Detailed information for compound 1241645

Basic information

Technical information
  • TDR Targets ID: 1241645
  • Name: 4-(dimethylaminomethylidene)-5-phenyl-2H-pyra zol-3-one
  • MW: 215.251 | Formula: C12H13N3O
  • H donors: 1 H acceptors: 1 LogP: 1.59 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN(/C=C/1\C(=O)NN=C1c1ccccc1)C
  • InChi: 1S/C12H13N3O/c1-15(2)8-10-11(13-14-12(10)16)9-6-4-3-5-7-9/h3-8H,1-2H3,(H,14,16)/b10-8-
  • InChiKey: RNQUOZAYQLCWJQ-NTMALXAHSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 4-(dimethylaminomethylene)-5-phenyl-2H-pyrazol-3-one
  • 4-[(dimethylamino)methylene]-5-phenyl-2,4-dihydro-3H-pyrazol-3-one
  • MLS000694687
  • SMR000332999
  • 9B-094
  • ZINC00164262
  • (4Z)-4-[(Dimethylamino)methylene]-5-phenyl-2,4-dihydro-3H-pyrazol-3-one
  • Pyrazol-5(4H)-one, 4-dimethylaminomethylideno-3-phenyl-
  • SR-01000641103-1

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni bromodomain containing protein 0.1008 0.5699 0.5699
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0109 0.0373 0.0085
Trypanosoma brucei hypothetical protein, conserved 0.0266 0.1303 1
Loa Loa (eye worm) beta-lactamase 0.0266 0.1303 0.2018
Schistosoma mansoni hypothetical protein 0.0586 0.32 0.32
Brugia malayi Type III restriction enzyme, res subunit family protein 0.006 0.0085 0.0124
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0266 0.1303 0.5
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.006 0.0085 0.0085
Schistosoma mansoni chromobox protein 0.006 0.0085 0.0085
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0349 0.1799 0.2647
Echinococcus granulosus histone lysine methyltransferase setb 0.0427 0.2259 0.2193
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0568 0.3096 0.3037
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0096 0.0301 0.043
Loa Loa (eye worm) hypothetical protein 0.006 0.0085 0.0093
Plasmodium falciparum JmjC domain-containing protein, putative 0.0107 0.0365 0.174
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0075 0.0172 0.0127
Loa Loa (eye worm) RNA binding protein 0.007 0.0144 0.0187
Onchocerca volvulus 0.0217 0.1015 0.1449
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0097 0.0305 0.0305
Loa Loa (eye worm) MBCTL1 0.011 0.038 0.056
Loa Loa (eye worm) jmjC domain-containing protein 0.0107 0.0365 0.0537
Trypanosoma cruzi hypothetical protein, conserved 0.0266 0.1303 1
Echinococcus multilocularis peregrin 0.0369 0.1918 0.1849
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0349 0.1799 0.2802
Giardia lamblia PHD finger protein 15 0.0332 0.1697 0.5
Plasmodium vivax hypothetical protein, conserved 0.006 0.0085 0.0489
Loa Loa (eye worm) jmjC domain-containing protein 0.0686 0.379 0.5948
Brugia malayi mbt repeat family protein 0.0096 0.0301 0.0443
Echinococcus multilocularis lysine specific demethylase 6a 0.0107 0.0365 0.0283
Echinococcus multilocularis muscleblind protein 1 0.0324 0.165 0.1579
Echinococcus multilocularis chromobox protein 1 0.0365 0.1894 0.1824
Brugia malayi jmjC domain containing protein 0.0107 0.0365 0.0537
Echinococcus multilocularis dnaJ subfamily B 0.1734 1 1
Echinococcus granulosus PHD finger protein rhinoceros 0.0332 0.1697 0.1626
Brugia malayi hypothetical protein 0.006 0.0085 0.0124
Loa Loa (eye worm) hypothetical protein 0.0266 0.1303 0.2018
Echinococcus granulosus chromobox protein 1 0.0365 0.1894 0.1824
Loa Loa (eye worm) hypothetical protein 0.0146 0.0593 0.0897
Brugia malayi Heterochromatin protein 1 0.0365 0.1894 0.2786
Brugia malayi jmjC domain containing protein 0.0107 0.0365 0.0537
Schistosoma mansoni methyl-cpg binding protein mbd 0.027 0.1328 0.1328
Plasmodium vivax hypothetical protein, conserved 0.0266 0.1303 0.7678
Echinococcus granulosus phd:f box containing protein 0.0107 0.0365 0.0283
Echinococcus granulosus methyl CpG binding domain protein 2 0.027 0.1328 0.1254
Brugia malayi beta-lactamase family protein 0.0266 0.1303 0.1917
Loa Loa (eye worm) hypothetical protein 0.0324 0.165 0.2567
Schistosoma mansoni tar DNA-binding protein 0.007 0.0144 0.0144
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0087 0.0248 0.0236
Echinococcus granulosus beta LACTamase domain containing family member 0.0266 0.1303 0.1229
Echinococcus multilocularis jumonji domain containing 1A 0.0107 0.0365 0.0283
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0217 0.1015 0.1015
Trichomonas vaginalis chromobox protein, putative 0.022 0.1035 0.1373
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0319 0.162 0.2518
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.1087 0.6169 0.6137
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0264 0.1294 0.1294
Brugia malayi SET domain containing protein 0.0068 0.0134 0.0197
Loa Loa (eye worm) hypothetical protein 0.011 0.038 0.056
Schistosoma mansoni chromobox protein 0.006 0.0085 0.0085
Onchocerca volvulus 0.0122 0.0452 0.0645
Echinococcus multilocularis Chromobox protein 3 0.006 0.0085 0.000000038651
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0097 0.0305 0.0222
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0087 0.0248 0.0236
Schistosoma mansoni phd/f-box containing protein 0.0107 0.0365 0.0365
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.038 0.1979 0.1911
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0349 0.1799 0.1799
Echinococcus granulosus zinc finger protein 0.0317 0.1605 0.1534
Loa Loa (eye worm) hypothetical protein 0.0332 0.1697 0.264
Brugia malayi jmjC domain containing protein 0.1087 0.6169 0.9077
Echinococcus granulosus endonuclease exonuclease phosphatase 0.038 0.1979 0.1911
Brugia malayi TAR-binding protein 0.007 0.0144 0.0212
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0073 0.016 0.0109
Schistosoma mansoni jumonji domain containing protein 0.0864 0.4846 0.4846
Plasmodium vivax SET domain protein, putative 0.0157 0.0661 0.3892
Schistosoma mansoni tar DNA-binding protein 0.007 0.0144 0.0144
Schistosoma mansoni tar DNA-binding protein 0.007 0.0144 0.0144
Loa Loa (eye worm) hypothetical protein 0.0427 0.2259 0.3528
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0349 0.1799 0.1799
Trichomonas vaginalis conserved hypothetical protein 0.0205 0.0943 0.124
Schistosoma mansoni hypothetical protein 0.006 0.0085 0.0085
Echinococcus multilocularis polycomb protein SCMH1 0.0096 0.0301 0.0219
Echinococcus multilocularis methyl CpG binding domain protein 2 0.027 0.1328 0.1254
Echinococcus multilocularis chromobox protein 1 0.0365 0.1894 0.1824
Schistosoma mansoni protein phosphatase 2C 0.0107 0.0365 0.0365
Loa Loa (eye worm) hypothetical protein 0.006 0.0085 0.0093
Loa Loa (eye worm) jmjC domain-containing protein 0.0107 0.0365 0.0537
Trichomonas vaginalis set domain proteins, putative 0.1229 0.7007 1
Loa Loa (eye worm) hypothetical protein 0.0682 0.3766 0.591
Schistosoma mansoni hypothetical protein 0.0109 0.0373 0.0373
Loa Loa (eye worm) hypothetical protein 0.0205 0.0943 0.145
Echinococcus multilocularis lysine specific demethylase 5A 0.0402 0.211 0.2043
Brugia malayi Pre-SET motif family protein 0.108 0.6125 0.9012
Brugia malayi beta-lactamase family protein 0.0266 0.1303 0.1917
Trypanosoma brucei ISWI complex protein 0.0242 0.1164 0.8513
Entamoeba histolytica hypothetical protein 0.0074 0.0167 1
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0364 0.1883 0.1814
Entamoeba histolytica hypothetical protein 0.0074 0.0167 1
Schistosoma mansoni hypothetical protein 0.0074 0.0167 0.0167
Brugia malayi Pre-SET motif family protein 0.0157 0.0661 0.0973
Trichomonas vaginalis conserved hypothetical protein 0.0075 0.0172 0.0127
Loa Loa (eye worm) jmjC domain-containing protein 0.0439 0.233 0.3641
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.011 0.038 0.0559
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.011 0.038 0.0298
Loa Loa (eye worm) mbt repeat family protein 0.0096 0.0301 0.0436
Mycobacterium ulcerans esterase/lipase LipP 0.0266 0.1303 0.5
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0109 0.0373 0.179
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0568 0.3096 0.3037
Brugia malayi jmjC domain containing protein 0.0107 0.0365 0.0537
Echinococcus granulosus chromobox protein 1 0.0365 0.1894 0.1824
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0087 0.0248 0.0236
Loa Loa (eye worm) hypothetical protein 0.0324 0.165 0.2567
Brugia malayi Associated with TFs and helicases family protein 0.006 0.0085 0.0124
Onchocerca volvulus Heterochromatin protein 1 homolog 0.022 0.1035 0.1477
Trichomonas vaginalis D-aminoacylase, putative 0.0266 0.1303 0.176
Loa Loa (eye worm) hypothetical protein 0.0266 0.1303 0.2018
Brugia malayi Bromodomain containing protein 0.0369 0.1918 0.2822
Brugia malayi CHD4 protein 0.0097 0.0305 0.0448
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0427 0.2259 0.2193
Loa Loa (eye worm) CHromoDomain protein family member 0.0097 0.0305 0.0441
Plasmodium vivax heterochromatin protein 1, putative 0.006 0.0085 0.0489
Onchocerca volvulus 0.0266 0.1303 0.186
Brugia malayi chromobox protein homolog 3 0.0205 0.0943 0.1387
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0427 0.2259 0.2259
Loa Loa (eye worm) CXXC zinc finger family protein 0.0122 0.0452 0.0673
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0097 0.0305 0.0222
Brugia malayi RNA binding protein 0.007 0.0144 0.0212
Trichomonas vaginalis penicillin-binding protein, putative 0.0266 0.1303 0.176
Trypanosoma cruzi ISWI complex protein 0.0242 0.1164 0.8513
Toxoplasma gondii PHD-finger domain-containing protein 0.0109 0.0373 0.179
Brugia malayi mbt repeat family protein 0.0096 0.0301 0.0443
Echinococcus granulosus fetal alzheimer antigen falz 0.0364 0.1883 0.1814
Schistosoma mansoni phosphatidylserine receptor 0.0107 0.0365 0.0365
Mycobacterium ulcerans beta-lactamase 0.0266 0.1303 0.5
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0096 0.0301 0.0301
Onchocerca volvulus 0.0266 0.1303 0.186
Onchocerca volvulus 0.006 0.0085 0.0121
Toxoplasma gondii histone lysine methyltransferase SET1 0.0274 0.1352 0.7863
Echinococcus granulosus polycomb protein SCMH1 0.0096 0.0301 0.0219
Echinococcus multilocularis PHD finger protein rhinoceros 0.0332 0.1697 0.1626
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0025 0.0037
Echinococcus multilocularis muscleblind protein 0.0324 0.165 0.1579
Loa Loa (eye worm) hypothetical protein 0.006 0.0085 0.0093
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0205 0.0943 0.1346
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0087 0.0248 0.0236
Toxoplasma gondii PHD-finger domain-containing protein 0.0332 0.1697 1
Schistosoma mansoni hypothetical protein 0.0332 0.1697 0.1697
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.1087 0.6169 0.6137
Brugia malayi CXXC zinc finger family protein 0.0122 0.0452 0.0664
Echinococcus granulosus lysine specific demethylase 6a 0.0107 0.0365 0.0283
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0364 0.1883 0.1883
Echinococcus multilocularis tar DNA binding protein 0.007 0.0144 0.006
Schistosoma mansoni hypothetical protein 0.0535 0.2898 0.2898
Echinococcus multilocularis cpg binding protein 0.0159 0.0672 0.0592
Loa Loa (eye worm) hypothetical protein 0.0107 0.0365 0.0537
Schistosoma mansoni transcription factor LCR-F1 0.0074 0.0167 0.0167
Trichomonas vaginalis penicillin-binding protein, putative 0.0266 0.1303 0.176
Echinococcus granulosus peregrin 0.0369 0.1918 0.1849
Schistosoma mansoni chromobox protein 0.0365 0.1894 0.1894
Plasmodium vivax JmjC domain containing protein 0.0107 0.0365 0.2144
Mycobacterium ulcerans hypothetical protein 0.0266 0.1303 0.5
Schistosoma mansoni cpg binding protein 0.0122 0.0452 0.0452
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0951 0.5364 0.5324
Loa Loa (eye worm) bromodomain containing protein 0.0279 0.1385 0.2148
Echinococcus granulosus SAM and MBT domain containing protein 0.0096 0.0301 0.0219
Trypanosoma cruzi ISWI complex protein 0.0242 0.1164 0.8513
Echinococcus granulosus muscleblind protein 0.0324 0.165 0.1579
Echinococcus granulosus tar DNA binding protein 0.007 0.0144 0.006
Schistosoma mansoni cpg binding protein 0.0159 0.0672 0.0672
Echinococcus granulosus JmjC domain containing protein 4 0.0107 0.0365 0.0283
Brugia malayi Bromodomain containing protein 0.0606 0.3318 0.4882
Loa Loa (eye worm) hypothetical protein 0.1119 0.6355 1
Trichomonas vaginalis chromobox protein, putative 0.0365 0.1894 0.2613
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.007 0.0144 0.0187
Onchocerca volvulus 0.0161 0.0681 0.0972
Loa Loa (eye worm) helicase 0.006 0.0085 0.0093
Loa Loa (eye worm) heterochromatin protein 1 0.0365 0.1894 0.2951
Schistosoma mansoni hypothetical protein 0.0242 0.1164 0.1164
Loa Loa (eye worm) jmjC domain-containing protein 0.0107 0.0365 0.0537
Schistosoma mansoni jumonji/arid domain-containing protein 0.0439 0.233 0.233
Loa Loa (eye worm) hypothetical protein 0.0107 0.0365 0.0537
Echinococcus multilocularis snurportin 1 0.0319 0.162 0.1548
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.006 0.0085 0.0085
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0427 0.2259 0.2259
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0087 0.0248 0.0236
Trichomonas vaginalis D-aminoacylase, putative 0.0266 0.1303 0.176
Brugia malayi AF-10 protein 0.0109 0.0373 0.0549
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0087 0.0248 0.0236
Loa Loa (eye worm) PHD-finger family protein 0.0326 0.1663 0.2588
Schistosoma mansoni methyl-cpg binding protein mbd 0.027 0.1328 0.1328
Trichomonas vaginalis chromobox protein, putative 0.022 0.1035 0.1373
Onchocerca volvulus Alhambra homolog 0.0332 0.1697 0.2421
Leishmania major hypothetical protein, conserved 0.0242 0.1164 0.8513
Trichomonas vaginalis conserved hypothetical protein 0.0145 0.0589 0.0729
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0157 0.0661 0.0582
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0349 0.1799 0.1729
Loa Loa (eye worm) hypothetical protein 0.0075 0.0172 0.0232
Schistosoma mansoni tar DNA-binding protein 0.007 0.0144 0.0144
Schistosoma mansoni cpg binding protein 0.0159 0.0672 0.0672
Trichomonas vaginalis chromobox protein, putative 0.0365 0.1894 0.2613
Loa Loa (eye worm) hypothetical protein 0.006 0.0085 0.0093
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0266 0.1303 0.1303
Echinococcus multilocularis jumonji domain containing protein 0.0462 0.2466 0.2402
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0074 0.0167 0.0083
Brugia malayi PHD-finger family protein 0.0401 0.2105 0.3097
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0349 0.1799 0.1799
Echinococcus multilocularis zinc finger protein 0.0317 0.1605 0.1534
Entamoeba histolytica hypothetical protein 0.0074 0.0167 1
Brugia malayi hypothetical protein 0.0074 0.0167 0.0246
Schistosoma mansoni hypothetical protein 0.0326 0.1663 0.1663
Schistosoma mansoni sex comb on midleg homolog 0.0096 0.0301 0.0301
Brugia malayi Muscleblind-like protein 0.0324 0.165 0.2428
Brugia malayi Protein cec-1. 0.006 0.0085 0.0124
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0107 0.0365 0.0365
Onchocerca volvulus 0.1229 0.7007 1
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0144 0.0585 0.0505
Loa Loa (eye worm) hypothetical protein 0.006 0.0085 0.0093
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0144 0.0585 0.0505
Echinococcus granulosus cpg binding protein 0.0159 0.0672 0.0592
Schistosoma mansoni myelin transcription factor 1 myt1 0.011 0.038 0.038
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0149 0.0612 0.0532
Mycobacterium tuberculosis Possible penicillin-binding protein 0.1697 0.9777 1
Mycobacterium leprae Probable lipase LipE 0.0266 0.1303 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0145 0.0589 0.0729
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0349 0.1799 0.1729
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0157 0.0661 0.0661
Echinococcus granulosus snurportin 1 0.0319 0.162 0.1548
Schistosoma mansoni tar DNA-binding protein 0.007 0.0144 0.0144
Brugia malayi PHD-finger family protein 0.0332 0.1697 0.2496
Brugia malayi jmjC domain containing protein 0.0107 0.0365 0.0537
Loa Loa (eye worm) hypothetical protein 0.0266 0.1303 0.2018
Schistosoma mansoni sex comb on midleg homolog 0.0096 0.0301 0.0301
Echinococcus granulosus lysine specific demethylase 5A 0.0439 0.233 0.2265
Schistosoma mansoni jumonji/arid domain-containing protein 0.0439 0.233 0.233
Echinococcus multilocularis beta LACTamase domain containing family member 0.0266 0.1303 0.1229
Mycobacterium leprae conserved hypothetical protein 0.0266 0.1303 0.5
Brugia malayi beta-lactamase 0.0266 0.1303 0.1917
Schistosoma mansoni hypothetical protein 0.0535 0.2898 0.2898
Echinococcus granulosus Chromobox protein 3 0.006 0.0085 0.000000038651
Brugia malayi RNA recognition motif domain containing protein 0.007 0.0144 0.0212
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0349 0.1799 0.1729
Plasmodium vivax hypothetical protein, conserved 0.0332 0.1697 1
Toxoplasma gondii PHD-finger domain-containing protein 0.0332 0.1697 1
Loa Loa (eye worm) TAR-binding protein 0.007 0.0144 0.0187
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0266 0.1303 0.1917
Brugia malayi Valyl-tRNA synthetase 0.006 0.0085 0.0124
Schistosoma mansoni zinc finger protein 0.0317 0.1605 0.1605
Loa Loa (eye worm) hypothetical protein 0.0266 0.1303 0.2018
Schistosoma mansoni hypothetical protein 0.0319 0.162 0.162
Loa Loa (eye worm) hypothetical protein 0.0161 0.0681 0.1036
Schistosoma mansoni zinc finger protein 0.0242 0.1164 0.1164
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0074 0.0167 0.0083
Echinococcus multilocularis geminin 0.0535 0.2898 0.2837
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.108 0.6125 0.9637
Brugia malayi F/Y-rich N-terminus family protein 0.0182 0.0806 0.1186
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0109 0.0373 0.0085
Loa Loa (eye worm) PHD-finger family protein 0.0332 0.1697 0.264
Schistosoma mansoni jumonji domain containing protein 0.0107 0.0365 0.0365
Loa Loa (eye worm) hypothetical protein 0.0569 0.3101 0.4859
Trichomonas vaginalis conserved hypothetical protein 0.0205 0.0943 0.124
Schistosoma mansoni chromobox protein 0.0365 0.1894 0.1894
Echinococcus multilocularis JmjC domain containing protein 4 0.0107 0.0365 0.0283
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0107 0.0365 0.174
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0332 0.1697 0.1697
Brugia malayi Bromodomain containing protein 0.1193 0.6797 1
Echinococcus granulosus histone acetyltransferase MYST2 0.011 0.038 0.0298
Leishmania major hypothetical protein, conserved 0.0266 0.1303 1
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.011 0.038 0.0298
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0951 0.5364 0.5324
Loa Loa (eye worm) hypothetical protein 0.006 0.0085 0.0093
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0087 0.0248 0.0236
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0266 0.1303 0.1303
Onchocerca volvulus 0.0266 0.1303 0.186
Onchocerca volvulus 0.006 0.0085 0.0121
Mycobacterium ulcerans lipase LipD 0.0266 0.1303 0.5
Plasmodium vivax hypothetical protein, conserved 0.0116 0.0417 0.2451
Onchocerca volvulus 0.0096 0.0301 0.043
Loa Loa (eye worm) hypothetical protein 0.0644 0.3546 0.5563
Loa Loa (eye worm) hypothetical protein 0.0096 0.0301 0.0436
Loa Loa (eye worm) hypothetical protein 0.0266 0.1303 0.2018
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0087 0.0248 0.0236
Schistosoma mansoni hypothetical protein 0.1734 1 1
Echinococcus multilocularis phd:f box containing protein 0.0107 0.0365 0.0283
Loa Loa (eye worm) hypothetical protein 0.0607 0.3325 0.5212
Echinococcus multilocularis histone acetyltransferase MYST2 0.011 0.038 0.0298
Schistosoma mansoni chromodomain helicase DNA binding protein 0.006 0.0085 0.0085
Echinococcus granulosus jumonji domain containing protein 0.0462 0.2466 0.2402
Toxoplasma gondii ABC1 family protein 0.0266 0.1303 0.7559
Trichomonas vaginalis D-aminoacylase, putative 0.0266 0.1303 0.176
Loa Loa (eye worm) hypothetical protein 0.0266 0.1303 0.2018
Loa Loa (eye worm) hypothetical protein 0.006 0.0085 0.0093
Echinococcus multilocularis SAM and MBT domain containing protein 0.0096 0.0301 0.0219
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0107 0.0365 0.174
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0157 0.0661 0.3578
Plasmodium vivax hypothetical protein, conserved 0.006 0.0085 0.0489
Brugia malayi RNA, U transporter 1 0.0085 0.0234 0.0344
Trichomonas vaginalis esterase, putative 0.0266 0.1303 0.176
Plasmodium falciparum phd finger protein, putative 0.0332 0.1697 1
Brugia malayi M-phase phosphoprotein, mpp8 0.006 0.0085 0.0124
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0349 0.1799 0.1729
Trypanosoma cruzi hypothetical protein, conserved 0.0266 0.1303 1
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0116 0.0417 0.2063
Schistosoma mansoni bromodomain containing protein 0.0075 0.0172 0.0172
Echinococcus granulosus geminin 0.0535 0.2898 0.2837
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0144 0.0586 0.0586
Echinococcus granulosus jumonji domain containing 1A 0.0107 0.0365 0.0283
Entamoeba histolytica hypothetical protein 0.0074 0.0167 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0025 0.0037
Brugia malayi jmjC domain containing protein 0.0439 0.233 0.3428
Brugia malayi PHD-finger family protein 0.0146 0.0593 0.0873
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0266 0.1303 0.2018

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.1585 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.9953 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 20.7865 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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