Detailed information for compound 1241476

Basic information

Technical information
  • TDR Targets ID: 1241476
  • Name: N-(1,5-dimethyl-3-oxo-2-phenylpyrazol-4-yl)-4 -phenyloxane-4-carboxamide
  • MW: 391.463 | Formula: C23H25N3O3
  • H donors: 1 H acceptors: 2 LogP: 3.17 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1n(C)n(c(=O)c1NC(=O)C1(CCOCC1)c1ccccc1)c1ccccc1
  • InChi: 1S/C23H25N3O3/c1-17-20(21(27)26(25(17)2)19-11-7-4-8-12-19)24-22(28)23(13-15-29-16-14-23)18-9-5-3-6-10-18/h3-12H,13-16H2,1-2H3,(H,24,28)
  • InChiKey: RQTGBRJYZFSIQO-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • N-(1,5-dimethyl-3-oxo-2-phenyl-pyrazol-4-yl)-4-phenyl-tetrahydropyran-4-carboxamide
  • N-(1,5-dimethyl-3-oxo-2-phenyl-4-pyrazolyl)-4-phenyl-4-tetrahydropyrancarboxamide
  • N-(3-keto-1,5-dimethyl-2-phenyl-pyrazol-4-yl)-4-phenyl-tetrahydropyran-4-carboxamide
  • N-(1,5-dimethyl-3-oxo-2-phenyl-pyrazol-4-yl)-4-phenyl-oxane-4-carboxamide
  • ZINC01109823
  • MLS000049471
  • N-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-4-phenyltetrahydro-2H-pyran-4-carboxamide
  • SMR000075467

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Inositol monophosphatase 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania infantum myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus granulosus inositol monophosphatase 1 Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). Get druggable targets OG5_126810 All targets in OG5_126810
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania mexicana myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma japonicum ko:K01092 myo-inositol-1(or 4)-monophosphatase [EC3.1.3.25], putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma mansoni inositol monophosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis myo inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Loa Loa (eye worm) inositol-1 Get druggable targets OG5_126810 All targets in OG5_126810
Neospora caninum hypothetical protein Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Brugia malayi Inositol-1 Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania braziliensis myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania donovani myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis myo inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative Get druggable targets OG5_126810 All targets in OG5_126810
Entamoeba histolytica myo-inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus multilocularis inositol monophosphatase 1 Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma brucei gambiense inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma mansoni inositol monophosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma congolense inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium ulcerans extragenic suppressor protein SuhB Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB Get druggable targets OG5_126810 All targets in OG5_126810
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 300 aa 22.0 %
Trypanosoma brucei gambiense inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 309 aa 27.8 %
Dictyostelium discoideum 3',5'-bisphosphate nucleotidase 1 Inositol monophosphatase 1   277 aa 275 aa 22.2 %
Trypanosoma brucei inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 304 aa 27.3 %
Brugia malayi Inositol monophosphatase family protein Inositol monophosphatase 1   277 aa 238 aa 21.8 %
Onchocerca volvulus Putative 28S ribosomal protein S10, mitochondrial Inositol monophosphatase 1   277 aa 271 aa 46.1 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 306 aa 22.5 %
Trichomonas vaginalis inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 258 aa 21.7 %
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative Inositol monophosphatase 1   277 aa 263 aa 24.0 %
Loa Loa (eye worm) hypothetical protein Inositol monophosphatase 1   277 aa 298 aa 23.8 %
Trypanosoma congolense inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 304 aa 28.9 %
Onchocerca volvulus Inositol monophosphatase 1   277 aa 238 aa 22.7 %
Trichomonas vaginalis myo inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 276 aa 21.4 %
Trypanosoma cruzi myo-inositol-1 phosphatase, putative Inositol monophosphatase 1   277 aa 284 aa 30.6 %
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative Inositol monophosphatase 1   277 aa 287 aa 22.3 %
Trichomonas vaginalis diphosphonucleoside phosphohydrolase, putative Inositol monophosphatase 1   277 aa 263 aa 21.7 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 307 aa 22.5 %
Onchocerca volvulus Putative trans-2-enoyl-CoA reductase 1, mitochondrial Inositol monophosphatase 1   277 aa 278 aa 23.0 %
Trypanosoma cruzi inositol polyphosphate 1-phosphatase, putative Inositol monophosphatase 1   277 aa 291 aa 23.7 %
Trichomonas vaginalis inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 268 aa 22.4 %
Dictyostelium discoideum 3',5'-bisphosphate nucleotidase Inositol monophosphatase 1   277 aa 230 aa 25.2 %
Schistosoma mansoni pap-inositol-14-phosphatase Inositol monophosphatase 1   277 aa 279 aa 22.9 %
Schistosoma japonicum ko:K01082 3'(2'), 5'-bisphosphate nucleotidase [EC3.1.3.7], putative Inositol monophosphatase 1   277 aa 275 aa 21.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii non-specific serine/threonine protein kinase 0.002 0.0073 0.0293
Onchocerca volvulus 0.0026 0.0326 0.3477
Loa Loa (eye worm) hypothetical protein 0.0041 0.0937 0.1613
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0096 0.3139 0.5403
Echinococcus multilocularis inositol monophosphatase 1 0.0045 0.1066 0.1835
Onchocerca volvulus 0.0041 0.0937 1
Mycobacterium ulcerans formate dehydrogenase H FdhF 0.0161 0.5809 1
Leishmania major hypothetical protein, conserved 0.0062 0.1762 0.3033
Toxoplasma gondii ABC1 family protein 0.0041 0.0937 0.3737
Trypanosoma brucei S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative 0.0062 0.1762 0.3033
Trichomonas vaginalis PIKK family atypical protein kinase 0.0071 0.2143 0.3609
Giardia lamblia Hypothetical protein 0.0143 0.5063 1
Trichomonas vaginalis esterase, putative 0.0041 0.0937 0.1505
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.1352 0.2229
Entamoeba histolytica type A flavoprotein, putative 0.0062 0.1762 0.3358
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0096 0.3139 0.5403
Giardia lamblia GTOR 0.0096 0.3139 0.6198
Schistosoma mansoni inositol monophosphatase 0.0045 0.1066 0.1835
Mycobacterium ulcerans hypothetical protein 0.0041 0.0937 0.1613
Trichomonas vaginalis PIKK family atypical protein kinase 0.0057 0.1553 0.2579
Schistosoma mansoni NADPH flavin oxidoreductase 0.0081 0.2557 0.4402
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0032 0.0557 0.096
Trichomonas vaginalis PIKK family atypical protein kinase 0.0076 0.2344 0.3959
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.1352 0.2229
Trichomonas vaginalis NADPH fad oxidoreductase, putative 0.0143 0.5063 0.8701
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0557 0.0844
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0937 0.1505
Trichomonas vaginalis PIKK family atypical protein kinase 0.0071 0.2143 0.3609
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0076 0.2347 0.4041
Mycobacterium tuberculosis Probable lipase LipE 0.0041 0.0937 0.0937
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.1352 0.2229
Mycobacterium tuberculosis Conserved protein 0.0041 0.0937 0.0937
Brugia malayi flavodoxin family protein 0.0161 0.5809 1
Leishmania major hypothetical protein, conserved 0.0041 0.0937 0.1613
Echinococcus multilocularis musashi 0.0026 0.0326 0.0561
Trichomonas vaginalis PIKK family atypical protein kinase 0.0096 0.3139 0.5345
Mycobacterium tuberculosis Conserved protein 0.0041 0.0937 0.0937
Trichomonas vaginalis PIKK family atypical protein kinase 0.0071 0.2143 0.3609
Onchocerca volvulus 0.0026 0.0326 0.3477
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0096 0.3139 0.5403
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0096 0.3139 0.5403
Leishmania major phosphatidylinositol 3-kinase, putative 0.0032 0.0557 0.096
Leishmania major NADPH-cytochrome p450 reductase-like protein 0.0161 0.5809 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0557 0.0844
Brugia malayi beta-lactamase family protein 0.0041 0.0937 0.1613
Echinococcus multilocularis lamin 0.0026 0.0326 0.0561
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0937 0.1613
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0161 0.5809 1
Brugia malayi beta-lactamase family protein 0.0041 0.0937 0.1613
Entamoeba histolytica type A flavoprotein, putative 0.0062 0.1762 0.3358
Plasmodium falciparum NADPH--cytochrome P450 reductase, putative 0.0062 0.1762 0.3033
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.004 0.0876 0.0876
Schistosoma mansoni 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase 0.01 0.3302 0.5684
Trichomonas vaginalis PIKK family atypical protein kinase 0.0064 0.186 0.3115
Loa Loa (eye worm) hypothetical protein 0.0041 0.0937 0.1613
Echinococcus granulosus NADPH dependent diflavin oxidoreductase 1 0.0161 0.5809 1
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0096 0.3139 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0557 0.0844
Trichomonas vaginalis PIKK family atypical protein kinase 0.0071 0.2143 0.3609
Loa Loa (eye worm) hypothetical protein 0.0161 0.5809 1
Trypanosoma cruzi NADPH--cytochrome P450 reductase, putative 0.0062 0.1762 0.3033
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0096 0.3139 0.5403
Mycobacterium tuberculosis Probable hydrolase 0.0041 0.0937 0.0937
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0096 0.3139 0.5403
Brugia malayi FAD binding domain containing protein 0.01 0.3302 0.5684
Giardia lamblia Nitric oxide synthase, inducible 0.0143 0.5063 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0071 0.2143 0.3609
Mycobacterium tuberculosis Conserved protein 0.0041 0.0937 0.0937
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0256 0.044
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0045 0.1092 0.1879
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.1349 0.2224
Trichomonas vaginalis PIKK family atypical protein kinase 0.0076 0.2344 0.3959
Leishmania major cytochrome P450 reductase, putative 0.0143 0.5063 0.8717
Loa Loa (eye worm) hypothetical protein 0.0041 0.0937 0.1613
Echinococcus granulosus beta LACTamase domain containing family member 0.0041 0.0937 0.1613
Loa Loa (eye worm) flavodoxin family protein 0.0062 0.1762 0.3033
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0062 0.1762 0.2944
Toxoplasma gondii flavodoxin domain-containing protein 0.008 0.2507 1
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0032 0.0557 0.096
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.1349 0.2224
Trypanosoma brucei NADPH-dependent diflavin oxidoreductase 1 0.0161 0.5809 1
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0045 0.1066 0.5
Schistosoma mansoni cytochrome P450 reductase 0.0161 0.5809 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0041 0.0937 0.1613
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0041 0.0937 0.0937
Chlamydia trachomatis sulfite reductase 0.01 0.3302 1
Echinococcus multilocularis lamin dm0 0.0026 0.0326 0.0561
Mycobacterium tuberculosis Probable esterase LipL 0.0041 0.0937 0.0937
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.1066 0.173
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0062 0.1762 0.2944
Loa Loa (eye worm) hypothetical protein 0.0041 0.0937 0.1613
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0096 0.3139 0.5403
Echinococcus granulosus inositol monophosphatase 1 0.0045 0.1066 0.1835
Loa Loa (eye worm) hypothetical protein 0.0026 0.0326 0.0561
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0062 0.1762 0.2944
Brugia malayi hypothetical protein 0.0025 0.0256 0.044
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0256 0.044
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0032 0.0557 0.096
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0096 0.3139 0.5403
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0096 0.3139 0.5403
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0041 0.0937 0.0937
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0045 0.1066 0.4252
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0256 0.044
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0041 0.0937 0.1613
Loa Loa (eye worm) hypothetical protein 0.002 0.0073 0.0126
Loa Loa (eye worm) FAD binding domain-containing protein 0.0161 0.5809 1
Mycobacterium leprae conserved hypothetical protein 0.0041 0.0937 1
Entamoeba histolytica type A flavoprotein, putative 0.0062 0.1762 0.3358
Trichomonas vaginalis PIKK family atypical protein kinase 0.0076 0.2344 0.3959
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0096 0.3139 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.0937 0.1505
Entamoeba histolytica type A flavoprotein, putative 0.0062 0.1762 0.3358
Loa Loa (eye worm) hypothetical protein 0.0041 0.0937 0.1613
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0937 0.1613
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0032 0.0557 0.096
Schistosoma mansoni lamin 0.0026 0.0326 0.0561
Trichomonas vaginalis PIKK family atypical protein kinase 0.0057 0.1576 0.2619
Loa Loa (eye worm) FAD binding domain-containing protein 0.01 0.3302 0.5684
Mycobacterium leprae Probable lipase LipE 0.0041 0.0937 1
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0032 0.0557 0.096
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0937 0.1505
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0045 0.1066 0.1835
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0326 0.0561
Loa Loa (eye worm) phosphatidylinositol 3 0.0032 0.0557 0.096
Plasmodium vivax NADPH-cytochrome p450 reductase, putative 0.0161 0.5809 1
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.1066 0.1835
Schistosoma mansoni inositol monophosphatase 0.0045 0.1066 0.1835
Trichomonas vaginalis PIKK family atypical protein kinase 0.0096 0.3139 0.5345
Brugia malayi flavodoxin family protein 0.0062 0.1762 0.3033
Trichomonas vaginalis PIKK family atypical protein kinase 0.0082 0.2571 0.4354
Trypanosoma cruzi NADPH-dependent FMN/FAD containing oxidoreductase, putative 0.0161 0.5809 1
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0096 0.3139 0.5403
Trichomonas vaginalis PIKK family atypical protein kinase 0.0071 0.2143 0.3609
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0041 0.0937 0.1613
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0032 0.0557 0.096
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.0937 0.1505
Echinococcus multilocularis methionine synthase reductase 0.01 0.3302 0.5684
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.1066 0.1835
Trichomonas vaginalis PIKK family atypical protein kinase 0.0071 0.2143 0.3609
Trichomonas vaginalis PIKK family atypical protein kinase 0.0057 0.1576 0.2619
Toxoplasma gondii target of rapamycin (TOR), putative 0.0071 0.2143 0.855
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0557 0.0844
Loa Loa (eye worm) hypothetical protein 0.0025 0.0256 0.044
Echinococcus granulosus NADPH cytochrome P450 reductase 0.0161 0.5809 1
Leishmania major p450 reductase, putative 0.0161 0.5809 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.008
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0256 0.102
Echinococcus granulosus lamin dm0 0.0026 0.0326 0.0561
Brugia malayi beta-lactamase 0.0041 0.0937 0.1613
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0161 0.5809 1
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0032 0.0557 0.096
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0076 0.2347 0.4041
Treponema pallidum flavodoxin 0.0062 0.1762 1
Onchocerca volvulus 0.0041 0.0937 1
Plasmodium vivax hypothetical protein, conserved 0.0041 0.0937 0.1613
Entamoeba histolytica type A flavoprotein, putative 0.0062 0.1762 0.3358
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.1066 0.1835
Plasmodium falciparum S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative 0.0062 0.1762 0.3033
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.1066 0.1835
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0032 0.0557 0.096
Echinococcus multilocularis NADPH cytochrome P450 reductase 0.0161 0.5809 1
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0062 0.1762 0.2944
Mycobacterium ulcerans lipase LipD 0.0041 0.0937 0.1613
Trypanosoma cruzi Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative 0.0062 0.1762 0.3033
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.1352 0.2229
Echinococcus granulosus lamin 0.0026 0.0326 0.0561
Trypanosoma cruzi target of rapamycin kinase 3 0.0076 0.2347 0.4041
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0161 0.5809 1
Onchocerca volvulus 0.0041 0.0937 1
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0032 0.0557 0.096
Trichomonas vaginalis PIKK family atypical protein kinase 0.0057 0.1576 0.2619
Loa Loa (eye worm) beta-lactamase 0.0041 0.0937 0.1613
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0256 0.044
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.1349 0.2224
Mycobacterium ulcerans beta-lactamase 0.0041 0.0937 0.1613
Trichomonas vaginalis sulfite reductase, putative 0.0161 0.5809 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0256 0.044
Schistosoma mansoni intermediate filament proteins 0.0026 0.0326 0.0561
Loa Loa (eye worm) hypothetical protein 0.0026 0.0306 0.0527
Leishmania major hypothetical protein, conserved 0.0025 0.0256 0.044
Trypanosoma brucei hypothetical protein, conserved 0.0041 0.0937 0.1613
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0256 0.044
Schistosoma mansoni diflavin oxidoreductase 0.008 0.2507 0.4316
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.0937 0.1613
Plasmodium vivax flavodoxin domain containing protein 0.0143 0.5063 0.8717
Echinococcus granulosus methionine synthase reductase 0.01 0.3302 0.5684
Schistosoma mansoni lamin 0.0026 0.0326 0.0561
Trypanosoma cruzi p450 reductase, putative 0.0161 0.5809 1
Trichomonas vaginalis inositol monophosphatase, putative 0.0045 0.1066 0.173
Brugia malayi intermediate filament protein 0.0026 0.0326 0.0561
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0557 0.0844
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.0937 0.1613
Loa Loa (eye worm) phosphatidylinositol 3 0.0096 0.3139 0.5403
Trichomonas vaginalis PIKK family atypical protein kinase 0.0062 0.1776 0.2969
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0041 0.0937 0.0937
Trichomonas vaginalis PIKK family atypical protein kinase 0.0076 0.2344 0.3959
Mycobacterium tuberculosis Probable lipase LipD 0.0041 0.0937 0.0937
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0326 0.0561
Brugia malayi FAD binding domain containing protein 0.0161 0.5809 1
Echinococcus multilocularis NADPH dependent diflavin oxidoreductase 1 0.0161 0.5809 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0096 0.3139 0.5345
Trypanosoma cruzi Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative 0.0062 0.1762 0.3033
Plasmodium falciparum nitric oxide synthase, putative 0.0161 0.5809 1
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.1066 0.173
Mycobacterium ulcerans esterase/lipase LipP 0.0041 0.0937 0.1613
Trichomonas vaginalis PIKK family atypical protein kinase 0.0076 0.2344 0.3959
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0326 0.0561
Echinococcus multilocularis beta LACTamase domain containing family member 0.0041 0.0937 0.1613
Echinococcus granulosus intermediate filament protein 0.0026 0.0326 0.0561
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.004 0.0868 0.1494
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0161 0.5809 1
Brugia malayi Inositol-1 0.0045 0.1066 0.1835
Trichomonas vaginalis PIKK family atypical protein kinase 0.0057 0.1553 0.2579
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0297 0.039
Plasmodium vivax hypothetical protein, conserved 0.0062 0.1762 0.3033
Toxoplasma gondii flavodoxin domain-containing protein 0.008 0.2507 1
Loa Loa (eye worm) inositol-1 0.0045 0.1066 0.1835
Trypanosoma brucei NADPH-cytochrome p450 reductase, putative 0.0161 0.5809 1
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0937 0.1505
Loa Loa (eye worm) hypothetical protein 0.0041 0.0937 0.1613

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.7943 um PUBCHEM_BIOASSAY: qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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