TDR Targets

Basic information

Technical information

TDR Targets ID: 1245097
Name: N-[(4-tert-butylphenyl)methyl]-N-(furan-2-ylm ethyl)-5-(4-methylphenyl)-1,2-oxazole-3-carbo xamide
MW: 428.523 | Formula: C27H28N2O3
H donors: 0 H acceptors: 2 LogP: 5.95 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: Cc1ccc(cc1)c1onc(c1)C(=O)N(Cc1ccco1)Cc1ccc(cc1)C(C)(C)C
InChi: 1S/C27H28N2O3/c1-19-7-11-21(12-8-19)25-16-24(28-32-25)26(30)29(18-23-6-5-15-31-23)17-20-9-13-22(14-10-20)27(2,3)4/h5-16H,17-18H2,1-4H3
InChiKey: NMYZDKKALQLCBE-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-[(4-tert-butylphenyl)methyl]-N-(2-furylmethyl)-5-(4-methylphenyl)isoxazole-3-carboxamide
N-[(4-tert-butylphenyl)methyl]-N-(2-furylmethyl)-5-(4-methylphenyl)-3-isoxazolecarboxamide
N-(4-tert-butylbenzyl)-N-(2-furylmethyl)-5-(4-methylphenyl)isoxazole-3-carboxamide
D337-0505
NCGC00118764-01

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	nuclear factor, erythroid 2-like 2	Starlite/ChEMBL	No references
Homo sapiens	lamin A/C	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma mansoni	intermediate filament proteins	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Brugia malayi	Intermediate filament tail domain containing protein	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus multilocularis	cytoplasmic intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus multilocularis	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma japonicum	Lamin-C, putative	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma japonicum	ko:K07611 lamin, putative	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma mansoni	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus multilocularis	lamin dm0	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma japonicum	expressed protein	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus granulosus	lamin dm0	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus granulosus	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus granulosus	cytoplasmic intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Onchocerca volvulus		Get druggable targets OG5_128723	All targets in OG5_128723
Onchocerca volvulus		Get druggable targets OG5_128723	All targets in OG5_128723
Brugia malayi	intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus multilocularis	musashi	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma japonicum	expressed protein	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma mansoni	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus granulosus	intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma japonicum	Intermediate filament protein ifa-1, putative	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0043	0.021	0.0606
Loa Loa (eye worm)	carboxylesterase	0.0343	0.3456	0.4779
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0367	0.0507
Echinococcus multilocularis	lysine specific demethylase 5A	0.004	0.017	0.0491
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0005	0.5
Brugia malayi	Carboxylesterase family protein	0.0058	0.0367	0.0507
Echinococcus granulosus	intermediate filament protein	0.0033	0.0092	0.0265
Loa Loa (eye worm)	carboxylesterase	0.0058	0.0367	0.0507
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0367	0.0507
Brugia malayi	MH2 domain containing protein	0.0116	0.0998	0.1381
Treponema pallidum	fructose-bisphosphate aldolase	0.0947	1	0.5
Loa Loa (eye worm)	jmjC domain-containing protein	0.0068	0.0474	0.0655
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0033	0.0095	0.0275
Loa Loa (eye worm)	intermediate filament protein	0.0033	0.0092	0.0127
Echinococcus granulosus	acetylcholinesterase	0.0343	0.3456	1
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0005	0.0046
Brugia malayi	intermediate filament protein	0.0033	0.0092	0.0127
Echinococcus granulosus	chromobox protein 1	0.0147	0.1334	0.386
Trichomonas vaginalis	set domain proteins, putative	0.0787	0.8268	0.8268
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.0058	0.0367	0.1062
Echinococcus multilocularis	acetylcholinesterase	0.0343	0.3456	1
Echinococcus granulosus	acetylcholinesterase	0.0343	0.3456	1
Onchocerca volvulus		0.0033	0.0092	0.0111
Brugia malayi	Intermediate filament tail domain containing protein	0.0033	0.0092	0.0127
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.0122	0.1061	1
Echinococcus multilocularis	jumonji domain containing protein	0.0046	0.0234	0.0678
Schistosoma mansoni	jumonji/arid domain-containing protein	0.004	0.017	0.0491
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.0122	0.1061	1
Echinococcus multilocularis	BC026374 protein (S09 family)	0.0058	0.0367	0.1062
Loa Loa (eye worm)	acetylcholinesterase 1	0.0343	0.3456	0.4779
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0367	0.0507
Trichomonas vaginalis	chromobox protein, putative	0.0147	0.1334	0.1334
Brugia malayi	Pre-SET motif family protein	0.0692	0.7232	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0947	1	1
Entamoeba histolytica	hypothetical protein	0.0043	0.021	0.021
Loa Loa (eye worm)	hypothetical protein	0.0065	0.044	0.0608
Echinococcus granulosus	PHD finger protein rhinoceros	0.0033	0.0095	0.0275
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0108	0.0905	0.2618
Echinococcus granulosus	jumonji domain containing protein	0.0046	0.0234	0.0678
Entamoeba histolytica	hypothetical protein	0.0043	0.021	0.021
Toxoplasma gondii	cathepsin CPC1	0.0122	0.1061	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0947	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0058	0.0372	0.0372
Schistosoma mansoni	neuroligin 3 (S09 family)	0.0058	0.0367	0.1062
Echinococcus multilocularis	neuroligin	0.0058	0.0367	0.1062
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0058	0.0367	0.1062
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0947	1	1
Toxoplasma gondii	PHD-finger domain-containing protein	0.0033	0.0095	0.0894
Plasmodium vivax	ataxin-2 like protein, putative	0.0025	0.0005	0.0046
Schistosoma mansoni	intermediate filament proteins	0.0033	0.0092	0.0265
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0367	0.0507
Brugia malayi	Carboxylesterase family protein	0.0343	0.3456	0.4779
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0005	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0095	0.0131
Plasmodium falciparum	phd finger protein, putative	0.0033	0.0095	0.0894
Trichomonas vaginalis	chromobox protein, putative	0.0089	0.0701	0.0701
Entamoeba histolytica	hypothetical protein	0.0043	0.021	0.021
Loa Loa (eye worm)	MH2 domain-containing protein	0.0116	0.0998	0.1381
Brugia malayi	Muscleblind-like protein	0.03	0.2984	0.4126
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0122	0.1061	0.0975
Brugia malayi	chromobox protein homolog 3	0.0083	0.0633	0.0875
Onchocerca volvulus		0.0787	0.8268	1
Onchocerca volvulus		0.0058	0.0367	0.0444
Loa Loa (eye worm)	heterochromatin protein 1	0.0147	0.1334	0.1845
Onchocerca volvulus		0.0058	0.0367	0.0444
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0085	0.0118
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0947	1	1
Brugia malayi	PHD-finger family protein	0.0033	0.0095	0.0131
Onchocerca volvulus		0.0058	0.0367	0.0444
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0947	1	1
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.0463	0.4751	0.5
Echinococcus multilocularis	Chromobox protein 3	0.0024	0.00000004502	0.00000013026
Echinococcus granulosus	histone lysine methyltransferase setb	0.0099	0.0814	0.2354
Schistosoma mansoni	acetylcholinesterase	0.0058	0.0367	0.1062
Brugia malayi	Pre-SET motif family protein	0.0099	0.0814	0.1125
Schistosoma mansoni	gliotactin	0.0058	0.0367	0.1062
Echinococcus granulosus	muscleblind protein	0.03	0.2984	0.8634
Schistosoma mansoni	lamin	0.0033	0.0092	0.0265
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0349	0.0483
Onchocerca volvulus		0.0024	0.00000004502	0.000000054453
Trichomonas vaginalis	chromobox protein, putative	0.0147	0.1334	0.1334
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0099	0.0814	0.2354
Trichomonas vaginalis	spcc417.12 protein, putative	0.0058	0.0367	0.0367
Trichomonas vaginalis	chromobox protein, putative	0.0089	0.0701	0.0701
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0083	0.0633	0.0766
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0058	0.0367	0.1062
Entamoeba histolytica	hypothetical protein	0.0043	0.021	0.021
Echinococcus multilocularis	lamin dm0	0.0033	0.0092	0.0265
Schistosoma mansoni	hypothetical protein	0.0033	0.0095	0.0275
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0005	0.5
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.0463	0.4751	1
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0089	0.0701	0.0848
Loa Loa (eye worm)	transcription factor SMAD2	0.0116	0.0998	0.1381
Echinococcus granulosus	carboxylesterase 5A	0.0343	0.3456	1
Brugia malayi	Carboxylesterase family protein	0.0058	0.0367	0.0507
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0108	0.0905	0.2618
Loa Loa (eye worm)	hypothetical protein	0.0343	0.3456	0.4779
Toxoplasma gondii	PHD-finger domain-containing protein	0.0033	0.0095	0.0894
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0099	0.0814	0.2354
Echinococcus granulosus	neuroligin	0.0058	0.0367	0.1062
Echinococcus multilocularis	acetylcholinesterase	0.0343	0.3456	1
Schistosoma mansoni	chromobox protein	0.0147	0.1334	0.386
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0367	0.0507
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0947	1	1
Brugia malayi	hypothetical protein	0.0043	0.021	0.029
Toxoplasma gondii	preprocathepsin c precursor, putative	0.0122	0.1061	1
Onchocerca volvulus		0.0033	0.0092	0.0111
Echinococcus multilocularis	muscleblind protein 1	0.03	0.2984	0.8634
Echinococcus granulosus	peregrin	0.0033	0.0095	0.0275
Echinococcus granulosus	para nitrobenzyl esterase	0.0058	0.0367	0.1062
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.0463	0.4751	1
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0343	0.3456	1
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0367	0.0507
Schistosoma mansoni	jumonji domain containing protein	0.0086	0.0665	0.1925
Brugia malayi	SET domain containing protein	0.0028	0.004	0.0055
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0122	0.1061	0.3069
Trichomonas vaginalis	conserved hypothetical protein	0.0083	0.0633	0.0633
Brugia malayi	jmjC domain containing protein	0.004	0.017	0.0235
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0033	0.0092	0.0127
Echinococcus multilocularis	chromobox protein 1	0.0147	0.1334	0.386
Schistosoma mansoni	chromobox protein	0.0147	0.1334	0.386
Plasmodium vivax	hypothetical protein, conserved	0.0033	0.0095	0.0894
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.0058	0.0367	0.1062
Brugia malayi	hypothetical protein	0.0025	0.0005	0.0007
Brugia malayi	hypothetical protein	0.0058	0.0367	0.0507
Echinococcus granulosus	chromobox protein 1	0.0147	0.1334	0.386
Onchocerca volvulus		0.0058	0.0367	0.0444
Echinococcus granulosus	lysine specific demethylase 5A	0.004	0.017	0.0491
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0058	0.0367	0.1062
Trichomonas vaginalis	conserved hypothetical protein	0.0058	0.0372	0.0372
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0043	0.021	0.0606
Onchocerca volvulus		0.0065	0.044	0.0532
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0033	0.0095	0.0275
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0947	1	1
Schistosoma mansoni	jumonji/arid domain-containing protein	0.004	0.017	0.0491
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0692	0.7232	1
Echinococcus multilocularis	musashi	0.0033	0.0092	0.0265
Plasmodium falciparum	dipeptidyl aminopeptidase 2	0.0122	0.1061	1
Echinococcus granulosus	BC026374 protein S09 family	0.0058	0.0367	0.1062
Loa Loa (eye worm)	jmjC domain-containing protein	0.004	0.017	0.0235
Leishmania major	hypothetical protein, conserved	0.0025	0.0005	0.5
Loa Loa (eye worm)	hypothetical protein	0.0343	0.3456	0.4779
Brugia malayi	Carboxylesterase family protein	0.0058	0.0367	0.0507
Brugia malayi	jmjC domain containing protein	0.0108	0.0905	0.1251
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0367	0.0507
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0122	0.1061	0.1061
Toxoplasma gondii	LsmAD domain-containing protein	0.0025	0.0005	0.0046
Schistosoma mansoni	hypothetical protein	0.0043	0.021	0.0606
Echinococcus multilocularis	chromobox protein 1	0.0147	0.1334	0.386
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0123	0.1075	0.311
Onchocerca volvulus		0.0058	0.0367	0.0444
Trichomonas vaginalis	conserved hypothetical protein	0.0083	0.0633	0.0633
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0633	0.0875
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0099	0.0814	0.767
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0092	0.0127
Loa Loa (eye worm)	carboxylesterase	0.0058	0.0367	0.0507
Schistosoma mansoni	BC026374 protein (S09 family)	0.0058	0.0367	0.1062
Brugia malayi	Carboxylesterase family protein	0.0343	0.3456	0.4779
Brugia malayi	Carboxylesterase family protein	0.0058	0.0367	0.0507
Onchocerca volvulus		0.0123	0.1075	0.13
Brugia malayi	Heterochromatin protein 1	0.0147	0.1334	0.1845
Echinococcus granulosus	lamin dm0	0.0033	0.0092	0.0265
Loa Loa (eye worm)	hypothetical protein	0.0099	0.0814	0.1125
Echinococcus multilocularis	lamin	0.0033	0.0092	0.0265
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0947	1	1
Loa Loa (eye worm)	hypothetical protein	0.03	0.2984	0.4126
Echinococcus granulosus	lamin	0.0033	0.0092	0.0265
Echinococcus multilocularis	para nitrobenzyl esterase	0.0058	0.0367	0.1062
Schistosoma mansoni	transcription factor LCR-F1	0.0043	0.021	0.0606
Plasmodium falciparum	dipeptidyl aminopeptidase 1	0.0122	0.1061	1
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0099	0.0814	0.2354
Echinococcus multilocularis	peregrin	0.0033	0.0095	0.0275
Trypanosoma brucei	PAB1-binding protein , putative	0.0025	0.0005	0.5
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0099	0.0814	0.2354
Loa Loa (eye worm)	hypothetical protein	0.03	0.2984	0.4126
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.0058	0.0367	0.0367
Echinococcus multilocularis	carboxylesterase 5A	0.0343	0.3456	1
Brugia malayi	Bromodomain containing protein	0.0033	0.0095	0.0131
Echinococcus multilocularis	muscleblind protein	0.03	0.2984	0.8634
Plasmodium vivax	SET domain protein, putative	0.0099	0.0814	0.767
Schistosoma mansoni	lamin	0.0033	0.0092	0.0265
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0096	0.0774	0.224
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0099	0.0814	0.2354
Giardia lamblia	Fructose-bisphosphate aldolase	0.0947	1	1
Loa Loa (eye worm)	PHD-finger family protein	0.0033	0.0095	0.0131
Onchocerca volvulus	Alhambra homolog	0.0033	0.0095	0.0115
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0947	1	1
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0005	0.0046
Echinococcus granulosus	Chromobox protein 3	0.0024	0.00000004502	0.00000013026

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	= 5.0119 um	PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	9.2 uM	PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648]	ChEMBL.	No reference
Potency (functional)	22.3872 uM	PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (binding)	= 31.6228 um	PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)]	ChEMBL.	No reference
Potency (functional)	79.4328 uM	PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962]	ChEMBL.	No reference
Potency (functional)	100 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1326626

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1245097