Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0021 | 1 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 1 | 1 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0011 | 0 | 0.5 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0021 | 1 | 1 |
Schistosoma mansoni | DNA polymerase eta | 0.0021 | 1 | 1 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0021 | 1 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0021 | 1 | 0.5 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0021 | 1 | 1 |
Onchocerca volvulus | 0.0011 | 0 | 0.5 | |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0021 | 1 | 0.5 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0021 | 1 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0021 | 1 | 0.5 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0021 | 1 | 1 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0021 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 1 | 1 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0011 | 0 | 0.5 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0021 | 1 | 0.5 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0021 | 1 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0011 | 0 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 1 | 1 |
Leishmania major | DNA polymerase kappa, putative | 0.0021 | 1 | 0.5 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0021 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 1 | 1 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0021 | 1 | 1 |
Giardia lamblia | DINP protein human, muc B family | 0.0021 | 1 | 0.5 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0021 | 1 | 0.5 |
Leishmania major | DNA polymerase eta, putative | 0.0021 | 1 | 0.5 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0021 | 1 | 0.5 |
Echinococcus granulosus | dna polymerase kappa | 0.0021 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 1 | 1 |
Echinococcus multilocularis | dna polymerase eta | 0.0021 | 1 | 1 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0021 | 1 | 1 |
Echinococcus granulosus | dna polymerase eta | 0.0021 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 1 | 1 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0021 | 1 | 0.5 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0021 | 1 | 0.5 |
Echinococcus multilocularis | dna polymerase kappa | 0.0021 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 1 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0021 | 1 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 1 | 1 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0021 | 1 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0021 | 1 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 1 | 1 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0021 | 1 | 0.5 |
Trypanosoma brucei | unspecified product | 0.0021 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 4.6535 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (binding) | = 22.3872 um | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] | ChEMBL. | No reference |
Potency (functional) | 23.1093 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.