Detailed information for compound 1242407

Basic information

Technical information
  • TDR Targets ID: 1242407
  • Name: 3-([1,2,4]triazolo[4,5-a]pyridin-3-ylmethyl)- [1,2,4]triazolo[4,5-a]pyridine
  • MW: 250.259 | Formula: C13H10N6
  • H donors: 0 H acceptors: 4 LogP: 2.42 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: c1ccn2c(c1)nnc2Cc1nnc2n1cccc2
  • InChi: 1S/C13H10N6/c1-3-7-18-10(5-1)14-16-12(18)9-13-17-15-11-6-2-4-8-19(11)13/h1-8H,9H2
  • InChiKey: HFFOEWOEDWOWKD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4930-92-1
  • AG-690/36281028
  • ZINC00484931
  • Enamine_001249
  • MLS000055038
  • SMR000065850
  • NSC80523
  • T0503-8151

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0066 0.0135 0.0135
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0043 0.003 0.0235
Brugia malayi TATA binding protein associated factor 0.0116 0.0369 0.0818
Brugia malayi hypothetical protein 0.0237 0.093 0.2065
Mycobacterium ulcerans bacterioferritin BfrB 0.0043 0.003 0.0158
Loa Loa (eye worm) hypothetical protein 0.0054 0.0079 0.0079
Schistosoma mansoni ferritin 0.0043 0.003 0.003
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0066 0.0135 0.0135
Plasmodium vivax hypothetical protein, conserved 0.012 0.0385 1
Loa Loa (eye worm) leukotriene A4 hydrolase 0.2188 1 1
Schistosoma mansoni phd/f-box containing protein 0.0054 0.0079 0.0079
Onchocerca volvulus 0.0083 0.0216 0.0669
Brugia malayi Pre-SET motif family protein 0.0093 0.0259 0.0574
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0116 0.0369 0.2924
Echinococcus granulosus expressed protein 0.0043 0.003 0.003
Echinococcus granulosus aminopeptidase N 0.0116 0.0369 0.0369
Schistosoma mansoni ferritin 0.0043 0.003 0.003
Echinococcus granulosus JmjC domain containing protein 4 0.0054 0.0079 0.0079
Schistosoma mansoni hypothetical protein 0.0039 0.001 0.001
Schistosoma mansoni hypothetical protein 0.0867 0.386 0.386
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0308 0.1261 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0046 0.0046
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0046 0.0046
Plasmodium vivax SET domain protein, putative 0.0093 0.0259 0.6713
Schistosoma mansoni hypothetical protein 0.0066 0.0135 0.0135
Echinococcus multilocularis lysosomal alpha glucosidase 0.0159 0.0569 0.0569
Toxoplasma gondii aminopeptidase N, putative 0.0116 0.0369 0.9571
Echinococcus granulosus jun protein 0.0099 0.0291 0.0291
Toxoplasma gondii aminopeptidase n, putative 0.0116 0.0369 0.9571
Brugia malayi glutaminase DH11.1 0.0274 0.1102 0.2447
Brugia malayi PHD-finger family protein 0.012 0.0385 0.0855
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0027 0.0068
Echinococcus multilocularis L aminoadipate semialdehyde 0.0083 0.0216 0.0216
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0443 0.189 1
Schistosoma mansoni ferritin 0.0043 0.003 0.003
Brugia malayi Latrophilin receptor protein 2 0.0066 0.0135 0.03
Echinococcus multilocularis chromobox protein 1 0.0071 0.0159 0.0159
Echinococcus granulosus survival motor neuron protein 1 0.0237 0.093 0.093
Trypanosoma cruzi aminopeptidase, putative 0.0116 0.0369 0.2924
Brugia malayi PHD-finger family protein 0.0041 0.0018 0.0039
Onchocerca volvulus 0.073 0.3223 1
Loa Loa (eye worm) hypothetical protein 0.012 0.0385 0.0385
Plasmodium vivax hypothetical protein, conserved 0.0041 0.0018 0.0472
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0116 0.0369 0.0369
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.0121 0.0121
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0116 0.0369 0.2924
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0093 0.0259 0.0259
Brugia malayi Calcitonin receptor-like protein seb-1 0.0209 0.0799 0.1773
Echinococcus granulosus lysine specific demethylase 6a 0.0054 0.0079 0.0079
Schistosoma mansoni mixed-lineage leukemia protein mll 0.005 0.0058 0.0058
Brugia malayi Glycosyl hydrolases family 31 protein 0.0159 0.0569 0.1262
Trypanosoma brucei aminopeptidase, putative 0.0116 0.0369 0.2924
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.0598 0.1478
Plasmodium vivax JmjC domain containing protein 0.0054 0.0079 0.2057
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.0598 0.1478
Brugia malayi Peptidase family M1 containing protein 0.0116 0.0369 0.0818
Echinococcus granulosus geminin 0.0867 0.386 0.386
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0116 0.0369 0.0369
Onchocerca volvulus Glucosylceramidase homolog 0.0166 0.0598 0.1856
Echinococcus granulosus histone lysine methyltransferase setb 0.0093 0.0259 0.0259
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0046 0.0103
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0054 0.0079 0.0628
Onchocerca volvulus Heterochromatin protein 1 homolog 0.004 0.0013 0.0042
Brugia malayi jmjC domain containing protein 0.0054 0.0079 0.0176
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0043 0.003 0.0158
Echinococcus multilocularis lysine specific demethylase 5A 0.0202 0.077 0.077
Schistosoma mansoni lipoxygenase 0.014 0.0478 0.0478
Echinococcus granulosus dnaJ subfamily B 0.04 0.1687 0.1687
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0252 0.1002 0.1002
Echinococcus granulosus lysine specific demethylase 5A 0.0204 0.0777 0.0777
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0252 0.1002 0.2224
Treponema pallidum fructose-bisphosphate aldolase 0.0908 0.4048 1
Echinococcus granulosus PHD finger protein rhinoceros 0.012 0.0385 0.0385
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0066 0.0135 0.0135
Trypanosoma brucei Aminopeptidase M1, putative 0.0116 0.0369 0.2924
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0043 0.003 0.0235
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.0091 0.2368
Loa Loa (eye worm) jmjC domain-containing protein 0.0054 0.0079 0.0079
Loa Loa (eye worm) latrophilin receptor protein 2 0.0066 0.0135 0.0135
Schistosoma mansoni ferritin light chain 0.0043 0.003 0.003
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0116 0.0369 0.0369
Echinococcus granulosus GPCR family 2 0.0066 0.0135 0.0135
Loa Loa (eye worm) hypothetical protein 0.0041 0.0018 0.0018
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.003 0.0235
Loa Loa (eye worm) hypothetical protein 0.0116 0.0369 0.0369
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.0598 0.1478
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0116 0.0369 0.0369
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0209 0.0799 0.0799
Leishmania major mitochondrial DNA polymerase beta 0.0308 0.1261 1
Schistosoma mansoni apoferritin-2 0.0043 0.003 0.003
Echinococcus granulosus phd:f box containing protein 0.0054 0.0079 0.0079
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0046 0.0046
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0054 0.0079 0.2057
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0054 0.0079 0.0628
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0116 0.0369 0.2924
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0908 0.4048 1
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0054 0.0079 0.0079
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.0116 0.0369 0.955
Onchocerca volvulus 0.0078 0.0191 0.0593
Plasmodium falciparum JmjC domain-containing protein, putative 0.0054 0.0079 0.1664
Trichomonas vaginalis ferritin, putative 0.0043 0.003 0.0074
Loa Loa (eye worm) glutaminase 0.0274 0.1102 0.1102
Brugia malayi hypothetical protein 0.0116 0.0369 0.0818
Loa Loa (eye worm) hypothetical protein 0.0083 0.0216 0.0216
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0046 0.0046
Mycobacterium ulcerans glutaminase 0.0274 0.1102 0.5833
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0116 0.0369 0.0369
Schistosoma mansoni hypothetical protein 0.0143 0.0492 0.0492
Schistosoma mansoni jumonji domain containing protein 0.0369 0.1545 0.1545
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0908 0.4048 1
Schistosoma mansoni hypothetical protein 0.0066 0.0135 0.0135
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0043 0.003 0.0158
Brugia malayi jmjC domain containing protein 0.0054 0.0079 0.0176
Loa Loa (eye worm) hypothetical protein 0.0237 0.093 0.093
Brugia malayi F/Y-rich N-terminus family protein 0.0051 0.0066 0.0146
Brugia malayi Peptidase family M1 containing protein 0.0116 0.0369 0.0818
Mycobacterium tuberculosis Conserved hypothetical protein 0.0162 0.0583 0.3084
Schistosoma mansoni aminopeptidase A (M01 family) 0.0116 0.0369 0.0369
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0039 0.001 0.0081
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0053 0.0118
Brugia malayi hypothetical protein 0.012 0.0385 0.0855
Loa Loa (eye worm) jmjC domain-containing protein 0.0204 0.0777 0.0777
Schistosoma mansoni chromobox protein 0.0071 0.0159 0.0159
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0013 0.0033
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0443 0.189 1
Brugia malayi Cytochrome P450 family protein 0.0058 0.0097 0.0215
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0908 0.4048 1
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0146 0.0506 0.4015
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0099 0.0291 0.0291
Echinococcus multilocularis jumonji domain containing protein 0.0167 0.0603 0.0603
Echinococcus granulosus ferritin 0.0043 0.003 0.003
Brugia malayi Pre-SET motif family protein 0.0642 0.2812 0.6241
Echinococcus multilocularis dnaJ subfamily B 0.04 0.1687 0.1687
Loa Loa (eye worm) aminopeptidase N 0.0116 0.0369 0.0369
Echinococcus granulosus jumonji domain containing protein 0.0167 0.0603 0.0603
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.0598 0.1478
Plasmodium falciparum M1-family alanyl aminopeptidase 0.0116 0.0369 0.955
Brugia malayi AF-10 protein 0.0039 0.001 0.0023
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0908 0.4048 1
Schistosoma mansoni lipoxygenase 0.0098 0.0282 0.0282
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0056 0.0087 0.0087
Onchocerca volvulus 0.0048 0.0053 0.0164
Trichomonas vaginalis glucosylceramidase, putative 0.0252 0.1002 0.2475
Schistosoma mansoni ferritin 0.0043 0.003 0.003
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0046 0.0046
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0116 0.0369 0.0369
Echinococcus granulosus peregrin 0.012 0.0385 0.0385
Echinococcus multilocularis GPCR, family 2 0.0066 0.0135 0.0135
Echinococcus multilocularis survival motor neuron protein 1 0.0237 0.093 0.093
Schistosoma mansoni survival motor neuron protein 0.0048 0.0053 0.0053
Echinococcus multilocularis jun protein 0.0099 0.0291 0.0291
Echinococcus multilocularis PHD finger protein rhinoceros 0.012 0.0385 0.0385
Echinococcus multilocularis lysine specific demethylase 6a 0.0054 0.0079 0.0079
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0209 0.0799 0.1773
Schistosoma mansoni alpha-glucosidase 0.0137 0.0466 0.0466
Onchocerca volvulus 0.0116 0.0369 0.1144
Trypanosoma brucei Aminopeptidase M1, putative 0.0116 0.0369 0.2924
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0066 0.0135 0.0135
Schistosoma mansoni jumonji/arid domain-containing protein 0.0204 0.0777 0.0777
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0116 0.0369 0.0911
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.0598 0.1478
Schistosoma mansoni phosphatidylserine receptor 0.0054 0.0079 0.0079
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0443 0.189 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0146 0.0506 0.4015
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0046 0.0046
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0908 0.4048 1
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0116 0.0369 0.2924
Trichomonas vaginalis glucosylceramidase, putative 0.0252 0.1002 0.2475
Echinococcus multilocularis jumonji domain containing 1A 0.0054 0.0079 0.0079
Onchocerca volvulus Huntingtin homolog 0.012 0.0385 0.1194
Loa Loa (eye worm) jmjC domain-containing protein 0.0054 0.0079 0.0079
Loa Loa (eye worm) heterochromatin protein 1 0.0071 0.0159 0.0159
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0043 0.003 0.5
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0116 0.0369 0.2924
Plasmodium falciparum phd finger protein, putative 0.012 0.0385 1
Echinococcus multilocularis leukotriene A 4 hydrolase 0.2188 1 1
Loa Loa (eye worm) hypothetical protein 0.0143 0.0492 0.0492
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0093 0.0259 0.6713
Echinococcus granulosus arachidonate 5 lipoxygenase 0.014 0.0478 0.0478
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0116 0.0369 0.0369
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0236 0.0926 0.49
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.003 0.0235
Brugia malayi Bromodomain containing protein 0.012 0.0385 0.0855
Echinococcus multilocularis lysosomal alpha glucosidase 0.0159 0.0569 0.0569
Loa Loa (eye worm) hypothetical protein 0.0054 0.0079 0.0079
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0908 0.4048 1
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0908 0.4048 1
Echinococcus multilocularis aminopeptidase N 0.0116 0.0369 0.0369
Loa Loa (eye worm) hypothetical protein 0.0209 0.0799 0.0799
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0089 0.024 0.024
Giardia lamblia Fructose-bisphosphate aldolase 0.0908 0.4048 1
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.045 0.192 0.192
Loa Loa (eye worm) TATA binding protein associated factor 0.0116 0.0369 0.0369
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0083 0.0216 0.0216
Schistosoma mansoni chromobox protein 0.0071 0.0159 0.0159
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0083 0.0216 0.0479
Schistosoma mansoni hypothetical protein 0.0081 0.0204 0.0204
Brugia malayi Peptidase family M1 containing protein 0.0116 0.0369 0.0818
Brugia malayi hypothetical protein 0.0078 0.0191 0.0425
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0116 0.0369 0.0369
Schistosoma mansoni hypothetical protein 0.0066 0.0135 0.0135
Schistosoma mansoni alpha-glucosidase 0.0137 0.0466 0.0466
Schistosoma mansoni hypothetical protein 0.012 0.0385 0.0385
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0146 0.0506 0.4015
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.2188 1 1
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0116 0.0369 0.0369
Schistosoma mansoni jumonji domain containing protein 0.0054 0.0079 0.0079
Trichomonas vaginalis set domain proteins, putative 0.073 0.3223 0.7963
Loa Loa (eye worm) hypothetical protein 0.012 0.0385 0.0385
Onchocerca volvulus Huntingtin homolog 0.012 0.0385 0.1194
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0046 0.0046
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0027 0.0068
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0116 0.0369 0.9571
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0116 0.0369 0.0369
Loa Loa (eye worm) hypothetical protein 0.0221 0.0854 0.0854
Loa Loa (eye worm) cytochrome P450 family protein 0.0058 0.0097 0.0097
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0039 0.001 0.0081
Trichomonas vaginalis chromobox protein, putative 0.0071 0.0159 0.0392
Trichomonas vaginalis chromobox protein, putative 0.0071 0.0159 0.0392
Echinococcus multilocularis JmjC domain containing protein 4 0.0054 0.0079 0.0079
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0908 0.4048 1
Echinococcus multilocularis expressed protein 0.0043 0.003 0.003
Echinococcus multilocularis geminin 0.0867 0.386 0.386
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0099 0.0291 0.0291
Schistosoma mansoni jun-related protein 0.0081 0.0204 0.0204
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.064 0.158
Toxoplasma gondii PHD-finger domain-containing protein 0.012 0.0385 1
Loa Loa (eye worm) hypothetical protein 0.0116 0.0369 0.0369
Loa Loa (eye worm) hypothetical protein 0.0097 0.0278 0.0278
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0116 0.0369 0.0369
Schistosoma mansoni hypothetical protein 0.0066 0.0135 0.0135
Echinococcus granulosus lysosomal alpha glucosidase 0.0159 0.0569 0.0569
Schistosoma mansoni apoferritin-2 0.0043 0.003 0.003
Toxoplasma gondii PHD-finger domain-containing protein 0.0039 0.001 0.0265
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0066 0.0135 0.0135
Loa Loa (eye worm) hypothetical protein 0.004 0.0013 0.0013
Brugia malayi jmjC domain containing protein 0.0054 0.0079 0.0176
Trichomonas vaginalis glucosylceramidase, putative 0.0252 0.1002 0.2475
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0116 0.0369 0.2924
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0908 0.4048 1
Echinococcus granulosus L aminoadipate semialdehyde 0.0083 0.0216 0.0216
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0116 0.0369 0.0911
Echinococcus multilocularis peregrin 0.012 0.0385 0.0385
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.014 0.0478 0.0478
Toxoplasma gondii aminopeptidase N protein 0.0116 0.0369 0.9571
Schistosoma mansoni hypothetical protein 0.04 0.1687 0.1687
Echinococcus multilocularis phd:f box containing protein 0.0054 0.0079 0.0079
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0046 0.0046
Onchocerca volvulus 0.0092 0.0256 0.0796
Onchocerca volvulus 0.0104 0.0313 0.097
Schistosoma mansoni protein phosphatase 2C 0.0054 0.0079 0.0079
Loa Loa (eye worm) hypothetical protein 0.0116 0.0369 0.0369
Echinococcus multilocularis ferritin 0.0043 0.003 0.003
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0056 0.0087 0.0087
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0159 0.0569 0.0569
Echinococcus granulosus chromobox protein 1 0.0071 0.0159 0.0159
Echinococcus multilocularis chromobox protein 1 0.0071 0.0159 0.0159
Schistosoma mansoni glutaminase 0.0274 0.1102 0.1102
Echinococcus granulosus jumonji domain containing 1A 0.0054 0.0079 0.0079
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0116 0.0369 0.2924
Brugia malayi bZIP transcription factor family protein 0.0099 0.0291 0.0645
Echinococcus granulosus chromobox protein 1 0.0071 0.0159 0.0159
Brugia malayi Heterochromatin protein 1 0.0071 0.0159 0.0352
Brugia malayi latrophilin 2 splice variant baaae 0.0143 0.0492 0.1092
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.012 0.0385 0.0385
Toxoplasma gondii PHD-finger domain-containing protein 0.012 0.0385 1
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0039 0.001 0.0265
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0116 0.0369 0.0911
Loa Loa (eye worm) hypothetical protein 0.0093 0.0259 0.0259
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0054 0.0079 0.2057
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0116 0.0369 0.0369
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0116 0.0369 0.9571
Loa Loa (eye worm) PHD-finger family protein 0.012 0.0385 0.0385
Loa Loa (eye worm) hypothetical protein 0.012 0.0385 0.0385
Schistosoma mansoni hypothetical protein 0.0867 0.386 0.386
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.0598 0.1478
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0116 0.0369 0.2924
Brugia malayi jmjC domain containing protein 0.045 0.192 0.4261
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0054 0.0079 0.0628
Leishmania major hypothetical protein, conserved 0.0054 0.0079 0.0628
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.045 0.192 0.192
Trypanosoma cruzi aminopeptidase, putative 0.0116 0.0369 0.2924
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.064 0.158
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0116 0.0369 0.0369
Trichomonas vaginalis glutaminase, putative 0.0274 0.1102 0.2723
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0116 0.0369 0.2924
Trichomonas vaginalis glucosylceramidase, putative 0.0252 0.1002 0.2475
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0308 0.1261 1
Mycobacterium ulcerans bacterioferritin BfrA 0.0043 0.003 0.0158
Brugia malayi hypothetical protein 0.0116 0.0369 0.0818
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0043 0.003 0.0158
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0116 0.0369 0.0369
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.0598 0.1478
Brugia malayi hypothetical protein 0.1006 0.4505 1
Trypanosoma cruzi Aminopeptidase M1, putative 0.0116 0.0369 0.2924
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0066 0.0135 0.03
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0093 0.0259 0.0259
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0104 0.0313 0.0313
Trichomonas vaginalis glucosylceramidase, putative 0.0252 0.1002 0.2475
Brugia malayi jmjC domain containing protein 0.0204 0.0777 0.1725
Toxoplasma gondii hypothetical protein 0.005 0.0059 0.1538
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0116 0.0369 0.2924
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0093 0.0259 0.0259
Loa Loa (eye worm) peptidase family M1 containing protein 0.0116 0.0369 0.0369
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0093 0.0259 0.0259
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0908 0.4048 1
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0308 0.1261 1
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0116 0.0369 0.0369
Schistosoma mansoni jumonji/arid domain-containing protein 0.0204 0.0777 0.0777
Schistosoma mansoni ferritin light chain 0.0043 0.003 0.003
Mycobacterium ulcerans aminopeptidase N PepN 0.0116 0.0369 0.1951
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0642 0.2812 0.2812
Brugia malayi chromobox protein homolog 3 0.004 0.0013 0.003
Loa Loa (eye worm) jmjC domain-containing protein 0.0247 0.0978 0.0978
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0013 0.0033
Onchocerca volvulus 0.0116 0.0369 0.1144
Trichomonas vaginalis glucosylceramidase, putative 0.0252 0.1002 0.2475
Loa Loa (eye worm) glutaminase 2 0.0274 0.1102 0.1102
Mycobacterium ulcerans hypothetical protein 0.0162 0.0583 0.3084
Onchocerca volvulus 0.0116 0.0369 0.1144
Onchocerca volvulus Alhambra homolog 0.012 0.0385 0.1195
Loa Loa (eye worm) jmjC domain-containing protein 0.0054 0.0079 0.0079
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0053 0.0074 0.0584
Brugia malayi jmjC domain containing protein 0.0054 0.0079 0.0176
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0043 0.0027 0.0085
Mycobacterium ulcerans aminopeptidase N PepN 0.0116 0.0369 0.1951
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0093 0.0259 0.0259
Schistosoma mansoni hypothetical protein 0.0048 0.0053 0.0053

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 25.1189 uM PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.1189 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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