TDR Targets

Basic information

Technical information

TDR Targets ID: 1239710
Name: 2-amino-N-[(4-methoxyphenyl)methyl]pyrimidine -5-sulfonamide
MW: 294.33 | Formula: C12H14N4O3S
H donors: 2 H acceptors: 4 LogP: 0.29 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(cc1)CNS(=O)(=O)c1cnc(nc1)N
InChi: 1S/C12H14N4O3S/c1-19-10-4-2-9(3-5-10)6-16-20(17,18)11-7-14-12(13)15-8-11/h2-5,7-8,16H,6H2,1H3,(H2,13,14,15)
InChiKey: DBABZQAUZXGHGS-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-amino-N-[(4-methoxyphenyl)methyl]-5-pyrimidinesulfonamide
2-amino-N-(4-methoxybenzyl)pyrimidine-5-sulfonamide
G830-0861
NCGC00134774-01

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	lamin A/C	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus granulosus	cytoplasmic intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus granulosus	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Onchocerca volvulus		Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus granulosus	intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Onchocerca volvulus		Get druggable targets OG5_128723	All targets in OG5_128723
Brugia malayi	intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus multilocularis	musashi	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma japonicum	expressed protein	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma japonicum	Intermediate filament protein ifa-1, putative	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus granulosus	lamin dm0	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma mansoni	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Brugia malayi	Intermediate filament tail domain containing protein	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma mansoni	intermediate filament proteins	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus multilocularis	cytoplasmic intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma japonicum	Lamin-C, putative	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus multilocularis	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma japonicum	ko:K07611 lamin, putative	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus multilocularis	lamin dm0	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma mansoni	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma japonicum	expressed protein	Get druggable targets OG5_128723	All targets in OG5_128723

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Leishmania major	protein kinase, putative	0.0034	0.0342	1
Loa Loa (eye worm)	AGC/DMPK/GEK protein kinase	0.0157	0.2964	0.2964
Loa Loa (eye worm)	hypothetical protein	0.0157	0.2964	0.2964
Schistosoma mansoni	intermediate filament proteins	0.0033	0.0321	0.0079
Trypanosoma brucei	protein kinase, putative	0.0034	0.0342	0.0074
Trichomonas vaginalis	AGC family protein kinase	0.0034	0.0342	0.0074
Plasmodium falciparum	RAC-beta serine/threonine protein kinase	0.0305	0.6097	1
Trypanosoma cruzi	Serine/threonine-protein kinase NEK17, putative	0.0034	0.0342	0.0111
Schistosoma mansoni	serine/threonine protein kinase	0.0157	0.2964	0.4166
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	0.0157	0.2964	0.2964
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0157	0.2964	0.4166
Entamoeba histolytica	hypothetical protein	0.0034	0.0342	0.0074
Trichomonas vaginalis	AGC family protein kinase	0.0034	0.0342	0.0074
Echinococcus granulosus	protein kinase c epsilon type	0.0157	0.2964	0.4166
Brugia malayi	PH domain containing protein	0.003	0.027	0.027
Echinococcus granulosus	Protein kinase C brain isozyme	0.0157	0.2964	0.4166
Trichomonas vaginalis	AGC family protein kinase	0.0034	0.0342	0.0074
Plasmodium vivax	rac-beta serine/threonine protein kinase, putative	0.0305	0.6097	1
Brugia malayi	probable spectrin beta chain	0.003	0.027	0.027
Loa Loa (eye worm)	hypothetical protein	0.003	0.027	0.027
Loa Loa (eye worm)	hypothetical protein	0.003	0.027	0.027
Entamoeba histolytica	protein kinase, putative	0.0034	0.0342	0.0074
Schistosoma mansoni	serine/threonine kinase	0.0157	0.2964	0.4166
Trichomonas vaginalis	AGC family protein kinase	0.0034	0.0342	0.0074
Loa Loa (eye worm)	intermediate filament protein	0.0033	0.0321	0.0321
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.0458	0.936	0.936
Brugia malayi	PH domain containing protein	0.003	0.027	0.027
Trichomonas vaginalis	AGC family protein kinase	0.0488	1	1
Brugia malayi	GTPase-activator protein for Ras-like GTPase containing protein	0.003	0.027	0.027
Loa Loa (eye worm)	GTP-ase activating protein for Arf containing protein	0.003	0.027	0.027
Schistosoma mansoni	lamin	0.0033	0.0321	0.0079
Brugia malayi	intermediate filament protein	0.0033	0.0321	0.0321
Entamoeba histolytica	protein kinase, putative	0.0488	1	1
Echinococcus granulosus	lamin dm0	0.0033	0.0321	0.0079
Echinococcus multilocularis	serine:threonine protein kinase 38	0.0157	0.2964	0.4166
Echinococcus multilocularis	ribosomal protein s6 kinase beta 1	0.0157	0.2964	0.4166
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	0.0301	0.6025	0.8899
Loa Loa (eye worm)	hypothetical protein	0.003	0.027	0.027
Echinococcus multilocularis	Protein kinase C, brain isozyme	0.0157	0.2964	0.4166
Plasmodium vivax	calcium-dependent protein kinase 7, putative	0.0034	0.0342	0.0123
Schistosoma mansoni	serine/threonine-protein kinase	0.0335	0.6738	1
Echinococcus granulosus	Glutaredoxin protein 5	0.0301	0.6025	0.8899
Brugia malayi	PH domain containing protein	0.003	0.027	0.027
Brugia malayi	Hr1 repeat family protein	0.0157	0.2964	0.2964
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0033	0.0321	0.0321
Echinococcus granulosus	protein kinase c iota type	0.0157	0.2964	0.4166
Brugia malayi	Protein kinase domain containing protein	0.0157	0.2964	0.2964
Brugia malayi	Variant SH3 domain containing protein	0.003	0.027	0.027
Trypanosoma cruzi	Serine/threonine-protein kinase NEK21, putative	0.0034	0.0342	0.0111
Trichomonas vaginalis	AGC family protein kinase	0.0034	0.0342	0.0074
Brugia malayi	PH domain containing protein	0.003	0.027	0.027
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0488	1	1
Onchocerca volvulus		0.0033	0.0321	1
Echinococcus granulosus	nervana 2	0.0301	0.6025	0.8899
Brugia malayi	PH domain containing protein	0.003	0.027	0.027
Brugia malayi	protein kinase C II.	0.0157	0.2964	0.2964
Loa Loa (eye worm)	oxysterol binding protein	0.003	0.027	0.027
Schistosoma mansoni	atypical protein kinase C	0.0157	0.2964	0.4166
Schistosoma mansoni	serine/threonine protein kinase	0.0157	0.2964	0.4166
Loa Loa (eye worm)	AGC/RSK/RSK protein kinase	0.0157	0.2964	0.2964
Brugia malayi	PH domain containing protein	0.003	0.027	0.027
Leishmania major	protein kinase, putative,serine/threonine protein kinase, putative	0.0034	0.0342	1
Trichomonas vaginalis	AGC family protein kinase	0.0157	0.2964	0.2769
Echinococcus granulosus	NDR protein kinase	0.0157	0.2964	0.4166
Loa Loa (eye worm)	GTP-ase activating protein for Arf containing protein	0.003	0.027	0.027
Echinococcus multilocularis	rac serine:threonine kinase	0.0335	0.6738	1
Trichomonas vaginalis	AGC family protein kinase	0.0034	0.0342	0.0074
Schistosoma mansoni	serine/threonine-protein kinase	0.0335	0.6738	1
Trypanosoma cruzi	NIMA-related kinase, putative	0.0034	0.0342	0.0111
Echinococcus multilocularis	musashi	0.0033	0.0321	0.0079
Echinococcus multilocularis	nervana 2	0.0301	0.6025	0.8899
Brugia malayi	GTP-ase activating protein for Arf containing protein	0.003	0.027	0.027
Loa Loa (eye worm)	hypothetical protein	0.003	0.027	0.027
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0034	0.0342	0.0074
Trypanosoma brucei	rac serine-threonine kinase, putative	0.0488	1	1
Trypanosoma cruzi	serine/threonine protein kinase, putative	0.0034	0.0342	0.0111
Trichomonas vaginalis	AGC family protein kinase	0.0187	0.3604	0.3427
Schistosoma mansoni	serine/threonine protein kinase	0.0157	0.2964	0.4166
Echinococcus granulosus	serine threonine protein kinase nrc	0.0305	0.6097	0.901
Entamoeba histolytica	protein kinase 2, putative	0.0305	0.6097	0.5989
Loa Loa (eye worm)	hypothetical protein	0.003	0.027	0.027
Trypanosoma cruzi	Serine/threonine-protein kinase NEK17, putative	0.0034	0.0342	0.0111
Brugia malayi	GTP-ase activating protein for Arf containing protein	0.003	0.027	0.027
Echinococcus multilocularis	protein kinase c epsilon type	0.0157	0.2964	0.4166
Trichomonas vaginalis	AGC family protein kinase	0.0034	0.0342	0.0074
Trichomonas vaginalis	AGC family protein kinase	0.0157	0.2964	0.2769
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0305	0.6097	0.901
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0034	0.0342	0.0074
Loa Loa (eye worm)	uncoordinated protein 104	0.003	0.027	0.027
Loa Loa (eye worm)	hypothetical protein	0.003	0.027	0.027
Trichomonas vaginalis	AGC family protein kinase	0.0488	1	1
Echinococcus granulosus	intermediate filament protein	0.0033	0.0321	0.0079
Trichomonas vaginalis	AGC family protein kinase	0.0034	0.0342	0.0074
Entamoeba histolytica	p21-activated kinase	0.0034	0.0342	0.0074
Trichomonas vaginalis	AGC family protein kinase	0.0034	0.0342	0.0074
Entamoeba histolytica	protein kinase, putative	0.0034	0.0342	0.0074
Trichomonas vaginalis	AGC family protein kinase	0.0034	0.0342	0.0074
Schistosoma mansoni	serine/threonine protein kinase	0.0157	0.2964	0.4166
Entamoeba histolytica	protein kinase, putative	0.0034	0.0342	0.0074
Leishmania major	protein kinase, putative	0.0034	0.0342	1
Brugia malayi	PH domain containing protein	0.003	0.027	0.027
Brugia malayi	Oxysterol-binding protein	0.003	0.027	0.027
Loa Loa (eye worm)	hypothetical protein	0.003	0.027	0.027
Brugia malayi	Dynamin	0.003	0.027	0.027
Loa Loa (eye worm)	AGC/RSK/MSK protein kinase	0.0157	0.2964	0.2964
Echinococcus multilocularis	nervana 2	0.0301	0.6025	0.8899
Trypanosoma cruzi	serine/threonine-protein kinase NRKB, putative	0.0034	0.0342	0.0111
Brugia malayi	Dynamin	0.003	0.027	0.027
Loa Loa (eye worm)	hypothetical protein	0.003	0.027	0.027
Trypanosoma brucei	Serine/threonine-protein kinase NEK21, putative	0.0034	0.0342	0.0074
Loa Loa (eye worm)	hypothetical protein	0.003	0.027	0.027
Brugia malayi	Oxysterol binding protein	0.003	0.027	0.027
Trichomonas vaginalis	AGC family protein kinase	0.0488	1	1
Leishmania major	folate/biopterin transporter, putative	0.0034	0.0342	1
Entamoeba histolytica	protein kinase, putative	0.0157	0.2964	0.2769
Trypanosoma cruzi	NIMA-related kinase, putative	0.0034	0.0342	0.0111
Echinococcus granulosus	ribosomal protein s6 kinase beta 1	0.0157	0.2964	0.4166
Trichomonas vaginalis	serine/threonine-protein kinase sgk, putative	0.0154	0.2892	0.2695
Entamoeba histolytica	protein kinase, putative	0.0458	0.936	0.9342
Echinococcus granulosus	ribosomal protein S6 kinase alpha 3	0.0157	0.2964	0.4166
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	0.0301	0.6025	0.8899
Echinococcus multilocularis	protein kinase c iota type	0.0157	0.2964	0.4166
Brugia malayi	Syntrophin-1	0.003	0.027	0.027
Entamoeba histolytica	hypothetical protein	0.0034	0.0342	0.0074
Schistosoma mansoni	lamin	0.0033	0.0321	0.0079
Brugia malayi	Uncoordinated protein 104	0.003	0.027	0.027
Loa Loa (eye worm)	hypothetical protein	0.003	0.027	0.027
Trypanosoma brucei	serine/threonine-protein kinase NRKB, putative	0.0034	0.0342	0.0074
Giardia lamblia	Kinase, AGC PKA	0.0305	0.6097	0.5
Brugia malayi	Intermediate filament tail domain containing protein	0.0033	0.0321	0.0321
Brugia malayi	PH domain containing protein	0.003	0.027	0.027
Loa Loa (eye worm)	rho-GTPase-activating	0.003	0.027	0.027
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0335	0.6738	1
Brugia malayi	hypothetical protein	0.003	0.027	0.027
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0308	0.0308
Echinococcus multilocularis	ribosomal protein S6 kinase alpha 3	0.0157	0.2964	0.4166
Echinococcus granulosus	serine:threonine protein kinase N2	0.0157	0.2964	0.4166
Trichomonas vaginalis	AGC family protein kinase	0.0034	0.0342	0.0074
Onchocerca volvulus		0.0033	0.0321	1
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0034	0.0342	0.0074
Brugia malayi	Protein kinase domain containing protein	0.0157	0.2964	0.2964
Loa Loa (eye worm)	AGC/NDR protein kinase	0.0157	0.2964	0.2964
Trichomonas vaginalis	AGC family protein kinase	0.0034	0.0342	0.0074
Schistosoma mansoni	serine/threonine protein kinase	0.0157	0.2964	0.4166
Echinococcus multilocularis	Ribosomal protein S6 kinase beta 2	0.0157	0.2964	0.4166
Echinococcus granulosus	lamin	0.0033	0.0321	0.0079
Toxoplasma gondii	protein kinase domain-containing protein	0.0034	0.0342	0.0079
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.003	0.027	0.027
Echinococcus multilocularis	Glutaredoxin protein 5	0.0301	0.6025	0.8899
Trypanosoma brucei	NEK family Serine/threonine-protein kinase, putative	0.0034	0.0342	0.0074
Echinococcus multilocularis	serine threonine protein kinase	0.0157	0.2964	0.4166
Trichomonas vaginalis	AGC family protein kinase	0.0034	0.0342	0.0074
Loa Loa (eye worm)	RhoGEF domain-containing protein	0.003	0.027	0.027
Brugia malayi	TBC domain containing protein	0.003	0.027	0.027
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0157	0.2964	0.4166
Echinococcus granulosus	serine/threonine protein kinase	0.0335	0.6738	1
Trichomonas vaginalis	AGC family protein kinase	0.0488	1	1
Loa Loa (eye worm)	hypothetical protein	0.003	0.027	0.027
Loa Loa (eye worm)	hypothetical protein	0.003	0.027	0.027
Loa Loa (eye worm)	syntrophin-1	0.003	0.027	0.027
Loa Loa (eye worm)	hypothetical protein	0.003	0.027	0.027
Loa Loa (eye worm)	AGC/PKN protein kinase	0.0157	0.2964	0.2964
Loa Loa (eye worm)	hypothetical protein	0.003	0.027	0.027
Brugia malayi	MAX-1A	0.003	0.027	0.027
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0321	0.0321
Echinococcus granulosus	calcium:calmodulin dependent protein kinase	0.0305	0.6097	0.901
Echinococcus multilocularis	serine threonine protein kinase nrc serine threonine protein kinase gad	0.0305	0.6097	0.901
Toxoplasma gondii	AGC kinase	0.0458	0.936	1
Trichomonas vaginalis	AGC family protein kinase	0.0034	0.0342	0.0074
Loa Loa (eye worm)	hypothetical protein	0.003	0.027	0.027
Loa Loa (eye worm)	hypothetical protein	0.003	0.027	0.027
Brugia malayi	PH domain containing protein	0.003	0.027	0.027
Schistosoma mansoni	serine/threonine protein kinase	0.0157	0.2964	0.4166
Echinococcus multilocularis	lamin dm0	0.0033	0.0321	0.0079
Brugia malayi	Plekhf2 protein	0.003	0.027	0.027
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0335	0.6738	0.6647
Trichomonas vaginalis	3-phosphoinositide dependent protein kinase-1, putative	0.0034	0.0342	0.0074
Echinococcus multilocularis	lamin	0.0033	0.0321	0.0079
Loa Loa (eye worm)	PH domain-containing protein	0.003	0.027	0.027
Trichomonas vaginalis	AGC family protein kinase	0.0034	0.0342	0.0074
Trichomonas vaginalis	AGC family protein kinase	0.0034	0.0342	0.0074
Echinococcus granulosus	Ribosomal protein S6 kinase beta 2	0.0157	0.2964	0.4166
Trichomonas vaginalis	AGC family protein kinase	0.0488	1	1
Brugia malayi	Cytohesin 3	0.003	0.027	0.027
Brugia malayi	Cadps2 protein	0.003	0.027	0.027
Trichomonas vaginalis	AGC family protein kinase	0.0034	0.0342	0.0074
Entamoeba histolytica	protein kinase, putative	0.0034	0.0342	0.0074
Trichomonas vaginalis	AGC family protein kinase	0.0034	0.0342	0.0074
Loa Loa (eye worm)	hypothetical protein	0.003	0.027	0.027
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0335	0.6738	0.6647
Brugia malayi	Pleckstrin Homology Domain	0.003	0.027	0.027
Entamoeba histolytica	protein kinase, putative	0.0034	0.0342	0.0074
Loa Loa (eye worm)	hypothetical protein	0.003	0.027	0.027
Trichomonas vaginalis	AGC family protein kinase	0.0488	1	1
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0034	0.0342	0.0111
Trichomonas vaginalis	AGC family protein kinase	0.0034	0.0342	0.0074
Trypanosoma brucei	serine/threonine-protein kinase NrkA	0.0034	0.0342	0.0074
Loa Loa (eye worm)	cytohesin 3	0.003	0.027	0.027
Schistosoma mansoni	serine/threonine protein kinase	0.0157	0.2964	0.4166
Trypanosoma cruzi	Serine/threonine-protein kinase NEK21, putative	0.0034	0.0342	0.0111
Entamoeba histolytica	protein kinase, putative	0.0488	1	1
Leishmania major	rac serine-threonine kinase, putative,protein kinase, putative	0.0034	0.0342	1
Toxoplasma gondii	calcium dependent protein kinase CDPK7	0.0034	0.0342	0.0079
Trichomonas vaginalis	AGC family protein kinase	0.0034	0.0342	0.0074
Brugia malayi	Variant SH3 domain containing protein	0.003	0.027	0.027
Echinococcus granulosus	protein kinase C gamma type	0.0157	0.2964	0.4166
Loa Loa (eye worm)	hypothetical protein	0.003	0.027	0.027
Trypanosoma cruzi	NEK family Serine/threonine-protein kinase, putative	0.0034	0.0342	0.0111
Trichomonas vaginalis	AGC family protein kinase	0.0488	1	1
Brugia malayi	p70 ribosomal S6 kinase beta	0.0458	0.936	0.936
Echinococcus granulosus	nervana 2	0.0301	0.6025	0.8899
Leishmania major	serine/threonine-protein kinase a, putative	0.0034	0.0342	1
Trypanosoma cruzi	Protein kinase B	0.0335	0.6738	1
Trichomonas vaginalis	ribosomal protein S6 kinase, 90kD, polypeptide, putative	0.0034	0.0342	0.0074
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0034	0.0342	0.0074
Trichomonas vaginalis	AGC family protein kinase	0.0157	0.2964	0.2769
Loa Loa (eye worm)	hypothetical protein	0.003	0.027	0.027
Plasmodium falciparum	calcium-dependent protein kinase 7	0.0034	0.0342	0.0123
Loa Loa (eye worm)	Plekhf2 protein	0.003	0.027	0.027

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	= 6.3096 um	PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1326509

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1239710