Detailed information for compound 1245468

Basic information

Technical information
  • TDR Targets ID: 1245468
  • Name: [2-[(1,1-dioxothiolan-3-yl)amino]-2-oxoethyl] 3-methylthiophene-2-carboxylate
  • MW: 317.381 | Formula: C12H15NO5S2
  • H donors: 1 H acceptors: 4 LogP: 1.07 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(NC1CCS(=O)(=O)C1)COC(=O)c1sccc1C
  • InChi: 1S/C12H15NO5S2/c1-8-2-4-19-11(8)12(15)18-6-10(14)13-9-3-5-20(16,17)7-9/h2,4,9H,3,5-7H2,1H3,(H,13,14)
  • InChiKey: CIZGMBWKKXBBGN-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • [2-[(1,1-dioxothiolan-3-yl)amino]-2-oxo-ethyl] 3-methylthiophene-2-carboxylate
  • 3-methyl-2-thiophenecarboxylic acid [2-[(1,1-dioxo-3-thiolanyl)amino]-2-oxoethyl] ester
  • 3-methylthiophene-2-carboxylic acid [2-[(1,1-diketothiolan-3-yl)amino]-2-keto-ethyl] ester
  • T5238023
  • MLS000771740
  • SMR000376393

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis grf14, putative 0.0011 0.0057 0.0057
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0758 0.0942
Loa Loa (eye worm) nuclear receptor nhr-7B 0.001 0.004 0.0024
Leishmania major heat shock protein 83-1 0.0078 0.1123 0.1898
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0019 0.0181 0.0221
Giardia lamblia Heat shock protein HSP 90-alpha 0.0078 0.1123 0.1072
Trichomonas vaginalis 14-3-3 protein sigma, gamma, zeta, beta/alpha, putative 0.0011 0.0057 0.0057
Plasmodium vivax SET domain protein, putative 0.0037 0.046 0.3963
Brugia malayi Endoplasmin precursor 0.0078 0.1123 0.2818
Schistosoma mansoni nuclear hormone receptor 0.001 0.004 0.002
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.069 0.1168
Echinococcus multilocularis inhibitor of apoptosis protein 0.0065 0.0914 0.1145
Loa Loa (eye worm) steroid hormone receptor 0.0022 0.0225 0.0504
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.0016 0.0129 0.0174
Echinococcus granulosus endoplasmin 0.0062 0.0869 0.1086
Onchocerca volvulus 0.0065 0.0914 0.1989
Schistosoma mansoni hypothetical protein 0.0011 0.0057 0.0041
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0022 0.0225 0.0421
Trichomonas vaginalis 14-3-3 protein sigma, gamma, zeta, beta/alpha, putative 0.0011 0.0057 0.0057
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0019 0.0181 0.039
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.006 0.0045
Leishmania major heat shock protein 83-1 0.0078 0.1123 0.1898
Trypanosoma cruzi heat shock protein 85, putative 0.0062 0.0869 0.1485
Trichomonas vaginalis 14-3-3 protein sigma, gamma, zeta, beta/alpha, putative 0.0011 0.0057 0.0057
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0225 0.0481
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0225 0.025
Schistosoma mansoni mixed-lineage leukemia protein mll 0.001 0.0033 0.001
Loa Loa (eye worm) hypothetical protein 0.001 0.004 0.0024
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0016 0.0129 0.0203
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0633 1 1
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.0016 0.0129 0.0125
Schistosoma mansoni hypothetical protein 0.0065 0.0914 0.1154
Leishmania major DNA topoisomerase ii 0.0016 0.0129 0.0129
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0044 0.0584 0.6151
Loa Loa (eye worm) inositol-1 0.0044 0.0584 0.1436
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0181 0.1421
Brugia malayi Hsp90 protein 0.0032 0.0386 0.0901
Trichomonas vaginalis inositol monophosphatase, putative 0.0044 0.0584 0.0584
Brugia malayi 14-3-3 protein 0.0011 0.0057 0.0043
Trichomonas vaginalis 14-3-3 protein sigma, gamma, zeta, beta/alpha, putative 0.0011 0.0057 0.0057
Plasmodium falciparum DNA topoisomerase 2 0.0016 0.0129 0.0679
Brugia malayi CXXC zinc finger family protein 0.0034 0.0426 0.1005
Schistosoma mansoni DNA helicase recq1 0.0019 0.0181 0.0203
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0022 0.0225 0.0481
Trichomonas vaginalis 14-3-3 protein sigma, gamma, zeta, beta/alpha, putative 0.0011 0.0057 0.0057
Loa Loa (eye worm) hypothetical protein 0.0022 0.0225 0.0504
Leishmania major heat shock protein 83-1 0.0078 0.1123 0.1898
Loa Loa (eye worm) hypothetical protein 0.0065 0.0914 0.2293
Brugia malayi hypothetical protein 0.0012 0.006 0.0052
Brugia malayi hypothetical protein 0.0012 0.006 0.0052
Trypanosoma brucei heat shock protein, putative 0.0078 0.1123 0.1898
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0022 0.0225 0.0504
Leishmania major heat shock protein 83-1 0.0078 0.1123 0.1898
Plasmodium vivax heat shock protein 86, putative 0.0078 0.1123 1
Giardia lamblia Fructose-bisphosphate aldolase 0.0633 1 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0022 0.0225 0.025
Echinococcus multilocularis 14-3-3 protein 0.0011 0.0057 0.0031
Brugia malayi Bloom's syndrome protein homolog 0.0019 0.0181 0.0367
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0051 0.069 0.1128
Trichomonas vaginalis 14-3-3 protein sigma, gamma, zeta, beta/alpha, putative 0.0011 0.0057 0.0057
Plasmodium vivax heat shock protein 90, putative 0.0032 0.0386 0.3291
Echinococcus multilocularis dnaJ subfamily B 0.0491 0.7728 1
Echinococcus granulosus bloom syndrome protein 0.0019 0.0181 0.0192
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0062 0.0869 0.1086
Onchocerca volvulus 0.0285 0.4435 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.004 0.0009
Loa Loa (eye worm) hypothetical protein 0.001 0.004 0.0024
Giardia lamblia Heat shock protein HSP 90-alpha 0.0062 0.0869 0.0817
Toxoplasma gondii 14-3-3 superfamily protein 0.0011 0.0057 0.0289
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0016 0.0129 0.0129
Brugia malayi kinase, mitochondrial precursor 0.0016 0.0129 0.0232
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.004 0.0009
Trypanosoma cruzi heat shock protein 85, putative 0.0078 0.1123 0.1935
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0016 0.0129 0.0232
Leishmania major heat shock protein 83-1 0.0078 0.1123 0.1898
Loa Loa (eye worm) hypothetical protein 0.0022 0.0225 0.0504
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0016 0.0129 0.0125
Brugia malayi Pre-SET motif family protein 0.0251 0.3883 1
Plasmodium vivax 14-3-3 protein, putative 0.0011 0.0057 0.0289
Entamoeba histolytica 14-3-3 protein 3 0.0011 0.0057 0.0032
Giardia lamblia Pms1-like protein 0.0016 0.0129 0.0073
Echinococcus multilocularis FTZ F1 alpha 0.0022 0.0225 0.025
Trichomonas vaginalis two component sensor and regulator histidine kinase bacteria, putative 0.0016 0.0129 0.0129
Leishmania major developmentally regulated phosphoprotein-like protein 0.0016 0.0129 0.0129
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0022 0.0225 0.025
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0022 0.0225 0.0481
Schistosoma mansoni inositol monophosphatase 0.0044 0.0584 0.0726
Trichomonas vaginalis DNA helicase recq1, putative 0.0019 0.0181 0.0181
Trypanosoma cruzi 14-3-3 protein 1, putative 0.0011 0.0057 0.0046
Echinococcus granulosus 14-3-3 protein gamma 0.0011 0.0057 0.0031
Trichomonas vaginalis 14-3-3 protein sigma, gamma, zeta, beta/alpha, putative 0.0011 0.0057 0.0057
Trichomonas vaginalis heat shock protein, putative 0.0078 0.1123 0.1123
Trypanosoma cruzi 14-3-3 protein 1, putative 0.0011 0.0057 0.0046
Trypanosoma cruzi heat shock protein 85, putative 0.0078 0.1123 0.1935
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.00000000012621 0.00000000012621
Trypanosoma cruzi heat shock protein 90, putative 0.0046 0.0612 0.1029
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0022 0.0225 0.025
Trypanosoma cruzi heat shock protein, putative 0.0032 0.0386 0.063
Trichomonas vaginalis DNA topoisomerase II, putative 0.0016 0.0129 0.0129
Trypanosoma cruzi Heat shock protein 83, putative 0.0078 0.1123 0.1935
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0016 0.0129 0.0129
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0225 0.026
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0363 0.5673 1
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0012 0.006 0.0035
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0057 0.0057
Trichomonas vaginalis 14-3-3 protein sigma, gamma, zeta, beta/alpha, putative 0.0011 0.0057 0.0057
Loa Loa (eye worm) hypothetical protein 0.001 0.004 0.0024
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.006 0.0052
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0031 0.0054
Echinococcus multilocularis 0.0011 0.0057 0.0031
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0012 0.006 0.0045
Loa Loa (eye worm) nuclear hormone receptor 0.001 0.004 0.0024
Toxoplasma gondii heat shock protein 90, putative 0.0078 0.1123 1
Onchocerca volvulus Protein ultraspiracle homolog 0.0022 0.0225 0.0421
Loa Loa (eye worm) hypothetical protein 0.0022 0.0225 0.0504
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0633 1 1
Echinococcus multilocularis heat shock protein 0.0078 0.1123 0.1417
Loa Loa (eye worm) TOPoisomerase family member 0.0016 0.0129 0.0255
Trichomonas vaginalis 14-3-3 protein, putative 0.0011 0.0057 0.0057
Schistosoma mansoni hypothetical protein 0.0011 0.0057 0.0041
Treponema pallidum heat shock protein 90 0.0062 0.0869 0.084
Loa Loa (eye worm) hypothetical protein 0.0022 0.0225 0.0504
Echinococcus granulosus heat shock protein 90 0.0078 0.1123 0.1417
Echinococcus granulosus heat shock protein 90 0.0062 0.0869 0.1086
Schistosoma mansoni pyruvate dehydrogenase 0.0016 0.0129 0.0135
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.006 0.0052
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0022 0.0225 0.025
Loa Loa (eye worm) heat shock protein 90 0.0078 0.1123 0.2835
Mycobacterium ulcerans heat shock protein 90 0.0062 0.0869 0.1577
Toxoplasma gondii DNA topoisomerase 2, putative 0.0016 0.0129 0.0948
Plasmodium falciparum DNA topoisomerase VI, b subunit, putative 0.0016 0.0129 0.0679
Echinococcus granulosus ecdysone induced protein 78C 0.0022 0.0225 0.025
Trypanosoma brucei heat shock protein, putative 0.0078 0.1123 0.1898
Loa Loa (eye worm) CXXC zinc finger family protein 0.0034 0.0426 0.1026
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0044 0.0584 0.098
Loa Loa (eye worm) hypothetical protein 0.001 0.004 0.0024
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0016 0.0129 0.0232
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0022 0.0225 0.025
Plasmodium vivax heat shock protein, putative 0.0032 0.0386 0.3291
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0044 0.0584 0.0584
Trichomonas vaginalis heat shock protein, putative 0.0062 0.0869 0.0869
Trypanosoma cruzi Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0016 0.0129 0.0174
Entamoeba histolytica 14-3-3 protein 1 0.0011 0.0057 0.0032
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0022 0.0225 0.0504
Loa Loa (eye worm) hypothetical protein 0.0012 0.006 0.0075
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0225 0.025
Leishmania major heat shock protein 83-1 0.0078 0.1123 0.1898
Schistosoma mansoni hypothetical protein 0.0011 0.0057 0.0041
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0758 0.0952
Loa Loa (eye worm) hypothetical protein 0.0011 0.0057 0.0067
Schistosoma mansoni steroid hormone receptor ad4bp 0.0022 0.0225 0.026
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0051 0.069 0.1168
Echinococcus granulosus nuclear receptor nhr 48 0.001 0.004 0.0009
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0022 0.0225 0.025
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0065 0.0914 0.2274
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0019 0.0181 0.0192
Trichomonas vaginalis sensor histidine kinase, putative 0.0016 0.0129 0.0129
Trypanosoma brucei heat shock protein, putative 0.0078 0.1123 0.1898
Leishmania major heat shock protein 83-1 0.0078 0.1123 0.1898
Chlamydia trachomatis DNA gyrase subunit B 0.0016 0.0129 0.5
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0016 0.0129 0.0948
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.001 0.004 0.002
Schistosoma mansoni DNA topoisomerase II 0.0016 0.0129 0.0135
Plasmodium vivax DNA topoisomerase II, putative 0.0016 0.0129 0.0948
Giardia lamblia Sgs1 DNA helicase, putative 0.0019 0.0181 0.0125
Echinococcus granulosus histone lysine methyltransferase setb 0.0037 0.046 0.0555
Trichomonas vaginalis DNA helicase recq, putative 0.0019 0.0181 0.0181
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0363 0.5673 1
Echinococcus granulosus 14-3-3 protein zeta:delta 0.0011 0.0057 0.0031
Trypanosoma brucei heat shock protein, putative 0.0078 0.1123 0.1898
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0022 0.0225 0.026
Trypanosoma brucei Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0016 0.0129 0.0129
Echinococcus granulosus inositol monophosphatase 1 0.0044 0.0584 0.0716
Leishmania major heat shock protein 83-1 0.0078 0.1123 0.1898
Brugia malayi heat shock protein 90 0.0078 0.1123 0.2818
Trichomonas vaginalis 14-3-3 protein sigma, gamma, zeta, beta/alpha, putative 0.0011 0.0057 0.0057
Loa Loa (eye worm) hypothetical protein 0.0012 0.006 0.0075
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0065 0.0914 0.2274
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.0016 0.0129 0.0098
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0016 0.0129 0.0948
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0022 0.0225 0.0504
Trichomonas vaginalis 14-3-3 protein sigma, gamma, zeta, beta/alpha, putative 0.0011 0.0057 0.0057
Schistosoma mansoni hypothetical protein 0.0011 0.0057 0.0041
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0044 0.0584 0.098
Toxoplasma gondii heat shock protein 75, putative 0.0032 0.0386 0.3291
Schistosoma mansoni heat shock protein 0.0078 0.1123 0.1425
Echinococcus granulosus dnaJ subfamily B 0.0491 0.7728 1
Leishmania major mitochondrial DNA polymerase beta 0.0363 0.5673 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0633 1 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0022 0.0225 0.025
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.001 0.004 0.0009
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.00000000012621 0.00000000012621
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0044 0.0584 0.0939
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0758 0.0942
Loa Loa (eye worm) endoplasmin 0.0078 0.1123 0.2835
Schistosoma mansoni coup transcription factor 0.0022 0.0225 0.026
Loa Loa (eye worm) hypothetical protein 0.001 0.004 0.0024
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0037 0.046 0.3963
Brugia malayi steroid hormone receptor 0.0022 0.0225 0.0481
Brugia malayi Steroid receptor seven-up type 2 0.0022 0.0225 0.0481
Plasmodium vivax DNA gyrase subunit B, putative 0.0016 0.0129 0.0948
Brugia malayi nuclear receptor NHR-88 0.0022 0.0225 0.0481
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0172 0.2619 0.4562
Loa Loa (eye worm) hypothetical protein 0.0012 0.006 0.0075
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0032 0.0386 0.0459
Loa Loa (eye worm) heat shock protein 75 0.0032 0.0386 0.0923
Leishmania major hypothetical protein, conserved 0.0016 0.0129 0.0129
Echinococcus multilocularis baculoviral IAP repeat containing protein 0.0065 0.0914 0.1145
Brugia malayi photoreceptor-specific nuclear receptor 0.0022 0.0225 0.0481
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0016 0.0129 0.0129
Trichomonas vaginalis 14-3-3 protein sigma, gamma, zeta, beta/alpha, putative 0.0011 0.0057 0.0057
Plasmodium falciparum heat shock protein 90, putative 0.0032 0.0386 0.3091
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.3883 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0225 0.0481
Trichomonas vaginalis mismatch repair protein Mlh1C (mutL homolog) 0.0016 0.0129 0.0129
Echinococcus multilocularis 14-3-3 protein 0.0011 0.0057 0.0031
Leishmania major heat shock protein 83-1 0.0078 0.1123 0.1898
Schistosoma mansoni endoplasmin 0.0078 0.1123 0.1425
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0022 0.0225 0.0504
Loa Loa (eye worm) hypothetical protein 0.0016 0.0129 0.0255
Echinococcus multilocularis inositol monophosphatase 1 0.0044 0.0584 0.0716
Trichomonas vaginalis sensory transduction histidine kinase, putative 0.0016 0.0129 0.0129
Echinococcus granulosus inhibitor of apoptosis protein 0.0065 0.0914 0.1145
Plasmodium falciparum DNA gyrase subunit B 0.0016 0.0129 0.0679
Loa Loa (eye worm) hypothetical protein 0.0022 0.0225 0.0504
Plasmodium vivax 14-3-3 protein, putative 0.0011 0.0057 0.0289
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0151 0.2292 0.2936
Schistosoma mansoni endoplasmin 0.0078 0.1123 0.1425
Trichomonas vaginalis heat shock protein, putative 0.0048 0.0641 0.0641
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0022 0.0225 0.026
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0012 0.006 0.0035
Brugia malayi ecdysteroid receptor 0.0022 0.0225 0.0481
Toxoplasma gondii hypothetical protein 0.0011 0.0057 0.0289
Plasmodium falciparum heat shock protein 90, putative 0.0032 0.0386 0.3091
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.00000000012621 0.00000000012621
Trichomonas vaginalis 14-3-3 protein sigma, gamma, zeta, beta/alpha, putative 0.0011 0.0057 0.0057
Brugia malayi Inositol-1 0.0044 0.0584 0.1416
Entamoeba histolytica heat shock protein 90, putative 0.0078 0.1123 0.1101
Echinococcus granulosus baculoviral IAP repeat containing protein 0.0065 0.0914 0.1145
Leishmania major mitochondrial DNA topoisomerase II 0.0016 0.0129 0.0129
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0044 0.0584 0.0584
Trichomonas vaginalis 14-3-3 protein sigma, gamma, zeta, beta/alpha, putative 0.0011 0.0057 0.0057
Leishmania major heat shock protein 83-1 0.0078 0.1123 0.1898
Schistosoma mansoni cpg binding protein 0.0036 0.0458 0.0562
Plasmodium vivax endoplasmin, putative 0.0078 0.1123 1
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0016 0.0129 0.0174
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0037 0.046 0.0565
Loa Loa (eye worm) hypothetical protein 0.001 0.004 0.0024
Loa Loa (eye worm) hypothetical protein 0.001 0.004 0.0024
Loa Loa (eye worm) RecQ helicase 0.0019 0.0181 0.039
Loa Loa (eye worm) hypothetical protein 0.0037 0.046 0.1114
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.001 0.004 0.0009
Loa Loa (eye worm) hypothetical protein 0.0011 0.0057 0.0067
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0022 0.0225 0.0481
Schistosoma mansoni hypothetical protein 0.0011 0.0057 0.0041
Echinococcus multilocularis bloom syndrome protein 0.0019 0.0181 0.0192
Plasmodium falciparum heat shock protein 90 0.0078 0.1123 1
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0016 0.0129 0.0174
Loa Loa (eye worm) hypothetical protein 0.001 0.004 0.0024
Trypanosoma brucei DNA topoisomerase ii 0.0016 0.0129 0.0129
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0012 0.0067 0.0044
Echinococcus multilocularis thyroid hormone receptor alpha 0.0173 0.2642 0.3391
Schistosoma mansoni hypothetical protein 0.0011 0.0057 0.0041
Echinococcus multilocularis endoplasmin 0.0062 0.0869 0.1086
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0022 0.0225 0.0481
Brugia malayi 14-3-3-like protein 2 0.0011 0.0057 0.0043
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0225 0.0481
Schistosoma mansoni inhibitor of apoptosis protein 0.0065 0.0914 0.1154
Trypanosoma brucei heat shock protein, putative 0.0078 0.1123 0.1898
Entamoeba histolytica heat shock protein 90, putative 0.0078 0.1123 0.1101
Loa Loa (eye worm) hypothetical protein 0.0012 0.006 0.0075
Trypanosoma brucei Heat shock protein 83, putative 0.0078 0.1123 0.1898
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0225 0.0481
Treponema pallidum fructose-bisphosphate aldolase 0.0633 1 1
Echinococcus multilocularis ecdysone induced protein 78C 0.0022 0.0225 0.025
Trypanosoma brucei heat shock protein 90, putative 0.0078 0.1123 0.1898
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0016 0.0129 0.0948
Trichomonas vaginalis 14-3-3 protein sigma, gamma, zeta, beta/alpha, putative 0.0011 0.0057 0.0057
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0022 0.0225 0.0504
Trichomonas vaginalis 14-3-3 protein sigma, gamma, zeta, beta/alpha, putative 0.0011 0.0057 0.0057
Toxoplasma gondii 14-3-3 protein 0.0011 0.0057 0.0289
Schistosoma mansoni hypothetical protein 0.0011 0.0057 0.0041
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0044 0.0584 0.097
Trypanosoma cruzi heat shock protein 90, putative 0.0078 0.1123 0.1935
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0022 0.0225 0.0481
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0016 0.0129 0.0125
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0032 0.0386 0.0459
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0633 1 1
Leishmania major heat shock protein 83-1 0.0078 0.1123 0.1898
Echinococcus granulosus heat shock protein 0.0078 0.1123 0.1417
Echinococcus multilocularis 14-3-3 protein zeta:delta 0.0011 0.0057 0.0031
Onchocerca volvulus 0.0022 0.0225 0.0421
Brugia malayi 14-3-3-like protein 2 0.0011 0.0057 0.0043
Trichomonas vaginalis receptor histidine kinase, putative 0.0016 0.0129 0.0129
Mycobacterium ulcerans hypothetical protein 0.0191 0.2929 0.5968
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0019 0.0181 0.0266
Treponema pallidum chemotaxis histidine kinase (cheA) 0.0016 0.0129 0.0098
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.046 0.0565
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0062 0.0869 0.1577
Toxoplasma gondii heat shock protein HSP90 0.0078 0.1123 1
Plasmodium vivax hypothetical protein, conserved 0.0016 0.0129 0.0948
Schistosoma mansoni nuclear hormone receptor 0.0022 0.0225 0.026
Schistosoma mansoni nuclear hormone receptor 0.001 0.004 0.002
Echinococcus granulosus FTZ F1 alpha 0.0022 0.0225 0.025
Echinococcus multilocularis heat shock protein 90 0.0078 0.1123 0.1417
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0225 0.025
Loa Loa (eye worm) histone methyltransferase 0.0012 0.0067 0.0093
Schistosoma mansoni cpg binding protein 0.0034 0.0426 0.0521
Loa Loa (eye worm) hypothetical protein 0.001 0.004 0.0024
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0363 0.5673 1
Onchocerca volvulus Deterin homolog 0.0065 0.0914 0.1989
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0051 0.069 0.1168
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0044 0.0584 0.056
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0012 0.006 0.0075
Schistosoma mansoni nuclear receptor nhr-48 0.001 0.004 0.002
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0012 0.0067 0.0044
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0225 0.0481
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.00000000032766
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0181 0.0367
Trypanosoma cruzi 14-3-3 protein 2, putative 0.0011 0.0057 0.0046
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.1066 0.1351
Onchocerca volvulus Bile acid receptor homolog 0.0022 0.0225 0.0421
Brugia malayi Pre-SET motif family protein 0.0037 0.046 0.1093
Schistosoma mansoni hypothetical protein 0.0011 0.0057 0.0041
Loa Loa (eye worm) nuclear receptor NHR-67 0.001 0.004 0.0024
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0633 1 1
Trichomonas vaginalis 14-3-3 protein sigma, gamma, zeta, beta/alpha, putative 0.0011 0.0057 0.0057
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0309 0.4821 1
Schistosoma mansoni hypothetical protein 0.0011 0.0057 0.0041
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0181 0.1421
Echinococcus multilocularis nuclear receptor nhr 48 0.001 0.004 0.0009
Trypanosoma brucei heat shock protein 90, putative 0.0078 0.1123 0.1898
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.00000000012621 0.00000000012621
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0044 0.0584 0.0939
Trypanosoma brucei heat shock protein, putative 0.0078 0.1123 0.1898
Schistosoma mansoni DNA helicase recq5 0.0019 0.0181 0.0203
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.046 0.0565
Loa Loa (eye worm) hypothetical protein 0.0016 0.0129 0.0255
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0022 0.0225 0.025
Trichomonas vaginalis endoplasmin, putative 0.0048 0.0641 0.0641
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.00000000012621 0.00000000012621
Schistosoma mansoni RAR-like nuclear receptor 0.0022 0.0225 0.026
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.001 0.0031 0.0054
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0019 0.0181 0.0192
Schistosoma mansoni heat shock protein 0.0032 0.0386 0.0469
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0062 0.0869 1
Chlamydia trachomatis DNA gyrase subunit B 0.0016 0.0129 0.5
Echinococcus granulosus Nuclear hormone receptor HR96 0.001 0.004 0.0009
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0019 0.0181 0.0192
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0758 0.0952
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0309 0.4821 1
Trypanosoma cruzi DNA topoisomerase II, putative 0.0016 0.0129 0.0174
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0022 0.0225 0.0481
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0633 1 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0225 0.025
Trichomonas vaginalis heat shock protein, putative 0.0062 0.0869 0.0869
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0022 0.0225 0.0481
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0225 0.0481
Trypanosoma brucei developmentally regulated phosphoprotein 0.0016 0.0129 0.0129
Brugia malayi F/Y-rich N-terminus family protein 0.0012 0.0065 0.0063
Echinococcus multilocularis 14-3-3 protein beta:alpha 0.0011 0.0057 0.0031
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0019 0.0181 0.1165
Echinococcus granulosus 14-3-3 protein beta:alpha 0.0011 0.0057 0.0031
Loa Loa (eye worm) hypothetical protein 0.001 0.004 0.0024
Schistosoma mansoni nuclear receptor 0.001 0.004 0.002
Trichomonas vaginalis 14-3-3 protein sigma, gamma, zeta, beta/alpha, putative 0.0011 0.0057 0.0057
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0032 0.0386 0.0788
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0309 0.4821 1
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0062 0.0869 0.1577
Trichomonas vaginalis heat shock protein, putative 0.0062 0.0869 0.0869
Loa Loa (eye worm) hypothetical protein 0.001 0.004 0.0024
Trichomonas vaginalis 14-3-3 protein sigma, gamma, zeta, beta/alpha, putative 0.0011 0.0057 0.0057
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0758 0.0942
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0172 0.2619 0.4587
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0016 0.0129 0.0203
Entamoeba histolytica recQ family helicase, putative 0.0019 0.0181 0.0156
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0022 0.0225 0.0504
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0225 0.0481
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.001 0.004 0.002
Echinococcus multilocularis Nuclear hormone receptor HR96 0.001 0.004 0.0009
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0016 0.0129 0.0203
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0037 0.046 0.0555
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0062 0.0869 0.1446
Loa Loa (eye worm) hypothetical protein 0.001 0.004 0.0024
Brugia malayi nuclear hormone receptor 0.0022 0.0225 0.0481
Leishmania major heat shock protein 83-1 0.0078 0.1123 0.1898
Brugia malayi nuclear receptor RXR 0.0012 0.006 0.0052
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0019 0.0181 0.0192
Leishmania major heat shock protein 83-1 0.0078 0.1123 0.1898
Echinococcus granulosus 14-3-3 protein 0.0011 0.0057 0.0031
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0758 0.1887
Onchocerca volvulus 0.0034 0.0426 0.0879
Schistosoma mansoni nuclear receptor 0.001 0.004 0.002
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0022 0.0225 0.026
Mycobacterium tuberculosis Conserved hypothetical protein 0.0191 0.2929 0.5968
Echinococcus granulosus 14-3-3 protein epsilon 0.0011 0.0057 0.0031
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0032 0.0386 0.0362
Schistosoma mansoni blooms syndrome DNA helicase 0.001 0.0031 0.0008
Echinococcus multilocularis Nuclear hormone receptor HR96 0.001 0.004 0.0009
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0016 0.0129 0.5
Schistosoma mansoni retinoic acid receptor RXR 0.0022 0.0225 0.026
Loa Loa (eye worm) hypothetical protein 0.0022 0.0225 0.0504
Schistosoma mansoni cpg binding protein 0.0036 0.0458 0.0562
Entamoeba histolytica recQ family DNA helicase 0.001 0.0031 0.0006
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0151 0.2292 0.2936
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0062 0.0869 0.1485
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0427 0.0512
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0019 0.0181 0.1165
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.046 0.0565
Echinococcus multilocularis cpg binding protein 0.0036 0.0458 0.0552
Echinococcus multilocularis 14-3-3 protein epsilon 0.0011 0.0057 0.0031
Trichomonas vaginalis heat shock protein, putative 0.0032 0.0386 0.0386
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.00000000012621 0.00000000012621
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0037 0.046 0.0555
Loa Loa (eye worm) hypothetical protein 0.0012 0.006 0.0075
Echinococcus granulosus cpg binding protein 0.0036 0.0458 0.0552
Leishmania major heat shock protein 83-1 0.0078 0.1123 0.1898
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.00000000012621 0.00000000012621
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0633 1 1
Onchocerca volvulus 0.0037 0.046 0.0956
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0758 0.0942
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0016 0.0129 0.0125
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.00000000012621 0.00000000012621
Entamoeba histolytica 14-3-3 protein 2 0.0011 0.0057 0.0032
Echinococcus granulosus Nuclear hormone receptor HR96 0.001 0.004 0.0009
Loa Loa (eye worm) hypothetical protein 0.001 0.004 0.0024
Loa Loa (eye worm) hypothetical protein 0.0065 0.0914 0.2293
Brugia malayi Probable DNA topoisomerase II 0.0016 0.0129 0.0232
Trypanosoma brucei heat shock protein, putative 0.0078 0.1123 0.1898
Trichomonas vaginalis receptor histidine kinase, putative 0.0016 0.0129 0.0129
Loa Loa (eye worm) hypothetical protein 0.0019 0.0181 0.039
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0172 0.2619 0.4562
Toxoplasma gondii hypothetical protein 0.0059 0.081 0.7151
Schistosoma mansoni hypothetical protein 0.0151 0.2292 0.2943
Trichomonas vaginalis 14-3-3 protein sigma, gamma, zeta, beta/alpha, putative 0.0011 0.0057 0.0057
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0022 0.0225 0.026
Loa Loa (eye worm) hypothetical protein 0.0022 0.0225 0.0504
Trypanosoma cruzi heat shock protein 90, putative 0.0062 0.0869 0.1485
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0016 0.0129 0.0129
Schistosoma mansoni thyroid hormone receptor 0.0173 0.2642 0.3398
Entamoeba histolytica DNA topoisomerase II, putative 0.0016 0.0129 0.0104
Giardia lamblia Grp94/Hsp90 0.0062 0.0869 0.0817
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0758 0.1868
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0758 0.0952
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0181 0.0367
Leishmania major heat shock protein 83-1 0.0078 0.1123 0.1898
Trypanosoma cruzi heat shock protein 85, putative 0.0078 0.1123 0.1935
Trypanosoma brucei heat shock protein, putative 0.0078 0.1123 0.1898
Trichomonas vaginalis DNA helicase recq, putative 0.0019 0.0181 0.0181
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0057 0.0057
Schistosoma mansoni zinc finger protein 0.001 0.004 0.002
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0019 0.0181 0.0221
Trichomonas vaginalis 14-3-3 protein sigma, gamma, zeta, beta/alpha, putative 0.0011 0.0057 0.0057
Echinococcus multilocularis heat shock protein 90 0.0062 0.0869 0.1086
Toxoplasma gondii histone lysine methyltransferase SET1 0.0067 0.0941 0.8339
Schistosoma mansoni inhibitor of apoptosis (iap) domain family member 0.0065 0.0914 0.1154
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0016 0.0129 0.0125
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0022 0.0225 0.026
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.004 0.051 0.0811
Echinococcus granulosus thyroid hormone receptor alpha 0.001 0.004 0.0009
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0044 0.0584 0.5092
Toxoplasma gondii Hsp90 domain-containing protein 0.0032 0.0386 0.3291
Leishmania major heat shock protein 83-1 0.0078 0.1123 0.1898
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.004 0.051 0.0811
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.001 0.004 0.0009
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0633 1 1
Schistosoma mansoni thyroid hormone receptor 0.0173 0.2642 0.3398
Trichomonas vaginalis 14-3-3 protein sigma, gamma, zeta, beta/alpha, putative 0.0011 0.0057 0.0057
Schistosoma mansoni inositol monophosphatase 0.0044 0.0584 0.0726
Loa Loa (eye worm) hypothetical protein 0.0022 0.0225 0.0504
Trichomonas vaginalis set domain proteins, putative 0.0285 0.4435 0.4435
Loa Loa (eye worm) DR-78 0.001 0.004 0.0024
Trypanosoma cruzi 14-3-3 protein 2, putative 0.0011 0.0057 0.0046
Plasmodium falciparum endoplasmin, putative 0.0048 0.0641 0.5475
Leishmania major heat shock protein, putative 0.0032 0.0386 0.0587
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0633 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0022 0.0225 0.0504
Leishmania major heat shock protein 83-1 0.0078 0.1123 0.1898
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0022 0.0225 0.025
Schistosoma mansoni heat shock protein 0.0078 0.1123 0.1425
Trypanosoma cruzi DNA topoisomerase II, putative 0.0016 0.0129 0.0174
Schistosoma mansoni hypothetical protein 0.0491 0.7728 1
Echinococcus granulosus 14-3-3 protein 0.0011 0.0057 0.0031
Loa Loa (eye worm) hypothetical protein 0.0016 0.0129 0.0255
Trypanosoma brucei heat shock protein 84, putative 0.0032 0.0386 0.0587

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1.9953 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 89.1251 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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