TDR Targets

Basic information

Technical information

TDR Targets ID: 1240729
Name: N-[2-(2-chlorophenyl)ethyl]-6-oxo-1-[[3-(trif luoromethyl)phenyl]methyl]piperidine-3-carbox amide
MW: 438.87 | Formula: C22H22ClF3N2O2
H donors: 1 H acceptors: 2 LogP: 4.03 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: O=C(C1CCC(=O)N(C1)Cc1cccc(c1)C(F)(F)F)NCCc1ccccc1Cl
InChi: 1S/C22H22ClF3N2O2/c23-19-7-2-1-5-16(19)10-11-27-21(30)17-8-9-20(29)28(14-17)13-15-4-3-6-18(12-15)22(24,25)26/h1-7,12,17H,8-11,13-14H2,(H,27,30)
InChiKey: FBPQELGZQDQSII-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-[2-(2-chlorophenyl)ethyl]-6-oxo-1-[[3-(trifluoromethyl)phenyl]methyl]-3-piperidinecarboxamide
N-[2-(2-chlorophenyl)ethyl]-6-keto-1-[3-(trifluoromethyl)benzyl]nipecotamide

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	glucagon-like peptide 1 receptor	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Loa Loa (eye worm)	pigment dispersing factor receptor c	glucagon-like peptide 1 receptor	463 aa	388 aa	25.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.003	0.0035	0.0036
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.0067	0.0311	0.0303
Schistosoma mansoni	cpg binding protein	0.0029	0.0021	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0056	0.0069
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.0433	0.3039	0.5
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.003	0.0035	0.0036
Echinococcus multilocularis	chromobox protein 1	0.0146	0.0899	0.09
Loa Loa (eye worm)	hypothetical protein	0.0399	0.2782	0.4448
Brugia malayi	PHD-finger family protein	0.0091	0.0487	0.0732
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0311	0.0479
Leishmania major	C-8 sterol isomerase-like protein	0.0719	0.5173	1
Brugia malayi	hypothetical protein	0.0067	0.0311	0.0468
Brugia malayi	mbt repeat family protein	0.0046	0.0152	0.0229
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0887	0.6423	0.901
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.003	0.0035	0.0036
Echinococcus multilocularis	geminin	0.0173	0.1098	0.1102
Onchocerca volvulus		0.0981	0.7127	1
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0114	0.0655	0.2275
Brugia malayi	Bromodomain containing protein	0.0037	0.0084	0.0127
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0862	0.6239	1
Brugia malayi	jmjC domain containing protein	0.0029	0.0027	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0141	0.0861	0.1362
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0067	0.0311	0.1056
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0102	0.0143
Brugia malayi	C2-HC type zinc finger protein C.e-MyT1	0.0052	0.02	0.03
Trichomonas vaginalis	chromobox protein, putative	0.0146	0.0899	0.125
Schistosoma mansoni	hypothetical protein	0.028	0.1898	0.6676
Echinococcus granulosus	lysine specific demethylase 6a	0.0029	0.0027	0.0015
Trichomonas vaginalis	conserved hypothetical protein	0.0082	0.042	0.0577
Plasmodium vivax	SET domain protein, putative	0.0124	0.0735	1
Echinococcus granulosus	PHD finger protein rhinoceros	0.0091	0.0487	0.0474
Echinococcus multilocularis	cpg binding protein	0.0032	0.0047	0.0035
Loa Loa (eye worm)	carboxylesterase	0.0067	0.0311	0.0479
Toxoplasma gondii	WD domain, G-beta repeat-containing protein	0.003	0.003	0.0039
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0091	0.0487	0.0481
Onchocerca volvulus		0.0067	0.0311	0.0408
Schistosoma mansoni	bromodomain containing protein	0.0063	0.0277	0.0934
Schistosoma mansoni	hypothetical protein	0.0173	0.1098	0.3844
Loa Loa (eye worm)	jmjC domain-containing protein	0.0188	0.1209	0.1921
Echinococcus granulosus	histone lysine methyltransferase setb	0.0141	0.0858	0.0846
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.0067	0.0311	0.0424
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0298	0.203	0.202
Giardia lamblia	Fructose-bisphosphate aldolase	0.0887	0.6423	1
Trypanosoma brucei	PHD-zinc-finger like domain containing protein, putative	0.003	0.003	0.0005
Echinococcus multilocularis	chromobox protein 1	0.0146	0.0899	0.09
Brugia malayi	jmjC domain containing protein	0.0298	0.203	0.3053
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0141	0.0858	0.2992
Plasmodium falciparum	phd finger protein, putative	0.0091	0.0487	1
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.003	0.0035	0.0036
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0027	0.0023
Echinococcus multilocularis	histone acetyltransferase MYST2	0.0052	0.02	0.019
Echinococcus multilocularis	polycomb protein SCMH1	0.0046	0.0152	0.0142
Echinococcus granulosus	BC026374 protein S09 family	0.0067	0.0311	0.0299
Schistosoma mansoni	neuroligin 3 (S09 family)	0.0067	0.0311	0.1056
Brugia malayi	Carboxylesterase family protein	0.0067	0.0311	0.0468
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0887	0.6423	0.901
Brugia malayi	jmjC domain containing protein	0.0114	0.0655	0.0985
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0041	0.0117	0.0368
Schistosoma mansoni	hypothetical protein	0.0173	0.1098	0.3844
Onchocerca volvulus		0.0067	0.0311	0.0408
Echinococcus multilocularis	para nitrobenzyl esterase	0.0067	0.0311	0.0303
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0085	0.0116
Echinococcus granulosus	polycomb protein SCMH1	0.0046	0.0152	0.014
Treponema pallidum	fructose-bisphosphate aldolase	0.0887	0.6423	0.5
Brugia malayi	Carboxylesterase family protein	0.0399	0.2782	0.4185
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0065	0.0295	0.0283
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0887	0.6423	0.901
Brugia malayi	Pre-SET motif family protein	0.0862	0.6239	0.9384
Plasmodium vivax	hypothetical protein, conserved	0.0031	0.0043	0.0222
Echinococcus granulosus	geminin	0.0173	0.1098	0.1087
Schistosoma mansoni	hypothetical protein	0.0091	0.0487	0.1678
Schistosoma mansoni	chromobox protein	0.0146	0.0899	0.3138
Loa Loa (eye worm)	jmjC domain-containing protein	0.0029	0.0027	0.0023
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0065	0.0295	0.0454
Loa Loa (eye worm)	hypothetical protein	0.0399	0.2782	0.4448
Echinococcus multilocularis	GPCR, family 2	0.0065	0.0295	0.0287
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0887	0.6423	0.5
Echinococcus multilocularis	BC026374 protein (S09 family)	0.0067	0.0311	0.0303
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.0182	0.1163	0.1168
Schistosoma mansoni	cpg binding protein	0.0032	0.0047	0.0121
Echinococcus granulosus	phd:f box containing protein	0.0029	0.0027	0.0015
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0124	0.0735	0.0733
Echinococcus granulosus	SAM and MBT domain containing protein	0.0046	0.0152	0.014
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.0433	0.3039	1
Echinococcus multilocularis	jumonji domain containing 1A	0.0029	0.0027	0.0015
Plasmodium vivax	hypothetical protein, conserved	0.0091	0.0487	0.6493
Echinococcus multilocularis	SAM and MBT domain containing protein	0.0046	0.0152	0.0142
Loa Loa (eye worm)	mbt repeat family protein	0.0046	0.0152	0.0224
Echinococcus granulosus	acetylcholinesterase	0.0399	0.2782	0.2773
Echinococcus granulosus	jumonji domain containing 1A	0.0029	0.0027	0.0015
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0065	0.0293	0.0994
Echinococcus granulosus	histone acetyltransferase MYST2	0.0052	0.02	0.0187
Loa Loa (eye worm)	acetylcholinesterase 1	0.0399	0.2782	0.4448
Schistosoma mansoni	hypothetical protein	0.0065	0.0295	0.1001
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.003	0.0035	0.0036
Onchocerca volvulus		0.0067	0.0311	0.0408
Brugia malayi	Carboxylesterase family protein	0.0399	0.2782	0.4185
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.003	0.0035	0.0036
Brugia malayi	Bromodomain containing protein	0.0074	0.0361	0.0543
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.003	0.0035	0.0036
Schistosoma mansoni	jumonji domain containing protein	0.0237	0.1573	0.5525
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0088	0.0466	0.0626
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0119	0.0696	0.0684
Brugia malayi	Heterochromatin protein 1	0.0146	0.0899	0.1352
Loa Loa (eye worm)	jmjC domain-containing protein	0.0029	0.0027	0.0023
Toxoplasma gondii	PHD-finger domain-containing protein	0.0091	0.0487	0.6493
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0311	0.0479
Echinococcus multilocularis	lysine specific demethylase 6a	0.0029	0.0027	0.0015
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0311	0.0479
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0148	0.0913	0.3188
Brugia malayi	PHD-finger family protein	0.0033	0.0056	0.0084
Brugia malayi	CXXC zinc finger family protein	0.0029	0.0021	0.0032
Schistosoma mansoni	BC026374 protein (S09 family)	0.0067	0.0311	0.1056
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0082	0.042	0.0561
Schistosoma mansoni	scm-relatedprotein containing 4 mbt domains (sfmbt)	0.0046	0.0152	0.0494
Plasmodium falciparum	conserved Plasmodium membrane protein, unknown function	0.0031	0.0043	0.0342
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0206	0.1348	0.2027
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0035	0.0067	0.0055
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0298	0.203	0.2048
Trichomonas vaginalis	conserved hypothetical protein	0.0082	0.042	0.0577
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0027	0.0013	0.0005
Brugia malayi	Latrophilin receptor protein 2	0.0065	0.0295	0.0444
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.0433	0.3039	1
Echinococcus granulosus	Jumonji AT rich interactive domain 1B	0.0033	0.0053	0.004
Loa Loa (eye worm)	hypothetical protein	0.0156	0.0971	0.1539
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0887	0.6423	0.5
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0141	0.0858	0.2992
Loa Loa (eye worm)	hypothetical protein	0.0052	0.02	0.03
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0029	0.0021	0.0013
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0124	0.0735	1
Schistosoma mansoni	gliotactin	0.0067	0.0311	0.1056
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0035	0.0067	0.0055
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0065	0.0295	0.0444
Schistosoma mansoni	acetylcholinesterase	0.0067	0.0311	0.1056
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0206	0.1348	0.2144
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.0182	0.1163	0.1152
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0887	0.6423	0.901
Loa Loa (eye worm)	hypothetical protein	0.0719	0.5173	0.8287
Echinococcus multilocularis	Jumonji, AT rich interactive domain 1B	0.0033	0.0053	0.0041
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0065	0.0295	0.0287
Loa Loa (eye worm)	jmjC domain-containing protein	0.0114	0.0655	0.1032
Brugia malayi	jmjC domain containing protein	0.0029	0.0027	0.0041
Echinococcus granulosus	neuroligin	0.0067	0.0311	0.0299
Brugia malayi	Carboxylesterase family protein	0.0067	0.0311	0.0468
Loa Loa (eye worm)	MBCTL1	0.0052	0.02	0.03
Toxoplasma gondii	PHD-finger domain-containing protein	0.0091	0.0487	0.6493
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0887	0.6423	0.901
Schistosoma mansoni	protein phosphatase 2C	0.0029	0.0027	0.0052
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0295	0.0454
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0288	0.0441
Echinococcus granulosus	chromobox protein 1	0.0146	0.0899	0.0887
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0059	0.0251	0.0242
Schistosoma mansoni	hypothetical protein	0.0141	0.0861	0.3002
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0067	0.0311	0.1056
Loa Loa (eye worm)	PHD-finger family protein	0.0091	0.0487	0.0761
Brugia malayi	Pre-SET motif family protein	0.0124	0.0735	0.1105
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.0067	0.0311	0.0299
Schistosoma mansoni	jumonji domain containing protein	0.0029	0.0027	0.0052
Schistosoma mansoni	sex comb on midleg homolog	0.0046	0.0152	0.0494
Echinococcus multilocularis	JmjC domain containing protein 4	0.0029	0.0027	0.0015
Loa Loa (eye worm)	carboxylesterase	0.0399	0.2782	0.4448
Echinococcus granulosus	para nitrobenzyl esterase	0.0067	0.0311	0.0299
Schistosoma mansoni	hypothetical protein	0.003	0.003	0.0061
Echinococcus multilocularis	acetylcholinesterase	0.0399	0.2782	0.2812
Echinococcus granulosus	peregrin	0.0093	0.0504	0.0492
Echinococcus granulosus	lysine specific demethylase 5A	0.0114	0.0655	0.0643
Brugia malayi	SET domain containing protein	0.0029	0.0025	0.0038
Brugia malayi	Serotonin receptor	0.0917	0.6649	1
Schistosoma mansoni	cpg binding protein	0.0032	0.0047	0.0121
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0124	0.0735	0.2557
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0013	0.0005
Loa Loa (eye worm)	heterochromatin protein 1	0.0146	0.0899	0.1423
Loa Loa (eye worm)	hypothetical protein	0.0368	0.255	0.4075
Brugia malayi	Bromodomain containing protein	0.0093	0.0504	0.0758
Echinococcus multilocularis	phd:f box containing protein	0.0029	0.0027	0.0015
Echinococcus multilocularis	acetylcholinesterase	0.0399	0.2782	0.2812
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0311	0.0479
Loa Loa (eye worm)	hypothetical protein	0.0206	0.1348	0.2144
Echinococcus granulosus	jumonji domain containing protein	0.0127	0.0752	0.074
Onchocerca volvulus		0.0148	0.0913	0.1256
Echinococcus multilocularis	jumonji domain containing protein	0.0127	0.0752	0.0751
Brugia malayi	Carboxylesterase family protein	0.0067	0.0311	0.0468
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0311	0.0479
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0311	0.0479
Schistosoma mansoni	hypothetical protein	0.0406	0.2837	1
Schistosoma mansoni	ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related	0.0029	0.0027	0.0052
Onchocerca volvulus	Alhambra homolog	0.0091	0.0487	0.0655
Toxoplasma gondii	PHD-finger domain-containing protein	0.003	0.003	0.0039
Onchocerca volvulus		0.0067	0.0311	0.0408
Echinococcus multilocularis	carboxylesterase 5A	0.0399	0.2782	0.2812
Echinococcus granulosus	carboxylesterase 5A	0.0399	0.2782	0.2773
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0141	0.0858	0.0858
Echinococcus multilocularis	lysine specific demethylase 5A	0.011	0.0629	0.0626
Loa Loa (eye worm)	carboxylesterase	0.0067	0.0311	0.0479
Onchocerca volvulus		0.0064	0.0288	0.0375
Trichomonas vaginalis	set domain proteins, putative	0.0981	0.7127	1
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0065	0.0295	0.0283
Trichomonas vaginalis	chromobox protein, putative	0.0146	0.0899	0.125
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0059	0.0251	0.0238
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0152	0.0224
Trichomonas vaginalis	conserved hypothetical protein	0.0058	0.0241	0.0326
Trichomonas vaginalis	conserved hypothetical protein	0.0058	0.0241	0.0326
Schistosoma mansoni	hypothetical protein	0.0065	0.0295	0.1001
Onchocerca volvulus		0.0046	0.0152	0.0185
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0887	0.6423	0.901
Brugia malayi	F/Y-rich N-terminus family protein	0.0045	0.0143	0.0215
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0206	0.1348	0.2027
Onchocerca volvulus	Polycomb protein Sfmbt homolog	0.0046	0.0152	0.0185
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0067	0.0311	0.1056
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0887	0.6423	0.901
Brugia malayi	latrophilin 2 splice variant baaae	0.0141	0.0861	0.1294
Trypanosoma brucei	PHD-zinc-finger like domain containing protein, putative	0.003	0.003	0.0005
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.003	0.0035	0.0036
Schistosoma mansoni	hypothetical protein	0.0065	0.0295	0.1001
Brugia malayi	ERG2 and Sigma1 receptor like protein	0.0719	0.5173	0.778
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0887	0.6423	0.901
Echinococcus multilocularis	dnaJ subfamily B	0.0406	0.2837	0.2868
Loa Loa (eye worm)	hypothetical protein	0.0141	0.0858	0.1357
Schistosoma mansoni	sex comb on midleg homolog	0.0046	0.0152	0.0494
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0065	0.0295	0.0287
Brugia malayi	CHD4 protein	0.0027	0.0013	0.0019
Schistosoma mansoni	hypothetical protein	0.0065	0.0295	0.1001
Echinococcus multilocularis	neuroligin	0.0067	0.0311	0.0303
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0114	0.0655	0.2275
Trichomonas vaginalis	chromobox protein, putative	0.0088	0.0466	0.0642
Echinococcus multilocularis	peregrin	0.0093	0.0504	0.0498
Echinococcus granulosus	cpg binding protein	0.0032	0.0047	0.0034
Brugia malayi	jmjC domain containing protein	0.0029	0.0027	0.0041
Onchocerca volvulus		0.0067	0.0311	0.0408
Echinococcus granulosus	acetylcholinesterase	0.0399	0.2782	0.2773
Loa Loa (eye worm)	hypothetical protein	0.0091	0.0487	0.0761
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0318	0.049
Trypanosoma brucei	C-8 sterol isomerase, putative	0.0719	0.5173	1
Brugia malayi	mbt repeat family protein	0.0046	0.0152	0.0229
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0128	0.0185
Loa Loa (eye worm)	hypothetical protein	0.0082	0.042	0.0653
Echinococcus granulosus	JmjC domain containing protein 4	0.0029	0.0027	0.0015
Echinococcus multilocularis	conserved hypothetical protein	0.1348	0.9861	1
Brugia malayi	jmjC domain containing protein	0.0029	0.0027	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0027	0.0023
Trypanosoma cruzi	C-8 sterol isomerase, putative	0.0719	0.5173	1
Brugia malayi	Carboxylesterase family protein	0.0067	0.0311	0.0468
Echinococcus granulosus	suppression of tumorigenicity 18 protein	0.0052	0.02	0.0187
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0091	0.0487	0.1678
Loa Loa (eye worm)	jmjC domain-containing protein	0.0029	0.0027	0.0023
Trichomonas vaginalis	spcc417.12 protein, putative	0.0067	0.0311	0.0424
Brugia malayi	chromobox protein homolog 3	0.0082	0.042	0.0631
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0061	0.0262	0.3321
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0399	0.2782	0.9807
Brugia malayi	AF-10 protein	0.003	0.003	0.0045
Echinococcus granulosus	dnaJ subfamily B	0.0406	0.2837	0.2828
Schistosoma mansoni	phosphatidylserine receptor	0.0029	0.0027	0.0052
Echinococcus multilocularis	suppression of tumorigenicity 18 protein	0.0052	0.02	0.019
Schistosoma mansoni	myelin transcription factor 1 myt1	0.0052	0.02	0.0662
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0311	0.0479
Schistosoma mansoni	chromobox protein	0.0146	0.0899	0.3138
Echinococcus granulosus	chromobox protein 1	0.0146	0.0899	0.0887
Schistosoma mansoni	phd/f-box containing protein	0.0029	0.0027	0.0052
Trichomonas vaginalis	chromobox protein, putative	0.0088	0.0466	0.0642
Echinococcus granulosus	GPCR family 2	0.0065	0.0295	0.0283

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	0.0026 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	4.4668 uM	PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	25.1189 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the Phosphatase Activity of Eya2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488939]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1350942

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1240729