malayi hypothetical protein 0.0025 0.0209 0.0221
Schistosoma mansoni DNA polymerase eta 0.002 0.0099 0.0107
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.046 0.0609
Giardia lamblia PHD finger protein 15 0.0035 0.0417 0.4906
Schistosoma mansoni hypothetical protein 0.0037 0.046 0.0703
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.0747 0.7743
Loa Loa (eye worm) hypothetical protein 0.0065 0.1038 0.1187
Brugia malayi Pre-SET motif family protein 0.0434 0.8748 1
Echinococcus multilocularis lysine specific demethylase 5A 0.0042 0.057 0.0759
Echinococcus multilocularis Peptidase C54 0.0061 0.0955 0.1281
Loa Loa (eye worm) hypothetical protein 0.0023 0.0157 0.0179
Echinococcus multilocularis zinc finger protein 0.0021 0.0131 0.0162
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0085 0.1464 1
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0028 0.0276 0.1298
Echinococcus granulosus fetal alzheimer antigen falz 0.0025 0.0199 0.0253
Trypanosoma brucei cytochrome P450, putative 0.0023 0.0175 0.1531
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0023 0.0157 0.0161
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0209 0.0112
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0099 0.0703
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0065 0.1043 0.1402
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0099 0.0095
Loa Loa (eye worm) steroid hormone receptor 0.0023 0.0157 0.0179
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0027 0.0253 0.0327
Brugia malayi M-phase phosphoprotein, mpp8 0.0025 0.0209 0.0221
Echinococcus granulosus lamin 0.0032 0.0362 0.0475
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0025 0.0209 0.1291
Schistosoma mansoni RAR-like nuclear receptor 0.0023 0.0157 0.0203
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0028 0.0276 0.1298
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0023 0.0157 0.0196
Schistosoma mansoni survival motor neuron protein 0.0048 0.069 0.1083
Echinococcus multilocularis Chromo domain 0.0025 0.0209 0.0268
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0029 0.0299 0.0191
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0025 0.0209 0.0609
Leishmania major cytochrome p450-like protein 0.0023 0.0175 0.1531
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0099 0.0703
Echinococcus granulosus ecdysone induced protein 78C 0.0023 0.0157 0.0196
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0747 0.0654
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0023 0.0157 0.0203
Schistosoma mansoni smad1 5 8 and 0.0017 0.004 0.0011
Loa Loa (eye worm) intermediate filament protein 0.0032 0.0362 0.0414
Echinococcus granulosus Chromobox protein 3 0.0025 0.0209 0.0268
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0209 0.0112
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0056 0.0851 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0209 0.0239
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0747 0.0654
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0115 0.2078 0.2809
Loa Loa (eye worm) hypothetical protein 0.0023 0.0157 0.0179
Entamoeba histolytica peptidase, C54 family 0.0024 0.0181 0.0959
Brugia malayi Latrophilin receptor protein 2 0.0065 0.1038 0.1171
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0023 0.0157 0.0196
Trypanosoma brucei protein kinase, putative 0.0051 0.0747 0.7743
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0638 0.0997
Echinococcus multilocularis cysteine protease atg4b 0.0061 0.0955 0.1281
Leishmania major DNA polymerase kappa, putative 0.002 0.0099 0.0703
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0099 0.0107
Trichomonas vaginalis Heterochromatin protein, putative 0.0025 0.0209 0.0112
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0638 0.0997
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0092 0.1613 0.148
Entamoeba histolytica hypothetical protein 0.0037 0.046 0.4221
Brugia malayi Steroid receptor seven-up type 2 0.0023 0.0157 0.0161
Echinococcus multilocularis FTZ F1 alpha 0.0023 0.0157 0.0196
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0029 0.0299 0.1278
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0023 0.0157 0.0196
Loa Loa (eye worm) hypothetical protein 0.0025 0.0209 0.0239
Echinococcus multilocularis Chromobox protein 3 0.0025 0.0209 0.0268
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0029 0.0299 0.1278
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0051 0.0747 0.4633
Brugia malayi SET domain containing protein 0.0027 0.0257 0.0276
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0023 0.0157 0.0203
Plasmodium vivax hypothetical protein, conserved 0.0025 0.0209 0.0609
Echinococcus multilocularis musashi 0.0032 0.0362 0.0475
Loa Loa (eye worm) hypothetical protein 0.0163 0.3082 0.3523
Brugia malayi MH2 domain containing protein 0.0249 0.4884 0.5575
Schistosoma mansoni intermediate filament proteins 0.0032 0.0362 0.0541
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0023 0.0157 0.0196
Schistosoma mansoni hypothetical protein 0.0173 0.3308 0.5404
Loa Loa (eye worm) hypothetical protein 0.0067 0.1091 0.1247
Echinococcus multilocularis L aminoadipate semialdehyde 0.01 0.1783 0.2408
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0099 0.0703
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.046 0.0609
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0025 0.0199 0.0253
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0061 0.0955 0.0864
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0362 0.7237 0.827
Schistosoma mansoni serine/threonine protein kinase 0.0051 0.0747 0.1176
Loa Loa (eye worm) hypothetical protein 0.0032 0.035 0.04
Trichomonas vaginalis hypothetical protein 0.0025 0.0209 0.0112
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0023 0.0157 0.0161
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0286 0.1186
Schistosoma mansoni coup transcription factor 0.0023 0.0157 0.0203
Echinococcus granulosus chromobox protein 1 0.0153 0.2882 0.3902
Echinococcus multilocularis peregrin 0.0038 0.047 0.0623
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0986 0.1571
Schistosoma mansoni cellular tumor antigen P53 0.0054 0.081 0.1281
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0128 0.1021
Loa Loa (eye worm) hypothetical protein 0.0061 0.0955 0.1091
Loa Loa (eye worm) hypothetical protein 0.01 0.1783 0.2038
Brugia malayi PHD-finger family protein 0.0027 0.0253 0.0271
Brugia malayi Cytochrome P450 family protein 0.0023 0.0175 0.0182
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0028 0.0276 0.1108
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0209 0.0112
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0099 0.0107
Schistosoma mansoni hypothetical protein 0.0151 0.284 0.4631
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0065 0.1043 0.1402
Echinococcus multilocularis mothers against decapentaplegic 5 0.0017 0.004 0.0038
Leishmania major importin beta-1 subunit, putative 0.0023 0.0173 0.1509
Echinococcus multilocularis ecdysone induced protein 78C 0.0023 0.0157 0.0196
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0175 0.02
Loa Loa (eye worm) transcription factor SMAD2 0.0249 0.4884 0.5583
Entamoeba histolytica peptidase, C54 family 0.0024 0.0181 0.0959
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0099 0.0703
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0023 0.0157 0.0196
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0307 0.6093 0.6965
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0638 0.073
Brugia malayi chromobox protein homolog 3 0.0086 0.1477 0.1673
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0023 0.0157 0.0161
Schistosoma mansoni chromobox protein 0.0025 0.0209 0.0289
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0051 0.0747 0.0854
Loa Loa (eye worm) hypothetical protein 0.0046 0.0656 0.0749
Schistosoma mansoni chromobox protein 0.0025 0.0209 0.0289
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0128 0.0128
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0023 0.0157 0.0203
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0081 0.1374 0.2211
Echinococcus granulosus intermediate filament protein 0.0032 0.0362 0.0475
Echinococcus multilocularis chromobox protein 1 0.0153 0.2882 0.3902
Loa Loa (eye worm) hypothetical protein 0.0025 0.0209 0.0239
Brugia malayi MH1 domain containing protein 0.0017 0.004 0.0028
Schistosoma mansoni ran 0.0021 0.0128 0.0155
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0017 0.004 0.0011
Echinococcus multilocularis mitogen activated protein kinase 3 0.0051 0.0747 0.0999
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.0417 0.2161
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0025 0.0209 0.0268
Loa Loa (eye worm) hypothetical protein 0.0025 0.0209 0.0239
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0638 0.0851
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0056 0.0851 0.4844
Loa Loa (eye worm) latrophilin receptor protein 2 0.0065 0.1038 0.1187
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0025 0.0209 0.0112
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0039 0.0503 0.0667
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0027 0.0253 0.0361
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0085 0.1464 1
Entamoeba histolytica peptidase, C54 family 0.0061 0.0955 1
Brugia malayi MH2 domain containing protein 0.0017 0.004 0.0028
Schistosoma mansoni jumonji/arid domain-containing protein 0.0044 0.0614 0.0957
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0051 0.0747 0.7743
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0222 0.4316 0.5852
Trichomonas vaginalis set domain proteins, putative 0.0494 1 1
Schistosoma mansoni hypothetical protein 0.0065 0.1038 0.1658
Schistosoma mansoni hypothetical protein 0.0022 0.0155 0.02
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0023 0.0157 0.0179
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0025 0.0209 0.0609
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0023 0.0157 0.0161
Echinococcus multilocularis PHD finger protein rhinoceros 0.0035 0.0417 0.055
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0099 0.0703
Brugia malayi Protein cec-1. 0.0025 0.0209 0.0221
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0638 0.0712
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0023 0.0157 0.0161
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0085 0.1464 1
Brugia malayi MAP kinase sur-1 0.0051 0.0747 0.0837
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0099 0.0703
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0099 0.0703
Loa Loa (eye worm) hypothetical protein 0.0025 0.0209 0.0239
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0025 0.0209 0.1291
Echinococcus granulosus survival motor neuron protein 1 0.0236 0.4608 0.6249
Schistosoma mansoni family C54 unassigned peptidase (C54 family) 0.0061 0.0955 0.1519
Loa Loa (eye worm) hypothetical protein 0.0025 0.0209 0.0239
Loa Loa (eye worm) jmjC domain-containing protein 0.0044 0.0614 0.0702
Leishmania major AUT2/APG4/ATG4 cysteine peptidase, putative 0.0061 0.0955 1
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0209 0.0112
Onchocerca volvulus 0.0032 0.0362 0.0208
Echinococcus granulosus FTZ F1 alpha 0.0023 0.0157 0.0196
Trichomonas vaginalis chromobox protein, putative 0.0025 0.0209 0.0112
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0023 0.0157 0.0203
Schistosoma mansoni hypothetical protein 0.0065 0.1038 0.1658
Loa Loa (eye worm) follicle stimulating hormone receptor 0.028 0.5527 0.6318
Loa Loa (eye worm) bromodomain containing protein 0.0019 0.0088 0.01
Loa Loa (eye worm) hypothetical protein 0.0025 0.0209 0.0239
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0209 0.0112
Echinococcus multilocularis lamin 0.0032 0.0362 0.0475
Schistosoma mansoni hypothetical protein 0.0048 0.069 0.1083
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0173 0.0075
Loa Loa (eye worm) Smad1 0.0017 0.004 0.0046
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0025 0.0209 0.0112
Brugia malayi Peptidase family C54 containing protein 0.0061 0.0955 0.1075
Schistosoma mansoni retinoic acid receptor RXR 0.0023 0.0157 0.0203
Brugia malayi Valyl-tRNA synthetase 0.0025 0.0209 0.0221
Onchocerca volvulus 0.0048 0.069 0.0542
Brugia malayi MH2 domain containing protein 0.0017 0.004 0.0028
Echinococcus granulosus zinc finger protein 0.0021 0.0131 0.0162
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0085 0.1464 0.1974
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0028 0.0276 0.1108
Brugia malayi Heterochromatin protein 1 0.0153 0.2882 0.3282
Onchocerca volvulus 0.01 0.1783 0.1652
Brugia malayi Bromodomain containing protein 0.0082 0.1391 0.1574
Schistosoma mansoni Smad4 0.0017 0.004 0.0011
Trypanosoma cruzi AUT2/APG4/ATG4 cysteine peptidase, putative 0.0024 0.0181 0.1595
Loa Loa (eye worm) hypothetical protein 0.0163 0.3082 0.3523
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0209 0.0112
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0099 0.0118
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0025 0.0199 0.0272
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0028 0.0276 0.2355
Brugia malayi Probable ClpP-like protease 0.0085 0.1464 0.1658
Echinococcus granulosus cysteine protease atg4b 0.0061 0.0955 0.1281
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0099 0.0703
Echinococcus multilocularis dna polymerase kappa 0.002 0.0099 0.0118
Echinococcus multilocularis survival motor neuron protein 1 0.0236 0.4608 0.6249
Loa Loa (eye worm) hypothetical protein 0.0023 0.0157 0.0179
Schistosoma mansoni importin beta-1 0.0029 0.0286 0.0417
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0747 0.0654
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0065 0.1038 0.1395
Echinococcus granulosus smad 0.0017 0.004 0.0038
Schistosoma mansoni nuclear hormone receptor 0.0023 0.0157 0.0203
Schistosoma mansoni family C54 unassigned peptidase (C54 family) 0.0061 0.0955 0.1519
Trichomonas vaginalis chromobox protein, putative 0.0153 0.2882 0.2811
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0099 0.0703
Loa Loa (eye worm) hypothetical protein 0.014 0.2608 0.2981
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0051 0.0747 0.7743
Echinococcus multilocularis thyroid hormone receptor alpha 0.0174 0.3311 0.4485
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0099 0.0703
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0065 0.1038 0.1395
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0025 0.0209 0.0609
Echinococcus granulosus GPCR family 2 0.0065 0.1038 0.1395
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0099 0.0703
Echinococcus granulosus PHD finger protein rhinoceros 0.0035 0.0417 0.055
Brugia malayi hypothetical protein 0.0037 0.046 0.0508
Brugia malayi Smad1 0.0017 0.004 0.0028
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0085 0.1464 1
Echinococcus multilocularis chromobox protein 1 0.0153 0.2882 0.3902
Echinococcus granulosus lamin dm0 0.0032 0.0362 0.0475
Schistosoma mansoni bromodomain containing protein 0.0069 0.1125 0.18
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0062 0.0986 0.6424
Loa Loa (eye worm) hypothetical protein 0.0085 0.1464 0.1673
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0151 0.284 0.3845
Echinococcus granulosus chromobox protein 1 0.0153 0.2882 0.3902
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0025 0.0209 0.0609
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0955 0.0864
Brugia malayi jmjC domain containing protein 0.0044 0.0614 0.0684
Leishmania major AUT2/APG4/ATG4 cysteine peptidase, putative 0.0024 0.0181 0.1595
Brugia malayi nuclear hormone receptor 0.0023 0.0157 0.0161
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0027 0.0253 0.0327
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0023 0.0157 0.0179
Loa Loa (eye worm) hypothetical protein 0.0023 0.0157 0.0179
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0638 0.0851
Schistosoma mansoni lamin 0.0032 0.0362 0.0541
Echinococcus granulosus mitogen activated protein kinase 0.0051 0.0747 0.0999
Trichomonas vaginalis conserved hypothetical protein 0.0086 0.1477 0.1392
Echinococcus granulosus tumor protein p63 0.0368 0.7366 1
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0128 0.0146
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0025 0.0209 0.0112
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0023 0.0157 0.0179
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0209 0.0112
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0025 0.0209 0.0289
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.004 0.0046
Echinococcus multilocularis peptidase Clp (S14 family) 0.0056 0.0851 0.1141
Loa Loa (eye worm) hypothetical protein 0.0044 0.0612 0.07
Echinococcus granulosus snurportin 1 0.0307 0.6093 0.8268
Trichomonas vaginalis chromobox protein, putative 0.0092 0.1613 0.153
Giardia lamblia Kinase, CMGC MAPK 0.0051 0.0747 1
Brugia malayi CHD4 protein 0.0027 0.0253 0.0271
Echinococcus granulosus lysine specific demethylase 5A 0.0044 0.0614 0.0818
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0151 0.284 0.3845
Entamoeba histolytica hypothetical protein 0.0037 0.046 0.4221
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0056 0.0851 1
Entamoeba histolytica hypothetical protein 0.0023 0.0173 0.0866
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0023 0.0157 0.0196
Brugia malayi follicle stimulating hormone receptor 0.028 0.5527 0.6311
Loa Loa (eye worm) hypothetical protein 0.0042 0.0558 0.0638
Entamoeba histolytica peptidase, C54 family 0.0024 0.0181 0.0959
Leishmania major DNA polymerase eta, putative 0.002 0.0099 0.0703
Entamoeba histolytica hypothetical protein 0.0028 0.0276 0.2071
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0085 0.1464 1
Onchocerca volvulus 0.0067 0.1091 0.0949
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0023 0.0157 0.0196
Loa Loa (eye worm) hypothetical protein 0.0081 0.1374 0.157
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0955 0.0864
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0061 0.0955 0.0864
Leishmania major GTP-binding protein, putative 0.0021 0.0128 0.1021
Brugia malayi ecdysteroid receptor 0.0023 0.0157 0.0161
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0081 0.1374 0.2211
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.004 0.0046
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0085 0.1464 1
Trypanosoma brucei AUT2/APG4/ATG4 cysteine peptidase, putative 0.0061 0.0955 1
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0025 0.0209 0.1291
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.01 0.1783 0.2023
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0023 0.0157 0.0179
Loa Loa (eye worm) MH2 domain-containing protein 0.0249 0.4884 0.5583
Schistosoma mansoni hypothetical protein 0.0307 0.6093 1
Brugia malayi Associated with TFs and helicases family protein 0.0025 0.0209 0.0221
Schistosoma mansoni hypothetical protein 0.0065 0.1038 0.1658
Echinococcus multilocularis Smad4 0.0017 0.004 0.0038
Loa Loa (eye worm) hypothetical protein 0.0133 0.2471 0.2824
Brugia malayi Bromodomain containing protein 0.0038 0.047 0.052
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0051 0.0747 0.7743
Brugia malayi MH1 domain containing protein 0.0017 0.004 0.0028
Echinococcus multilocularis mitogen activated protein kinase 0.0051 0.0747 0.0999
Echinococcus multilocularis tumor protein p63 0.0368 0.7366 1
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0128 0.1021
Schistosoma mansoni chromobox protein 0.0153 0.2882 0.47
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0085 0.1464 1
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0209 0.0112
Brugia malayi intermediate filament protein 0.0032 0.0362 0.0396
Entamoeba histolytica hypothetical protein 0.0025 0.0209 0.1291
Brugia malayi Intermediate filament tail domain containing protein 0.0032 0.0362 0.0396
Onchocerca volvulus 0.0054 0.081 0.0664
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0023 0.0157 0.0161
Brugia malayi Bromodomain containing protein 0.0042 0.0557 0.0619
Echinococcus granulosus geminin 0.0173 0.3308 0.4481
Brugia malayi RNA, U transporter 1 0.0082 0.1393 0.1576
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0023 0.0157 0.0161
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0023 0.0157 0.0161
Echinococcus granulosus dna polymerase eta 0.002 0.0099 0.0118
Schistosoma mansoni hypothetical protein 0.0065 0.1038 0.1658
Echinococcus multilocularis GPCR, family 2 0.0065 0.1038 0.1395
Brugia malayi hypothetical protein 0.0236 0.4608 0.5258
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0023 0.0157 0.0203
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.0417 0.2161
Entamoeba histolytica hypothetical protein 0.0037 0.046 0.4221
Echinococcus multilocularis snurportin 1 0.0307 0.6093 0.8268
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0025 0.0209 0.0221
Loa Loa (eye worm) hypothetical protein 0.0133 0.2471 0.2824
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0051 0.0747 0.7743
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0085 0.1464 1
Trichomonas vaginalis chromobox protein, putative 0.0025 0.0209 0.0112
Schistosoma mansoni ran 0.0021 0.0128 0.0155
Schistosoma mansoni peptidase Clp (S14 family) 0.0085 0.1464 0.236
Loa Loa (eye worm) hypothetical protein 0.0362 0.7237 0.8273
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0173 0.0075
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.046 0.0703
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0025 0.0209 0.0112
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0128 0.0157
Toxoplasma gondii hypothetical protein 0.0029 0.0299 0.1278
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0286 0.2742
Echinococcus granulosus Smad4 0.0017 0.004 0.0038
Entamoeba histolytica hypothetical protein 0.0025 0.0209 0.1291
Leishmania major phosphopantetheinyl transferase-like protein 0.0028 0.0276 0.2629
Onchocerca volvulus 0.0025 0.0209 0.0053
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0061 0.0955 0.0864
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0085 0.1464 0.1974
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0209 0.0112
Schistosoma mansoni chromobox protein 0.0153 0.2882 0.47
Echinococcus granulosus L aminoadipate semialdehyde 0.01 0.1783 0.2408
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0085 0.1464 1
Trypanosoma brucei hypothetical protein, conserved 0.0028 0.0276 0.2629
Schistosoma mansoni hypothetical protein 0.0173 0.3308 0.5404
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0085 0.1464 1
Onchocerca volvulus 0.0025 0.0209 0.0053
Plasmodium falciparum cysteine protease ATG4, putative 0.0024 0.0181 0.0396
Trypanosoma cruzi cysteine peptidase, Clan CA, family C54, putative 0.0024 0.0181 0.1595
Onchocerca volvulus Alhambra homolog 0.0035 0.0417 0.0264
Brugia malayi Nuclear hormone receptor-like 1 0.0023 0.0157 0.0161
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0081 0.1374 0.1851
Echinococcus granulosus jumonji domain containing protein 0.0049 0.0703 0.0939
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0099 0.0118
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0638 0.0997
Echinococcus granulosus histone lysine methyltransferase setb 0.0081 0.1374 0.1851
Plasmodium vivax importin-beta 2, putative 0.0029 0.0286 0.1186
Brugia malayi PHD-finger family protein 0.0035 0.0417 0.0459
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.006 0.0938 0.1259
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0028 0.0276 0.1108
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0099 0.0703
Echinococcus granulosus peptidase Clp S14 family 0.0056 0.0851 0.1141
Plasmodium vivax hypothetical protein, conserved 0.0025 0.0209 0.0609
Loa Loa (eye worm) hypothetical protein 0.002 0.0099 0.0113
Brugia malayi steroid hormone receptor 0.0023 0.0157 0.0161
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0205 0.396 0.4527
Echinococcus granulosus muscleblind protein 0.0163 0.3082 0.4174
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0087 0.1509 0.2435
Onchocerca volvulus 0.0087 0.1509 0.1374
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0209 0.0112
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0035 0.0417 0.0632
Onchocerca volvulus Huntingtin homolog 0.0133 0.2471 0.2351
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0023 0.0157 0.0196
Schistosoma mansoni smad1 5 8 and 0.0017 0.004 0.0011
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0209 0.0112
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0747 0.0654
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0023 0.0157 0.0161
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0209 0.0112
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0023 0.0157 0.0161
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0023 0.0157 0.0196
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0209 0.0112
Echinococcus granulosus chromobox protein 2 0.0025 0.0209 0.0268
Schistosoma mansoni hypothetical protein 0.0035 0.0417 0.0632
Brugia malayi hypothetical protein 0.0133 0.2471 0.2811
Echinococcus multilocularis geminin 0.0173 0.3308 0.4481
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0023 0.0157 0.0161
Loa Loa (eye worm) heterochromatin protein 1 0.0153 0.2882 0.3294
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0128 0.045
Brugia malayi photoreceptor-specific nuclear receptor 0.0023 0.0157 0.0161
Echinococcus granulosus methyl CpG binding domain protein 2 0.0019 0.0074 0.0084
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0023 0.0157 0.0196
Loa Loa (eye worm) hypothetical protein 0.0023 0.0157 0.0179
Brugia malayi jmjC domain containing protein 0.0115 0.2078 0.2362
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0029 0.0299 0.0191
Schistosoma mansoni methyl-cpg binding protein mbd 0.0019 0.0074 0.0066
Entamoeba histolytica Ran family GTPase 0.0021 0.0128 0.0341
Schistosoma mansoni smad 0.0017 0.004 0.0011
Echinococcus multilocularis jumonji domain containing protein 0.0049 0.0703 0.0939
Loa Loa (eye worm) hypothetical protein 0.0032 0.0362 0.0414
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0099 0.0703
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0023 0.0157 0.0196
Loa Loa (eye worm) jmjC domain-containing protein 0.0072 0.1194 0.1365
Trichomonas vaginalis chromobox protein, putative 0.0025 0.0209 0.0112
Schistosoma mansoni smad1 5 8 and 0.0017 0.004 0.0011
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0028 0.0276 0.1108
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0286 0.0373
Brugia malayi Cytochrome P450 family protein 0.0023 0.0175 0.0182
Loa Loa (eye worm) helicase 0.0025 0.0209 0.0239
Onchocerca volvulus 0.0032 0.0362 0.0208
Onchocerca volvulus Huntingtin homolog 0.0133 0.2471 0.2351
Plasmodium falciparum heterochromatin protein 1 0.0025 0.0209 0.0609
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0209 0.0112
Trypanosoma cruzi AUT2/APG4/ATG4 cysteine peptidase, putative 0.0061 0.0955 1
Plasmodium falciparum phd finger protein, putative 0.0035 0.0417 0.2161
Trichomonas vaginalis chromobox protein, putative 0.0153 0.2882 0.2811
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0025 0.0209 0.0289
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0017 0.004 0.0038
Trichomonas vaginalis ran, putative 0.0021 0.0128 0.0029
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0023 0.0157 0.0179
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.0175 0.1531
Echinococcus granulosus Chromo domain 0.0025 0.0209 0.0268
Echinococcus granulosus peregrin 0.0038 0.047 0.0623
Echinococcus multilocularis lamin dm0 0.0032 0.0362 0.0475
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0023 0.0157 0.0179
Brugia malayi Importin beta-1 subunit 0.0029 0.0286 0.0309
Loa Loa (eye worm) hypothetical protein 0.0023 0.0157 0.0179
Loa Loa (eye worm) hypothetical protein 0.0016 0.0012 0.0014
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0209 0.0112
Schistosoma mansoni lamin 0.0032 0.0362 0.0541
Trypanosoma brucei cysteine peptidase, Clan CA, family C54, putative 0.0024 0.0181 0.1595
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0065 0.1038 0.1171
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0417 0.2161
Brugia malayi latrophilin 2 splice variant baaae 0.014 0.2608 0.2968
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0099 0.0703
Echinococcus multilocularis smad 0.0017 0.004 0.0038
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0025 0.0209 0.0112
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0051 0.0747 0.7743
Trichomonas vaginalis conserved hypothetical protein 0.0086 0.1477 0.1392
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0173 0.1509
Echinococcus granulosus Peptidase C54 0.0061 0.0955 0.1281
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0115 0.2078 0.2809
Echinococcus multilocularis muscleblind protein 1 0.0163 0.3082 0.4174
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0023 0.0157 0.0196
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0209 0.0112
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0209 0.0112
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0023 0.0157 0.0161
Entamoeba histolytica peptidase, C54 family 0.0024 0.0181 0.0959
Schistosoma mansoni jumonji/arid domain-containing protein 0.0044 0.0614 0.0957
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0128 0.1021
Loa Loa (eye worm) hypothetical protein 0.0236 0.4608 0.5267
Loa Loa (eye worm) hypothetical protein 0.0086 0.1477 0.1689
Loa Loa (eye worm) hypothetical protein 0.0023 0.0157 0.0179
Entamoeba histolytica hypothetical protein 0.0025 0.0209 0.1291
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0086 0.1477 0.1342
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0023 0.0157 0.0196
Trichomonas vaginalis chromobox protein, putative 0.0092 0.1613 0.153
Toxoplasma gondii autophagy-related cysteine peptidase atg4, putative 0.0024 0.0181 0.0396
Echinococcus granulosus importin subunit beta 1 0.0029 0.0286 0.0373

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) = 5.011872336 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp3a4 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 5.011872336 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp1a2 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 12.58925412 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2d6 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 25.11886432 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c9 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 25.11886432 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c19 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
Potency (ADMET) = 5.0119 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Cytochrome P450 3A4. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference
Potency (ADMET) = 5.0119 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Anthrax Lethal Toxin Internalization. (Class of assay: confirmatory) ChEMBL. No reference
Potency (ADMET) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2D6. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (ADMET) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C19. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference
Potency (ADMET) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C9. (Class of assay: confirmatory) [Related pubchem assays: 885, 884, 410 ] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.