Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Brugia malayi | MH2 domain containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Loa Loa (eye worm) | transcription factor SMAD2 | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Loa Loa (eye worm) | MH2 domain-containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, putative | 0.0032 | 0.1669 | 0.5 |
Trypanosoma brucei | peptidyl-prolyl cis-trans isomerase/rotamase, putative | 0.0032 | 0.1669 | 1 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0013 | 0.0179 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0074 | 0.477 | 1 |
Onchocerca volvulus | 0.0013 | 0.0179 | 0.5 | |
Onchocerca volvulus | 0.0013 | 0.0179 | 0.5 | |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase | 0.0032 | 0.1669 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0013 | 0.0179 | 0.5 |
Schistosoma mansoni | rotamase | 0.0033 | 0.1728 | 0.3373 |
Wolbachia endosymbiont of Brugia malayi | parvulin-like peptidyl-prolyl isomerase, PPID | 0.001 | 0 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0074 | 0.477 | 1 |
Leishmania major | peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative | 0.0032 | 0.1669 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0033 | 0.1728 | 1 |
Brugia malayi | Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 | 0.0033 | 0.1728 | 0.1577 |
Echinococcus multilocularis | expressed protein | 0.0033 | 0.1728 | 0.3373 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0013 | 0.0179 | 0.5 |
Trichomonas vaginalis | rotamase, putative | 0.0033 | 0.1728 | 1 |
Toxoplasma gondii | peptidylprolyl isomerase | 0.0032 | 0.1669 | 1 |
Onchocerca volvulus | 0.0013 | 0.0179 | 0.5 | |
Brugia malayi | Carboxylesterase family protein | 0.0074 | 0.477 | 0.4675 |
Echinococcus granulosus | acetylcholinesterase | 0.0074 | 0.477 | 1 |
Trichomonas vaginalis | rotamase, putative | 0.0032 | 0.1669 | 0.9623 |
Brugia malayi | Carboxylesterase family protein | 0.0074 | 0.477 | 0.4675 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase | 0.0032 | 0.1669 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0074 | 0.477 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.477 | 0.4675 |
Loa Loa (eye worm) | Pin1-type peptidyl-prolyl cis-trans isomerase | 0.0033 | 0.1728 | 0.1577 |
Onchocerca volvulus | 0.0013 | 0.0179 | 0.5 | |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0074 | 0.477 | 0.4675 |
Onchocerca volvulus | 0.0013 | 0.0179 | 0.5 | |
Echinococcus granulosus | carboxylesterase 5A | 0.0074 | 0.477 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0074 | 0.477 | 0.4675 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.477 | 0.4675 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0074 | 0.477 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0013 | 0.0179 | 0.5 |
Echinococcus granulosus | expressed protein | 0.0033 | 0.1728 | 0.3373 |
Echinococcus granulosus | acetylcholinesterase | 0.0074 | 0.477 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 2.2387 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.