Detailed information for compound 1239551

Basic information

Technical information
  • TDR Targets ID: 1239551
  • Name: N-(3-diethylaminopropyl)-2-[(4-methoxyphenyl) amino]quinoline-4-carboxamide
  • MW: 406.521 | Formula: C24H30N4O2
  • H donors: 2 H acceptors: 2 LogP: 4.44 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN(CCCNC(=O)c1cc(Nc2ccc(cc2)OC)nc2c1cccc2)CC
  • InChi: 1S/C24H30N4O2/c1-4-28(5-2)16-8-15-25-24(29)21-17-23(27-22-10-7-6-9-20(21)22)26-18-11-13-19(30-3)14-12-18/h6-7,9-14,17H,4-5,8,15-16H2,1-3H3,(H,25,29)(H,26,27)
  • InChiKey: MLWGTFZLSMWJNM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(3-diethylaminopropyl)-2-[(4-methoxyphenyl)amino]-4-quinolinecarboxamide
  • N-(3-diethylaminopropyl)-2-[(4-methoxyphenyl)amino]cinchoninamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.009 0.0205
Schistosoma mansoni loxhd1 0.0022 0.0011 0.0011
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.0168 0.0168
Trichomonas vaginalis DNA polymerase eta, putative 0.0107 0.0328 0.0924
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0299 0.105 0.3098
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0087 0.0423
Trypanosoma brucei DNA polymerase kappa, putative 0.0107 0.0328 0.7187
Echinococcus multilocularis acetylcholinesterase 0.2688 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0038 0.0047
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0054 0.0132 0.2805
Trypanosoma brucei DNA polymerase kappa, putative 0.0107 0.0328 0.7187
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0039 0.005
Trichomonas vaginalis 6-phosphofructokinase, putative 0.003 0.0039 0.005
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0039 0.0076 0.036
Echinococcus multilocularis lysine specific demethylase 5A 0.0078 0.022 0.022
Echinococcus multilocularis JmjC domain containing protein 4 0.0021 0.0006 0.0006
Echinococcus granulosus tumor protein p63 0.0408 0.1457 0.1457
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0438 0.1569 0.1569
Loa Loa (eye worm) PHD-finger family protein 0.0064 0.0169 0.0169
Mycobacterium tuberculosis Carboxylesterase LipT 0.0454 0.163 1
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.014 0.0454 1
Trichomonas vaginalis glucosylceramidase, putative 0.029 0.1014 0.2995
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0071 0.0147
Brugia malayi 6-phosphofructokinase 0.0109 0.0338 0.0338
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0068 0.0068
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0039 0.141
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0038 0.0047
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0109 0.0338 0.1415
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.3051 0.3051
Brugia malayi Carboxylesterase family protein 0.2688 1 1
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0068 0.1375
Onchocerca volvulus 0.0454 0.163 0.9079
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.0338 0.0952
Loa Loa (eye worm) hypothetical protein 0.0093 0.0278 0.0278
Loa Loa (eye worm) glutaminase 2 0.0908 0.3331 0.3331
Brugia malayi Carboxylesterase family protein 0.0454 0.163 0.163
Echinococcus multilocularis L aminoadipate semialdehyde 0.0093 0.0278 0.0278
Loa Loa (eye worm) hypothetical protein 0.2688 1 1
Echinococcus granulosus para nitrobenzyl esterase 0.0454 0.163 0.163
Echinococcus multilocularis cpg binding protein 0.0064 0.0167 0.0167
Trypanosoma cruzi DNA polymerase kappa, putative 0.0107 0.0328 0.7187
Echinococcus granulosus histone acetyltransferase MYST2 0.0055 0.0133 0.0133
Trypanosoma brucei DNA polymerase kappa, putative 0.0072 0.0199 0.4296
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0154 0.0154
Toxoplasma gondii histone lysine methyltransferase SET1 0.0124 0.0393 1
Schistosoma mansoni hypothetical protein 0.0041 0.0083 0.0083
Echinococcus granulosus carboxylesterase 5A 0.2688 1 1
Echinococcus multilocularis jumonji domain containing protein 0.0089 0.0263 0.0263
Trichomonas vaginalis glucosylceramidase, putative 0.019 0.064 0.1867
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0132 0.033
Loa Loa (eye worm) jmjC domain-containing protein 0.0021 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0072 0.0199 0.0199
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0136 0.0136
Brugia malayi polk-prov protein 0.0072 0.0199 0.0199
Echinococcus granulosus lysine specific demethylase 6a 0.0021 0.0006 0.0006
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0039 0.1258
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0071 0.0147
Treponema pallidum fructose-bisphosphate aldolase 0.0613 0.2225 1
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.021 0.0716 0.0716
Onchocerca volvulus Glucosylceramidase homolog 0.019 0.064 0.3528
Schistosoma mansoni cellular tumor antigen P53 0.006 0.0152 0.0152
Onchocerca volvulus 0.0075 0.0211 0.1119
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0054 0.0132 0.0132
Brugia malayi jmjC domain containing protein 0.021 0.0716 0.0716
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0068 0.0136
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0132 0.0424 0.0424
Mycobacterium ulcerans carboxylesterase, LipT 0.0454 0.163 0.4853
Trypanosoma cruzi target of rapamycin kinase 3 0.0043 0.0091 0.1881
Brugia malayi ImpB/MucB/SamB family protein 0.005 0.0117 0.0117
Brugia malayi PHD-finger family protein 0.0064 0.0169 0.0169
Loa Loa (eye worm) inositol-1 0.0077 0.0219 0.0219
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0613 0.2225 1
Loa Loa (eye worm) mbt repeat family protein 0.0048 0.0108 0.0108
Trichomonas vaginalis chromobox protein, putative 0.007 0.0191 0.0508
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.003 0.0039 0.0056
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0039 0.005
Trypanosoma cruzi DNA polymerase kappa, putative 0.0107 0.0328 0.7187
Brugia malayi Doublecortin family protein 0.0022 0.0011 0.0011
Trichomonas vaginalis glucosylceramidase, putative 0.019 0.064 0.1867
Trypanosoma brucei DNA polymerase kappa, putative 0.0107 0.0328 0.7187
Onchocerca volvulus 0.0031 0.0044 0.0182
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0613 0.2225 0.6657
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0054 0.0132 0.2805
Echinococcus multilocularis tumor protein p63 0.0408 0.1457 0.1457
Leishmania major ATP-dependent phosphofructokinase 0.0109 0.0338 0.7398
Loa Loa (eye worm) hypothetical protein 0.0021 0.0006 0.0006
Plasmodium falciparum histone acetyltransferase GCN5 0.0083 0.024 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0102 0.024
Echinococcus granulosus lipoxygenase domain containing protein 0.0022 0.0011 0.0011
Schistosoma mansoni neuroligin 3 (S09 family) 0.0454 0.163 0.163
Loa Loa (eye worm) hypothetical protein 0.0022 0.0011 0.0011
Trypanosoma cruzi DNA polymerase kappa, putative 0.0107 0.0328 0.7187
Giardia lamblia Transcriptional regulator, Sir2 family 0.0052 0.0123 0.0436
Giardia lamblia Fructose-bisphosphate aldolase 0.0613 0.2225 1
Echinococcus granulosus lysine specific demethylase 5A 0.0081 0.0232 0.0232
Echinococcus granulosus JmjC domain containing protein 4 0.0021 0.0006 0.0006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.005 0.0083
Brugia malayi Ets-domain containing protein 0.0087 0.0253 0.0253
Trichomonas vaginalis glucosylceramidase, putative 0.019 0.064 0.1867
Loa Loa (eye worm) hypothetical protein 0.0454 0.163 0.163
Plasmodium vivax hypothetical protein, conserved 0.0064 0.0169 0.6216
Trypanosoma brucei DNA polymerase kappa, putative 0.0049 0.0111 0.2333
Toxoplasma gondii phosphofructokinase domain-containing protein 0.003 0.0039 0.0852
Schistosoma mansoni lipoxygenase 0.0132 0.0424 0.0424
Trypanosoma brucei unspecified product 0.0035 0.0058 0.116
Trichomonas vaginalis glucosylceramidase, putative 0.029 0.1014 0.2995
Loa Loa (eye worm) glutaminase 0.0908 0.3331 0.3331
Entamoeba histolytica acetyltransferase, GNAT family 0.0083 0.024 0.097
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0068 0.1375
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.0168 0.0168
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0308 0.1083 0.1083
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.008 0.0173
Echinococcus granulosus PHD finger protein rhinoceros 0.0064 0.0169 0.0169
Echinococcus multilocularis carboxylesterase 5A 0.2688 1 1
Entamoeba histolytica transcription factor BTF3, putative 0.0038 0.0071 0.0203
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0087 0.0253 0.0253
Echinococcus granulosus cpg binding protein 0.0064 0.0167 0.0167
Loa Loa (eye worm) 6-phosphofructokinase 0.0109 0.0338 0.0338
Schistosoma mansoni 6-phosphofructokinase 0.0109 0.0338 0.0338
Loa Loa (eye worm) hypothetical protein 0.0454 0.163 0.163
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0077 0.0219 0.0593
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.008 0.0173
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0026 0.0025 0.0414
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0038 0.0048
Loa Loa (eye worm) hypothetical protein 0.006 0.0154 0.0154
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0299 0.105 0.6383
Schistosoma mansoni hypothetical protein 0.0373 0.1326 0.1326
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0109 0.0338 0.1939
Trichomonas vaginalis bromodomain-containing protein, putative 0.0091 0.0268 0.0742
Schistosoma mansoni gliotactin 0.0454 0.163 0.163
Brugia malayi mbt repeat family protein 0.0048 0.0108 0.0108
Brugia malayi hypothetical protein 0.0022 0.0011 0.0011
Echinococcus multilocularis PHD finger protein rhinoceros 0.0064 0.0169 0.0169
Echinococcus granulosus flap endonuclease 1 0.0026 0.0027 0.0027
Schistosoma mansoni acetylcholinesterase 0.0454 0.163 0.163
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0054 0.0132 0.0132
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.014 0.0454 0.1946
Trypanosoma cruzi DNA polymerase eta, putative 0.005 0.0117 0.2462
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0132 0.033
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0136 0.0136
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.008 0.0173
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0069 0.0188 0.1007
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0037 0.0068 0.1375
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0026 0.0027 0.0534
Schistosoma mansoni hypothetical protein 0.0373 0.1326 0.1326
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0069 0.0188 0.1578
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0454 0.163 1
Loa Loa (eye worm) carboxylesterase 0.0454 0.163 0.163
Trypanosoma brucei DNA polymerase kappa, putative 0.0049 0.0111 0.2333
Trypanosoma brucei DNA polymerase kappa, putative 0.0064 0.0169 0.3634
Schistosoma mansoni hypothetical protein 0.0291 0.102 0.102
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0076 0.016
Brugia malayi beta-NAC-like protein 0.0038 0.0071 0.0071
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0055 0.0133 0.0133
Brugia malayi acetyltransferase, GNAT family protein 0.0308 0.1083 0.1083
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0077 0.0219 0.0593
Schistosoma mansoni jumonji/arid domain-containing protein 0.0081 0.0232 0.0232
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0454 0.163 0.163
Echinococcus multilocularis jumonji domain containing 1A 0.0021 0.0006 0.0006
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0087 0.0194
Trypanosoma brucei DNA polymerase IV, putative 0.0107 0.0328 0.7187
Mycobacterium ulcerans glutaminase 0.0908 0.3331 1
Echinococcus multilocularis transcription factor btf3 0.0038 0.0071 0.0071
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.029 0.1014 0.1014
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0026 0.0027 0.0456
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0454 0.163 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0072 0.0199 0.4296
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.0338 0.0952
Brugia malayi Ets-domain containing protein 0.0087 0.0253 0.0253
Echinococcus granulosus acetylcholinesterase 0.2688 1 1
Plasmodium vivax multidomain scavenger receptor, putative 0.0022 0.0011 0.02
Brugia malayi glutaminase DH11.1 0.0908 0.3331 0.3331
Echinococcus granulosus transcription factor btf3 0.0038 0.0071 0.0071
Schistosoma mansoni chromatin regulatory protein sir2 0.0052 0.0123 0.0123
Entamoeba histolytica phosphofructokinase, putative 0.0109 0.0338 0.1415
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0037 0.0068 0.0187
Schistosoma mansoni chromobox protein 0.007 0.0191 0.0191
Toxoplasma gondii PHD-finger domain-containing protein 0.0021 0.0007 0.0025
Loa Loa (eye worm) hypothetical protein 0.0064 0.0168 0.0168
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0023 0.0013 0.0153
Echinococcus multilocularis dna polymerase eta 0.005 0.0117 0.0117
Schistosoma mansoni phosphatidylserine receptor 0.0021 0.0006 0.0006
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0054 0.0132 0.2805
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0077 0.0219 0.5496
Schistosoma mansoni hypothetical protein 0.0058 0.0146 0.0146
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0052 0.0123 0.0302
Echinococcus multilocularis geminin 0.0373 0.1326 0.1326
Echinococcus granulosus chromobox protein 1 0.007 0.0191 0.0191
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0083 0.0083
Trichomonas vaginalis glucosylceramidase, putative 0.019 0.064 0.1867
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0021 0.0007 0.0007
Echinococcus granulosus SAM and MBT domain containing protein 0.0048 0.0108 0.0108
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0054 0.0132 0.2805
Schistosoma mansoni myelin transcription factor 1 myt1 0.0055 0.0133 0.0133
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0613 0.2225 0.6657
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0052 0.0123 0.0302
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.005 0.0117 0.0117
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0033 0.003
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0107 0.0328 0.0924
Onchocerca volvulus 0.0498 0.1795 1
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0077 0.0219 1
Echinococcus multilocularis histone acetyltransferase MYST2 0.0055 0.0133 0.0133
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.003 0.0039 0.0057
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0033 0.003
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0026 0.0027 0.0528
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0109 0.0338 0.3038
Trichomonas vaginalis glucosylceramidase, putative 0.019 0.064 0.1867
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0091 0.0268 0.6771
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0061 0.0115
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0108 0.0108
Brugia malayi Bromodomain containing protein 0.0072 0.0197 0.0197
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0454 0.163 0.163
Loa Loa (eye worm) doublecortin family protein 0.0022 0.0011 0.0011
Echinococcus granulosus phd:f box containing protein 0.0021 0.0006 0.0006
Echinococcus granulosus GA binding protein alpha chain 0.0087 0.0253 0.0253
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0308 0.1083 0.1083
Plasmodium vivax hypothetical protein, conserved 0.0025 0.0021 0.0563
Echinococcus granulosus BC026374 protein S09 family 0.0454 0.163 0.163
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0054 0.0132 0.2805
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0026 0.0027 0.0456
Leishmania major NAD dependent deacetylase, putative,transcriptional regulator, Sir2 family protein, nicotinic acid mononucleotide 5,6-dimethylbe 0.0052 0.0123 0.2596
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0049 0.0079
Brugia malayi CXXC zinc finger family protein 0.006 0.0154 0.0154
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0024 0.0019 0.0019
Trichomonas vaginalis glucosylceramidase, putative 0.019 0.064 0.1867
Schistosoma mansoni hypothetical protein 0.0858 0.3142 0.3142
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0091 0.0268 1
Echinococcus multilocularis BC026374 protein (S09 family) 0.0454 0.163 0.163
Loa Loa (eye worm) hypothetical protein 0.006 0.0152 0.0152
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.008 0.0173
Brugia malayi jmjC domain containing protein 0.0021 0.0006 0.0006
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0024 0.0019 0.0019
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0021 0.0007 0.0007
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.009 0.0205
Trypanosoma brucei Silent information regulator 2 related protein 3 0.0052 0.0123 0.2596
Loa Loa (eye worm) hypothetical protein 0.0041 0.0083 0.0083
Plasmodium falciparum LCCL domain-containing protein 0.0022 0.0011 0.0224
Trichomonas vaginalis inositol monophosphatase, putative 0.0077 0.0219 0.0593
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.008 0.0173
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0136 0.0136
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0454 0.163 0.163
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0048 0.0108 0.0542
Loa Loa (eye worm) hypothetical protein 0.0454 0.163 0.163
Echinococcus granulosus jumonji domain containing 1A 0.0021 0.0006 0.0006
Leishmania major DNA polymerase eta, putative 0.005 0.0117 0.2462
Trichomonas vaginalis glutaminase, putative 0.0908 0.3331 1
Onchocerca volvulus 0.0454 0.163 0.9079
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0052 0.0123 0.2596
Schistosoma mansoni rab6-interacting 0.0022 0.0011 0.0011
Brugia malayi F/Y-rich N-terminus family protein 0.0042 0.0085 0.0085
Echinococcus granulosus lipoxygenase domain containing protein 0.0022 0.0011 0.0011
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.005 0.0117 0.0117
Trypanosoma brucei unspecified product 0.0035 0.0058 0.116
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0071 0.0147
Trypanosoma brucei transcription factor BTF3, putative 0.0038 0.0071 0.1451
Loa Loa (eye worm) acetylcholinesterase 1 0.2688 1 1
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.0039 1
Schistosoma mansoni gabp alpha 0.0087 0.0253 0.0253
Loa Loa (eye worm) acetyltransferase 0.0308 0.1083 0.1083
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0068 0.1375
Trichomonas vaginalis flap endonuclease-1, putative 0.0026 0.0027 0.0012
Schistosoma mansoni cpg binding protein 0.0064 0.0167 0.0167
Onchocerca volvulus 0.0454 0.163 0.9079
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.014 0.0454 1
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0025 0.0021 0.0631
Trypanosoma brucei DNA polymerase kappa, putative 0.0107 0.0328 0.7187
Trichomonas vaginalis spcc417.12 protein, putative 0.0454 0.163 0.486
Trichomonas vaginalis glucosylceramidase, putative 0.029 0.1014 0.2995
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0021 0.0007 0.0022
Schistosoma mansoni jumonji/arid domain-containing protein 0.0081 0.0232 0.0232
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0189 0.0636 0.0636
Echinococcus multilocularis transcription factor Dp 1 0.0081 0.0233 0.0233
Trichomonas vaginalis glucosylceramidase, putative 0.019 0.064 0.1867
Echinococcus granulosus geminin 0.0373 0.1326 0.1326
Onchocerca volvulus Alhambra homolog 0.0064 0.0169 0.0884
Plasmodium vivax basic transcription factor 3b, putative 0.0038 0.0071 0.2484
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0068 0.0136
Echinococcus granulosus jumonji domain containing protein 0.0089 0.0263 0.0263
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.0168 0.0168
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0037 0.0068 0.0187
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0064 0.0168 0.4185
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0093 0.0278 0.0278
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.005 0.0117 0.0117
Echinococcus multilocularis neuroligin 0.0454 0.163 0.163
Schistosoma mansoni hypothetical protein 0.0021 0.0007 0.0007
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0048 0.0108 0.0108
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.008 0.0173
Echinococcus granulosus Polycystic kidney disease protein 0.0022 0.0011 0.0011
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.2688 1 1
Trypanosoma brucei DNA polymerase IV, putative 0.0093 0.0276 0.6015
Trypanosoma cruzi DNA polymerase kappa, putative 0.0107 0.0328 0.7187
Loa Loa (eye worm) 6-phosphofructokinase 0.0109 0.0338 0.0338
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0068 0.0068
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0065 0.0128
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.014 0.0454 0.0454
Brugia malayi ImpB/MucB/SamB family protein 0.005 0.0117 0.0117
Schistosoma mansoni BC026374 protein (S09 family) 0.0454 0.163 0.163
Echinococcus multilocularis dna polymerase kappa 0.0107 0.0328 0.0328
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0077 0.0219 0.4743
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.021 0.0716 0.0716
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.014 0.0454 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0613 0.2225 0.6657
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0613 0.2225 0.6657
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0052 0.0123 0.0302
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0064 0.0169 0.3634
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0054 0.0132 0.0479
Brugia malayi Pre-SET motif family protein 0.0438 0.1569 0.1569
Giardia lamblia PHD finger protein 15 0.0064 0.0169 0.0648
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0021 0.0007 0.0025
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0189 0.0636 0.0636
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.014 0.0454 0.0454
Onchocerca volvulus 0.006 0.0154 0.0801
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0613 0.2225 0.6657
Mycobacterium tuberculosis Transcriptional regulatory protein 0.0052 0.0123 0.0597
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0136 0.0136
Echinococcus granulosus histone acetyltransferase KAT2B 0.03 0.1051 0.1051
Trichomonas vaginalis glucosylceramidase, putative 0.02 0.0679 0.1983
Toxoplasma gondii NAC domain-containing protein 0.0038 0.0071 0.1682
Brugia malayi Pre-SET motif family protein 0.0064 0.0168 0.0168
Loa Loa (eye worm) hypothetical protein 0.0037 0.0068 0.0068
Schistosoma mansoni hypothetical protein 0.0064 0.0169 0.0169
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0109 0.0338 0.7398
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0043 0.0091 0.1881
Leishmania major basic transcription factor 3a, putative 0.0038 0.0071 0.1451
Echinococcus granulosus inositol monophosphatase 1 0.0077 0.0219 0.0219
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0613 0.2225 1
Schistosoma mansoni lipoxygenase 0.0092 0.0275 0.0275
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.009 0.0205
Loa Loa (eye worm) hypothetical protein 0.0055 0.0133 0.0133
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0136 0.0136
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0091 0.0268 0.0742
Loa Loa (eye worm) hypothetical protein 0.011 0.0341 0.0341
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0077 0.0219 0.4743
Mycobacterium leprae Probable NAD-dependent deacetylase NpdA (Regulatory protein SIR2 homolog) 0.0035 0.0061 0.0331
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.014 0.0454 1
Schistosoma mansoni ets-related 0.0263 0.0914 0.0914
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0068 0.0136
Toxoplasma gondii phosphofructokinase PFKII 0.003 0.0039 0.0852
Schistosoma mansoni DNA polymerase eta 0.005 0.0117 0.0117
Loa Loa (eye worm) histone methyltransferase 0.0021 0.0007 0.0007
Echinococcus granulosus chromobox protein 1 0.007 0.0191 0.0191
Schistosoma mansoni glutaminase 0.0908 0.3331 0.3331
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.014 0.0454 0.0454
Schistosoma mansoni jumonji domain containing protein 0.0021 0.0006 0.0006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0038 0.0048
Schistosoma mansoni rab6-interacting 0.0022 0.0011 0.0011
Onchocerca volvulus 0.0093 0.0278 0.1494
Echinococcus granulosus dnaJ subfamily B 0.0858 0.3142 0.3142
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0068 0.0068
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0043 0.0091 0.1881
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.003 0.004 0.0861
Toxoplasma gondii target of rapamycin (TOR), putative 0.004 0.008 0.1904
Brugia malayi jmjC domain containing protein 0.0081 0.0232 0.0232
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0064 0.0169 0.0169
Echinococcus multilocularis chromobox protein 1 0.007 0.0191 0.0191
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0037 0.0068 0.0068
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0154 0.0154
Echinococcus granulosus dna polymerase kappa 0.0107 0.0328 0.0328
Plasmodium falciparum flap endonuclease 1 0.0026 0.0027 0.0875
Echinococcus granulosus ubiquitin specific protease 41 0.0037 0.0068 0.0068
Echinococcus multilocularis RUN 0.0022 0.0011 0.0011
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0026 0.0027 0.0534
Echinococcus granulosus neuroligin 0.0454 0.163 0.163
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.006 0.0155 0.0155
Entamoeba histolytica hypothetical protein 0.0026 0.0027 0.0001
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0055 0.0133 0.0133
Trypanosoma brucei DNA polymerase kappa, putative 0.0107 0.0328 0.7187
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0068 0.0068
Echinococcus multilocularis peregrin 0.0072 0.0197 0.0197
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0038 0.0048
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0087 0.0194
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0076 0.016
Onchocerca volvulus 0.0454 0.163 0.9079
Loa Loa (eye worm) hypothetical protein 0.2688 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0107 0.0328 0.7187
Schistosoma mansoni flap endonuclease-1 0.0024 0.0017 0.0017
Brugia malayi PHD-finger family protein 0.0024 0.002 0.002
Mycobacterium ulcerans NAD-dependent deacetylase 0.0052 0.0123 0.029
Toxoplasma gondii PHD-finger domain-containing protein 0.0064 0.0169 0.4209
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.005 0.0117 0.0117
Loa Loa (eye worm) hypothetical protein 0.0454 0.163 0.163
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0052 0.0123 0.2596
Loa Loa (eye worm) jmjC domain-containing protein 0.0021 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0074 0.0206 0.0206
Trypanosoma brucei DNA polymerase kappa, putative 0.0049 0.0111 0.2333
Schistosoma mansoni 6-phosphofructokinase 0.0109 0.0338 0.0338
Mycobacterium ulcerans DNA polymerase IV 0.0107 0.0328 0.0912
Trypanosoma brucei DNA polymerase kappa, putative 0.0107 0.0328 0.7187
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.009 0.0205
Brugia malayi jmjC domain containing protein 0.0021 0.0006 0.0006
Loa Loa (eye worm) flap endonuclease-1 0.0026 0.0027 0.0027
Echinococcus multilocularis lipoxygenase domain containing protein 0.0022 0.0011 0.0011
Echinococcus multilocularis flap endonuclease 1 0.0026 0.0027 0.0027
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0039 0.005
Brugia malayi jmjC domain containing protein 0.0021 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0454 0.163 0.163
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0039 0.005
Schistosoma mansoni hypothetical protein 0.0022 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0048 0.0108 0.0108
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.0039 1
Echinococcus multilocularis dnaJ subfamily B 0.0858 0.3142 0.3142
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0054 0.0132 0.0132
Loa Loa (eye worm) hypothetical protein 0.005 0.0117 0.0117
Loa Loa (eye worm) heterochromatin protein 1 0.007 0.0191 0.0191
Loa Loa (eye worm) carboxylesterase 0.0454 0.163 0.163
Mycobacterium ulcerans 6-phosphofructokinase 0.0109 0.0338 0.0941
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0613 0.2225 0.6657
Trichomonas vaginalis glucosylceramidase, putative 0.029 0.1014 0.2995
Leishmania major phosphopantetheinyl transferase-like protein 0.0026 0.0027 0.0461
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0054 0.0132 0.0479
Loa Loa (eye worm) hypothetical protein 0.0039 0.0076 0.0076
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0039 0.005
Trichomonas vaginalis chromobox protein, putative 0.007 0.0191 0.0508
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0038 0.0072 0.0072
Trypanosoma brucei DNA polymerase IV, putative 0.0107 0.0328 0.7187
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0026 0.0027 0.0884
Entamoeba histolytica phosphofructokinase, putative 0.0109 0.0338 0.1415
Schistosoma mansoni chromobox protein 0.007 0.0191 0.0191
Echinococcus granulosus 6 phosphofructokinase 0.0109 0.0338 0.0338
Onchocerca volvulus 0.0048 0.0108 0.0542
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0039 0.1258
Trypanosoma brucei DNA polymerase kappa, putative 0.0107 0.0328 0.7187
Toxoplasma gondii 6-phosphofructokinase 0.003 0.0039 0.0852
Echinococcus multilocularis ubiquitin specific protease 41 0.0037 0.0068 0.0068
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0613 0.2225 0.6657
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.009 0.0205
Brugia malayi Carboxylesterase family protein 0.0454 0.163 0.163
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.005 0.0083
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0064 0.0169 0.0887
Loa Loa (eye worm) hypothetical protein 0.0024 0.002 0.002
Plasmodium vivax flap endonuclease 1, putative 0.0026 0.0027 0.078
Brugia malayi mbt repeat family protein 0.0048 0.0108 0.0108
Echinococcus multilocularis lipoxygenase domain containing protein 0.0022 0.0011 0.0011
Loa Loa (eye worm) carboxylesterase 0.2688 1 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0006 0.0006
Giardia lamblia DINP protein human, muc B family 0.0064 0.0169 0.0648
Loa Loa (eye worm) jmjC domain-containing protein 0.0021 0.0006 0.0006
Toxoplasma gondii PHD-finger domain-containing protein 0.0064 0.0169 0.4209
Brugia malayi hypothetical protein 0.0022 0.0011 0.0011
Brugia malayi AF-10 protein 0.0021 0.0007 0.0007
Schistosoma mansoni terminal deoxycytidyl transferase 0.005 0.0117 0.0117
Brugia malayi hypothetical protein 0.0454 0.163 0.163
Loa Loa (eye worm) CXXC zinc finger family protein 0.006 0.0154 0.0154
Trypanosoma brucei hypothetical protein, conserved 0.0026 0.0027 0.0461
Brugia malayi phosphofructokinase 0.0109 0.0338 0.0338
Loa Loa (eye worm) hypothetical protein 0.0454 0.163 0.163
Echinococcus granulosus histone acetyltransferase KAT2B 0.0091 0.0268 0.0268
Echinococcus granulosus acetylcholinesterase 0.2688 1 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0081 0.0232 0.0232
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0108 0.0108
Schistosoma mansoni phd/f-box containing protein 0.0021 0.0006 0.0006
Onchocerca volvulus 0.006 0.0152 0.079
Onchocerca volvulus 0.0454 0.163 0.9079
Leishmania major DNA polymerase kappa, putative 0.0064 0.0169 0.3634
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.014 0.0454 0.0454
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0038 0.0047
Plasmodium falciparum transcriptional regulatory protein sir2a 0.0052 0.0123 0.4981
Schistosoma mansoni cpg binding protein 0.0064 0.0167 0.0167
Trypanosoma brucei DNA polymerase kappa, putative 0.0107 0.0328 0.7187
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0049 0.0079
Echinococcus granulosus L aminoadipate semialdehyde 0.0093 0.0278 0.0278
Trypanosoma brucei unspecified product 0.0093 0.0276 0.6015
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0613 0.2225 0.6657
Entamoeba histolytica hypothetical protein 0.0038 0.0071 0.0203
Echinococcus granulosus microtubule associated protein 2 0.0833 0.3051 0.3051
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0091 0.0268 0.6771
Schistosoma mansoni protein phosphatase 2C 0.0021 0.0006 0.0006
Toxoplasma gondii histone deacetylase SIR2 0.0052 0.0123 0.3009
Loa Loa (eye worm) fli-1 protein 0.0263 0.0914 0.0914
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0109 0.0338 0.7398
Brugia malayi Carboxylesterase family protein 0.0454 0.163 0.163
Loa Loa (eye worm) hypothetical protein 0.0022 0.0011 0.0011
Echinococcus granulosus transcription factor Dp 1 0.0081 0.0233 0.0233
Brugia malayi jmjC domain containing protein 0.0021 0.0006 0.0006
Plasmodium vivax NAD-dependent deacetylase, putative 0.0052 0.0123 0.4443
Schistosoma mansoni inositol monophosphatase 0.0077 0.0219 0.0219
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0454 0.163 0.486
Trichomonas vaginalis glucosylceramidase, putative 0.02 0.0679 0.1983
Brugia malayi chromobox protein homolog 3 0.0039 0.0076 0.0076
Schistosoma mansoni jumonji domain containing protein 0.0167 0.0554 0.0554
Brugia malayi Inositol-1 0.0077 0.0219 0.0219
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.0338 0.0952
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0136 0.0136
Plasmodium falciparum phd finger protein, putative 0.0064 0.0169 0.6968
Echinococcus multilocularis Polycystic kidney disease protein 0.0022 0.0011 0.0011
Schistosoma mansoni inositol monophosphatase 0.0077 0.0219 0.0219
Echinococcus multilocularis SAM and MBT domain containing protein 0.0048 0.0108 0.0108
Mycobacterium tuberculosis Conserved hypothetical protein 0.005 0.0117 0.0559
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0136 0.0136
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.014 0.0454 0.0454
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0037 0.0068 0.0068
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0132 0.0424 0.0424
Loa Loa (eye worm) MBCTL1 0.0055 0.0133 0.0133
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0064 0.0168 0.0168
Echinococcus multilocularis inositol monophosphatase 1 0.0077 0.0219 0.0219
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.029 0.1014 0.1014
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0054 0.0132 0.2805
Brugia malayi Fli-1 protein 0.0263 0.0914 0.0914
Echinococcus multilocularis phd:f box containing protein 0.0021 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0064 0.0169 0.0169
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0039 0.005
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0037 0.0068 0.0068
Loa Loa (eye worm) jmjC domain-containing protein 0.0132 0.0425 0.0425
Trypanosoma cruzi transcription factor btf3, putative 0.0038 0.0071 0.1451
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0943 0.3462 0.3462
Loa Loa (eye worm) phosphatidylinositol 3 0.0054 0.0132 0.0132
Trichomonas vaginalis set domain proteins, putative 0.0498 0.1795 0.5356
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.005 0.0083
Schistosoma mansoni cpg binding protein 0.006 0.0154 0.0154
Echinococcus granulosus polycomb protein SCMH1 0.0048 0.0108 0.0108
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0054 0.0132 0.0132
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0026 0.0027 0.0788
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.3051 0.3051
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0077 0.0219 0.0581
Giardia lamblia GTOR 0.0054 0.0132 0.0479
Brugia malayi 6-phosphofructokinase 0.0109 0.0338 0.0338
Plasmodium vivax SET domain protein, putative 0.0064 0.0168 0.618
Brugia malayi Heterochromatin protein 1 0.007 0.0191 0.0191
Giardia lamblia Histone acetyltransferase GCN5 0.0083 0.024 0.097
Echinococcus multilocularis GA binding protein alpha chain 0.0087 0.0253 0.0253
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0038 0.0048
Entamoeba histolytica phosphofructokinase, putative 0.0109 0.0338 0.1415
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0093 0.0278 0.0278
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0021 0.0007 0.0022
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.008 0.0173
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0075 0.0211 0.0211
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0154 0.0154
Trypanosoma brucei DNA polymerase eta, putative 0.005 0.0117 0.2462
Loa Loa (eye worm) hypothetical protein 0.0031 0.0044 0.0044
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0077 0.0219 0.4743
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0454 0.163 0.163
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0021 0.0006 0.0006
Loa Loa (eye worm) ICD-1 protein 0.0038 0.0071 0.0071
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.003 0.0039 0.0057
Brugia malayi Flap endonuclease-1 0.0026 0.0027 0.0027
Echinococcus granulosus RUN 0.0022 0.0011 0.0011
Plasmodium falciparum basic transcription factor 3b, putative 0.0038 0.0071 0.2785
Loa Loa (eye worm) hypothetical protein 0.0454 0.163 0.163
Echinococcus multilocularis polycomb protein SCMH1 0.0048 0.0108 0.0108
Echinococcus multilocularis lysine specific demethylase 6a 0.0021 0.0006 0.0006
Trichomonas vaginalis glucosylceramidase, putative 0.029 0.1014 0.2995
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0136 0.0136
Schistosoma mansoni mixed-lineage leukemia protein mll 0.013 0.0416 0.0416
Schistosoma mansoni transcription factor btf3 0.0038 0.0071 0.0071
Echinococcus multilocularis chromobox protein 1 0.007 0.0191 0.0191
Echinococcus granulosus dna polymerase eta 0.005 0.0117 0.0117
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0132 0.033
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.0338 0.0952
Echinococcus multilocularis 6 phosphofructokinase 0.0109 0.0338 0.0338
Echinococcus multilocularis acetylcholinesterase 0.2688 1 1
Schistosoma mansoni polycystin 1-related 0.0022 0.0011 0.0011
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0052 0.0123 0.0436
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0299 0.105 1
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0039 0.141
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0055 0.0133 0.0133
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0026 0.0027 0.0456
Trypanosoma cruzi transcription factor btf3, putative 0.0038 0.0071 0.1451
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0136 0.0136
Mycobacterium ulcerans DNA polymerase IV 0.0107 0.0328 0.0912
Loa Loa (eye worm) phosphofructokinase 0.0109 0.0338 0.0338
Entamoeba histolytica deoxycytidyl transferase, putative 0.005 0.0117 0.0409
Echinococcus multilocularis para nitrobenzyl esterase 0.0454 0.163 0.163
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0077 0.0219 0.4743
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0454 0.163 0.163
Trichomonas vaginalis glucosylceramidase, putative 0.029 0.1014 0.2995
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0077 0.0219 0.0874
Echinococcus granulosus peregrin 0.0072 0.0197 0.0197
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0064 0.0168 0.0168
Echinococcus granulosus histone lysine methyltransferase setb 0.0064 0.0168 0.0168
Brugia malayi Carboxylesterase family protein 0.0454 0.163 0.163

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 2.8184 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 4.4668 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 6.3096 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 13.1154 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 18.3564 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 70.7946 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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