Detailed information for compound 1241834

Basic information

Technical information
  • TDR Targets ID: 1241834
  • Name: 2-(6-methyl-3-oxo-1,4-benzoxazin-4-yl)-N-(5-m ethylpyridin-2-yl)acetamide
  • MW: 311.335 | Formula: C17H17N3O3
  • H donors: 1 H acceptors: 3 LogP: 1.95 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(CN1C(=O)COc2c1cc(C)cc2)Nc1ccc(cn1)C
  • InChi: 1S/C17H17N3O3/c1-11-3-5-14-13(7-11)20(17(22)10-23-14)9-16(21)19-15-6-4-12(2)8-18-15/h3-8H,9-10H2,1-2H3,(H,18,19,21)
  • InChiKey: XUJXDMRTEKJMGY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(6-methyl-3-oxo-1,4-benzoxazin-4-yl)-N-(5-methyl-2-pyridyl)acetamide
  • 2-(3-keto-6-methyl-1,4-benzoxazin-4-yl)-N-(5-methyl-2-pyridyl)acetamide
  • 2-(6-methyl-3-oxo-1,4-benzoxazin-4-yl)-N-(5-methylpyridin-2-yl)ethanamide
  • SMR000007344
  • ASN 06913289
  • ZINC01362124
  • 2-(6-Methyl-3-oxo-2,3-dihydro-benzo[1,4]oxazin-4-yl)-N-(5-methyl-pyridin-2-yl)-acetamide
  • MLS000074477

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.1243 0.2296
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0338 1 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0236 0.047
Loa Loa (eye worm) inositol-1 0.0043 0.0856 0.1219
Schistosoma mansoni aldehyde dehydrogenase 0.007 0.1707 0.3243
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0019 0.0118 0.0163
Mycobacterium ulcerans aldehyde dehydrogenase 0.007 0.1707 0.3336
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0338 1 1
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0165 0.4646 1
Echinococcus granulosus geminin 0.0177 0.5019 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0019 0.0118 0.0163
Brugia malayi Inositol-1 0.0043 0.0856 0.1219
Schistosoma mansoni hypothetical protein 0.0045 0.094 0.1676
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.1243 0.2477
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0023 0.0236 0.0119
Toxoplasma gondii aldehyde dehydrogenase 0.007 0.1707 1
Toxoplasma gondii FATC domain-containing protein 0.0026 0.0337 0.1376
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0856 0.464
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0241 0.6986 1
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0026 0.0337 0.2966
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.007 0.1707 0.3402
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0236 0.0119
Mycobacterium ulcerans aldehyde dehydrogenase 0.007 0.1707 0.3336
Trypanosoma cruzi ISWI complex protein 0.0034 0.0576 0.6208
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0019 0.0118 0.0236
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0131 0.3604 0.7181
Loa Loa (eye worm) hypothetical protein 0.0156 0.4355 0.6231
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.1243 0.2296
Loa Loa (eye worm) hypothetical protein 0.0084 0.2149 0.3072
Echinococcus granulosus fetal alzheimer antigen falz 0.005 0.107 0.2132
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0338 1 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0045 0.0927 0.165
Leishmania major hypothetical protein, conserved 0.0034 0.0576 0.288
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0043 0.0856 0.1405
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0165 0.4646 1
Schistosoma mansoni methyl-cpg binding protein mbd 0.0038 0.0696 0.1178
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0033 0.0562 0.1121
Onchocerca volvulus 0.0274 0.8016 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.0236 0.1597
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0338 1 1
Loa Loa (eye worm) hypothetical protein 0.0072 0.1765 0.2521
Treponema pallidum fructose-bisphosphate aldolase 0.0338 1 1
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0043 0.0856 0.0746
Echinococcus multilocularis inositol monophosphatase 1 0.0043 0.0856 0.1705
Echinococcus granulosus lysine specific demethylase 5A 0.0045 0.0927 0.1847
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0043 0.0856 0.464
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.1243 0.2477
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0072 0.1765 0.336
Schistosoma mansoni inositol monophosphatase 0.0043 0.0856 0.1505
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.1243 0.2296
Echinococcus granulosus histone lysine methyltransferase setb 0.0072 0.1765 0.3516
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0026 0.0337 0.0476
Giardia lamblia Fructose-bisphosphate aldolase 0.0338 1 1
Echinococcus granulosus zinc finger protein 0.0043 0.0868 0.1729
Loa Loa (eye worm) MH2 domain-containing protein 0.0125 0.3398 0.486
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.0236 0.1597
Schistosoma mansoni zinc finger protein 0.0034 0.0576 0.0934
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0236 0.0332
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.007 0.1707 0.3402
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0019 0.0118 0.0236
Plasmodium vivax SET domain protein, putative 0.0035 0.0602 1
Brugia malayi PHD-finger family protein 0.0055 0.1231 0.1757
Loa Loa (eye worm) phosphatidylinositol 3 0.0019 0.0118 0.0163
Schistosoma mansoni zinc finger protein 0.0043 0.0868 0.1529
Plasmodium falciparum phd finger protein, putative 0.0034 0.0577 1
Echinococcus multilocularis peregrin 0.0039 0.0738 0.1471
Echinococcus granulosus serine protein kinase ATM 0.0026 0.0337 0.0671
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0026 0.0337 0.0446
Brugia malayi Bromodomain containing protein 0.0039 0.0738 0.1051
Schistosoma mansoni jumonji/arid domain-containing protein 0.0045 0.0927 0.165
Toxoplasma gondii exonuclease III APE 0.0023 0.0236 0.0741
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0043 0.0856 0.0746
Echinococcus granulosus peregrin 0.0039 0.0738 0.1471
Mycobacterium ulcerans aldehyde dehydrogenase 0.007 0.1707 0.3336
Loa Loa (eye worm) hypothetical protein 0.0058 0.1323 0.1888
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0079 0.1983 0.3951
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0337 0.0221
Echinococcus granulosus PHD finger protein rhinoceros 0.0034 0.0577 0.1149
Brugia malayi jmjC domain containing protein 0.0045 0.0927 0.1321
Echinococcus multilocularis zinc finger protein 0.0043 0.0868 0.1729
Loa Loa (eye worm) hypothetical protein 0.009 0.231 0.3303
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0236 0.047
Brugia malayi Pre-SET motif family protein 0.0241 0.6986 1
Entamoeba histolytica hypothetical protein 0.0026 0.0337 0.0221
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0338 1 1
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0856 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0045 0.0927 0.1321
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.007 0.1707 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.007 0.1707 0.3336
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0023 0.0236 0.0119
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0165 0.4646 1
Schistosoma mansoni bromodomain containing protein 0.0139 0.3848 0.7611
Loa Loa (eye worm) PHD-finger family protein 0.0045 0.094 0.134
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0038 0.0717 0.109
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0022 0.0224 0.1438
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0338 1 1
Loa Loa (eye worm) transcription factor SMAD2 0.0125 0.3398 0.486
Loa Loa (eye worm) hypothetical protein 0.0022 0.0224 0.0315
Schistosoma mansoni ap endonuclease 0.0023 0.0236 0.024
Brugia malayi jmjC domain containing protein 0.011 0.2952 0.4222
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0043 0.0856 0.0746
Brugia malayi Pre-SET motif family protein 0.0035 0.0602 0.0856
Echinococcus granulosus inositol monophosphatase 1 0.0043 0.0856 0.1705
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0019 0.0118 0.0163
Toxoplasma gondii PHD-finger domain-containing protein 0.0034 0.0577 0.2886
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.1243 0.1774
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0043 0.0856 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.1243 0.2477
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0856 1
Brugia malayi MH2 domain containing protein 0.0125 0.3398 0.486
Schistosoma mansoni ap endonuclease 0.0023 0.0236 0.024
Echinococcus multilocularis PHD finger protein rhinoceros 0.0034 0.0577 0.1149
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0034 0.0577 0.0936
Toxoplasma gondii PHD-finger domain-containing protein 0.0034 0.0577 0.2886
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.011 0.2952 0.5883
Brugia malayi PHD-finger family protein 0.0034 0.0577 0.082
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0072 0.1765 0.3516
Trichomonas vaginalis set domain proteins, putative 0.0274 0.8016 0.7992
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0236 0.0332
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0338 1 1
Schistosoma mansoni jumonji domain containing protein 0.0088 0.225 0.4349
Schistosoma mansoni hypothetical protein 0.0177 0.5019 1
Echinococcus granulosus methyl CpG binding domain protein 2 0.0038 0.0696 0.1386
Trichomonas vaginalis inositol monophosphatase, putative 0.0043 0.0856 0.0746
Loa Loa (eye worm) jmjC domain-containing protein 0.007 0.1689 0.2412
Loa Loa (eye worm) bromodomain containing protein 0.0039 0.0737 0.105
Schistosoma mansoni inositol monophosphatase 0.0043 0.0856 0.1505
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0019 0.0118 0.0236
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.005 0.107 0.1942
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.0236 0.1597
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0338 1 1
Brugia malayi F/Y-rich N-terminus family protein 0.0016 0.0044 0.0056
Schistosoma mansoni hypothetical protein 0.0034 0.0577 0.0936
Echinococcus multilocularis fetal alzheimer antigen, falz 0.005 0.107 0.2132
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0072 0.1765 0.336
Leishmania major phosphatidylinositol kinase related protein, putative 0.0019 0.0119 0.0007
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0019 0.0118 0.0236
Schistosoma mansoni hypothetical protein 0.0177 0.5019 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0035 0.0602 0.3043
Loa Loa (eye worm) hypothetical protein 0.0094 0.2441 0.349
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0856 1
Echinococcus granulosus jumonji domain containing protein 0.0047 0.0986 0.1964
Echinococcus multilocularis lysine specific demethylase 5A 0.0041 0.0797 0.1587
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0131 0.3604 0.7181
Loa Loa (eye worm) PHD-finger family protein 0.0034 0.0577 0.082
Echinococcus multilocularis serine protein kinase ATM 0.0026 0.0337 0.0671
Plasmodium vivax hypothetical protein, conserved 0.0034 0.0577 0.9317
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.1243 0.1774
Echinococcus multilocularis jumonji domain containing protein 0.0047 0.0986 0.1964
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.1243 0.2477
Onchocerca volvulus 0.0035 0.0602 0.0034
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0023 0.0236 0.0741
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0019 0.0119 0.0015
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0035 0.0602 0.0987
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0038 0.0696 0.1386
Trypanosoma cruzi ISWI complex protein 0.0034 0.0576 0.6208
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0079 0.1983 0.3951
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0236 0.0119
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.011 0.2952 0.5883
Schistosoma mansoni hypothetical protein 0.0034 0.0576 0.0934
Brugia malayi Bromodomain containing protein 0.0165 0.4647 0.6649
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0035 0.0602 0.1199
Trypanosoma brucei ISWI complex protein 0.0034 0.0576 0.6208
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0338 1 1
Echinococcus multilocularis geminin 0.0177 0.5019 1
Brugia malayi Bromodomain containing protein 0.0084 0.2144 0.3065
Schistosoma mansoni methyl-cpg binding protein mbd 0.0038 0.0696 0.1178
Schistosoma mansoni aldehyde dehydrogenase 0.007 0.1707 0.3243
Giardia lamblia PHD finger protein 15 0.0034 0.0577 0.0464
Loa Loa (eye worm) hypothetical protein 0.0034 0.0577 0.082
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0026 0.0337 0.2966
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0602 0.0987

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1.5849 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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