Detailed information for compound 1240596

Basic information

Technical information
  • TDR Targets ID: 1240596
  • Name: 3a,8b-dihydroxy-1-prop-2-enyl-3H-indeno[2,3-d ]imidazole-2,4-dione
  • MW: 260.245 | Formula: C13H12N2O4
  • H donors: 3 H acceptors: 4 LogP: -0.42 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: C=CCN1C(=O)NC2(C1(O)c1ccccc1C2=O)O
  • InChi: 1S/C13H12N2O4/c1-2-7-15-11(17)14-12(18)10(16)8-5-3-4-6-9(8)13(12,15)19/h2-6,18-19H,1,7H2,(H,14,17)
  • InChiKey: NQIRCSRKAXWQMR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-allyl-3a,8b-dihydroxy-3H-indeno[2,3-d]imidazole-2,4-dione
  • 1-allyl-3a,8b-dihydroxy-3H-indeno[2,3-d]imidazole-2,4-quinone
  • 3-Allyl-3a,8a-dihydroxy-1,3,3a,8a-tetrahydro-indeno[1,2-d]imidazole-2,8-dione
  • BAS 01371038
  • Oprea1_208585
  • ChemDiv1_024053
  • MLS000067757
  • SMR000122385
  • Oprea1_191986
  • A2077/0087291

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens alkaline phosphatase, placental-like 2 Starlite/ChEMBL No references
Homo sapiens glucosidase, alpha Starlite/ChEMBL No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni alpha-glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma japonicum ko:K01077 alkaline phosphatase [EC3.1.3.1], putative Get druggable targets OG5_126976 All targets in OG5_126976
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis alkaline phosphatase, intestinal, gene 2 Get druggable targets OG5_126976 All targets in OG5_126976
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus alkaline phosphatase intestinal gene 2 Get druggable targets OG5_126976 All targets in OG5_126976
Candida albicans alkaline phosphatase Get druggable targets OG5_126976 All targets in OG5_126976
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans vacuolar alkaline phosphatase Get druggable targets OG5_126976 All targets in OG5_126976
Echinococcus multilocularis intestinal type alkaline phosphatase Get druggable targets OG5_126976 All targets in OG5_126976
Echinococcus multilocularis alkaline phosphatase Get druggable targets OG5_126976 All targets in OG5_126976
Loa Loa (eye worm) glycosyl hydrolase family 31 protein Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma mansoni hypothetical protein Get druggable targets OG5_126976 All targets in OG5_126976
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum Lysosomal alpha-glucosidase precursor, putative Get druggable targets OG5_127055 All targets in OG5_127055
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans vacuolar alkaline phosphatase Get druggable targets OG5_126976 All targets in OG5_126976
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus granulosus alkaline phosphatase Get druggable targets OG5_126976 All targets in OG5_126976
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose Get druggable targets OG5_127055 All targets in OG5_127055
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans alkaline phosphatase Get druggable targets OG5_126976 All targets in OG5_126976
Schistosoma mansoni alkaline phosphatase Get druggable targets OG5_126976 All targets in OG5_126976
Brugia malayi Glycosyl hydrolases family 31 protein Get druggable targets OG5_127055 All targets in OG5_127055
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K01187 alpha-glucosidase [EC3.2.1.20], putative Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus granulosus intestinal type alkaline phosphatase Get druggable targets OG5_126976 All targets in OG5_126976
Echinococcus multilocularis lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase Get druggable targets OG5_127055 All targets in OG5_127055
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma mansoni alkaline phosphatase Get druggable targets OG5_126976 All targets in OG5_126976
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus intestinal type alkaline phosphatase 1 Get druggable targets OG5_126976 All targets in OG5_126976
Schistosoma mansoni alpha-glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Onchocerca volvulus Get druggable targets OG5_127055 All targets in OG5_127055
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis intestinal type alkaline phosphatase 1 Get druggable targets OG5_126976 All targets in OG5_126976
Schistosoma japonicum Alkaline phosphatase, tissue-nonspecific isozyme precursor, putative Get druggable targets OG5_126976 All targets in OG5_126976
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0559 0.05
Echinococcus multilocularis cytochrome b5 reductase 4 0.0033 0.0292 0.0231
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0343 0.0463
Loa Loa (eye worm) pyruvate kinase 0.0066 0.1052 0.1716
Entamoeba histolytica type A flavoprotein, putative 0.011 0.2061 1
Leishmania major reductase, putative 0.0033 0.0292 0.0379
Onchocerca volvulus 0.0114 0.2142 1
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0026 0.0132 0.0255
Brugia malayi Cytochrome P450 family protein 0.006 0.0911 0.1487
Trichomonas vaginalis NADPH fad oxidoreductase, putative 0.0255 0.5377 0.8766
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0559 0.05
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0343 0.0612
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0559 0.0913
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0036 0.0365 0.0499
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0343 0.0558
Trypanosoma brucei NADH-cytochrome b5 reductase, putative 0.0033 0.0292 0.0379
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.4037 0.4
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0044 0.0541 0.0789
Echinococcus multilocularis pyruvate kinase 0.0066 0.1052 0.0997
Leishmania major NADH-dependent fumarate reductase-like protein 0.0033 0.0292 0.0379
Mycobacterium ulcerans hypothetical protein 0.0035 0.0343 0.0463
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0691 0.1127
Leishmania major cytochrome-b5 reductase, putative 0.0033 0.0292 0.0379
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.0942 0.1451
Mycobacterium tuberculosis Probable monooxygenase 0.0033 0.0292 0.05
Schistosoma mansoni pyruvate kinase 0.0066 0.1052 0.1633
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0559 0.05
Trypanosoma brucei NADH-dependent fumarate reductase 0.0033 0.0292 0.0379
Mycobacterium ulcerans beta-lactamase 0.0035 0.0343 0.0463
Trypanosoma cruzi p450 reductase, putative 0.0288 0.6125 1
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0026 0.0132 0.0116
Brugia malayi beta-lactamase 0.0035 0.0343 0.056
Trypanosoma brucei NADH-dependent fumarate reductase, putative 0.0033 0.0292 0.0379
Echinococcus multilocularis neuropeptide receptor A26 0.0458 1 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0343 0.0463
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0365 0.0499
Plasmodium falciparum pyruvate kinase 0.0066 0.1052 0.1633
Echinococcus multilocularis NADPH cytochrome P450 reductase 0.0288 0.6125 0.6101
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0043 0.0527 0.0861
Echinococcus multilocularis NADH cytochrome b5 reductase 3 0.0033 0.0292 0.0231
Plasmodium vivax flavodoxin domain containing protein 0.0255 0.5377 0.8766
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0942 0.1451
Onchocerca volvulus Pyruvate kinase homolog 0.0066 0.1052 0.4111
Loa Loa (eye worm) hypothetical protein 0.0066 0.1052 0.1716
Schistosoma mansoni hypothetical protein 0.0034 0.0328 0.0439
Schistosoma mansoni NADH-cytochrome B5 reductase 0.0033 0.0292 0.0379
Loa Loa (eye worm) beta-lactamase 0.0035 0.0343 0.0558
Brugia malayi Cytochrome P450 family protein 0.0036 0.0371 0.0606
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0328 0.0536
Leishmania major cytochrome-b5 reductase, putative 0.0033 0.0292 0.0379
Mycobacterium ulcerans pyruvate kinase 0.0066 0.1052 0.1633
Schistosoma mansoni hypothetical protein 0.0102 0.1874 0.2988
Trypanosoma brucei pyruvate kinase 1 0.0066 0.1052 0.1633
Trypanosoma brucei trypanothione reductase 0.0048 0.0632 0.094
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0541 0.0789
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0343 0.0463
Leishmania major cytochrome P450 reductase, putative 0.0255 0.5377 0.8766
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0288 0.6125 1
Entamoeba histolytica pyruvate kinase, putative 0.0046 0.0596 0.267
Entamoeba histolytica type A flavoprotein, putative 0.011 0.2061 1
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0043 0.0527 0.0859
Trypanosoma cruzi NADPH-dependent FMN/FAD containing oxidoreductase, putative 0.0288 0.6125 1
Loa Loa (eye worm) pyruvate kinase-PB 0.0046 0.0596 0.0971
Trypanosoma cruzi cytochrome P450, putative 0.0036 0.0371 0.051
Schistosoma mansoni 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase 0.0178 0.3608 0.5848
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0036 0.0365 0.1514
Entamoeba histolytica type A flavoprotein, putative 0.011 0.2061 1
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0365 0.0305
Echinococcus granulosus NADPH cytochrome P450 reductase 0.0288 0.6125 0.6101
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0043 0.0527 0.0468
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0691 0.1129
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0559 0.082
Trypanosoma brucei NADH-cytochrome b5 reductase, putative 0.0033 0.0292 0.0379
Plasmodium vivax NADPH-cytochrome p450 reductase, putative 0.0288 0.6125 1
Mycobacterium tuberculosis Hypothetical oxidoreductase 0.0033 0.0292 0.05
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0044 0.0541 0.0789
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0541 0.0789
Toxoplasma gondii pyruvate kinase PyKII 0.0034 0.0318 0.0931
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0541 0.0789
Trichomonas vaginalis maltase-glucoamylase, putative 0.0044 0.0541 0.0789
Trypanosoma brucei nitrate reductase, putative 0.0033 0.0292 0.0379
Trypanosoma brucei glucosidase, putative 0.0044 0.0541 0.0789
Echinococcus granulosus neuropeptide receptor A26 0.0458 1 1
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.0942 0.0885
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0541 0.0789
Plasmodium vivax hypothetical protein, conserved 0.011 0.2061 0.3297
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0559 0.082
Brugia malayi Flap endonuclease-1 0.0026 0.0132 0.0216
Brugia malayi Pyruvate kinase, M2 isozyme 0.0066 0.1052 0.1718
Loa Loa (eye worm) hypothetical protein 0.0034 0.0328 0.0533
Treponema pallidum ferredoxin-NADP(+) reductase subunit alpha 0.0033 0.0292 0.1148
Toxoplasma gondii NADH-cytochrome b5 reductase 1, putative 0.0033 0.0292 0.0835
Plasmodium falciparum S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative 0.011 0.2061 0.3297
Toxoplasma gondii pyruvate kinase PyK1 0.0066 0.1052 0.3605
Echinococcus granulosus ubiquitin specific protease 41 0.0036 0.0365 0.0305
Loa Loa (eye worm) hypothetical protein 0.0035 0.0343 0.0558
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.4037 0.4
Echinococcus granulosus lysosomal alpha glucosidase 0.0197 0.4037 0.4
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0942 0.1451
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0942 0.1451
Leishmania major pyruvate kinase 0.0066 0.1052 0.1633
Echinococcus granulosus cytochrome b5 reductase 4 0.0033 0.0292 0.0231
Trypanosoma cruzi oxidoreductase-protein, putative 0.0033 0.0292 0.0379
Giardia lamblia Hypothetical protein 0.0255 0.5377 1
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0343 0.0463
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0121 0.2304 0.4884
Treponema pallidum flavodoxin 0.011 0.2061 1
Trichomonas vaginalis NADPH cytochrome P450, putative 0.011 0.2061 0.3297
Echinococcus multilocularis pyruvate kinase 0.0034 0.0318 0.0257
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.0942 0.0885
Mycobacterium tuberculosis Possible electron transfer protein FdxB 0.0033 0.0292 0.05
Loa Loa (eye worm) FAD binding domain-containing protein 0.0178 0.3608 0.5889
Echinococcus granulosus pyruvate kinase 0.0034 0.0318 0.0257
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.0942 0.1916
Giardia lamblia Nitric oxide synthase, inducible 0.0255 0.5377 1
Trichomonas vaginalis flap endonuclease-1, putative 0.0026 0.0132 0.0116
Trypanosoma brucei NADH-cytochrome b5 reductase, putative 0.0033 0.0292 0.0379
Mycobacterium tuberculosis Conserved protein 0.0035 0.0343 0.0612
Entamoeba histolytica Flap nuclease, putative 0.0026 0.0132 0.0351
Echinococcus multilocularis alkaline phosphatase 0.0196 0.4029 0.3992
Brugia malayi flavodoxin family protein 0.011 0.2061 0.3365
Trichomonas vaginalis pyruvate kinase, putative 0.0066 0.1052 0.1633
Loa Loa (eye worm) hypothetical protein 0.0035 0.0343 0.0558
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0343 0.0612
Trichomonas vaginalis NADPH cytochrome P450, putative 0.011 0.2061 0.3297
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0343 0.0463
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0023 0.0062 0.5
Mycobacterium tuberculosis Probable reductase 0.0109 0.2027 0.428
Leishmania major nitrate reductase, putative 0.0033 0.0292 0.0379
Brugia malayi Cytochrome P450 family protein 0.0036 0.0371 0.0606
Mycobacterium ulcerans formate dehydrogenase H FdhF 0.0288 0.6125 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.0197 0.4037 0.6591
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0365 0.0499
Chlamydia trachomatis pyruvate kinase 0.0066 0.1052 0.2295
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.0033 0.0292 0.0379
Plasmodium vivax flap endonuclease 1, putative 0.0026 0.0132 0.0116
Plasmodium vivax glutathione reductase, putative 0.0048 0.0632 0.094
Echinococcus granulosus intestinal type alkaline phosphatase 0.0196 0.4029 0.3992
Onchocerca volvulus 0.0035 0.0343 0.0278
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0365 0.0499
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0343 0.0463
Trypanosoma cruzi reductase, putative 0.0033 0.0292 0.0379
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0109 0.2027 0.428
Echinococcus granulosus pyruvate kinase 0.0066 0.1052 0.0997
Echinococcus multilocularis thioredoxin glutathione reductase 0.0048 0.0632 0.0574
Trichomonas vaginalis NADPH cytochrome P450, putative 0.011 0.2061 0.3297
Plasmodium falciparum glutathione reductase 0.0048 0.0632 0.094
Trichomonas vaginalis sucrase-isomaltase, putative 0.0044 0.0541 0.0789
Leishmania major alpha glucosidase II subunit, putative 0.0044 0.0541 0.0789
Trypanosoma brucei NADH-cytochrome b5 reductase, putative 0.0033 0.0292 0.0379
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0121 0.2304 0.4884
Loa Loa (eye worm) hypothetical protein 0.0035 0.0343 0.0558
Brugia malayi Glycosyl hydrolases family 31 protein 0.0044 0.0541 0.0882
Plasmodium falciparum pyruvate kinase 2 0.0034 0.0318 0.0422
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0691 0.1129
Echinococcus multilocularis neutral alpha glucosidase AB 0.0044 0.0541 0.0481
Plasmodium falciparum nitric oxide synthase, putative 0.0288 0.6125 1
Trypanosoma brucei pyruvate kinase 1, putative 0.0066 0.1052 0.1633
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0343 0.0463
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0026 0.0132 0.0116
Giardia lamblia Flap structure-specific endonuclease 0.0026 0.0132 0.0132
Brugia malayi Thioredoxin reductase 0.0048 0.0632 0.1032
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0109 0.2027 0.428
Echinococcus multilocularis pyruvate kinase 0.0034 0.0318 0.0257
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0365 0.0499
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0559 0.05
Schistosoma mansoni cytochrome P450 reductase 0.0288 0.6125 1
Loa Loa (eye worm) FAD binding domain-containing protein 0.0288 0.6125 1
Schistosoma mansoni alpha-glucosidase 0.0169 0.3411 0.5524
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0343 0.0463
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0044 0.0541 0.2393
Echinococcus granulosus pyruvate kinase 0.0034 0.0318 0.0257
Echinococcus multilocularis methionine synthase reductase 0.0178 0.3608 0.3568
Trypanosoma cruzi trypanothione reductase, putative 0.0048 0.0632 0.094
Trypanosoma brucei cytochrome P450, putative 0.0036 0.0371 0.051
Mycobacterium ulcerans oxidoreductase 0.0033 0.0292 0.0379
Echinococcus granulosus thioredoxin glutathione reductase 0.0048 0.0632 0.0574
Toxoplasma gondii ferredoxin NADP+ oxidoreductase FNR 0.0033 0.0292 0.0835
Brugia malayi beta-lactamase family protein 0.0035 0.0343 0.056
Plasmodium falciparum NADPH--cytochrome P450 reductase, putative 0.011 0.2061 0.3297
Trypanosoma brucei S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative 0.011 0.2061 0.3297
Echinococcus granulosus NADPH dependent diflavin oxidoreductase 1 0.0288 0.6125 0.6101
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0541 0.0789
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0036 0.0365 0.0596
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0121 0.2304 1
Brugia malayi FAD binding domain containing protein 0.0288 0.6125 1
Onchocerca volvulus 0.0035 0.0343 0.0278
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.0033 0.0292 0.0379
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0044 0.0541 0.2393
Schistosoma mansoni cytochrome B5 0.0033 0.0292 0.0379
Loa Loa (eye worm) hypothetical protein 0.0036 0.0365 0.0593
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0343 0.0612
Loa Loa (eye worm) cytochrome b5 reductase 4 0.0033 0.0292 0.0474
Echinococcus granulosus alkaline phosphatase intestinal gene 2 0.0196 0.4029 0.3992
Echinococcus multilocularis pyruvate kinase 0.0066 0.1052 0.0997
Trypanosoma cruzi cytochrome-b5 reductase, putative 0.0033 0.0292 0.0379
Chlamydia trachomatis sulfite reductase 0.0178 0.3608 1
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0365 0.0305
Mycobacterium leprae Probable pyruvate kinase PykA 0.0066 0.1052 0.3617
Loa Loa (eye worm) thioredoxin reductase 0.0048 0.0632 0.103
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.004 0.0463 0.0661
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.0033 0.0292 0.0379
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0343 0.0612
Plasmodium falciparum ferredoxin--NADP reductase 0.0033 0.0292 0.0379
Mycobacterium tuberculosis Probable oxidoreductase 0.0121 0.2304 0.4884
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0036 0.0365 0.0499
Echinococcus multilocularis pyruvate kinase 0.0052 0.0735 0.0677
Schistosoma mansoni flap endonuclease-1 0.0023 0.0076 0.0022
Onchocerca volvulus 0.0035 0.0343 0.0278
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.0942 0.3201
Leishmania major oxidoreductase-like protein 0.0033 0.0292 0.0379
Loa Loa (eye worm) pyruvate kinase 0.0066 0.1052 0.1716
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0343 0.0612
Entamoeba histolytica type A flavoprotein, putative 0.011 0.2061 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0033 0.0292 0.05
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0109 0.2027 0.428
Loa Loa (eye worm) diaphorase 0.0033 0.0292 0.0474
Plasmodium vivax oxidoreductase NAD-binding domain containing protein 0.0033 0.0292 0.0379
Mycobacterium ulcerans monooxygenase 0.0033 0.0292 0.0379
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.0033 0.0292 0.0379
Onchocerca volvulus Pyruvate kinase homolog 0.0066 0.1052 0.4111
Brugia malayi diaphorase 0.0033 0.0292 0.0476
Leishmania major pyruvate kinase 0.0066 0.1052 0.1633
Brugia malayi FAD binding domain containing protein 0.0178 0.3608 0.589
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0343 0.056
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0197 0.4037 0.659
Brugia malayi beta-lactamase family protein 0.0035 0.0343 0.056
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.0033 0.0292 0.0379
Mycobacterium ulcerans electron transfer protein FdxB 0.0033 0.0292 0.0379
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.0033 0.0292 0.0379
Trypanosoma cruzi pyruvate kinase 2, putative 0.0066 0.1052 0.1633
Schistosoma mansoni voltage-gated potassium channel 0.0047 0.0618 0.0917
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0559 0.0911
Echinococcus multilocularis alkaline phosphatase, intestinal, gene 2 0.0196 0.4029 0.3992
Leishmania major cytochrome p450-like protein 0.0036 0.0371 0.051
Trypanosoma brucei NADH-cytochrome b5 reductase, putative 0.0033 0.0292 0.0379
Loa Loa (eye worm) hypothetical protein 0.0035 0.0343 0.0558
Mycobacterium tuberculosis Possible oxygenase 0.0033 0.0292 0.05
Toxoplasma gondii ABC1 family protein 0.0035 0.0343 0.1023
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0343 0.0283
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0044 0.0541 0.088
Leishmania major hypothetical protein, conserved 0.0035 0.0343 0.0463
Echinococcus granulosus cytochrome b5 reductase 4 0.0033 0.0292 0.0231
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0224 0.4653 1
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0044 0.0541 0.1742
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0043 0.0527 0.0468
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.0033 0.0292 0.0379
Mycobacterium ulcerans flavodoxin oxidoreductase 0.0033 0.0292 0.0379
Plasmodium vivax pyruvate kinase, putative 0.0066 0.1052 0.1633
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0343 0.0463
Trypanosoma brucei oxidoreductase-protein, putative 0.0033 0.0292 0.0379
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.004 0.0463 0.0661
Brugia malayi flavodoxin family protein 0.0288 0.6125 1
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0365 0.0305
Schistosoma mansoni alpha-glucosidase 0.0169 0.3411 0.5524
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.0033 0.0292 0.0379
Mycobacterium tuberculosis Conserved protein 0.0035 0.0343 0.0612
Mycobacterium tuberculosis Probable dehydrogenase 0.0109 0.2027 0.428
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.0033 0.0292 0.0379
Plasmodium falciparum thioredoxin reductase 0.0048 0.0632 0.094
Mycobacterium ulcerans oxygenase 0.0033 0.0292 0.0379
Trypanosoma brucei NADPH-dependent diflavin oxidoreductase 1 0.0288 0.6125 1
Echinococcus multilocularis pyruvate kinase 0.0034 0.0318 0.0257
Echinococcus granulosus neutral alpha glucosidase AB 0.0044 0.0541 0.0481
Echinococcus granulosus pyruvate kinase 0.0034 0.0318 0.0257
Schistosoma mansoni alkaline phosphatase 0.0196 0.4029 0.6542
Trypanosoma cruzi Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative 0.011 0.2061 0.3297
Schistosoma mansoni voltage-gated potassium channel 0.0047 0.0618 0.0917
Loa Loa (eye worm) hypothetical protein 0.0035 0.0343 0.0558
Trypanosoma brucei NADH-cytochrome b5 reductase, putative 0.0033 0.0292 0.0379
Loa Loa (eye worm) pyruvate kinase 0.0066 0.1052 0.1716
Schistosoma mansoni NADPH flavin oxidoreductase 0.0145 0.2859 0.4613
Brugia malayi Cytochrome b5-like Heme/Steroid binding domain containing protein 0.0033 0.0292 0.0476
Trypanosoma cruzi cytochrome P450, putative 0.0036 0.0371 0.051
Trypanosoma cruzi cytochrome-b5 reductase, putative 0.0033 0.0292 0.0379
Trypanosoma brucei NADH-dependent fumarate reductase, putative 0.0033 0.0292 0.0379
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0365 0.0499
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0288 0.6125 1
Leishmania major NADPH-cytochrome p450 reductase-like protein 0.0288 0.6125 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.0596 0.0971
Loa Loa (eye worm) hypothetical protein 0.0037 0.0397 0.0647
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0288 0.6125 1
Schistosoma mansoni alkaline phosphatase 0.0196 0.4029 0.6542
Brugia malayi glutathione reductase 0.0048 0.0632 0.1032
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0942 0.1451
Toxoplasma gondii flavodoxin domain-containing protein 0.0143 0.2809 1
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0343 0.0463
Trypanosoma brucei NADH-dependent fumarate reductase 0.0033 0.0292 0.0379
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0036 0.0371 0.051
Toxoplasma gondii thioredoxin reductase 0.0048 0.0632 0.2075
Loa Loa (eye worm) glutathione reductase 0.0048 0.0632 0.103
Plasmodium falciparum NADH-cytochrome b5 reductase, putative 0.0033 0.0292 0.0379
Trichomonas vaginalis pyruvate kinase, putative 0.0066 0.1052 0.1633
Echinococcus granulosus NADH cytochrome b5 reductase 3 0.0033 0.0292 0.0231
Loa Loa (eye worm) hypothetical protein 0.0288 0.6125 1
Plasmodium vivax thioredoxin reductase, putative 0.0048 0.0632 0.094
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0541 0.0789
Schistosoma mansoni pyruvate kinase 0.0034 0.0318 0.0422
Leishmania major NADH-dependent fumarate reductase, putative 0.0033 0.0292 0.0379
Leishmania major NADH-cytochrome b5 reductase, putative 0.0033 0.0292 0.0379
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0541 0.0789
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0343 0.0612
Trichomonas vaginalis esterase, putative 0.0035 0.0343 0.0463
Loa Loa (eye worm) cytochrome P450 family protein 0.0036 0.0371 0.0604
Trypanosoma cruzi NADPH--cytochrome P450 reductase, putative 0.011 0.2061 0.3297
Echinococcus multilocularis intestinal type alkaline phosphatase 1 0.0196 0.4029 0.3992
Plasmodium falciparum flap endonuclease 1 0.0026 0.0132 0.0116
Loa Loa (eye worm) flap endonuclease-1 0.0026 0.0132 0.0214
Brugia malayi Pyruvate kinase, muscle isozyme 0.0066 0.1052 0.1718
Loa Loa (eye worm) flavodoxin family protein 0.011 0.2061 0.3363
Trypanosoma brucei NADPH-cytochrome p450 reductase, putative 0.0288 0.6125 1
Echinococcus multilocularis intestinal type alkaline phosphatase 0.0196 0.4029 0.3992
Loa Loa (eye worm) hypothetical protein 0.0035 0.0343 0.0558
Mycobacterium tuberculosis Conserved protein 0.0035 0.0343 0.0612
Trichomonas vaginalis NADPH cytochrome P450, putative 0.011 0.2061 0.3297
Giardia lamblia Pyruvate kinase 0.0034 0.0318 0.0481
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0942 0.1451
Schistosoma mansoni diflavin oxidoreductase 0.0143 0.2809 0.4531
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0559 0.082
Echinococcus granulosus methionine synthase reductase 0.0178 0.3608 0.3568
Leishmania major NADH-cytochrome b5 reductase, putative 0.0033 0.0292 0.0379
Loa Loa (eye worm) CYP4Cod1 0.0036 0.0371 0.0604
Echinococcus granulosus pyruvate kinase 0.0066 0.1052 0.0997
Loa Loa (eye worm) hypothetical protein 0.005 0.0691 0.1127
Echinococcus multilocularis ubiquitin specific protease 41 0.0036 0.0365 0.0305
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0062 0.0101
Schistosoma mansoni pyruvate kinase 0.0066 0.1052 0.1633
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0066 0.1052 0.2157
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0109 0.2027 0.428
Trypanosoma cruzi p450 reductase, putative 0.0033 0.0292 0.0379
Plasmodium vivax pyruvate kinase 2, putative 0.0034 0.0318 0.0422
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0343 0.0463
Trypanosoma cruzi pyruvate kinase 2, putative 0.0066 0.1052 0.1633
Schistosoma mansoni alpha glucosidase 0.0044 0.0541 0.0789
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0036 0.0365 0.0569
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0048 0.0632 0.1242
Echinococcus granulosus alkaline phosphatase 0.0196 0.4029 0.3992
Trypanosoma cruzi Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative 0.011 0.2061 0.3297
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0062 0.0099
Mycobacterium ulcerans flavodoxin reductase Hmp 0.0033 0.0292 0.0379
Entamoeba histolytica type A flavoprotein, putative 0.011 0.2061 1
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.0033 0.0292 0.0379
Echinococcus multilocularis NADPH dependent diflavin oxidoreductase 1 0.0288 0.6125 0.6101
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0026 0.0132 0.0116
Mycobacterium ulcerans lipase LipD 0.0035 0.0343 0.0463
Echinococcus multilocularis flap endonuclease 1 0.0026 0.0132 0.0071
Echinococcus granulosus flap endonuclease 1 0.0026 0.0132 0.0071
Loa Loa (eye worm) cytochrome P450 family protein 0.0036 0.0371 0.0604
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0109 0.2027 0.8587
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0365 0.0305
Toxoplasma gondii flavodoxin domain-containing protein 0.0143 0.2809 1
Echinococcus multilocularis neuropeptide s receptor 0.0458 1 1
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0288 0.6125 1
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0365 0.0499
Loa Loa (eye worm) cytochrome P450 family protein 0.006 0.0911 0.1485
Giardia lamblia Pyruvate kinase 0.0066 0.1052 0.1863
Trichomonas vaginalis sulfite reductase, putative 0.0288 0.6125 1
Leishmania major NADH-cytochrome b5 reductase, putative 0.0033 0.0292 0.0379
Onchocerca volvulus Pyruvate kinase homolog 0.0066 0.1052 0.4111
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0033 0.0292 0.0379
Trypanosoma cruzi nitrate reductase, putative 0.0033 0.0292 0.0379
Leishmania major hypothetical protein, conserved 0.011 0.2061 0.3297
Trypanosoma brucei NADH-cytochrome b5 reductase-like protein 0.0033 0.0292 0.0379
Echinococcus granulosus intestinal type alkaline phosphatase 1 0.0196 0.4029 0.3992
Leishmania major p450 reductase, putative 0.0288 0.6125 1
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.0033 0.0292 0.0379
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0343 0.0463
Plasmodium vivax ferredoxin--NADP reductase, putative 0.0033 0.0292 0.0379
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.0033 0.0292 0.0379
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0036 0.0365 0.0499
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0343 0.0612
Leishmania major trypanothione reductase 0.0048 0.0632 0.094
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0343 0.0283
Giardia lamblia Flavohemoprotein lateral transfer candidate 0.0033 0.0292 0.0432
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0343 0.0463

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 999 um PUBCHEM_BIOASSAY: Luminescent assay for HTS discovery of chemical activators of placental alkaline phosphatase. (Class of assay: confirmatory) [Related pubchem assays: 518 ] ChEMBL. No reference
IC50 (functional) = 12.7 uM PUBCHEM_BIOASSAY: Luminescent assay for HTS discovery of chemical inhibitors of placental alkaline phosphatase confirmation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1577, AID518, AID690] ChEMBL. No reference
IC50 (functional) = 15.8 um PUBCHEM_BIOASSAY: Luminescent assay for HTS discovery of chemical inhibitors of placental alkaline phosphatase. (Class of assay: confirmatory) [Related pubchem assays: 1512, 518 ] ChEMBL. No reference
IC50 (binding) = 56.3 uM PUBCHEM_BIOASSAY: SAR analysis of an In Vitro TNAP Dose Response Luminescent Assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1548, AID1574, AID1577, AID1659, AID518] ChEMBL. No reference
Potency (functional) 0.0891 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 1.4125 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 997 ] ChEMBL. No reference
Potency (functional) = 1.4125 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 1467, 2100, 2112, 1473, 1466 ] ChEMBL. No reference
Potency (functional) 6.5733 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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