Detailed information for compound 1241980

Basic information

Technical information
  • TDR Targets ID: 1241980
  • Name: 2-[(2,6-dichlorophenyl)methylsulfanyl]-5-[(2S )-pyrrolidin-2-yl]-1,3,4-oxadiazole hydrochlo ride
  • MW: 366.694 | Formula: C13H14Cl3N3OS
  • H donors: 1 H acceptors: 2 LogP: 4.07 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1cccc(c1CSc1nnc(o1)[C@@H]1CCCN1)Cl.Cl
  • InChi: 1S/C13H13Cl2N3OS.ClH/c14-9-3-1-4-10(15)8(9)7-20-13-18-17-12(19-13)11-5-2-6-16-11;/h1,3-4,11,16H,2,5-7H2;1H/t11-;/m0./s1
  • InChiKey: SAODYUQQJHDADM-MERQFXBCSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[(2,6-dichlorophenyl)methylthio]-5-[(2S)-2-pyrrolidinyl]-1,3,4-oxadiazole hydrochloride
  • 2-[(2,6-dichlorobenzyl)thio]-5-[(2S)-pyrrolidin-2-yl]-1,3,4-oxadiazole hydrochloride
  • SMR000439498
  • 2-(2,6-Dichloro-benzylsulfanyl)-5-(S)-pyrrolidin-2-yl-[1,3,4]oxadiazole
  • MLS000763194

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ataxin 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Giardia lamblia Fructose-bisphosphate aldolase 0.0885 1 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0307 0.3346 0.4447
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0386 0.4253 0.4213
Leishmania major prostaglandin f synthase, putative 0.0307 0.3346 0.7833
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0307 0.3346 0.4447
Trichomonas vaginalis conserved hypothetical protein 0.0386 0.4253 0.4243
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0261 0.0461
Schistosoma mansoni alpha-glucosidase 0.0161 0.1657 0.2202
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0564 0.6304 0.8378
Mycobacterium tuberculosis Probable amidase AmiA2 (aminohydrolase) 0.0068 0.059 0.1106
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0307 0.3346 0.3334
Schistosoma mansoni hypothetical protein 0.0066 0.0573 0.0761
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0161 0.0214
Echinococcus multilocularis voltage gated potassium channel subunit 0.0089 0.0832 0.1105
Brugia malayi CXXC zinc finger family protein 0.0029 0.0141 0.0208
Brugia malayi jmjC domain containing protein 0.006 0.0494 0.0728
Loa Loa (eye worm) hypothetical protein 0.004 0.0271 0.0431
Schistosoma mansoni mixed-lineage leukemia protein mll 0.007 0.0613 0.0814
Loa Loa (eye worm) heterochromatin protein 1 0.0072 0.0636 0.1009
Plasmodium vivax JmjC domain containing protein 0.006 0.0494 0.1016
Schistosoma mansoni cpg binding protein 0.0031 0.016 0.0213
Echinococcus multilocularis chromobox protein 1 0.0072 0.0636 0.0845
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0307 0.3346 0.4935
Loa Loa (eye worm) acetyltransferase 0.0146 0.1494 0.2369
Echinococcus granulosus JmjC domain containing protein 4 0.006 0.0494 0.0656
Schistosoma mansoni cpg binding protein 0.0029 0.0141 0.0187
Brugia malayi amidase 0.0564 0.6304 0.9298
Loa Loa (eye worm) oxidoreductase 0.0307 0.3346 0.5308
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.006 0.0503 0.1324
Brugia malayi Pre-SET motif family protein 0.0444 0.492 0.7256
Chlamydia trachomatis glutamyl-tRNA(Gln) amidotransferase subunit A 0.0068 0.059 1
Leishmania major aldo/keto reductase, putative,aldo/keto reductase family-like protein 0.0089 0.0832 0.1824
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0209 0.0336
Loa Loa (eye worm) glutamate-cysteine ligase modifier subunit 0.0089 0.0832 0.1319
Brugia malayi jmjC domain containing protein 0.0605 0.6781 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0141 0.0223
Loa Loa (eye worm) hypothetical protein 0.0032 0.0171 0.0271
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0161 0.0256
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0307 0.3346 0.4935
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0161 0.0238
Brugia malayi NADH-dependent xylose reductase 0.0089 0.0832 0.1227
Mycobacterium ulcerans amidase 0.0068 0.059 0.1106
Onchocerca volvulus 0.0307 0.3346 0.5948
Schistosoma mansoni transcription factor LCR-F1 0.007 0.0615 0.0818
Echinococcus multilocularis JmjC domain containing protein 4 0.006 0.0494 0.0656
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0024 0.0085 0.0035
Echinococcus granulosus lysine specific demethylase 6a 0.006 0.0494 0.0656
Echinococcus granulosus aldo keto reductase 0.0307 0.3346 0.4447
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0209 0.0298
Trichomonas vaginalis bromodomain-containing protein, putative 0.0043 0.0303 0.0285
Leishmania major hypothetical protein, conserved 0.006 0.0494 0.1016
Echinococcus granulosus cpg binding protein 0.0031 0.016 0.0213
Echinococcus multilocularis abhydrolase domain containing 3 0.0023 0.0069 0.0091
Onchocerca volvulus 0.0307 0.3346 0.5948
Schistosoma mansoni aldo-keto reductase 0.0307 0.3346 0.4447
Loa Loa (eye worm) beta-lactamase 0.0035 0.0209 0.0332
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.0546 0.0726
Onchocerca volvulus Heterochromatin protein 1 homolog 0.004 0.0271 0.0483
Trypanosoma brucei glucosidase, putative 0.0041 0.0284 0.0514
Trypanosoma brucei aldo/keto reductase, putative 0.0089 0.0832 0.1824
Mycobacterium ulcerans hypothetical protein 0.0089 0.0832 0.1618
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0069 0.0051
Schistosoma mansoni microtubule-associated protein tau 0.067 0.7525 1
Echinococcus multilocularis microtubule associated protein 2 0.067 0.7525 1
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0564 0.6304 0.8378
Entamoeba histolytica aldose reductase, putative 0.0307 0.3346 0.33
Schistosoma mansoni hypothetical protein 0.0031 0.0161 0.0214
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0885 1 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.034 0.0452
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0432 0.4786 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0225 0.2403 0.3812
Loa Loa (eye worm) hypothetical protein 0.0066 0.0573 0.0908
Mycobacterium ulcerans hypothetical protein 0.0386 0.4253 0.887
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0209 0.0298
Echinococcus granulosus GPCR family 2 0.0031 0.0161 0.0214
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0069 0.0051
Loa Loa (eye worm) hypothetical protein 0.0023 0.0069 0.0109
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.006 0.0503 0.1037
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0307 0.0289
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.006 0.0494 0.1016
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0157 0.0212
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0161 0.0214
Echinococcus multilocularis Phospholipase carboxylesterase 0.0023 0.0069 0.0091
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0069 0.0051
Leishmania major alpha glucosidase II subunit, putative 0.0041 0.0284 0.0514
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0209 0.0192
Echinococcus multilocularis jumonji domain containing protein 0.0257 0.277 0.3681
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.0494 0.0783
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0885 1 1
Schistosoma mansoni glutamyl-tRNA(Gln) amidotransferase subunit A 0.0068 0.059 0.0785
Trichomonas vaginalis esterase, putative 0.0035 0.0209 0.0192
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0161 0.0214
Onchocerca volvulus 0.0307 0.3346 0.5948
Schistosoma mansoni hypothetical protein 0.0185 0.1936 0.2573
Echinococcus multilocularis cpg binding protein 0.0031 0.016 0.0213
Mycobacterium tuberculosis Conserved protein 0.0089 0.0832 0.1618
Echinococcus granulosus microtubule associated protein 2 0.067 0.7525 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0038 0.0241 0.0411
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0307 0.3346 0.4447
Loa Loa (eye worm) hypothetical protein 0.0064 0.0546 0.0866
Leishmania major hypothetical protein, conserved 0.0023 0.0069 0.000000073316
Loa Loa (eye worm) PHD-finger family protein 0.0185 0.1936 0.3071
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0023 0.0069 0.0051
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.0494 0.0783
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0307 0.3346 0.4447
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0023 0.0069 0.0051
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0043 0.0303 0.0714
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0038 0.0241 0.0365
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.034 0.0452
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.034 0.0502
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0023 0.0069 0.0051
Schistosoma mansoni hypothetical protein 0.0031 0.0161 0.0214
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0271 0.0254
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0041 0.0284 0.0266
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0136 0.0118
Giardia lamblia Aldose reductase 0.0307 0.3346 0.33
Leishmania major hypothetical protein, conserved 0.0068 0.059 0.1247
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0386 0.4253 0.4243
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0444 0.492 0.7804
Wolbachia endosymbiont of Brugia malayi aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0068 0.059 1
Plasmodium falciparum aldehyde reductase, putative 0.0089 0.0832 0.1824
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0089 0.0832 0.0815
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0885 1 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0209 0.0332
Echinococcus granulosus peregrin 0.0188 0.1977 0.2628
Toxoplasma gondii aldo/keto reductase family oxidoreductase 0.0089 0.0832 0.2329
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0307 0.3346 0.7833
Brugia malayi Protein C20orf22 0.0023 0.0069 0.0101
Trichomonas vaginalis conserved hypothetical protein 0.0089 0.0832 0.0815
Loa Loa (eye worm) hypothetical protein 0.003 0.0157 0.0249
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0307 0.3346 0.4447
Onchocerca volvulus Alhambra homolog 0.0185 0.1936 0.3441
Echinococcus granulosus fatty acid amide hydrolase 1 0.0564 0.6304 0.8378
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.0261 0.0194
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0023 0.0069 0.0051
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0885 1 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0161 0.0214
Loa Loa (eye worm) hypothetical protein 0.0564 0.6304 1
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0024 0.0085 0.0035
Mycobacterium leprae PROBABLE AMIDASE AMIC (AMINOHYDROLASE) 0.0068 0.059 0.1075
Echinococcus multilocularis peregrin 0.0188 0.1977 0.2628
Entamoeba histolytica aldose reductase, putative 0.0307 0.3346 0.33
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.034 0.0452
Brugia malayi Glycosyl hydrolases family 31 protein 0.0041 0.0284 0.0418
Plasmodium falciparum JmjC domain-containing protein, putative 0.006 0.0494 0.1016
Trichomonas vaginalis aldo-keto reductase, putative 0.0307 0.3346 0.3334
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0157 0.0212
Plasmodium falciparum esterase, putative 0.0386 0.4253 1
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0069 0.0051
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0097 0.0927 0.1367
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0284 0.0266
Onchocerca volvulus 0.0108 0.105 0.1866
Trichomonas vaginalis aldo-keto reductase, putative 0.0089 0.0832 0.0815
Echinococcus granulosus lysine specific demethylase 5A 0.0225 0.2403 0.3193
Brugia malayi chromobox protein homolog 3 0.004 0.0271 0.04
Schistosoma mansoni hypothetical protein 0.006 0.0503 0.0668
Schistosoma mansoni ap endonuclease 0.0038 0.0241 0.032
Brugia malayi PHD-finger family protein 0.0185 0.1936 0.2855
Echinococcus granulosus hypothetical protein 0.0307 0.3346 0.4447
Brugia malayi hypothetical protein 0.007 0.0615 0.0907
Echinococcus granulosus voltage gated potassium channel subunit 0.0089 0.0832 0.1105
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0284 0.0266
Entamoeba histolytica alcohol dehydrogenase, putative 0.0089 0.0832 0.0768
Schistosoma mansoni ap endonuclease 0.0038 0.0241 0.032
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0024 0.0085 0.0312
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.034 0.0452
Echinococcus multilocularis aldo keto reductase 0.0307 0.3346 0.4447
Loa Loa (eye worm) hypothetical protein 0.006 0.0494 0.0783
Echinococcus multilocularis lysosomal alpha glucosidase 0.0187 0.1956 0.26
Plasmodium falciparum phd finger protein, putative 0.0185 0.1936 0.4462
Echinococcus granulosus histone acetyltransferase KAT2B 0.0043 0.0303 0.0402
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0284 0.0266
Mycobacterium tuberculosis Probable oxidoreductase 0.0307 0.3346 0.6948
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0307 0.3346 0.4447
Brugia malayi Pre-SET motif family protein 0.0064 0.0546 0.0806
Trichomonas vaginalis set domain proteins, putative 0.0505 0.5626 0.5618
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0041 0.0284 0.0216
Echinococcus multilocularis aldehyde reductase 0.0218 0.2321 0.3084
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0038 0.0241 0.032
Echinococcus granulosus glutamyl tRNAGln amidotransferase subunit A 0.0068 0.059 0.0785
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0307 0.3346 0.4935
Loa Loa (eye worm) jmjC domain-containing protein 0.0382 0.4203 0.6667
Echinococcus granulosus neutral alpha glucosidase AB 0.0041 0.0284 0.0377
Toxoplasma gondii histone lysine demethylase JMJD6a 0.006 0.0494 0.1297
Leishmania major hypothetical protein, conserved 0.0035 0.0209 0.0336
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0239 0.2564 0.4067
Plasmodium vivax hypothetical protein, conserved 0.0062 0.0523 0.1086
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0605 0.6781 0.9011
Echinococcus granulosus phd:f box containing protein 0.006 0.0494 0.0656
Trichomonas vaginalis valacyclovir hydrolase, putative 0.0386 0.4253 0.4243
Mycobacterium ulcerans amidase 0.0068 0.059 0.1106
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.006 0.0503 0.1037
Entamoeba histolytica hypothetical protein 0.007 0.0615 0.055
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0386 0.4253 0.4243
Trichomonas vaginalis aldo-keto reductase, putative 0.0307 0.3346 0.3334
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0307 0.0289
Toxoplasma gondii histone lysine methyltransferase SET1 0.0061 0.0508 0.1341
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0386 0.4253 0.4213
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0038 0.0241 0.0173
Trichomonas vaginalis conserved hypothetical protein 0.0386 0.4253 0.4243
Onchocerca volvulus 0.0307 0.3346 0.5948
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0024 0.0085 0.005
Echinococcus granulosus fatty acid amide hydrolase 1 0.0068 0.059 0.0785
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0023 0.0069 0.0051
Brugia malayi F/Y-rich N-terminus family protein 0.0072 0.0632 0.0931
Loa Loa (eye worm) hypothetical protein 0.0317 0.3457 0.5484
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0432 0.4786 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0069 0.0109
Trichomonas vaginalis aldo/keto reductase, putative 0.0307 0.3346 0.3334
Brugia malayi Bromodomain containing protein 0.0188 0.1977 0.2916
Mycobacterium leprae Possible oxidoreductase 0.0089 0.0832 0.1589
Loa Loa (eye worm) hypothetical protein 0.0035 0.0209 0.0332
Toxoplasma gondii oxidoreductase, aldo/keto reductase family protein 0.0089 0.0832 0.2329
Trichomonas vaginalis aldo-keto reductase, putative 0.0307 0.3346 0.3334
Brugia malayi hypothetical protein 0.002 0.0033 0.0049
Plasmodium falciparum lysophospholipase, putative 0.0386 0.4253 1
Trypanosoma cruzi amidase, putative 0.0068 0.059 0.1247
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0209 0.0336
Toxoplasma gondii ABC1 family protein 0.0035 0.0209 0.0429
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0284 0.0514
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0209 0.0298
Schistosoma mansoni potassium channel beta 0.0089 0.0832 0.1105
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0161 0.0238
Toxoplasma gondii PHD-finger domain-containing protein 0.0185 0.1936 0.5697
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0064 0.0546 0.1457
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0209 0.0336
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.0085 0.0039
Mycobacterium leprae POSSIBLE LYSOPHOSPHOLIPASE 0.0386 0.4253 0.8866
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0085 0.0039
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.034 0.0452
Schistosoma mansoni alpha glucosidase 0.0041 0.0284 0.0377
Echinococcus multilocularis monoacylglycerol lipase abhd12 0.0023 0.0069 0.0091
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.034 0.0452
Mycobacterium ulcerans amidase 0.0068 0.059 0.1106
Onchocerca volvulus 0.0032 0.0171 0.0304
Echinococcus multilocularis neutral alpha glucosidase AB 0.0041 0.0284 0.0377
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0307 0.3346 0.4447
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0209 0.0336
Onchocerca volvulus 0.0035 0.0209 0.0372
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0157 0.0212
Brugia malayi acetyltransferase, GNAT family protein 0.0146 0.1494 0.2203
Trichomonas vaginalis aldo-keto reductase, putative 0.0307 0.3346 0.3334
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.0494 0.0783
Echinococcus granulosus PHD finger protein rhinoceros 0.0185 0.1936 0.2573
Echinococcus granulosus aldo keto reductase family 1, member B4 0.0089 0.0832 0.1105
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0146 0.1494 0.1985
Mycobacterium tuberculosis Conserved protein 0.0035 0.0209 0.0298
Leishmania major monoglyceride lipase, putative 0.0386 0.4253 1
Onchocerca volvulus 0.0076 0.0682 0.1212
Mycobacterium tuberculosis Probable amidase AmiC (aminohydrolase) 0.0068 0.059 0.1106
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0241 0.0411
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0209 0.0192
Schistosoma mansoni family S9 unassigned peptidase (S09 family) 0.0023 0.0069 0.0091
Entamoeba histolytica hypothetical protein 0.007 0.0615 0.055
Echinococcus granulosus aldehyde reductase 0.0218 0.2321 0.3084
Loa Loa (eye worm) hypothetical protein 0.006 0.0494 0.0783
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0064 0.0546 0.0726
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0241 0.0223
Mycobacterium tuberculosis Possible lysophospholipase 0.0386 0.4253 0.887
Trichomonas vaginalis aldo-keto reductase, putative 0.0089 0.0832 0.0815
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0209 0.0264
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0146 0.1494 0.1985
Mycobacterium ulcerans lipase LipD 0.0035 0.0209 0.0298
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0209 0.0278
Brugia malayi putative amidase 0.0068 0.059 0.0871
Echinococcus multilocularis GPCR, family 2 0.0031 0.0161 0.0214
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0885 1 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.0546 0.0726
Mycobacterium ulcerans aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0068 0.059 0.1106
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0157 0.027
Entamoeba histolytica hypothetical protein 0.0024 0.0085 0.0016
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0086 0.0796 0.1174
Echinococcus granulosus Phospholipase carboxylesterase 0.0023 0.0069 0.0091
Loa Loa (eye worm) hypothetical protein 0.0307 0.3346 0.5308
Brugia malayi AF-10 protein 0.006 0.0503 0.0741
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.034 0.0539
Loa Loa (eye worm) amidase 0.0068 0.059 0.0936
Trypanosoma brucei aldo-keto reductase, putative 0.0307 0.3346 0.7833
Entamoeba histolytica hypothetical protein 0.007 0.0615 0.055
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0023 0.0069 0.0051
Onchocerca volvulus 0.0307 0.3346 0.5948
Brugia malayi latrophilin 2 splice variant baaae 0.0066 0.0573 0.0845
Giardia lamblia Aldose reductase 0.0307 0.3346 0.33
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0605 0.6781 0.9011
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0157 0.0212
Onchocerca volvulus 0.0029 0.0141 0.025
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0086 0.0796 0.1058
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0885 1 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0284 0.0266
Brugia malayi Amidase family protein 0.0068 0.059 0.0871
Echinococcus multilocularis lysine specific demethylase 6a 0.006 0.0494 0.0656
Echinococcus multilocularis aldo keto reductase 0.0307 0.3346 0.4447
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0038 0.0241 0.0411
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0307 0.3346 0.7833
Echinococcus granulosus fatty acid amide hydrolase 1 0.0564 0.6304 0.8378
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0043 0.0303 0.0559
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0069 0.0051
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0209 0.0298
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0043 0.0303 0.0714
Schistosoma mansoni chromobox protein 0.0072 0.0636 0.0845
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0386 0.4253 0.4243
Echinococcus multilocularis lysosomal alpha glucosidase 0.0187 0.1956 0.26
Plasmodium falciparum aldo-keto reductase, putative 0.0089 0.0832 0.1824
Loa Loa (eye worm) hypothetical protein 0.0185 0.1936 0.3071
Echinococcus multilocularis chromobox protein 1 0.0072 0.0636 0.0845
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0307 0.3346 0.4447
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0043 0.0307 0.0545
Trichomonas vaginalis chromobox protein, putative 0.0072 0.0636 0.0619
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0043 0.0303 0.0285
Schistosoma mansoni alpha-glucosidase 0.0161 0.1657 0.2202
Trichomonas vaginalis aldo-keto reductase, putative 0.0307 0.3346 0.3334
Treponema pallidum exodeoxyribonuclease (exoA) 0.0038 0.0241 0.0157
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0038 0.0241 0.0173
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0061 0.0512 0.068
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0061 0.0513 0.0682
Trypanosoma cruzi aldo/keto reductase, putative 0.0307 0.3346 0.7833
Trichomonas vaginalis sucrase-isomaltase, putative 0.0041 0.0284 0.0266
Brugia malayi beta-lactamase family protein 0.0035 0.0209 0.0309
Loa Loa (eye worm) hypothetical protein 0.0035 0.0209 0.0332
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0038 0.0241 0.3081
Schistosoma mansoni protein phosphatase 2C 0.006 0.0494 0.0656
Schistosoma mansoni amidase 0.0564 0.6304 0.8378
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.006 0.0494 0.1297
Loa Loa (eye worm) oxidoreductase 0.0307 0.3346 0.5308
Brugia malayi MGC79044 protein 0.0023 0.0069 0.0101
Brugia malayi glutamate-cysteine ligase modifier subunit 0.0089 0.0832 0.1227
Entamoeba histolytica alcohol dehydrogenase, putative 0.0089 0.0832 0.0768
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0241 0.0223
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0064 0.0546 0.0726
Loa Loa (eye worm) hypothetical protein 0.0097 0.0927 0.1471
Echinococcus granulosus L aminoadipate semialdehyde 0.0086 0.0796 0.1058
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0307 0.3346 0.4447
Echinococcus multilocularis aldo keto reductase 0.0307 0.3346 0.4447
Toxoplasma gondii exonuclease III APE 0.0038 0.0241 0.0525
Schistosoma mansoni jumonji/arid domain-containing protein 0.0225 0.2403 0.3193
Trypanosoma cruzi aldo-keto reductase 0.0307 0.3346 0.7833
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0209 0.0298
Brugia malayi Calcitonin receptor-like protein seb-1 0.0097 0.0927 0.1367
Toxoplasma gondii PHD-finger domain-containing protein 0.0185 0.1936 0.5697
Loa Loa (eye worm) hypothetical protein 0.0023 0.0069 0.0109
Mycobacterium ulcerans oxidoreductase 0.0307 0.3346 0.6948
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0241 0.0411
Echinococcus granulosus jumonji domain containing 1A 0.006 0.0494 0.0656
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0432 0.4786 1
Trichomonas vaginalis aldo/keto reductase, putative 0.0307 0.3346 0.3334
Trypanosoma brucei monoglyceride lipase, putative 0.0386 0.4253 1
Brugia malayi Heterochromatin protein 1 0.0072 0.0636 0.0938
Loa Loa (eye worm) hypothetical protein 0.0031 0.0161 0.0256
Brugia malayi beta-lactamase family protein 0.0035 0.0209 0.0309
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0187 0.1956 0.3103
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0023 0.0069 0.0051
Trichomonas vaginalis aldo-keto reductase, putative 0.0089 0.0832 0.0815
Trypanosoma cruzi amidase, putative 0.0068 0.059 0.1247
Onchocerca volvulus 0.0086 0.0796 0.1416
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0041 0.0284 0.0266
Brugia malayi jmjC domain containing protein 0.006 0.0494 0.0728
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0062 0.0523 0.1086
Loa Loa (eye worm) hypothetical protein 0.0035 0.0209 0.0332
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0209 0.0192
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.034 0.0452
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0069 0.0051
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0157 0.0212
Schistosoma mansoni hypothetical protein 0.007 0.0615 0.0818
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.006 0.0494 0.0656
Echinococcus granulosus abhydrolase domain containing 3 0.0023 0.0069 0.0091
Trichomonas vaginalis aldo-keto reductase, putative 0.0307 0.3346 0.3334
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0209 0.0278
Mycobacterium ulcerans amidase 0.0068 0.059 0.1106
Entamoeba histolytica aldose reductase, putative 0.0307 0.3346 0.33
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0307 0.3346 0.4447
Echinococcus multilocularis phd:f box containing protein 0.006 0.0494 0.0656
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0307 0.3346 0.4447
Schistosoma mansoni jumonji/arid domain-containing protein 0.0225 0.2403 0.3193
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0284 0.0266
Plasmodium falciparum glutamyl-tRNA(Gln) amidotransferase subunit A 0.0068 0.059 0.1247
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0307 0.3346 0.4447
Treponema pallidum fructose-bisphosphate aldolase 0.0885 1 1
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0209 0.0298
Trichomonas vaginalis aldo-keto reductase, putative 0.0307 0.3346 0.3334
Schistosoma mansoni aldo-keto reductase 0.0307 0.3346 0.4447
Mycobacterium tuberculosis Conserved protein 0.0035 0.0209 0.0298
Schistosoma mansoni hypothetical protein 0.0031 0.0161 0.0214
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0307 0.3346 0.4447
Brugia malayi jmjC domain containing protein 0.006 0.0494 0.0728
Loa Loa (eye worm) amidase 0.0068 0.059 0.0936
Mycobacterium ulcerans peptide amidase, GatA 0.0068 0.059 0.1106
Onchocerca volvulus 0.0035 0.0209 0.0372
Onchocerca volvulus 0.0505 0.5626 1
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0157 0.0212
Toxoplasma gondii aldo-keto reductase 0.0089 0.0832 0.2329
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0069 0.0051
Plasmodium vivax SET domain protein, putative 0.0064 0.0546 0.1141
Echinococcus granulosus chromobox protein 1 0.0072 0.0636 0.0845
Leishmania major phosphopantetheinyl transferase-like protein 0.0024 0.0085 0.0039
Loa Loa (eye worm) oxidoreductase 0.0307 0.3346 0.5308
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0307 0.3346 0.6937
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.006 0.0494 0.1016
Plasmodium falciparum lysophospholipase, putative 0.0386 0.4253 1
Plasmodium falciparum lysophospholipase, putative 0.0386 0.4253 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0307 0.3346 0.4447
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0041 0.0284 0.045
Plasmodium vivax oxidoreductase, aldo/keto reductase domain containing protein 0.0089 0.0832 0.1824
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0209 0.0278
Toxoplasma gondii PHD-finger domain-containing protein 0.006 0.0503 0.1324
Schistosoma mansoni chromobox protein 0.0072 0.0636 0.0845
Mycobacterium leprae Probable lipase LipE 0.0035 0.0209 0.0264
Schistosoma mansoni jumonji domain containing protein 0.0481 0.5347 0.7106
Schistosoma mansoni family S9 unassigned peptidase (S09 family) 0.0023 0.0069 0.0091
Echinococcus granulosus aldo keto reductase 0.0307 0.3346 0.4447
Trichomonas vaginalis chromobox protein, putative 0.0072 0.0636 0.0619
Echinococcus granulosus histone acetyltransferase KAT2B 0.0142 0.1447 0.1922
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.0546 0.0726
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0038 0.0241 0.0411
Loa Loa (eye worm) hypothetical protein 0.0023 0.0069 0.0109
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0307 0.3346 0.4447
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0209 0.0298
Mycobacterium tuberculosis Probable amidase AmiD (acylamidase) (acylase) 0.0068 0.059 0.1106
Mycobacterium ulcerans amidase 0.0068 0.059 0.1106
Loa Loa (eye worm) oxidoreductase 0.0307 0.3346 0.5308
Schistosoma mansoni peptidase 0.0023 0.0069 0.0091
Brugia malayi hypothetical protein 0.003 0.0157 0.0232
Plasmodium vivax glutamyl-tRNA(Gln) amidotransferase subunit A, putative 0.0068 0.059 0.1247
Mycobacterium leprae Conserved hypothetical protein 0.0218 0.2321 0.4756
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0209 0.0192
Trypanosoma cruzi monoglyceride lipase, putative 0.0386 0.4253 1
Treponema pallidum aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0068 0.059 0.051
Echinococcus granulosus monoacylglycerol lipase abhd12 0.0023 0.0069 0.0091
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0023 0.0069 0.0051
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0041 0.0284 0.0216
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0209 0.0278
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0069 0.0051
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0064 0.0543 0.0721
Loa Loa (eye worm) oxidoreductase 0.0307 0.3346 0.5308
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0386 0.4253 0.4243
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0209 0.0332
Onchocerca volvulus 0.0089 0.0832 0.1479
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0209 0.0298
Schistosoma mansoni fatty-acid amide hydrolase 0.0564 0.6304 0.8378
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0307 0.3346 0.4447
Mycobacterium tuberculosis Conserved protein 0.0035 0.0209 0.0298
Echinococcus multilocularis L aminoadipate semialdehyde 0.0086 0.0796 0.1058
Trichomonas vaginalis aldo-keto reductase, putative 0.0307 0.3346 0.3334
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0024 0.0085 0.005
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0307 0.3346 0.4447
Trichomonas vaginalis aldo-keto reductase, putative 0.0307 0.3346 0.3334
Echinococcus granulosus aldo keto reductase 0.0307 0.3346 0.4447
Brugia malayi exodeoxyribonuclease III family protein 0.0038 0.0241 0.0355
Leishmania major aldo-keto reductase-like protein 0.0307 0.3346 0.7833
Echinococcus multilocularis PHD finger protein rhinoceros 0.0185 0.1936 0.2573
Plasmodium vivax aldehyde reductase, putative 0.0089 0.0832 0.1824
Trichomonas vaginalis aldo-keto reductase, putative 0.0307 0.3346 0.3334
Mycobacterium tuberculosis Possible amidase (aminohydrolase) 0.0068 0.059 0.1106
Loa Loa (eye worm) hypothetical protein 0.0086 0.0796 0.1263
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0069 0.0051
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0209 0.0298
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.006 0.0494 0.1016
Mycobacterium leprae PROBABLE GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE (SUBUNIT A) GATA (Glu-ADT SUBUNIT A) 0.0068 0.059 0.1075
Leishmania major hypothetical protein, conserved 0.003 0.0157 0.0212
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0085 0.0039
Brugia malayi PHD-finger family protein 0.0062 0.0522 0.0769
Schistosoma mansoni phosphatidylserine receptor 0.006 0.0494 0.0656
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0307 0.3346 0.4447
Mycobacterium ulcerans beta-lactamase 0.0035 0.0209 0.0298
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0307 0.3346 0.4935
Trypanosoma brucei fatty-acid amide hydrolase, putative 0.0068 0.059 0.1247
Loa Loa (eye worm) hypothetical protein 0.0062 0.0522 0.0827
Brugia malayi MGC83647 protein 0.0023 0.0069 0.0101
Trypanosoma brucei prostaglandin f synthase 0.0307 0.3346 0.7833
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0038 0.0241 0.032
Schistosoma mansoni cpg binding protein 0.0031 0.016 0.0213
Brugia malayi follicle stimulating hormone receptor 0.0239 0.2564 0.3781
Onchocerca volvulus 0.0035 0.0209 0.0372
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0061 0.0513 0.0682
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.007 0.0615 0.0818
Entamoeba histolytica hypothetical protein 0.007 0.0615 0.055
Trichomonas vaginalis aldo-keto reductase, putative 0.0307 0.3346 0.3334
Trypanosoma cruzi aldo/keto reductase, putative 0.0089 0.0832 0.1824
Echinococcus granulosus jumonji domain containing protein 0.0257 0.277 0.3681
Plasmodium vivax hypothetical protein, conserved 0.0185 0.1936 0.4462
Brugia malayi jmjC domain containing protein 0.006 0.0494 0.0728
Schistosoma mansoni fatty-acid amide hydrolase 0.0068 0.059 0.0785
Schistosoma mansoni hypothetical protein 0.0031 0.0161 0.0214
Brugia malayi Amidase family protein 0.0068 0.059 0.0871
Plasmodium vivax PST-A protein 0.0386 0.4253 1
Echinococcus multilocularis glutamyl tRNA(Gln) amidotransferase subunit A 0.0068 0.059 0.0785
Trichomonas vaginalis aldo-keto reductase, putative 0.0307 0.3346 0.3334
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0209 0.0192
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0136 0.0118
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0185 0.1936 0.2573
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0885 1 1
Giardia lamblia PHD finger protein 15 0.0185 0.1936 0.188
Trypanosoma brucei monoglyceride lipase, putative 0.0386 0.4253 1
Echinococcus granulosus chromobox protein 1 0.0072 0.0636 0.0845
Onchocerca volvulus 0.0307 0.3346 0.5948
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0041 0.0284 0.0656
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0885 1 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0076 0.0682 0.0906
Loa Loa (eye worm) hypothetical protein 0.0035 0.0209 0.0332
Brugia malayi jmjC domain containing protein 0.0225 0.2403 0.3544
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0284 0.0514
Trichomonas vaginalis maltase-glucoamylase, putative 0.0041 0.0284 0.0266
Echinococcus multilocularis lysine specific demethylase 5A 0.0224 0.2384 0.3168
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0038 0.0241 0.0411
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0307 0.3346 0.4447
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0024 0.0085 0.0035
Mycobacterium ulcerans lysophospholipase 0.0386 0.4253 0.887
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0038 0.0241 0.0382
Trichomonas vaginalis aldo/keto reductase, putative 0.0307 0.3346 0.3334
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0271 0.0254
Loa Loa (eye worm) hypothetical protein 0.0035 0.0209 0.0332
Schistosoma mansoni phd/f-box containing protein 0.006 0.0494 0.0656
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0023 0.0069 0.0051
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0261 0.0194
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0209 0.0309
Echinococcus granulosus abhydrolase domain containing protein 13 0.0023 0.0069 0.0091
Schistosoma mansoni pol-related 0.0307 0.3346 0.4447
Toxoplasma gondii aldose reductase, putative 0.0307 0.3346 1
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0068 0.059 0.0785
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0386 0.4253 0.4243
Echinococcus granulosus histone lysine methyltransferase setb 0.0064 0.0546 0.0726
Brugia malayi beta-lactamase 0.0035 0.0209 0.0309
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0307 0.3346 0.3334
Schistosoma mansoni jumonji domain containing protein 0.006 0.0494 0.0656
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0307 0.3346 0.3334
Mycobacterium ulcerans hypothetical protein 0.0035 0.0209 0.0298
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0038 0.0241 0.0365
Echinococcus multilocularis jumonji domain containing 1A 0.006 0.0494 0.0656
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.007 0.0615 0.0818
Brugia malayi Glycosyl hydrolases family 31 protein 0.0187 0.1956 0.2885
Echinococcus multilocularis aldo keto reductase 0.0307 0.3346 0.4447
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0223 0.2379 0.4898
Echinococcus granulosus lysosomal alpha glucosidase 0.0187 0.1956 0.26
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0307 0.3346 0.4447
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0885 1 1
Mycobacterium tuberculosis Probable amidase AmiB2 (aminohydrolase) 0.0068 0.059 0.1106
Loa Loa (eye worm) hypothetical protein 0.0023 0.0069 0.0109
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0097 0.0927 0.1471

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.0178 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.1122 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 7.3753 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 63.0957 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference
Potency (functional) 63.0957 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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