Detailed information for compound 1243501

Basic information

Technical information
  • TDR Targets ID: 1243501
  • Name: [2-(2,6-dimethylpiperidin-1-yl)-2-oxoethyl] 4 -hydroxybenzoate
  • MW: 291.342 | Formula: C16H21NO4
  • H donors: 1 H acceptors: 3 LogP: 2.66 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC1CCCC(N1C(=O)COC(=O)c1ccc(cc1)O)C
  • InChi: 1S/C16H21NO4/c1-11-4-3-5-12(2)17(11)15(19)10-21-16(20)13-6-8-14(18)9-7-13/h6-9,11-12,18H,3-5,10H2,1-2H3
  • InChiKey: VNOKFAABESUVFR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [2-(2,6-dimethyl-1-piperidyl)-2-oxo-ethyl] 4-hydroxybenzoate
  • 4-hydroxybenzoic acid [2-(2,6-dimethyl-1-piperidinyl)-2-oxoethyl] ester
  • 4-hydroxybenzoic acid [2-(2,6-dimethyl-1-piperidyl)-2-keto-ethyl] ester
  • [2-(2,6-dimethylpiperidin-1-yl)-2-oxo-ethyl] 4-hydroxybenzoate
  • SMR000150127
  • Oprea1_110872
  • MLS000570080
  • Enamine_004630
  • T0512-6926

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens bromodomain adjacent to zinc finger domain, 2B Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum expressed protein Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus granulosus bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum Conserved hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Brugia malayi Bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum ko:K01549 ATP synthase [EC3.6.3.14], putative Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum Cleft lip and palate transmembrane protein 1-like protein, putative Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma mansoni bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus multilocularis bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi PHD-finger family protein 0.003 0.0056 0.004
Trichomonas vaginalis flap endonuclease-1, putative 0.0027 0.0034 0.5
Brugia malayi hypothetical protein 0.0037 0.0098 0.0102
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0027 0.0034 0.1335
Loa Loa (eye worm) hypothetical protein 0.0113 0.0587 0.0849
Brugia malayi tailless protein 0.0053 0.0205 0.0257
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0053 0.0205 0.0191
Schistosoma mansoni nuclear hormone receptor 0.0113 0.0587 0.0574
Loa Loa (eye worm) hypothetical protein 0.0113 0.0587 0.0849
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0098 0.0084
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0098 0.0087
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.1106 0.6924 1
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.006 0.0246 0.0232
Brugia malayi nuclear receptor RXR 0.0053 0.0205 0.0257
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0113 0.0587 0.0596
Echinococcus granulosus dna polymerase eta 0.0046 0.0156 0.0141
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0113 0.0587 0.0574
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0162 0.0148
Loa Loa (eye worm) hypothetical protein 0.0053 0.0205 0.0296
Brugia malayi ecdysteroid receptor 0.0113 0.0587 0.0811
Loa Loa (eye worm) steroid hormone receptor 0.0113 0.0587 0.0849
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.1528 0.9618 1
Brugia malayi hypothetical protein 0.006 0.0246 0.0316
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0072 0.0324 0.031
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0043 0.0141 0.0131
Schistosoma mansoni nuclear hormone receptor 0.0053 0.0205 0.0191
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0277 0.0263
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0162 0.0234
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0277 0.0263
Schistosoma mansoni hypothetical protein 0.0025 0.0023 0.0008
Plasmodium falciparum flap endonuclease 1 0.0027 0.0034 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.0205 0.0296
Loa Loa (eye worm) DR-78 0.0053 0.0205 0.0296
Onchocerca volvulus Bile acid receptor homolog 0.0113 0.0587 1
Giardia lamblia Flap structure-specific endonuclease 0.0027 0.0034 0.5
Loa Loa (eye worm) hypothetical protein 0.0049 0.0178 0.0257
Schistosoma mansoni retinoic acid receptor RXR 0.1587 1 1
Brugia malayi nuclear receptor RXR 0.006 0.0246 0.0316
Echinococcus granulosus tar DNA binding protein 0.0065 0.0277 0.0263
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0065 0.0277 0.04
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0098 0.0084
Loa Loa (eye worm) hypothetical protein 0.006 0.0246 0.0355
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.1106 0.6924 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0113 0.0587 0.0849
Brugia malayi nuclear receptor NHR-88 0.0053 0.0205 0.0257
Loa Loa (eye worm) hypothetical protein 0.0053 0.0205 0.0296
Loa Loa (eye worm) hypothetical protein 0.0053 0.0205 0.0296
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0113 0.0587 0.0849
Brugia malayi nuclear receptor NHR-88 0.0113 0.0587 0.0811
Schistosoma mansoni flap endonuclease-1 0.0024 0.0017 0.0003
Loa Loa (eye worm) hypothetical protein 0.0046 0.016 0.0231
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0053 0.0205 0.0198
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.1106 0.6924 1
Schistosoma mansoni hypothetical protein 0.0173 0.0969 0.0955
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0113 0.0587 0.0574
Brugia malayi Bromodomain containing protein 0.0091 0.0442 0.06
Echinococcus granulosus FTZ F1 alpha 0.0113 0.0587 0.0574
Brugia malayi Nuclear hormone receptor-like 1 0.006 0.0246 0.0316
Loa Loa (eye worm) hypothetical protein 0.0113 0.0587 0.0849
Loa Loa (eye worm) hypothetical protein 0.0053 0.0205 0.0296
Loa Loa (eye worm) hypothetical protein 0.0053 0.0205 0.0296
Entamoeba histolytica hypothetical protein 0.0037 0.0098 0.0094
Trypanosoma cruzi DNA polymerase eta, putative 0.0032 0.0069 0.0059
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.006 0.0246 0.0232
Echinococcus granulosus thyroid hormone receptor alpha 0.0053 0.0205 0.0191
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0032 0.0069 1
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.1106 0.6924 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0162 0.0148
Loa Loa (eye worm) hypothetical protein 0.0026 0.0028 0.0041
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0113 0.0587 0.0596
Brugia malayi hypothetical protein 0.006 0.0246 0.0316
Loa Loa (eye worm) hypothetical protein 0.006 0.0246 0.0355
Echinococcus multilocularis transcription factor Dp 1 0.064 0.395 0.4098
Brugia malayi photoreceptor-specific nuclear receptor 0.0113 0.0587 0.0811
Onchocerca volvulus 0.0113 0.0587 1
Schistosoma mansoni thyroid hormone receptor 0.0113 0.0587 0.0574
Loa Loa (eye worm) hypothetical protein 0.0113 0.0587 0.0849
Loa Loa (eye worm) hypothetical protein 0.0053 0.0205 0.0296
Schistosoma mansoni zinc finger protein 0.0053 0.0205 0.0191
Brugia malayi Nuclear hormone receptor-like 1 0.0113 0.0587 0.0811
Schistosoma mansoni nuclear receptor 0.0053 0.0205 0.0191
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0162 0.0148
Entamoeba histolytica hypothetical protein 0.0037 0.0098 0.0094
Brugia malayi orphan nuclear receptor NR2E1 0.0053 0.0205 0.0257
Brugia malayi RNA recognition motif domain containing protein 0.0065 0.0277 0.0361
Schistosoma mansoni thyroid hormone receptor 0.0113 0.0587 0.0574
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0162 0.0194
Schistosoma mansoni hypothetical protein 0.0037 0.0098 0.0084
Loa Loa (eye worm) hypothetical protein 0.0113 0.0587 0.0849
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0113 0.0587 0.0811
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0162 0.0148
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0053 0.0205 0.0191
Echinococcus multilocularis geminin 0.0173 0.0969 0.0993
Brugia malayi nuclear hormone receptor family member nhr-6 0.0053 0.0205 0.0257
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0053 0.0205 0.0198
Loa Loa (eye worm) hypothetical protein 0.006 0.0246 0.0355
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0113 0.0587 0.0811
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0113 0.0587 0.0811
Loa Loa (eye worm) hypothetical protein 0.006 0.0246 0.0355
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0113 0.0587 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0113 0.0587 0.0596
Brugia malayi nuclear receptor NHR-67 0.0053 0.0205 0.0257
Brugia malayi Bromodomain containing protein 0.0046 0.0159 0.019
Brugia malayi conserved hypotetical protein 0.0053 0.0205 0.0257
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0113 0.0587 0.0574
Brugia malayi RNA binding protein 0.0065 0.0277 0.0361
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.006 0.0246 0.0355
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0113 0.0587 0.0811
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0113 0.0587 0.0811
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0027 0.0038 0.0023
Trypanosoma cruzi DNA polymerase eta, putative 0.0046 0.0156 0.0185
Schistosoma mansoni hypothetical protein 0.0173 0.0969 0.0955
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.1106 0.6924 1
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0027 0.0034 0.0008
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0027 0.0038 0.0024
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0113 0.0587 0.0811
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0053 0.0205 0.0296
Brugia malayi Nuclear hormone receptor E75 0.0053 0.0205 0.0257
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0162 0.0153
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0113 0.0587 0.0849
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0113 0.0587 0.0811
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0113 0.0587 0.0574
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0277 0.0263
Brugia malayi Nuclear hormone receptor-like 1 0.006 0.0246 0.0316
Echinococcus granulosus geminin 0.0173 0.0969 0.0955
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0053 0.0205 0.0191
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0113 0.0587 0.0574
Loa Loa (eye worm) nuclear hormone receptor 0.0053 0.0205 0.0296
Schistosoma mansoni DNA polymerase eta 0.0046 0.0156 0.0141
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0113 0.0587 0.0596
Brugia malayi Nuclear hormone receptor E75 0.0053 0.0205 0.0257
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.1106 0.6924 1
Loa Loa (eye worm) hypothetical protein 0.0085 0.0409 0.0591
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0113 0.0587 0.0574
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0113 0.0587 0.0574
Brugia malayi steroid hormone receptor 0.0113 0.0587 0.0811
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0027 0.0034 0.0008
Brugia malayi hypothetical protein 0.0053 0.0205 0.0257
Schistosoma mansoni nuclear receptor 0.0053 0.0205 0.0191
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0113 0.0587 0.0574
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0113 0.0587 0.0849
Loa Loa (eye worm) TAR-binding protein 0.0065 0.0277 0.04
Schistosoma mansoni coup transcription factor 0.0113 0.0587 0.0574
Loa Loa (eye worm) hypothetical protein 0.0053 0.0205 0.0296
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0027 0.0034 0.0008
Loa Loa (eye worm) flap endonuclease-1 0.0027 0.0034 0.0049
Brugia malayi Flap endonuclease-1 0.0027 0.0034 0.0008
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.1106 0.6924 0.7195
Brugia malayi hypothetical protein 0.0053 0.0205 0.0257
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0113 0.0587 0.0811
Brugia malayi nuclear hormone receptor family member odr-7 0.0053 0.0205 0.0257
Schistosoma mansoni retinoid-x-receptor (RXR) 0.006 0.0246 0.0232
Loa Loa (eye worm) hypothetical protein 0.0053 0.0205 0.0296
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0072 0.0324 0.0322
Loa Loa (eye worm) hypothetical protein 0.006 0.0246 0.0355
Echinococcus multilocularis ecdysone induced protein 78C 0.0113 0.0587 0.0596
Loa Loa (eye worm) RNA binding protein 0.0065 0.0277 0.04
Leishmania major DNA polymerase eta, putative 0.0032 0.0069 0.0059
Echinococcus granulosus fetal alzheimer antigen falz 0.0027 0.0038 0.0023
Echinococcus multilocularis flap endonuclease 1 0.0027 0.0034 0.002
Loa Loa (eye worm) hypothetical protein 0.0046 0.0156 0.0225
Schistosoma mansoni steroid hormone receptor ad4bp 0.0113 0.0587 0.0574
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0053 0.0205 0.0191
Loa Loa (eye worm) hypothetical protein 0.0053 0.0205 0.0296
Onchocerca volvulus Protein ultraspiracle homolog 0.0113 0.0587 1
Schistosoma mansoni bromodomain containing protein 0.0076 0.0352 0.0338
Loa Loa (eye worm) nuclear receptor NHR-67 0.0053 0.0205 0.0296
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0113 0.0587 0.0574
Echinococcus multilocularis tar DNA binding protein 0.0065 0.0277 0.0273
Brugia malayi Steroid receptor seven-up type 2 0.0113 0.0587 0.0811
Schistosoma mansoni nuclear receptor nhr-48 0.0053 0.0205 0.0191
Loa Loa (eye worm) hypothetical protein 0.0113 0.0587 0.0849
Loa Loa (eye worm) hypothetical protein 0.0053 0.0205 0.0296
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0113 0.0587 0.0811
Echinococcus granulosus flap endonuclease 1 0.0027 0.0034 0.0019
Echinococcus multilocularis thyroid hormone receptor alpha 0.0113 0.0587 0.0596
Loa Loa (eye worm) hypothetical protein 0.0113 0.0587 0.0849
Echinococcus multilocularis nuclear receptor nhr 48 0.0053 0.0205 0.0198
Loa Loa (eye worm) hypothetical protein 0.0113 0.0587 0.0849
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0162 0.0153
Brugia malayi TAR-binding protein 0.0065 0.0277 0.0361
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0113 0.0587 0.0849
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0277 0.0263
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0113 0.0587 0.0574
Trypanosoma brucei DNA polymerase eta, putative 0.0046 0.0156 0.0185
Entamoeba histolytica hypothetical protein 0.0037 0.0098 0.0094
Plasmodium vivax flap endonuclease 1, putative 0.0027 0.0034 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.0205 0.0296
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.006 0.0246 0.0241
Echinococcus multilocularis FTZ F1 alpha 0.0113 0.0587 0.0596
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0053 0.0205 0.0198
Echinococcus granulosus transcription factor Dp 1 0.064 0.395 0.3941
Brugia malayi ImpB/MucB/SamB family protein 0.0046 0.0156 0.0185
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.1106 0.6924 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0162 0.0148
Echinococcus granulosus Nuclear hormone receptor HR96 0.0053 0.0205 0.0191
Brugia malayi nuclear hormone receptor 0.0053 0.0205 0.0257
Echinococcus multilocularis dna polymerase eta 0.0046 0.0156 0.0147
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.1106 0.6924 0.6919
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0113 0.0587 0.0811
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0113 0.0587 0.0811
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0053 0.0205 0.0257
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0113 0.0587 0.0811
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0113 0.0587 0.0574
Loa Loa (eye worm) hypothetical protein 0.0052 0.0193 0.0278
Echinococcus granulosus ecdysone induced protein 78C 0.0113 0.0587 0.0574
Loa Loa (eye worm) hypothetical protein 0.0053 0.0205 0.0296
Schistosoma mansoni RAR-like nuclear receptor 0.0113 0.0587 0.0574
Brugia malayi nuclear hormone receptor 0.0113 0.0587 0.0811
Leishmania major DNA polymerase eta, putative 0.0046 0.0156 0.0185
Brugia malayi ecdysone receptor 0.0053 0.0205 0.0257
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0113 0.0587 0.0849
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0113 0.0587 0.0849
Loa Loa (eye worm) PHD-finger family protein 0.0025 0.0023 0.0033
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0053 0.0205 0.0198
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0277 0.0263
Echinococcus granulosus Nuclear hormone receptor HR96 0.0053 0.0205 0.0191
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0113 0.0587 0.0574
Echinococcus granulosus nuclear receptor nhr 48 0.0053 0.0205 0.0191
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0043 0.0141 0.0126
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.1106 0.6924 0.6919
Entamoeba histolytica hypothetical protein 0.0037 0.0098 0.0094
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0113 0.0587 0.0811
Schistosoma mansoni nuclear hormone receptor 0.0053 0.0205 0.0191
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0113 0.0587 0.0596
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0113 0.0587 0.0596

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.7079 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (binding) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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