Detailed information for compound 1243328

Basic information

Technical information
  • TDR Targets ID: 1243328
  • Name: dimethyl 5-(2,6-dimethylmorpholin-4-yl)sulfon yl-3-methylthiophene-2,4-dicarboxylate
  • MW: 391.46 | Formula: C15H21NO7S2
  • H donors: 0 H acceptors: 4 LogP: 1.98 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)c1c(C)c(sc1S(=O)(=O)N1CC(C)OC(C1)C)C(=O)OC
  • InChi: 1S/C15H21NO7S2/c1-8-6-16(7-9(2)23-8)25(19,20)15-11(13(17)21-4)10(3)12(24-15)14(18)22-5/h8-9H,6-7H2,1-5H3
  • InChiKey: SFSQREXTIJEFJC-UHFFFAOYSA-N  

Network

Hover on a compound node to display the structore

Synonyms

  • dimethyl 5-(2,6-dimethylmorpholin-4-yl)sulfonyl-3-methyl-thiophene-2,4-dicarboxylate
  • 5-[(2,6-dimethyl-4-morpholinyl)sulfonyl]-3-methylthiophene-2,4-dicarboxylic acid dimethyl ester
  • 5-(2,6-dimethylmorpholin-4-yl)sulfonyl-3-methyl-thiophene-2,4-dicarboxylic acid dimethyl ester
  • T5505219

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens bromodomain adjacent to zinc finger domain, 2B Starlite/ChEMBL No references
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum expressed protein Get druggable targets OG5_131570 All targets in OG5_131570
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Schistosoma japonicum hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
Schistosoma japonicum ko:K01549 ATP synthase [EC3.6.3.14], putative Get druggable targets OG5_131570 All targets in OG5_131570
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Schistosoma mansoni bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum Conserved hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Brugia malayi Bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum Cleft lip and palate transmembrane protein 1-like protein, putative Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Echinococcus multilocularis bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus granulosus bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570

By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0037 0.0036 0.0035
Brugia malayi Bromodomain containing protein 0.0092 0.0133 0.0289
Giardia lamblia Fructose-bisphosphate aldolase 0.0609 0.1045 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0003 0.0002
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0077 0.0106 0.2096
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0202 0.0327 0.0327
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.013 0.0199 0.0198
Echinococcus granulosus rhodopsin orphan GPCR 0.0018 0.0003 0.0002
Loa Loa (eye worm) transcription factor SMAD2 0.0125 0.0191 0.019
Loa Loa (eye worm) aminopeptidase N 0.0302 0.0503 0.0502
Loa Loa (eye worm) hypothetical protein 0.0453 0.077 0.0769
Trichomonas vaginalis glucosylceramidase, putative 0.0185 0.0296 0.1171
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0018 0.0003 0.0002
Loa Loa (eye worm) hypothetical protein 0.0094 0.0136 0.0136
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0609 0.1045 1
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0094 0.0136 0.2697
Loa Loa (eye worm) hypothetical protein 0.0202 0.0327 0.0327
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0018 0.0003 0.0002
Echinococcus granulosus alpha 1A adrenergic receptor 0.0018 0.0003 0.0002
Loa Loa (eye worm) jmjC domain-containing protein 0.0492 0.0839 0.0838
Onchocerca volvulus Huntingtin homolog 0.0135 0.0209 0.0823
Trypanosoma cruzi polo-like protein kinase, putative 0.0095 0.0137 0.2716
Loa Loa (eye worm) norepinephrine transporter 0.0453 0.077 0.0769
Schistosoma mansoni polycystin 1-related 0.0022 0.0009 0.0008
Echinococcus multilocularis fmrfamide receptor 0.0018 0.0003 0.0002
Schistosoma mansoni jumonji/arid domain-containing protein 0.0357 0.06 0.0599
Schistosoma mansoni rab6-interacting 0.0022 0.0009 0.0008
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0302 0.0503 0.0502
Echinococcus granulosus tm gpcr rhodopsin 0.0018 0.0003 0.0002
Plasmodium vivax SET domain protein, putative 0.0182 0.0291 0.578
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0609 0.1045 0.416
Brugia malayi hypothetical protein 0.0022 0.0009 0.0017
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0302 0.0503 1
Schistosoma mansoni alpha-glucosidase 0.0153 0.024 0.0239
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0095 0.0138 0.0299
Echinococcus multilocularis orexin receptor type 2 0.0018 0.0003 0.0002
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0041 0.0042 1
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0045 0.0166
Trypanosoma brucei polo-like protein kinase 0.0095 0.0137 0.2716
Echinococcus granulosus neuropeptide s receptor 0.0527 0.0899 0.0899
Echinococcus multilocularis proteasome (prosome, macropain) 0.0084 0.0119 0.0118
Plasmodium vivax amine transporter, putative 0.0077 0.0106 0.2096
Brugia malayi hypothetical protein 0.0302 0.0503 0.1097
Schistosoma mansoni sex comb on midleg homolog 0.0053 0.0063 0.0063
Brugia malayi hypothetical protein 0.0018 0.0003 0.0005
Brugia malayi G protein-coupled receptor 0.0018 0.0003 0.0005
Echinococcus multilocularis serotonin receptor 0.0018 0.0003 0.0002
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0077 0.0106 0.0105
Onchocerca volvulus 0.0077 0.0106 0.0412
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0077 0.0106 0.0105
Schistosoma mansoni hypothetical protein 0.0022 0.0009 0.0008
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0018 0.0003 0.0002
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0018 0.0003 0.0002
Schistosoma mansoni ferritin 0.0035 0.0033 0.0032
Brugia malayi proteasome subunit beta type 1 0.0065 0.0086 0.0185
Echinococcus granulosus histone lysine methyltransferase setb 0.0202 0.0327 0.0327
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0094 0.0136 0.0136
Plasmodium falciparum proteasome subunit beta type-5 0.0084 0.0119 0.2347
Trypanosoma cruzi ISWI complex protein 0.0018 0.0003 0.0044
Echinococcus granulosus serotonin transporter 0.0453 0.077 0.0769
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0302 0.0503 1
Brugia malayi Cytochrome P450 family protein 0.0054 0.0065 0.014
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0095 0.0137 0.0136
Echinococcus multilocularis sex peptide receptor 0.0018 0.0003 0.0002
Schistosoma mansoni phosphatidylserine receptor 0.0094 0.0136 0.0136
Loa Loa (eye worm) hypothetical protein 0.0077 0.0106 0.0105
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0004 0.0004
Mycobacterium ulcerans beta-lactamase 0.0081 0.0114 0.2193
Plasmodium falciparum flap endonuclease 1 0.0027 0.0017 0.0326
Loa Loa (eye worm) hypothetical protein 0.0018 0.0003 0.0002
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0042 0.0828
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0208 0.0337 0.0336
Schistosoma mansoni sex comb on midleg homolog 0.0053 0.0063 0.0063
Loa Loa (eye worm) hypothetical protein 0.0082 0.0115 0.0114
Schistosoma mansoni amine GPCR 0.0018 0.0003 0.0002
Echinococcus granulosus polycomb protein SCMH1 0.0053 0.0063 0.0063
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0078 0.0108 0.2131
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0018 0.0003 0.0002
Mycobacterium ulcerans esterase/lipase LipP 0.0081 0.0114 0.2193
Giardia lamblia PHD finger protein 15 0.0238 0.0391 0.3715
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0302 0.0503 0.1997
Echinococcus granulosus expressed protein 0.0035 0.0033 0.0032
Mycobacterium ulcerans bacterioferritin BfrB 0.0035 0.0033 0.0569
Loa Loa (eye worm) hypothetical protein 0.0081 0.0114 0.0113
Echinococcus multilocularis neuropeptides capa receptor 0.0018 0.0003 0.0002
Brugia malayi hypothetical protein 0.0302 0.0503 0.1097
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0004 0.0073
Onchocerca volvulus Serine\/threonine kinase homolog 0.0095 0.0137 0.0536
Trypanosoma cruzi Aminopeptidase M1, putative 0.0302 0.0503 1
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0042 0.0828
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0302 0.0503 0.0502
Brugia malayi TATA binding protein associated factor 0.0302 0.0503 0.1097
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.03 0.0499 0.1089
Brugia malayi ORL1-like opioid receptor 0.0018 0.0003 0.0005
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0004 0.0042
Leishmania major hypothetical protein, conserved 0.0018 0.0003 0.0044
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.004 0.0042 0.0155
Echinococcus multilocularis cpg binding protein 0.0035 0.0033 0.0032
Loa Loa (eye worm) hypothetical protein 0.0031 0.0024 0.0024
Brugia malayi G-protein coupled receptor 0.0018 0.0003 0.0005
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0053 0.0063 0.0241
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0302 0.0503 1
Schistosoma mansoni myosin xvIII 0.0018 0.0003 0.0002
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0302 0.0503 1
Brugia malayi beta-lactamase 0.0081 0.0114 0.0247
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0081 0.0114 0.1276
Brugia malayi Serotonin receptor 0.0018 0.0003 0.0005
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0018 0.0003 0.0002
Echinococcus multilocularis inositol monophosphatase 1 0.0041 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0077 0.0106 0.0105
Loa Loa (eye worm) leukotriene A4 hydrolase 0.5685 1 1
Brugia malayi hypothetical protein 0.0077 0.0106 0.023
Echinococcus granulosus 7tm_1 domain containing protein 0.0018 0.0003 0.0002
Brugia malayi hypothetical protein 0.0018 0.0003 0.0005
Onchocerca volvulus 0.0081 0.0114 0.0443
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0056 0.0055
Schistosoma mansoni methyl-cpg binding protein mbd 0.0021 0.0007 0.0006
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0004 0.0008
Echinococcus granulosus neuropeptide receptor 0.0018 0.0003 0.0002
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0018 0.0003 0.0002
Echinococcus granulosus rhodopsin orphan GPCR 0.0018 0.0003 0.0002
Echinococcus multilocularis chromobox protein 1 0.007 0.0093 0.0093
Trichomonas vaginalis glucosylceramidase, putative 0.0282 0.0467 0.1854
Schistosoma mansoni proteasome subunit beta 1 (T01 family) 0.0065 0.0086 0.0085
Trichomonas vaginalis penicillin-binding protein, putative 0.0081 0.0114 0.0442
Toxoplasma gondii aminopeptidase N protein 0.0302 0.0503 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0003 0.0002
Schistosoma mansoni hypothetical protein 0.0025 0.0014 0.0014
Schistosoma mansoni jumonji domain containing protein 0.0685 0.1178 0.1177
Brugia malayi hypothetical protein 0.0018 0.0003 0.0005
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0004 0.0008
Schistosoma mansoni zinc finger protein 0.0018 0.0003 0.0002
Echinococcus multilocularis beta LACTamase domain containing family member 0.0081 0.0114 0.0113
Loa Loa (eye worm) inositol-1 0.0041 0.0042 0.0042
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0077 0.0106 0.0105
Schistosoma mansoni bromodomain containing protein 0.0078 0.0108 0.0108
Echinococcus multilocularis aminopeptidase N 0.0302 0.0503 0.0502
Loa Loa (eye worm) hypothetical protein 0.0018 0.0003 0.0002
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0004 0.0073
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0018 0.0003 0.0002
Echinococcus granulosus sodium and chloride dependent glycine 0.0077 0.0106 0.0105
Loa Loa (eye worm) hypothetical protein 0.0018 0.0003 0.0002
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0092 0.0133 0.0133
Loa Loa (eye worm) hypothetical protein 0.0095 0.0138 0.0137
Brugia malayi Glycosyl hydrolases family 31 protein 0.0039 0.004 0.0085
Loa Loa (eye worm) peptidase family M1 containing protein 0.0302 0.0503 0.0502
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0056 0.0055
Echinococcus granulosus allatostatin A receptor 0.0018 0.0003 0.0002
Onchocerca volvulus 0.0081 0.0114 0.0443
Brugia malayi G-protein coupled receptor 0.0018 0.0003 0.0005
Schistosoma mansoni myelin transcription factor 1 myt1 0.006 0.0076 0.0075
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0077 0.0106 0.0105
Brugia malayi hypothetical protein 0.0018 0.0003 0.0005
Trichomonas vaginalis glucosylceramidase, putative 0.0195 0.0314 0.1241
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0065 0.0086 0.1689
Echinococcus multilocularis dnaJ subfamily B 0.0446 0.0757 0.0757
Echinococcus granulosus cpg binding protein 0.0035 0.0033 0.0032
Echinococcus granulosus rhodopsin orphan GPCR 0.0018 0.0003 0.0002
Schistosoma mansoni rab6-interacting 0.0022 0.0009 0.0008
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0018 0.0003 0.0002
Plasmodium vivax hypothetical protein, conserved 0.0081 0.0114 0.225
Loa Loa (eye worm) hypothetical protein 0.0077 0.0106 0.0105
Schistosoma mansoni apoferritin-2 0.0035 0.0033 0.0032
Brugia malayi hypothetical protein 0.0018 0.0003 0.0005
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0302 0.0503 0.0502
Onchocerca volvulus 0.0081 0.0114 0.0443
Loa Loa (eye worm) hypothetical protein 0.0018 0.0003 0.0002
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0302 0.0503 0.0502
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.0084 0.0119 0.1136
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0137 0.0536
Loa Loa (eye worm) hypothetical protein 0.0302 0.0503 0.0502
Brugia malayi jmjC domain containing protein 0.0094 0.0136 0.0296
Brugia malayi putative neuropeptide receptor NPR1 0.0018 0.0003 0.0005
Brugia malayi PHD-finger family protein 0.0032 0.0027 0.0056
Trypanosoma cruzi proteasome subunit beta type-2, putative 0.004 0.0042 0.0816
Schistosoma mansoni alpha-1 adrenergic receptor 0.0018 0.0003 0.0002
Brugia malayi hypothetical protein 0.0022 0.0009 0.0017
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0084 0.0119 0.2347
Echinococcus granulosus jun protein 0.0092 0.0133 0.0133
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.006 0.0076 0.0075
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0609 0.1045 0.416
Loa Loa (eye worm) hypothetical protein 0.0018 0.0003 0.0002
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0018 0.0003 0.0005
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0042 0.0828
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0004 0.0073
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0018 0.0003 0.0002
Brugia malayi hypothetical protein 0.0135 0.0209 0.0455
Schistosoma mansoni apoferritin-2 0.0035 0.0033 0.0032
Echinococcus granulosus orexin receptor type 2 0.0018 0.0003 0.0002
Plasmodium falciparum proteasome subunit beta type-2, putative 0.004 0.0042 0.0816
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0027 0.0017 0.0326
Brugia malayi RE15519p 0.0018 0.0003 0.0005
Echinococcus granulosus neuropeptide Y receptor 0.0018 0.0003 0.0002
Echinococcus granulosus g-protein coupled receptor 0.0018 0.0003 0.0002
Echinococcus granulosus neutral alpha glucosidase AB 0.0039 0.004 0.0039
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0298 0.0495 0.9841
Echinococcus granulosus dna polymerase kappa 0.0019 0.0004 0.0004
Echinococcus multilocularis neuropeptide receptor A26 0.0527 0.0899 0.0899
Echinococcus granulosus JmjC domain containing protein 4 0.0094 0.0136 0.0136
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0302 0.0503 0.0502
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0004 0.0073
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0042 0.0828
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0004 0.0073
Brugia malayi mbt repeat family protein 0.0053 0.0063 0.0137
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0095 0.0138 0.0137
Echinococcus multilocularis jumonji domain containing 1A 0.0094 0.0136 0.0136
Echinococcus granulosus methyl CpG binding domain protein 2 0.0021 0.0007 0.0006
Loa Loa (eye worm) hypothetical protein 0.0018 0.0003 0.0002
Loa Loa (eye worm) hypothetical protein 0.0018 0.0003 0.0002
Schistosoma mansoni inositol monophosphatase 0.0041 0.0042 0.0042
Loa Loa (eye worm) neuropeptide F receptor 0.0018 0.0003 0.0002
Onchocerca volvulus 0.0053 0.0063 0.0241
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0004 0.0004
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0057 0.0072 0.1348
Schistosoma mansoni alpha glucosidase 0.0039 0.004 0.0039
Loa Loa (eye worm) hypothetical protein 0.0453 0.077 0.0769
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0137 0.0536
Loa Loa (eye worm) hypothetical protein 0.0081 0.0114 0.0113
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0029 0.0021 0.0021
Echinococcus granulosus tm gpcr rhodopsin 0.0018 0.0003 0.0002
Echinococcus granulosus jumonji domain containing protein 0.0332 0.0556 0.0555
Loa Loa (eye worm) proteasome subunit beta type 2 0.004 0.0042 0.0041
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0057 0.0072 0.0071
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0084 0.0119 0.0462
Entamoeba histolytica serine/threonine protein kinase, putative 0.0095 0.0137 0.1313
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0302 0.0503 0.0502
Onchocerca volvulus 0.0073 0.0098 0.0381
Loa Loa (eye worm) hypothetical protein 0.0018 0.0003 0.0002
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0609 0.1045 0.416
Schistosoma mansoni histamine h1 receptor 0.0018 0.0003 0.0002
Brugia malayi sulfakinin receptor protein 0.0018 0.0003 0.0005
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.004 0.0147
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0053 0.0199
Schistosoma mansoni sodium-dependent amino acid transporter 0.0077 0.0106 0.0105
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0019 0.0065
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0302 0.0503 1
Echinococcus granulosus dro:myosuppressin receptor 0.0018 0.0003 0.0002
Onchocerca volvulus 0.0022 0.0009 0.0023
Schistosoma mansoni ferritin light chain 0.0035 0.0033 0.0032
Mycobacterium ulcerans aminopeptidase N PepN 0.0302 0.0503 1
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0018 0.0003 0.0002
Loa Loa (eye worm) PHD-finger family protein 0.0238 0.0391 0.039
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0453 0.077 0.1679
Toxoplasma gondii PHD-finger domain-containing protein 0.0238 0.0391 0.7766
Schistosoma mansoni sodium/chloride dependent transporter 0.0453 0.077 0.0769
Schistosoma mansoni hypothetical protein 0.032 0.0535 0.0535
Loa Loa (eye worm) hypothetical protein 0.0135 0.0209 0.0208
Plasmodium falciparum JmjC domain-containing protein, putative 0.0094 0.0136 0.2697
Schistosoma mansoni neuropeptide F-like receptor 0.0018 0.0003 0.0002
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0137 0.0536
Echinococcus multilocularis neuropeptide FF receptor 2 0.0018 0.0003 0.0002
Brugia malayi PHD-finger family protein 0.0238 0.0391 0.0852
Echinococcus granulosus histone acetyltransferase MYST2 0.006 0.0076 0.0075
Schistosoma mansoni hypothetical protein 0.0018 0.0003 0.0002
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0018 0.0003 0.0002
Schistosoma mansoni hypothetical protein 0.0238 0.0391 0.039
Trichomonas vaginalis ferritin, putative 0.0035 0.0033 0.0119
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.004 0.0147
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0018 0.0003 0.0002
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.004 0.0147
Loa Loa (eye worm) jmjC domain-containing protein 0.0094 0.0136 0.0136
Trypanosoma brucei proteasome beta 6 subunit 0.0065 0.0086 0.1689
Mycobacterium tuberculosis Conserved protein 0.0081 0.0114 0.1276
Echinococcus granulosus geminin 0.0876 0.1515 0.1515
Loa Loa (eye worm) hypothetical protein 0.0018 0.0003 0.0002
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0056 0.0055
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0238 0.0391 0.039
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0302 0.0503 1
Plasmodium falciparum LCCL domain-containing protein 0.0022 0.0009 0.0156
Loa Loa (eye worm) hypothetical protein 0.0085 0.0121 0.012
Brugia malayi AF-10 protein 0.0078 0.0108 0.0234
Plasmodium falciparum M1-family alanyl aminopeptidase 0.0302 0.0503 1
Schistosoma mansoni opsin-like receptor 0.0018 0.0003 0.0002
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.004 0.0147
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0077 0.0106 0.0105
Loa Loa (eye worm) beta-lactamase 0.0081 0.0114 0.0113
Schistosoma mansoni ferritin 0.0035 0.0033 0.0032
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0039 0.004 0.0039
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0004 0.0004
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0302 0.0503 1
Leishmania major DNA polymerase eta, putative 0.0019 0.0004 0.0073
Echinococcus granulosus g protein coupled receptor 0.0018 0.0003 0.0002
Echinococcus granulosus dnaJ subfamily B 0.0446 0.0757 0.0757
Brugia malayi Heterochromatin protein 1 0.007 0.0093 0.0202
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0039 0.004 0.0779
Loa Loa (eye worm) hypothetical protein 0.0453 0.077 0.0769
Mycobacterium leprae conserved hypothetical protein 0.0081 0.0114 0.1751
Loa Loa (eye worm) hypothetical protein 0.0039 0.0039 0.0039
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0004 0.0073
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0039 0.004 0.0147
Loa Loa (eye worm) hypothetical protein 0.0238 0.0391 0.039
Schistosoma mansoni hypothetical protein 0.0876 0.1515 0.1515
Loa Loa (eye worm) hypothetical protein 0.0081 0.0114 0.0113
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0018 0.0003 0.0002
Echinococcus granulosus g protein coupled receptor 0.0018 0.0003 0.0002
Trypanosoma brucei aminopeptidase, putative 0.0302 0.0503 1
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0037 0.0035 0.0042
Echinococcus multilocularis PHD finger protein rhinoceros 0.0238 0.0391 0.039
Echinococcus multilocularis neuropeptide receptor 0.0018 0.0003 0.0002
Loa Loa (eye worm) solute carrier family 6 member 4 0.0453 0.077 0.0769
Schistosoma mansoni methyl-cpg binding protein mbd 0.0021 0.0007 0.0006
Echinococcus multilocularis sodium and chloride dependent glycine 0.0077 0.0106 0.0105
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0004 0.0073
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0081 0.0114 0.1276
Plasmodium vivax hypothetical protein, conserved 0.0077 0.0106 0.2096
Echinococcus multilocularis rhodopsin orphan GPCR 0.0018 0.0003 0.0002
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0609 0.1045 0.416
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0077 0.0106 0.0105
Echinococcus granulosus biogenic amine 5HT receptor 0.0018 0.0003 0.0002
Loa Loa (eye worm) hypothetical protein 0.0018 0.0003 0.0002
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0077 0.0106 0.023
Brugia malayi Dopamine receptor protein 2 0.0018 0.0003 0.0005
Trypanosoma cruzi ISWI complex protein 0.0018 0.0003 0.0044
Brugia malayi AKH receptor 0.0018 0.0003 0.0005
Loa Loa (eye worm) TATA binding protein associated factor 0.0302 0.0503 0.0502
Loa Loa (eye worm) proteasome subunit beta type 1 0.0065 0.0086 0.0085
Schistosoma mansoni sodium/chloride dependent transporter 0.0077 0.0107 0.0106
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0004 0.0073
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0302 0.0503 0.0502
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0077 0.0106 0.0105
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0018 0.0003 0.0002
Plasmodium vivax hypothetical protein, conserved 0.0238 0.0391 0.7766
Loa Loa (eye worm) hypothetical protein 0.0018 0.0003 0.0002
Trypanosoma brucei glucosidase, putative 0.0039 0.004 0.0779
Loa Loa (eye worm) hypothetical protein 0.0018 0.0003 0.0002
Echinococcus multilocularis expressed protein 0.0035 0.0033 0.0032
Brugia malayi chromobox protein homolog 3 0.0039 0.0039 0.0084
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0077 0.0106 0.0105
Brugia malayi Peptidase family M1 containing protein 0.0302 0.0503 0.1097
Onchocerca volvulus 0.0453 0.077 0.3062
Brugia malayi hypothetical protein 0.0018 0.0003 0.0005
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0302 0.0503 0.0502
Toxoplasma gondii hypothetical protein 0.0077 0.0106 0.2096
Loa Loa (eye worm) hypothetical protein 0.0018 0.0003 0.0002
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.004 0.0779
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0004 0.0042
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0078 0.0108 0.2131
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0041 0.0042 0.076
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0077 0.0106 0.0105
Giardia lamblia Proteasome subunit beta type 5 precursor 0.0084 0.0119 0.1098
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0018 0.0003 0.0002
Schistosoma mansoni neuropeptide receptor 0.0018 0.0003 0.0002
Onchocerca volvulus 0.0022 0.0009 0.0023
Echinococcus multilocularis g protein coupled receptor 0.0018 0.0003 0.0002
Echinococcus granulosus lysine specific demethylase 6a 0.0094 0.0136 0.0136
Schistosoma mansoni jun-related protein 0.0075 0.0103 0.0102
Brugia malayi SET domain containing protein 0.0019 0.0003 0.0006
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0004 0.0073
Mycobacterium tuberculosis Conserved protein 0.0081 0.0114 0.1276
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0053 0.0063 0.0063
Echinococcus granulosus tm gpcr rhodopsin 0.0018 0.0003 0.0002
Echinococcus multilocularis fmrfamide receptor 0.0018 0.0003 0.0002
Echinococcus multilocularis g protein coupled receptor 0.0018 0.0003 0.0002
Plasmodium falciparum amino acid transporter, putative 0.0077 0.0106 0.2096
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0282 0.0467 0.0467
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0018 0.0003 0.0002
Echinococcus multilocularis dro:myosuppressin receptor 0.0018 0.0003 0.0002
Echinococcus granulosus neuropeptides capa receptor 0.0018 0.0003 0.0002
Entamoeba histolytica aminopeptidase, putative 0.0302 0.0503 0.4816
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0081 0.0114 0.0113
Loa Loa (eye worm) hypothetical protein 0.0018 0.0003 0.0002
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0095 0.0138 0.0137
Echinococcus granulosus GPCR family 2 0.0095 0.0138 0.0137
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0039 0.0039 0.0145
Echinococcus granulosus inositol monophosphatase 1 0.0041 0.0042 0.0042
Plasmodium falciparum proteasome subunit beta type-1, putative 0.0065 0.0086 0.1689
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0092 0.0133 0.0133
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0302 0.0503 1
Onchocerca volvulus 0.0031 0.0024 0.0086
Echinococcus granulosus rhodopsin orphan GPCR 0.0018 0.0003 0.0002
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0018 0.0003 0.0002
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0098 0.0143 0.0143
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0095 0.0137 0.0136
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0004 0.0073
Brugia malayi GnHR receptor homolog 0.0018 0.0003 0.0005
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0027 0.0017 0.0326
Trichomonas vaginalis chromobox protein, putative 0.007 0.0093 0.0361
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0057 0.0072 0.0071
Echinococcus granulosus chromobox protein 1 0.007 0.0093 0.0093
Echinococcus multilocularis neuropeptide Y receptor 0.0018 0.0003 0.0002
Echinococcus multilocularis sodium and chloride dependent glycine 0.0077 0.0106 0.0105
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0057 0.0072 0.0801
Echinococcus multilocularis jumonji domain containing protein 0.0332 0.0556 0.0555
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0018 0.0003 0.0005
Toxoplasma gondii proteasome subunit beta type 1, putative 0.0065 0.0086 0.1689
Loa Loa (eye worm) hypothetical protein 0.0018 0.0003 0.0002
Echinococcus granulosus biogenic amine 5HT receptor 0.0018 0.0003 0.0002
Echinococcus multilocularis chromobox protein 1 0.007 0.0093 0.0093
Trypanosoma cruzi hypothetical protein, conserved 0.0081 0.0114 0.225
Brugia malayi CXXC zinc finger family protein 0.0031 0.0026 0.0054
Echinococcus multilocularis RUN 0.0022 0.0009 0.0008
Loa Loa (eye worm) jmjC domain-containing protein 0.0357 0.06 0.0599
Schistosoma mansoni hypothetical protein 0.0078 0.0108 0.0107
Giardia lamblia Proteasome subunit beta type 1 0.0065 0.0086 0.078
Schistosoma mansoni amine GPCR 0.0018 0.0003 0.0002
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.004 0.0147
Echinococcus granulosus aminopeptidase N 0.0302 0.0503 0.0502
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0094 0.0136 0.2697
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0202 0.0327 0.0327
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0004 0.0073
Loa Loa (eye worm) hypothetical protein 0.0426 0.0722 0.0721
Echinococcus granulosus lipoxygenase domain containing protein 0.0022 0.0009 0.0008
Loa Loa (eye worm) serotonin transporter b 0.0453 0.077 0.0769
Loa Loa (eye worm) hypothetical protein 0.0053 0.0064 0.0064
Mycobacterium tuberculosis Probable hydrolase 0.0081 0.0114 0.1276
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0027 0.0017 0.0326
Schistosoma mansoni inositol monophosphatase 0.0041 0.0042 0.0042
Echinococcus multilocularis peregrin 0.0241 0.0396 0.0395
Brugia malayi larval opioid receptor 0.0018 0.0003 0.0005
Onchocerca volvulus Alhambra homolog 0.0238 0.0391 0.1549
Echinococcus multilocularis jun protein 0.0092 0.0133 0.0133
Echinococcus multilocularis rhodopsin orphan GPCR 0.0018 0.0003 0.0002
Loa Loa (eye worm) hypothetical protein 0.0018 0.0003 0.0002
Brugia malayi Glycosyl hydrolases family 31 protein 0.0178 0.0284 0.0618
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0004 0.0073
Toxoplasma gondii proteasome subunit beta type, putative 0.0084 0.0119 0.2347
Loa Loa (eye worm) hypothetical protein 0.0077 0.0106 0.0105
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.004 0.0779
Schistosoma mansoni neuropeptide f receptor 76f 0.0018 0.0003 0.0002
Onchocerca volvulus 0.0302 0.0503 0.1997
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0018 0.0003 0.0002
Brugia malayi Tachykinin-like peptides receptor 99D 0.0018 0.0003 0.0005
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0004 0.0073
Brugia malayi hypothetical protein 0.0018 0.0003 0.0005
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0302 0.0503 0.0502
Loa Loa (eye worm) hypothetical protein 0.0018 0.0003 0.0002
Brugia malayi Dopamine receptor 0.0018 0.0003 0.0005
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0029 0.0021 0.0021
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0302 0.0503 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0018 0.0003 0.0002
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0018 0.0003 0.0002
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.006 0.0076 0.0075
Trichomonas vaginalis maltase-glucoamylase, putative 0.0039 0.004 0.0147
Entamoeba histolytica probable proteasome subunit beta type 2, putative 0.004 0.0042 0.0399
Schistosoma mansoni amine GPCR 0.0018 0.0003 0.0002
Echinococcus multilocularis zinc finger protein 0.0025 0.0015 0.0014
Brugia malayi follicle stimulating hormone receptor 0.0249 0.0409 0.0892
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0035 0.0032 0.0115
Schistosoma mansoni jumonji/arid domain-containing protein 0.0357 0.06 0.0599
Echinococcus multilocularis rhodopsin orphan GPCR 0.0018 0.0003 0.0002
Echinococcus granulosus sodium and chloride dependent glycine 0.0077 0.0106 0.0105
Trichomonas vaginalis glucosylceramidase, putative 0.0282 0.0467 0.1854
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0077 0.0106 0.5
Echinococcus granulosus Polycystic kidney disease protein 0.0022 0.0009 0.0008
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0094 0.0136 0.2697
Brugia malayi Doublecortin family protein 0.0022 0.0009 0.0017
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0302 0.0503 0.1997
Schistosoma mansoni ferritin light chain 0.0035 0.0033 0.0032
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0018 0.0003 0.0005
Schistosoma mansoni DNA polymerase eta 0.0019 0.0004 0.0004
Loa Loa (eye worm) latrophilin receptor protein 2 0.0095 0.0138 0.0137
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0065 0.0086 0.0085
Echinococcus granulosus lysosomal alpha glucosidase 0.0178 0.0284 0.0283
Echinococcus multilocularis lipoxygenase domain containing protein 0.0022 0.0009 0.0008
Echinococcus granulosus rhodopsin orphan GPCR 0.0018 0.0003 0.0002
Echinococcus multilocularis Polycystic kidney disease protein 0.0022 0.0009 0.0008
Brugia malayi jmjC domain containing protein 0.0094 0.0136 0.0296
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0302 0.0503 0.1997
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0137 0.0536
Plasmodium vivax flap endonuclease 1, putative 0.0027 0.0017 0.0326
Schistosoma mansoni neuropeptide receptor 0.0018 0.0003 0.0002
Loa Loa (eye worm) bromodomain containing protein 0.0021 0.0008 0.0007
Schistosoma mansoni hypothetical protein 0.0446 0.0757 0.0757
Echinococcus multilocularis lysine specific demethylase 5A 0.0353 0.0593 0.0592
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0077 0.0106 0.2096
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0175 0.0278 0.0277
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0282 0.0467 0.1018
Toxoplasma gondii aminopeptidase N, putative 0.0302 0.0503 1
Trichomonas vaginalis D-aminoacylase, putative 0.0081 0.0114 0.0442
Loa Loa (eye worm) mbt repeat family protein 0.0053 0.0063 0.0063
Brugia malayi jmjC domain containing protein 0.0845 0.1461 0.3188
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0302 0.0503 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0018 0.0003 0.0002
Treponema pallidum fructose-bisphosphate aldolase 0.0609 0.1045 1
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0084 0.0119 0.2347
Schistosoma mansoni flap endonuclease-1 0.0024 0.0013 0.0012
Brugia malayi Flap endonuclease-1 0.0027 0.0017 0.0036
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0182 0.0291 0.029
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0208 0.0337 0.0336
Echinococcus granulosus proteasome prosome macropain subunit beta 0.004 0.0042 0.0041
Echinococcus multilocularis polycomb protein SCMH1 0.0053 0.0063 0.0063
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0081 0.0114 0.1276
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0077 0.0106 0.023
Brugia malayi Serotonin receptor 0.0018 0.0003 0.0005
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0065 0.0086 0.1689
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0095 0.0137 0.0136
Plasmodium vivax proteasome subunit beta type-5, putative 0.0084 0.0119 0.2347
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0037 0.0036 0.0035
Schistosoma mansoni hypothetical protein 0.0018 0.0003 0.0002
Trichomonas vaginalis glucosylceramidase, putative 0.0185 0.0296 0.1171
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0004 0.0073
Mycobacterium tuberculosis Conserved protein 0.0081 0.0114 0.1276
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0004 0.0073
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0018 0.0003 0.0002
Giardia lamblia Kinase, PLK 0.0095 0.0137 0.1276
Trichomonas vaginalis glucosylceramidase, putative 0.0185 0.0296 0.1171
Entamoeba histolytica proteasome subunit beta type 1, putative 0.0065 0.0086 0.0819
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0004 0.0073
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0018 0.0003 0.0002
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0041 0.0042 0.0157
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0302 0.0503 0.0502
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0037 0.0036 0.0035
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0048 0.0056 0.0055
Schistosoma mansoni serine/threonine protein kinase 0.0095 0.0137 0.0136
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.004 0.0042 0.0155
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0609 0.1045 1
Echinococcus granulosus lysine specific demethylase 5A 0.0357 0.06 0.0599
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0004 0.0004
Plasmodium vivax multidomain scavenger receptor, putative 0.0022 0.0009 0.0156
Treponema pallidum sodium- and chloride- dependent transporter 0.0453 0.077 0.7283
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0182 0.0291 0.578
Schistosoma mansoni neuropeptide receptor 0.0018 0.0003 0.0002
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0018 0.0003 0.0002
Echinococcus granulosus G protein coupled receptor 139 0.0018 0.0003 0.0002
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0035 0.0033 0.0362
Schistosoma mansoni protein phosphatase 2C 0.0094 0.0136 0.0136
Schistosoma mansoni opsin-like receptor 0.0018 0.0003 0.0002
Loa Loa (eye worm) neuropeptide F receptor 0.0018 0.0003 0.0002
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0018 0.0003 0.0002
Toxoplasma gondii histone lysine methyltransferase SET1 0.0069 0.0092 0.1813
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0018 0.0003 0.0005
Echinococcus granulosus rhodopsin orphan GPCR 0.0018 0.0003 0.0002
Leishmania major hypothetical protein, conserved 0.0094 0.0136 0.2697
Loa Loa (eye worm) hypothetical protein 0.0302 0.0503 0.0502
Loa Loa (eye worm) jmjC domain-containing protein 0.0094 0.0136 0.0136
Loa Loa (eye worm) hypothetical protein 0.0018 0.0003 0.0002
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0018 0.0003 0.0002
Schistosoma mansoni hypothetical protein 0.0095 0.0138 0.0137
Onchocerca volvulus Glucosylceramidase homolog 0.0185 0.0296 0.1172
Echinococcus multilocularis g-protein coupled receptor 0.0018 0.0003 0.0002
Loa Loa (eye worm) hypothetical protein 0.0018 0.0003 0.0002
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0026 0.0025
Echinococcus granulosus flap endonuclease 1 0.0027 0.0017 0.0016
Trypanosoma brucei unspecified product 0.0019 0.0004 0.0073
Echinococcus multilocularis JmjC domain containing protein 4 0.0094 0.0136 0.0136
Schistosoma mansoni adenoreceptor 0.0018 0.0003 0.0002
Schistosoma mansoni biogenic amine receptor 0.0018 0.0003 0.0002
Loa Loa (eye worm) doublecortin family protein 0.0022 0.0009 0.0008
Loa Loa (eye worm) jmjC domain-containing protein 0.0094 0.0136 0.0136
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0037 0.0036 0.0077
Plasmodium falciparum phd finger protein, putative 0.0238 0.0391 0.7766
Echinococcus multilocularis lipoxygenase domain containing protein 0.0022 0.0009 0.0008
Loa Loa (eye worm) hypothetical protein 0.0077 0.0106 0.0105
Loa Loa (eye worm) hypothetical protein 0.0018 0.0003 0.0002
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0077 0.0106 0.0105
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0077 0.0106 0.023
Loa Loa (eye worm) hypothetical protein 0.0018 0.0003 0.0002
Trypanosoma cruzi 20S proteasome subunit 0.004 0.0042 0.0816
Loa Loa (eye worm) cytochrome P450 family protein 0.0054 0.0065 0.0064
Loa Loa (eye worm) hypothetical protein 0.0018 0.0003 0.0002
Giardia lamblia Flap structure-specific endonuclease 0.0027 0.0017 0.0122
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0056 0.0055
Trypanosoma brucei Aminopeptidase M1, putative 0.0302 0.0503 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0003 0.0002
Echinococcus multilocularis rhodopsin orphan GPCR 0.0018 0.0003 0.0002
Loa Loa (eye worm) flap endonuclease-1 0.0027 0.0017 0.0016
Echinococcus granulosus arachidonate 5 lipoxygenase 0.013 0.0199 0.0198
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0018 0.0003 0.0002
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0043 0.0047 0.0046
Echinococcus granulosus jumonji domain containing 1A 0.0094 0.0136 0.0136
Loa Loa (eye worm) hypothetical protein 0.0081 0.0114 0.0113
Loa Loa (eye worm) hypothetical protein 0.0018 0.0003 0.0002
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0074 0.0101 0.01
Brugia malayi Pre-SET motif family protein 0.0182 0.0291 0.0634
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0056 0.0055
Loa Loa (eye worm) hypothetical protein 0.0077 0.0106 0.0105
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0137 0.0536
Echinococcus multilocularis lysosomal alpha glucosidase 0.0178 0.0284 0.0283
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0095 0.0137 0.2716
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0054 0.0065 0.0064
Brugia malayi Peptidase family M1 containing protein 0.0302 0.0503 0.1097
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0018 0.0003 0.0002
Onchocerca volvulus 0.0103 0.0152 0.0594
Schistosoma mansoni hypothetical protein 0.0018 0.0003 0.0002
Echinococcus granulosus neuropeptide receptor 0.0018 0.0003 0.0002
Trichomonas vaginalis glucosylceramidase, putative 0.0282 0.0467 0.1854
Onchocerca volvulus 0.0077 0.0106 0.0412
Schistosoma mansoni cpg binding protein 0.0035 0.0033 0.0032
Loa Loa (eye worm) G-protein coupled receptor 0.0018 0.0003 0.0002
Leishmania major proteasome beta 5 subunit, putative 0.0084 0.0119 0.2347
Brugia malayi Inositol-1 0.0041 0.0042 0.0091
Trichomonas vaginalis set domain proteins, putative 0.1438 0.2508 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0003 0.0002
Brugia malayi Latrophilin receptor protein 2 0.0095 0.0138 0.0299
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0081 0.0114 0.2193
Leishmania major hypothetical protein, conserved 0.0081 0.0114 0.225
Mycobacterium tuberculosis Possible penicillin-binding protein 0.052 0.0887 1
Entamoeba histolytica Flap nuclease, putative 0.0027 0.0017 0.0163
Brugia malayi hypothetical protein 0.0018 0.0003 0.0005
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0045 0.0166
Echinococcus multilocularis neuropeptide Y receptor 0.0018 0.0003 0.0002
Echinococcus multilocularis rhodopsin orphan GPCR 0.0018 0.0003 0.0002
Echinococcus granulosus PHD finger protein rhinoceros 0.0238 0.0391 0.039
Brugia malayi PHD-finger family protein 0.0082 0.0115 0.0249
Schistosoma mansoni chromobox protein 0.007 0.0093 0.0093
Onchocerca volvulus Huntingtin homolog 0.0135 0.0209 0.0823
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0018 0.0003 0.0002
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0845 0.1461 0.146
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0137 0.0536
Loa Loa (eye worm) hypothetical protein 0.0032 0.0027 0.0027
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.1264 0.22 0.2199
Trypanosoma brucei proteasome subunit beta type-5, putative 0.0084 0.0119 0.2347
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0004 0.0006
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0098 0.0143 0.0143
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0182 0.0291 0.029
Loa Loa (eye worm) hypothetical protein 0.0018 0.0003 0.0002
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0018 0.0003 0.0002
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0004 0.0073
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0302 0.0503 0.0502
Brugia malayi proteasome subunit beta type 2 0.004 0.0042 0.009
Brugia malayi Bromodomain containing protein 0.0241 0.0396 0.0863
Toxoplasma gondii proteasome subunit beta type 2, putative 0.004 0.0042 0.0816
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0178 0.0284 0.0283
Echinococcus granulosus peptide allatostatin:somatostatin 0.0018 0.0003 0.0002
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0004 0.0073
Echinococcus multilocularis rhodopsin orphan GPCR 0.0018 0.0003 0.0002
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0048 0.0056 0.012
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0302 0.0503 0.0502
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0039 0.004 0.0147
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0609 0.1045 0.416
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0039 0.0145
Echinococcus multilocularis geminin 0.0876 0.1515 0.1515
Schistosoma mansoni aminopeptidase A (M01 family) 0.0302 0.0503 0.0502
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0092 0.0133 0.0133
Echinococcus multilocularis phd:f box containing protein 0.0094 0.0136 0.0136
Loa Loa (eye worm) hypothetical protein 0.0046 0.0052 0.0051
Brugia malayi hypothetical protein 0.2614 0.4581 1
Trypanosoma cruzi hypothetical protein, conserved 0.0081 0.0114 0.225
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0081 0.0114 0.0113
Mycobacterium leprae Probable lipase LipE 0.0081 0.0114 0.1751
Brugia malayi F/Y-rich N-terminus family protein 0.0096 0.014 0.0305
Loa Loa (eye worm) hypothetical protein 0.0019 0.0004 0.0004
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0065 0.0086 0.0085
Trypanosoma brucei hypothetical protein, conserved 0.0081 0.0114 0.225
Schistosoma mansoni zinc finger protein 0.0025 0.0015 0.0014
Loa Loa (eye worm) hypothetical protein 0.0018 0.0003 0.0002
Onchocerca volvulus 0.1438 0.2508 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0003 0.0002
Loa Loa (eye worm) hypothetical protein 0.0018 0.0003 0.0002
Mycobacterium leprae proteasome (beta subunit) PrcB 0.0084 0.0119 0.1857
Trichomonas vaginalis glucosylceramidase, putative 0.0185 0.0296 0.1171
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0018 0.0003 0.0002
Echinococcus granulosus tachykinin peptides receptor 99D 0.0018 0.0003 0.0002
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0018 0.0003 0.0002
Brugia malayi putative neuropeptide receptor 0.0018 0.0003 0.0005
Loa Loa (eye worm) hypothetical protein 0.0302 0.0503 0.0502
Leishmania major DNA polymerase kappa, putative 0.0019 0.0004 0.0073
Loa Loa (eye worm) hypothetical protein 0.0018 0.0003 0.0002
Schistosoma mansoni neuropeptide F-like receptor 0.0018 0.0003 0.0002
Loa Loa (eye worm) hypothetical protein 0.0018 0.0003 0.0002
Echinococcus granulosus serotonin receptor 0.0018 0.0003 0.0002
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0004 0.0042
Echinococcus granulosus peregrin 0.0241 0.0396 0.0395
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0077 0.0106 0.0105
Loa Loa (eye worm) hypothetical protein 0.0018 0.0003 0.0002
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.0084 0.0119 0.0118
Brugia malayi bZIP transcription factor family protein 0.0092 0.0133 0.0289
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0018 0.0003 0.0002
Loa Loa (eye worm) hypothetical protein 0.0018 0.0003 0.0002
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0249 0.0409 0.0409
Loa Loa (eye worm) hypothetical protein 0.006 0.0076 0.0075
Trichomonas vaginalis flap endonuclease-1, putative 0.0027 0.0017 0.0056
Trypanosoma cruzi aminopeptidase, putative 0.0302 0.0503 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0081 0.0114 0.0442
Loa Loa (eye worm) heterochromatin protein 1 0.007 0.0093 0.0093
Onchocerca volvulus 0.0077 0.0106 0.0412
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0302 0.0503 0.0502
Echinococcus granulosus somatostatin receptor 0.0018 0.0003 0.0002
Echinococcus multilocularis neutral alpha glucosidase AB 0.0039 0.004 0.0039
Brugia malayi MH2 domain containing protein 0.0125 0.0191 0.0415
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0041 0.0042 0.0828
Echinococcus granulosus lipoxygenase domain containing protein 0.0022 0.0009 0.0008
Echinococcus granulosus g protein coupled receptor 0.0018 0.0003 0.0002
Schistosoma mansoni ferritin 0.0035 0.0033 0.0032
Schistosoma mansoni opsin-like receptor 0.0018 0.0003 0.0002
Brugia malayi beta-lactamase family protein 0.0081 0.0114 0.0247
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0056 0.0055
Loa Loa (eye worm) PHD-finger family protein 0.0025 0.0014 0.0014
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0043 0.0047 0.0046
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0077 0.0106 0.0105
Trichomonas vaginalis glucosylceramidase, putative 0.0185 0.0296 0.1171
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0041 0.0042 0.0157
Echinococcus granulosus beta LACTamase domain containing family member 0.0081 0.0114 0.0113
Echinococcus multilocularis G-protein coupled receptor, putative 0.0018 0.0003 0.0002
Echinococcus multilocularis ferritin 0.0035 0.0033 0.0032
Brugia malayi Bromodomain containing protein 0.0046 0.0052 0.0112
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.006 0.0076 0.0165
Echinococcus granulosus neuropeptide Y receptor 0.0018 0.0003 0.0002
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0609 0.1045 0.416
Echinococcus multilocularis lysosomal alpha glucosidase 0.0178 0.0284 0.0283
Echinococcus multilocularis GPCR, family 2 0.0095 0.0138 0.0137
Echinococcus multilocularis rhodopsin orphan GPCR 0.0018 0.0003 0.0002
Mycobacterium ulcerans lipase LipD 0.0081 0.0114 0.2193
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0074 0.0101 0.01
Loa Loa (eye worm) hypothetical protein 0.0018 0.0003 0.0002
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0077 0.0106 0.023
Echinococcus granulosus fmrfamide receptor 0.0018 0.0003 0.0002
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0018 0.0003 0.0002
Echinococcus granulosus sex peptide receptor 0.0018 0.0003 0.0002
Trichomonas vaginalis glucosylceramidase, putative 0.0282 0.0467 0.1854
Mycobacterium tuberculosis Probable lipase LipD 0.0081 0.0114 0.1276
Schistosoma mansoni voltage-gated potassium channel 0.0041 0.0042 0.0041
Loa Loa (eye worm) hypothetical protein 0.0018 0.0003 0.0002
Loa Loa (eye worm) G-protein coupled receptor 0.0018 0.0003 0.0002
Brugia malayi latrophilin 2 splice variant baaae 0.0205 0.0332 0.0723
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0077 0.0106 0.0105
Schistosoma mansoni hypothetical protein 0.0876 0.1515 0.1515
Brugia malayi jmjC domain containing protein 0.0094 0.0136 0.0296
Trichomonas vaginalis glucosylceramidase, putative 0.0282 0.0467 0.1854
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0021 0.0007 0.0006
Schistosoma mansoni biogenic amine receptor 0.0018 0.0003 0.0002
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.004 0.0042 0.0041
Echinococcus multilocularis serotonin transporter 0.0453 0.077 0.0769
Toxoplasma gondii hypothetical protein 0.0077 0.0106 0.2096
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0302 0.0503 0.0502
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0039 0.004 0.0382
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0018 0.0003 0.0002
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0035 0.0032 0.0115
Loa Loa (eye worm) hypothetical protein 0.0205 0.0332 0.0331
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0302 0.0503 1
Echinococcus multilocularis neuropeptides capa receptor 0.0018 0.0003 0.0002
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0057 0.0072 0.1412
Schistosoma mansoni hypothetical protein 0.0095 0.0138 0.0137
Toxoplasma gondii aminopeptidase n, putative 0.0302 0.0503 1
Echinococcus granulosus proteasome prosome macropain 0.0084 0.0119 0.0118
Schistosoma mansoni cpg binding protein 0.0035 0.0033 0.0032
Trichomonas vaginalis D-aminoacylase, putative 0.0081 0.0114 0.0442
Echinococcus granulosus neuropeptides capa receptor 0.0018 0.0003 0.0002
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0609 0.1045 0.416
Brugia malayi serine/threonine-protein kinase plk-2 0.0095 0.0137 0.0298
Echinococcus granulosus hypothetical protein 0.0018 0.0003 0.0002
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0018 0.0003 0.0002
Schistosoma mansoni chromobox protein 0.007 0.0093 0.0093
Loa Loa (eye worm) pigment dispersing factor receptor c 0.03 0.0499 0.0499
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0137 0.0536
Echinococcus granulosus RUN 0.0022 0.0009 0.0008
Echinococcus multilocularis dna polymerase eta 0.0019 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0135 0.0209 0.0208
Schistosoma mansoni sodium/chloride dependent transporter 0.0077 0.0106 0.0105
Loa Loa (eye worm) MH2 domain-containing protein 0.0125 0.0191 0.019
Loa Loa (eye worm) hypothetical protein 0.0018 0.0003 0.0002
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0077 0.0106 0.0105
Loa Loa (eye worm) TYRA-2 protein 0.0018 0.0003 0.0002
Mycobacterium tuberculosis Probable esterase LipL 0.0081 0.0114 0.1276
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0039 0.004 0.0382
Schistosoma mansoni hypothetical protein 0.0095 0.0138 0.0137
Echinococcus multilocularis somatostatin receptor 0.0018 0.0003 0.0002
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0018 0.0003 0.0002
Echinococcus multilocularis allatostatin A receptor 0.0018 0.0003 0.0002
Plasmodium vivax hypothetical protein, conserved 0.008 0.0111 0.2198
Schistosoma mansoni biogenic amine receptor 0.0018 0.0003 0.0002
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0004 0.0073
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0845 0.1461 0.146
Echinococcus granulosus neuropeptide receptor A26 0.0527 0.0899 0.0899
Loa Loa (eye worm) hypothetical protein 0.0081 0.0114 0.0113
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0302 0.0503 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0018 0.0003 0.0002
Schistosoma mansoni alpha-glucosidase 0.0153 0.024 0.0239
Brugia malayi beta-lactamase family protein 0.0081 0.0114 0.0247
Trichomonas vaginalis D-aminoacylase, putative 0.0081 0.0114 0.0442
Leishmania major alpha glucosidase II subunit, putative 0.0039 0.004 0.0779
Brugia malayi jmjC domain containing protein 0.0094 0.0136 0.0296
Echinococcus multilocularis flap endonuclease 1 0.0027 0.0017 0.0016
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0609 0.1045 0.416
Brugia malayi Proteasome A-type and B-type family protein 0.0084 0.0119 0.0257
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0018 0.0003 0.0002
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0053 0.0199
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.004 0.0042 0.0041
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0018 0.0003 0.0002
Schistosoma mansoni growth hormone secretagogue receptor 0.0018 0.0003 0.0002
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0202 0.0327 0.0327
Brugia malayi Melatonin receptor type 1A 0.0018 0.0003 0.0005
Loa Loa (eye worm) hypothetical protein 0.0049 0.0057 0.0056
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0019 0.0065
Schistosoma mansoni hypothetical protein 0.0018 0.0003 0.0002
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0077 0.0106 0.0105
Onchocerca volvulus 0.0302 0.0503 0.1997
Trichomonas vaginalis chromobox protein, putative 0.007 0.0093 0.0361
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0018 0.0003 0.0005
Schistosoma mansoni hypothetical protein 0.0095 0.0138 0.0137
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0037 0.0035 0.0384
Leishmania major proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative 0.0065 0.0086 0.1689
Brugia malayi hypothetical protein 0.0018 0.0003 0.0005
Trypanosoma brucei Aminopeptidase M1, putative 0.0302 0.0503 1
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0004 0.0006
Loa Loa (eye worm) hypothetical protein 0.0022 0.0009 0.0008
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.004 0.0042 0.0041
Echinococcus multilocularis G protein coupled receptor 139 0.0018 0.0003 0.0002
Loa Loa (eye worm) hypothetical protein 0.0018 0.0003 0.0002
Trichomonas vaginalis glucosylceramidase, putative 0.0195 0.0314 0.1241
Mycobacterium ulcerans bacterioferritin BfrA 0.0035 0.0033 0.0569
Schistosoma mansoni amine GPCR 0.0018 0.0003 0.0002
Toxoplasma gondii ABC1 family protein 0.0081 0.0114 0.225
Schistosoma mansoni ferritin 0.0035 0.0033 0.0032
Mycobacterium ulcerans hypothetical protein 0.0081 0.0114 0.2193
Trypanosoma brucei ISWI complex protein 0.0018 0.0003 0.0044
Brugia malayi Calcitonin receptor-like protein seb-1 0.03 0.0499 0.1089
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0004 0.0004
Onchocerca volvulus 0.0031 0.0026 0.0091
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0094 0.0136 0.2697
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0095 0.0138 0.0137
Echinococcus granulosus fetal alzheimer antigen falz 0.0029 0.0021 0.0021
Schistosoma mansoni phd/f-box containing protein 0.0094 0.0136 0.0136
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0057 0.0072 0.0155
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0077 0.0106 0.0105
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0095 0.0138 0.0137
Brugia malayi jmjC domain containing protein 0.0357 0.06 0.1308
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0298 0.0495 0.5581
Echinococcus multilocularis neuropeptide receptor 0.0018 0.0003 0.0002
Echinococcus granulosus ferritin 0.0035 0.0033 0.0032
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0081 0.0114 0.0247
Mycobacterium tuberculosis Probable lipase LipE 0.0081 0.0114 0.1276
Leishmania major proteasome beta 2 subunit, putative 0.004 0.0042 0.0816
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0065 0.0086 0.033
Brugia malayi Peptidase family M1 containing protein 0.0302 0.0503 0.1097
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0298 0.0495 1
Onchocerca volvulus 0.0193 0.0311 0.1231
Echinococcus granulosus neuropeptide FF receptor 2 0.0018 0.0003 0.0002
Onchocerca volvulus 0.0302 0.0503 0.1997
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0004 0.0073
Echinococcus multilocularis g protein coupled receptor 0.0018 0.0003 0.0002
Echinococcus granulosus dna polymerase eta 0.0019 0.0004 0.0004
Schistosoma mansoni cpg binding protein 0.0031 0.0026 0.0025
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0018 0.0003 0.0002
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0004 0.0004
Schistosoma mansoni neuropeptide receptor 0.0018 0.0003 0.0002
Loa Loa (eye worm) hypothetical protein 0.0018 0.0003 0.0002
Loa Loa (eye worm) hypothetical protein 0.0018 0.0003 0.0002
Schistosoma mansoni hypothetical protein 0.0018 0.0003 0.0002
Echinococcus multilocularis lysine specific demethylase 6a 0.0094 0.0136 0.0136
Loa Loa (eye worm) hypothetical protein 0.03 0.0499 0.0499
Brugia malayi Pre-SET motif family protein 0.1264 0.22 0.4801
Echinococcus multilocularis SAM and MBT domain containing protein 0.0053 0.0063 0.0063
Brugia malayi Dopamine receptor protein 1 0.0018 0.0003 0.0005
Brugia malayi hypothetical protein 0.0073 0.0098 0.0213
Trichomonas vaginalis glucosylceramidase, putative 0.0282 0.0467 0.1854
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0035 0.0033 0.0362
Schistosoma mansoni jumonji domain containing protein 0.0094 0.0136 0.0136
Giardia lamblia Proteasome subunit beta type 2 0.004 0.0042 0.0359
Loa Loa (eye worm) hypothetical protein 0.0081 0.0114 0.0113
Trypanosoma cruzi aminopeptidase, putative 0.0302 0.0503 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0003 0.0002
Loa Loa (eye worm) hypothetical protein 0.0022 0.0009 0.0008
Schistosoma mansoni hypothetical protein 0.0205 0.0332 0.0331
Schistosoma mansoni lipoxygenase 0.013 0.0199 0.0198
Echinococcus multilocularis histone acetyltransferase MYST2 0.006 0.0076 0.0075
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0018 0.0003 0.0002
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0081 0.0114 0.0113
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0057 0.0072 0.0071
Schistosoma mansoni hypothetical protein 0.0075 0.0103 0.0102
Echinococcus granulosus phd:f box containing protein 0.0094 0.0136 0.0136
Brugia malayi mbt repeat family protein 0.0053 0.0063 0.0137
Toxoplasma gondii PHD-finger domain-containing protein 0.0078 0.0108 0.2131
Loa Loa (eye worm) melatonin receptor type 1A 0.0018 0.0003 0.0002
Brugia malayi neuropeptide F receptor 0.0018 0.0003 0.0005
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0045 0.0166
Loa Loa (eye worm) hypothetical protein 0.009 0.0129 0.0128
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0084 0.0119 0.0118
Brugia malayi hypothetical protein 0.0018 0.0003 0.0005
Brugia malayi G protein-coupled receptor F59B2.13 0.0018 0.0003 0.0005
Plasmodium vivax proteasome subunit beta type-2, putative 0.004 0.0042 0.0816
Brugia malayi neuropeptide F receptor 0.0018 0.0003 0.0005
Mycobacterium ulcerans proteasome PrcB 0.0084 0.0119 0.2291
Schistosoma mansoni loxhd1 0.0022 0.0009 0.0008
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.0302 0.0503 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0003 0.0002
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.5685 1 1
Schistosoma mansoni amine GPCR 0.0018 0.0003 0.0002
Mycobacterium ulcerans aminopeptidase N PepN 0.0302 0.0503 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0018 0.0003 0.0002
Echinococcus granulosus zinc finger protein 0.0025 0.0015 0.0014
Echinococcus granulosus rhodopsin orphan GPCR 0.0018 0.0003 0.0002
Trichomonas vaginalis sucrase-isomaltase, putative 0.0039 0.004 0.0147
Schistosoma mansoni lipoxygenase 0.0091 0.013 0.013
Trichomonas vaginalis glucosylceramidase, putative 0.0185 0.0296 0.1171
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0018 0.0003 0.0002
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0057 0.0072 0.1348
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0018 0.0003 0.0002
Toxoplasma gondii PHD-finger domain-containing protein 0.0238 0.0391 0.7766
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0094 0.0136 0.2697
Trichomonas vaginalis glucosylceramidase, putative 0.0185 0.0296 0.1171
Echinococcus multilocularis rhodopsin orphan GPCR 0.0018 0.0003 0.0002
Plasmodium vivax proteasome subunit beta type-1, putative 0.0065 0.0086 0.1689
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0453 0.077 0.0769
Echinococcus granulosus chromobox protein 1 0.007 0.0093 0.0093
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0018 0.0003 0.0002
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0073 0.0099 0.0099
Loa Loa (eye worm) hypothetical protein 0.0094 0.0136 0.0136
Echinococcus multilocularis serotonin receptor 0.0018 0.0003 0.0002
Echinococcus granulosus 7TM GPCR rhodopsin 0.0018 0.0003 0.0002
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0302 0.0503 0.0502
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.008 0.0111 0.2198
Loa Loa (eye worm) hypothetical protein 0.0077 0.0106 0.0105
Echinococcus granulosus SAM and MBT domain containing protein 0.0053 0.0063 0.0063
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0193 0.0311 0.0311
Echinococcus multilocularis leukotriene A 4 hydrolase 0.5685 1 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.0063 0.0063
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0027 0.0017 0.0326
Loa Loa (eye worm) MBCTL1 0.006 0.0076 0.0075
Echinococcus multilocularis neuropeptide s receptor 0.0527 0.0899 0.0899
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0039 0.0145
Trypanosoma cruzi polo-like protein kinase, putative 0.0095 0.0137 0.2716
Trichomonas vaginalis inositol monophosphatase, putative 0.0041 0.0042 0.0157
Schistosoma mansoni kinase 0.0048 0.0055 0.0054
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0077 0.0106 0.0105
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0077 0.0106 0.2096
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0041 0.0042 0.0405
Schistosoma mansoni voltage-gated potassium channel 0.0041 0.0042 0.0041
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0056 0.0055
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0078 0.0108 0.2131
Loa Loa (eye worm) hypothetical protein 0.0018 0.0003 0.0002
Trichomonas vaginalis esterase, putative 0.0081 0.0114 0.0442
Loa Loa (eye worm) hypothetical protein 0.0018 0.0003 0.0002
Trypanosoma brucei proteasome subunit beta type-2, putative 0.004 0.0042 0.0816
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0018 0.0003 0.0002
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.0084 0.0119 0.1331
Plasmodium vivax JmjC domain containing protein 0.0094 0.0136 0.2697
Plasmodium falciparum transporter, putative 0.0077 0.0106 0.2096

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.1778 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) = 0.7079 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 0.7079 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 44.6684 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)] ChEMBL. No reference
Potency (functional) 63.0957 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 125.8925 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the Phosphatase Activity of Eya2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488939] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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