Detailed information for compound 1245671

Basic information

Technical information
  • TDR Targets ID: 1245671
  • Name: 4,5-dimethyl-1-(phenylmethyl)-3-pyridin-2-yls ulfonylpyrrol-2-amine
  • MW: 341.427 | Formula: C18H19N3O2S
  • H donors: 1 H acceptors: 3 LogP: 3.29 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1n(Cc2ccccc2)c(c(c1C)S(=O)(=O)c1ccccn1)N
  • InChi: 1S/C18H19N3O2S/c1-13-14(2)21(12-15-8-4-3-5-9-15)18(19)17(13)24(22,23)16-10-6-7-11-20-16/h3-11H,12,19H2,1-2H3
  • InChiKey: DZTHRJFRPZGMHW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4,5-dimethyl-1-(phenylmethyl)-3-(2-pyridylsulfonyl)pyrrol-2-amine
  • 4,5-dimethyl-1-(phenylmethyl)-3-(2-pyridylsulfonyl)-2-pyrrolamine
  • [1-(benzyl)-4,5-dimethyl-3-(2-pyridylsulfonyl)pyrrol-2-yl]amine
  • 4,5-dimethyl-1-(phenylmethyl)-3-pyridin-2-ylsulfonyl-pyrrol-2-amine
  • SR-01000638701-1
  • Oprea1_742453
  • 1-benzyl-4,5-dimethyl-3-(2-pyridylsulfonyl)-1H-pyrrol-2-amine
  • MLS000859542
  • SMR000461319
  • Maybridge1_008478

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed), beta Starlite/ChEMBL No references
Schistosoma mansoni Thioredoxin glutathione reductase Starlite/ChEMBL No references
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific demethylase 4A Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Cryptosporidium hominis thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Babesia bovis thiodoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi jmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_130965 All targets in OG5_130965
Plasmodium yoelii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania donovani trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Leishmania infantum mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Loa Loa (eye worm) thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum Probable JmjC domain-containing histone demethylation protein 3B, putative Get druggable targets OG5_127917 All targets in OG5_127917
Theileria parva thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus multilocularis Transcription factor, JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus multilocularis thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma mansoni jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Toxoplasma gondii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania infantum trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma cruzi trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania donovani mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Plasmodium berghei thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum Glutathione reductase, related Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania mexicana trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Echinococcus granulosus Transcription factor JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Leishmania major mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Mycobacterium tuberculosis Conserved hypothetical protein Get druggable targets OG5_130965 All targets in OG5_130965
Plasmodium yoelii hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Leishmania major trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
Leishmania braziliensis trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei gambiense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi Thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Trypanosoma congolense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium parvum thioredoxin reductase 1 Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium yoelii glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Trypanosoma congolense mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
Trypanosoma brucei mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Loa Loa (eye worm) jmjC domain-containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Plasmodium falciparum thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum JmjC domain-containing histone demethylation protein 3C, putative Get druggable targets OG5_127917 All targets in OG5_127917
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
Leishmania mexicana mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Neospora caninum MGC84926 protein, related Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei gambiense mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Leishmania braziliensis mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Leishmania mexicana acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 24.4 %
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 460 aa 25.4 %
Leishmania mexicana 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 452 aa 25.7 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 518 aa 24.9 %
Leishmania braziliensis 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 450 aa 25.6 %
Leishmania donovani acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 540 aa 23.3 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.3 %
Plasmodium berghei dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 539 aa 22.3 %
Leishmania infantum acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Leishmania donovani dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.5 %
Leishmania braziliensis dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 488 aa 21.9 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.6 %
Leishmania braziliensis acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 22.8 %
Neospora caninum hypothetical protein Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.0 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Plasmodium falciparum glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 500 aa 32.2 %
Onchocerca volvulus Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 57.3 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.9 %
Leishmania infantum dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Neospora caninum glutathione reductase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 32.7 %
Toxoplasma gondii NADPH-glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 529 aa 31.8 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 519 aa 23.7 %
Leishmania major acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative polymerase (DNA directed), beta 335 aa 303 aa 32.3 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 462 aa 25.8 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.5 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.5 %
Neospora caninum Dihydrolipoyl dehydrogenase (EC 1.8.1.4), related Thioredoxin reductase 1, cytoplasmic   499 aa 464 aa 24.8 %
Plasmodium berghei dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 26.9 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, point mutation,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.3 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Plasmodium falciparum thioredoxin reductase Thioredoxin reductase 1, cytoplasmic   499 aa 511 aa 45.2 %
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 454 aa 25.3 %
Trypanosoma brucei dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.4 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.2 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast Thioredoxin reductase 1, cytoplasmic   499 aa 506 aa 23.7 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.2 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi celfurPC protein 0.8014 0.8001 0.8001
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0691 0.0659 0.0822
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0081 0.0048 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.014 0.0107 0.2586
Echinococcus granulosus methyltransferase protein 5 0.0052 0.0019 0.0018
Loa Loa (eye worm) hypothetical protein 0.0071 0.0038 0.0038
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0036 0.0002 0.0001
Loa Loa (eye worm) hypothetical protein 0.009 0.0057 0.0057
Loa Loa (eye worm) hypothetical protein 0.0035 0.0002 0.0002
Trichomonas vaginalis WD repeat domain, putative 0.015 0.0117 0.0188
Brugia malayi aspartic protease BmAsp-2, identical 0.0038 0.0005 0.0005
Echinococcus multilocularis discoidin domain containing receptor 2 0.0043 0.001 0.001
Plasmodium vivax protein arginine N-methyltransferase 1, putative 0.0093 0.006 0.1432
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0078 0.0044 0.1036
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0054 0.0021 0.0024
Plasmodium vivax subtilisin-like protease 2, putative 0.044 0.0408 1
Plasmodium vivax aspartyl proteinase, putative 0.0038 0.0005 0.008
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.6118 0.6101 1
Brugia malayi hypothetical protein 0.0035 0.0002 0.0002
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0003 0.0001
Brugia malayi Carm1-pending protein 0.0052 0.0019 0.0019
Onchocerca volvulus 0.0035 0.0002 0.0005
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.005 0.0017 0.0172
Echinococcus multilocularis chromatin regulatory protein sir2 0.0723 0.0691 0.0862
Plasmodium vivax subtilisin-like serine protease, putative 0.044 0.0408 1
Loa Loa (eye worm) hypothetical protein 0.0749 0.0717 0.0717
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.044 0.0408 0.0408
Brugia malayi Protein arginine N-methyltransferase 0.0052 0.0019 0.0019
Mycobacterium ulcerans Type I modular polyketide synthase 0.0077 0.0044 0.1026
Plasmodium vivax LCCL domain-containing protein 0.0043 0.001 0.0203
Loa Loa (eye worm) thioredoxin reductase 0.0103 0.007 0.007
Brugia malayi aspartic protease BmAsp-1, identical 0.0038 0.0005 0.0005
Toxoplasma gondii hypothetical protein 0.009 0.0057 0.1357
Toxoplasma gondii bicoid-interacting protein BIN3 0.0052 0.0019 0.043
Trichomonas vaginalis conserved hypothetical protein 0.044 0.0408 0.0666
Trypanosoma cruzi protein arginine n-methyltransferase 7 0.0052 0.0019 0.0244
Echinococcus granulosus protein arginine N methyltransferase 8 0.0093 0.006 0.0058
Mycobacterium ulcerans membrane-anchored mycosin MycP3 0.044 0.0408 1
Brugia malayi transcriptional regulator, Sir2 family protein 0.0107 0.0073 0.0073
Schistosoma mansoni hypothetical protein 0.0052 0.0019 0.0017
Schistosoma mansoni chromatin regulatory protein sir2 0.0723 0.0691 0.069
Loa Loa (eye worm) transcriptional regulator 0.0107 0.0073 0.0073
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2434 0.2407 0.3943
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0691 0.0659 0.0657
Trypanosoma cruzi UDP-galactopyranose mutase 0.014 0.0107 0.1524
Schistosoma mansoni chromatin regulatory protein sir2 0.0107 0.0073 0.0072
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.6118 0.6101 0.61
Mycobacterium ulcerans NAD-dependent deacetylase 0.0107 0.0073 0.1754
Loa Loa (eye worm) hypothetical protein 0.072 0.0688 0.0688
Mycobacterium ulcerans protoporphyrinogen oxidase 0.014 0.0107 0.2586
Toxoplasma gondii subtilisin SUB6 0.044 0.0408 1
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.0109 0.0076 0.0076
Onchocerca volvulus 0.044 0.0408 0.5681
Loa Loa (eye worm) TK/EGFR protein kinase 0.0648 0.0616 0.0616
Plasmodium falciparum plasmepsin VII 0.0038 0.0005 0.008
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.044 0.0408 0.0408
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0081 0.0048 1
Schistosoma mansoni hypothetical protein 0.1994 0.1965 0.1964
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0677 0.0645 0.0804
Loa Loa (eye worm) pregnancy-associated plasma protein-E 0.0035 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0035 0.0002 0.0002
Toxoplasma gondii subtilisin SUB9 0.044 0.0408 1
Giardia lamblia Sirtuin type 2 0.0107 0.0073 0.0196
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0103 0.007 0.1659
Schistosoma mansoni glutamate receptor NMDA 0.0267 0.0234 0.0233
Loa Loa (eye worm) WD40 repeat protein 0.015 0.0117 0.0117
Plasmodium vivax plasmepsin IV, putative 0.0038 0.0005 0.008
Onchocerca volvulus 0.015 0.0117 0.1617
Trypanosoma brucei subtilisin peptidase 0.044 0.0408 0.5892
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0048 0.0015 0.0013
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0365 0.0332 0.4789
Loa Loa (eye worm) hypothetical protein 0.0035 0.0002 0.0002
Plasmodium falciparum plasmepsin V 0.043 0.0398 0.9739
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0113 0.008 0.0098
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.044 0.0408 0.0666
Brugia malayi Sushi domain 0.0035 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0691 0.0659 0.0659
Onchocerca volvulus 0.0035 0.0002 0.0005
Schistosoma mansoni amine oxidase 0.014 0.0107 0.0106
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0039 0.0006 0.0004
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0466 0.0434 0.6265
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.001 0.0013
Schistosoma mansoni septate junction protein 0.0052 0.0019 0.0017
Onchocerca volvulus 0.0036 0.0003 0.0019
Toxoplasma gondii subtilisin SUB5 0.044 0.0408 1
Echinococcus granulosus NAD dependent deacetylase sirtuin 1 0.0107 0.0073 0.0072
Brugia malayi Calcium binding EGF domain containing protein 0.0035 0.0001 0.0001
Plasmodium falciparum plasmepsin IX 0.0038 0.0005 0.008
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0003 0.0001
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0107 0.0073 0.0117
Trichomonas vaginalis conserved hypothetical protein 0.044 0.0408 0.0666
Loa Loa (eye worm) hypothetical protein 0.3889 0.3866 0.3866
Toxoplasma gondii NADPH-glutathione reductase 0.0036 0.0002 0.0015
Loa Loa (eye worm) hypothetical protein 0.0052 0.0019 0.0019
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0234 0.0202 0.4911
Loa Loa (eye worm) hypothetical protein 0.0054 0.0021 0.0021
Schistosoma mansoni protein arginine n-methyltransferase 0.0052 0.0019 0.0017
Onchocerca volvulus 0.0035 0.0002 0.0005
Toxoplasma gondii aspartyl protease ASP3 0.0038 0.0005 0.008
Brugia malayi angiogenesis inhibito 0.0052 0.0019 0.0019
Brugia malayi Eukaryotic aspartyl protease family protein 0.0038 0.0005 0.0005
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.044 0.0408 0.0666
Trichomonas vaginalis hypothetical protein 0.0043 0.001 0.0013
Schistosoma mansoni hypothetical protein 0.0054 0.0021 0.0019
Giardia lamblia High cysteine protein 0.009 0.0057 0.015
Echinococcus granulosus growth factor receptor bound protein 2 0.0125 0.0091 0.009
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0038 0.0005 0.0003
Schistosoma mansoni growth factor receptor-bound protein 0.0125 0.0091 0.009
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0036 0.0002 0.0015
Echinococcus granulosus NAD dependent deacetylase sirtuin 3 0.0723 0.0691 0.069
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2434 0.2407 0.3943
Brugia malayi Protein kinase domain containing protein 0.0071 0.0038 0.0038
Plasmodium falciparum thioredoxin reductase 0.0036 0.0002 0.0015
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0081 0.0048 0.1127
Schistosoma mansoni btb and poz domain-containing protein 0.0043 0.001 0.0008
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0038 0.0005 0.0003
Loa Loa (eye worm) integrin alpha pat-2 0.13 0.127 0.127
Loa Loa (eye worm) hypothetical protein 0.0035 0.0001 0.0001
Brugia malayi protein kinase C II. 0.0094 0.006 0.006
Mycobacterium ulcerans oxidoreductase 0.014 0.0107 0.2586
Echinococcus multilocularis Furin 1 0.2434 0.2407 0.3007
Plasmodium vivax LCCL domain-containing protein 0.0043 0.001 0.0203
Echinococcus multilocularis membrane bound transcription factor site 1 0.044 0.0408 0.0508
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0093 0.006 0.0058
Mycobacterium tuberculosis Probable reductase 0.0234 0.0202 0.4911
Onchocerca volvulus 0.0071 0.0038 0.0515
Echinococcus multilocularis protein jagged 2 0.009 0.0057 0.0069
Brugia malayi Furin-like cysteine rich region family protein 0.0648 0.0616 0.0616
Brugia malayi Protein kinase domain containing protein 0.0043 0.001 0.001
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0036 0.0002 0.0015
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0173 0.014 0.1994
Trichomonas vaginalis conserved hypothetical protein 0.044 0.0408 0.0666
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0107 0.0073 0.0117
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0261 0.0228 0.5557
Echinococcus multilocularis SWI:SNF complex subunit SMARCC2 0.0058 0.0025 0.0029
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0077 0.0044 0.1026
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 1.0007 1 1
Mycobacterium ulcerans hypothetical protein 0.0192 0.0159 0.3865
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0062 0.0028 0.064
Echinococcus multilocularis discoidin domain receptor 0.0043 0.001 0.001
Echinococcus multilocularis 0.8014 0.8001 1
Toxoplasma gondii subtilisin SUB7 0.044 0.0408 1
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0036 0.0002 0.0015
Mycobacterium leprae Probable polyketide synthase Pks1 0.0082 0.0049 0.0979
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.001 0.0013
Onchocerca volvulus 0.0038 0.0005 0.005
Loa Loa (eye worm) transcriptional regulator 0.0723 0.0691 0.0691
Brugia malayi Thioredoxin reductase 0.0103 0.007 0.007
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.044 0.0408 0.0666
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0107 0.0073 0.0117
Trichomonas vaginalis hypothetical protein 0.009 0.0057 0.0089
Plasmodium falciparum plasmepsin X 0.0038 0.0005 0.008
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.1994 0.1965 0.3219
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0081 0.0048 0.4358
Plasmodium falciparum plasmepsin III 0.0038 0.0005 0.008
Loa Loa (eye worm) hypothetical protein 0.0058 0.0025 0.0025
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0002 0.0005
Schistosoma mansoni discoidin domain receptor 0.0043 0.001 0.0008
Plasmodium falciparum plasmepsin VI 0.0038 0.0005 0.008
Loa Loa (eye worm) proprotein convertase 2 0.2434 0.2407 0.2407
Plasmodium vivax subtilisin-like protease 1 0.044 0.0408 1
Echinococcus granulosus chromatin regulatory protein sir2 0.0723 0.0691 0.069
Mycobacterium ulcerans Type I modular polyketide synthase 0.0077 0.0044 0.1026
Echinococcus multilocularis growth factor receptor bound protein 2 0.0125 0.0091 0.0112
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2434 0.2407 0.3943
Mycobacterium leprae PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3) 0.044 0.0408 1
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0115 0.0082 0.0101
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0494 0.0462 0.046
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0093 0.006 0.0058
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0057 0.0024 0.054
Leishmania major trypanothione reductase 0.0103 0.007 0.0977
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0723 0.0691 1
Echinococcus granulosus discoidin domain containing receptor 2 0.0043 0.001 0.0009
Chlamydia trachomatis glutamine binding protein 0.0081 0.0048 0.4358
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0052 0.0019 0.0417
Plasmodium falciparum transcriptional regulatory protein sir2b 0.0107 0.0073 0.1767
Echinococcus multilocularis NAD dependent deacetylase sirtuin 1 0.0107 0.0073 0.009
Echinococcus multilocularis discoidin domain containing receptor 2 0.0043 0.001 0.001
Echinococcus granulosus thioredoxin glutathione reductase 0.0103 0.007 0.0069
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.001 0.0013
Echinococcus granulosus integrin alpha ps 0.025 0.0217 0.0216
Mycobacterium tuberculosis Conserved hypothetical protein 0.0192 0.0159 0.3865
Loa Loa (eye worm) Carm1-pending protein 0.0052 0.0019 0.0019
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0052 0.0019 0.0028
Schistosoma mansoni growth factor receptor-bound protein 0.0125 0.0091 0.009
Trypanosoma cruzi arginine N-methyltransferase, type III 0.0052 0.0019 0.0244
Loa Loa (eye worm) PHD-finger family protein 0.0035 0.0002 0.0002
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.0002 0.0005
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0048 0.0015 0.0013
Toxoplasma gondii aspartyl protease 0.0038 0.0005 0.008
Echinococcus multilocularis protein arginine N methyltransferase 7 0.0052 0.0019 0.0022
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.005 0.0017 0.0357
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0048 0.0015 0.0013
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0038 0.0005 0.0003
Trypanosoma brucei trypanothione reductase 0.0103 0.007 0.0977
Leishmania major sir2-family protein-like protein 0.0107 0.0073 0.1033
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0125 0.0092 0.0091
Mycobacterium tuberculosis Possible oxidoreductase 0.014 0.0107 0.2586
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0003 0.0001
Plasmodium falciparum protein arginine N-methyltransferase 1 0.0093 0.006 0.1432
Leishmania major arginine N-methyltransferase-like protein 0.0093 0.006 0.0836
Onchocerca volvulus 0.0043 0.001 0.012
Echinococcus granulosus fibrillin 1 0.0092 0.0059 0.0058
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0025 0.0037
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.004 0.0007 0.0134
Schistosoma mansoni serine/threonine protein kinase 0.0227 0.0194 0.0192
Schistosoma mansoni SWI/SNF complex-related 0.0058 0.0025 0.0023
Loa Loa (eye worm) hypothetical protein 0.009 0.0057 0.0057
Echinococcus multilocularis integrin beta 2 0.2329 0.2301 0.2875
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0048 0.0015 0.0016
Trichomonas vaginalis conserved hypothetical protein 0.1994 0.1965 0.3219
Toxoplasma gondii histone deacetylase SIR2-like 0.0107 0.0073 0.1767
Schistosoma mansoni tyrosine kinase 0.0648 0.0616 0.0615
Loa Loa (eye worm) hypothetical protein 0.0643 0.0611 0.0611
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.044 0.0408 0.0666
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.044 0.0408 0.0666
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.001 0.0013
Echinococcus granulosus histone arginine methyltransferase CARMER 0.0052 0.0019 0.0018
Plasmodium falciparum LCCL domain-containing protein 0.0043 0.001 0.0203
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0723 0.0691 1
Giardia lamblia Tenascin precursor 0.009 0.0057 0.015
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0093 0.006 0.0094
Brugia malayi hypothetical protein 0.0038 0.0005 0.0005
Echinococcus granulosus protein kinase c epsilon type 0.0094 0.006 0.0059
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0036 0.0002 0.0001
Schistosoma mansoni chromatin regulatory protein sir2 0.0723 0.0691 0.069
Echinococcus multilocularis discoidin domain containing receptor 2 0.0043 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.006 0.0027 0.0027
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0082 0.0049 0.1149
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0038 0.0005 0.0005
Schistosoma mansoni integrin beta subunit 0.1849 0.182 0.1819
Toxoplasma gondii thioredoxin reductase 0.0103 0.007 0.1672
Loa Loa (eye worm) endoprotease bli-4 1.0007 1 1
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.014 0.0107 0.2598
Onchocerca volvulus 0.0139 0.0106 0.1464
Loa Loa (eye worm) hypothetical protein 0.009 0.0057 0.0057
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0038 0.0005 0.008
Leishmania major arginine N-methyltransferase, type III, putative;with=GeneDB:Tb927.7.5490 0.0052 0.0019 0.0244
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0115 0.0082 0.0081
Brugia malayi amine oxidase, flavin-containing family protein 0.0199 0.0166 0.0166
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.044 0.0408 0.0666
Loa Loa (eye worm) glutathione reductase 0.0103 0.007 0.007
Echinococcus multilocularis protein will die slowly 0.015 0.0117 0.0144
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.6118 0.6101 1
Echinococcus granulosus fibrillin 2 0.009 0.0057 0.0055
Plasmodium vivax aspartyl protease, putative 0.0038 0.0005 0.008
Toxoplasma gondii aspartyl protease ASP1 0.0038 0.0005 0.008
Brugia malayi Bromodomain containing protein 0.0035 0.0002 0.0002
Echinococcus granulosus serine:threonine protein kinase N2 0.0076 0.0043 0.0042
Schistosoma mansoni furin-1 (S08 family) 0.433 0.4307 0.4306
Brugia malayi ADAMTS-like protease 0.0052 0.0019 0.0019
Onchocerca volvulus 0.0035 0.0002 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.1994 0.1965 0.3219
Loa Loa (eye worm) hypothetical protein 0.014 0.0107 0.0107
Loa Loa (eye worm) integrin beta-2 0.3148 0.3123 0.3123
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.044 0.0408 0.0666
Plasmodium vivax hypothetical protein, conserved 0.014 0.0107 0.2598
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0062 0.0028 0.0461
Schistosoma mansoni adam (A disintegrin and metalloprotease 0.0117 0.0084 0.0083
Echinococcus granulosus discoidin domain receptor 0.0043 0.001 0.0009
Loa Loa (eye worm) hypothetical protein 0.0107 0.0073 0.0073
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.0002 0.0005
Schistosoma mansoni chromatin regulatory protein sir2 0.0107 0.0073 0.0072
Plasmodium falciparum thioredoxin reductase 0.0103 0.007 0.1672
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.044 0.0408 0.0666
Echinococcus multilocularis glutamate receptor 2 0.0048 0.0015 0.0016
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0466 0.0434 0.6265
Schistosoma mansoni site-1 peptidase (S08 family) 0.044 0.0408 0.0407
Trypanosoma cruzi arginine N-methyltransferase, type I 0.0052 0.0019 0.0244
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.044 0.0408 0.0666
Trypanosoma cruzi trypanothione reductase, putative 0.0103 0.007 0.0977
Schistosoma mansoni hypothetical protein 0.0071 0.0038 0.0037
Loa Loa (eye worm) hypothetical protein 0.044 0.0408 0.0408
Entamoeba histolytica arginine N-methyltransferase protein, putative 0.0145 0.0112 0.1388
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0723 0.0691 0.113
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0036 0.0002 0.0002
Mycobacterium tuberculosis Probable dehydrogenase 0.0234 0.0202 0.4911
Mycobacterium ulcerans dehydrogenase 0.014 0.0107 0.2586
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.044 0.0408 0.0666
Brugia malayi transcriptional regulator, Sir2 family protein 0.0107 0.0073 0.0073
Leishmania major silent information regulator 2, putative 0.0723 0.0691 1
Trichomonas vaginalis conserved hypothetical protein 0.1994 0.1965 0.3219
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.044 0.0408 0.0666
Loa Loa (eye worm) hypothetical protein 0.0691 0.0659 0.0659
Onchocerca volvulus 0.0043 0.001 0.012
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.0613 0.0581 0.0581
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0038 0.0005 0.0004
Echinococcus multilocularis epidermal growth factor receptor 0.0648 0.0616 0.0768
Giardia lamblia High cysteine membrane protein Group 2 0.3684 0.366 1
Echinococcus granulosus neuroendocrine convertase 2 0.6323 0.6306 0.6306
Entamoeba histolytica PH domain containing protein kinase, putative 0.0076 0.0043 0.0359
Echinococcus granulosus NAD dependent deacetylase sirtuin 6 0.0107 0.0073 0.0072
Trichomonas vaginalis conserved hypothetical protein 0.1994 0.1965 0.3219
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.044 0.0408 0.0666
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0093 0.006 0.0058
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.044 0.0408 0.0666
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0227 0.0194 0.024
Loa Loa (eye worm) hypothetical protein 0.0145 0.0112 0.0112
Giardia lamblia Furin precursor putative serine protease 0.1994 0.1965 0.5367
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0117 0.0084 0.2004
Entamoeba histolytica hypothetical protein 0.0058 0.0025 0.009
Schistosoma mansoni protein kinase 0.0125 0.0092 0.009
Toxoplasma gondii aspartyl protease ASP5 0.0392 0.0359 0.8797
Toxoplasma gondii subtilisin SUB1 0.044 0.0408 1
Echinococcus multilocularis disintegrin and metalloproteinase 0.0037 0.0004 0.0003
Echinococcus multilocularis Coagulation factor 5 8 type, C terminal 0.0043 0.001 0.001
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0048 0.0015 0.0016
Toxoplasma gondii F5/8 type C domain-containing protein 0.0043 0.001 0.0203
Brugia malayi glutathione reductase 0.0103 0.007 0.007
Trichomonas vaginalis hypothetical protein 0.1994 0.1965 0.3219
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0062 0.0028 0.064
Echinococcus multilocularis integrin alpha 3 0.0698 0.0666 0.0831
Onchocerca volvulus 0.0038 0.0005 0.005
Giardia lamblia hypothetical protein 0.009 0.0057 0.015
Leishmania major mitochondrial DNA polymerase beta 0.0365 0.0332 0.4789
Brugia malayi EGF-like domain containing protein 0.009 0.0057 0.0057
Brugia malayi hypothetical protein 0.0035 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 1.0007 1 1
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0045 0.0012 0.0244
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0107 0.0073 0.1033
Toxoplasma gondii subtilisin SUB4 0.044 0.0408 1
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0093 0.006 0.0094
Brugia malayi Will die slowly protein 0.015 0.0117 0.0117
Brugia malayi pregnancy-associated plasma protein-A 0.0035 0.0002 0.0002
Echinococcus multilocularis protein arginine methyltransferase 0.0093 0.006 0.0073
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.001 0.0013
Echinococcus granulosus Furin 1 0.2434 0.2407 0.2406
Brugia malayi SWIRM domain containing protein 0.0058 0.0025 0.0025
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.014 0.0107 0.2586
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.044 0.0408 0.0407
Schistosoma mansoni protein kinase 0.0125 0.0092 0.009
Entamoeba histolytica SWIRM domain protein 0.0058 0.0025 0.009
Echinococcus granulosus glutamate NMDA receptor subunit 0.0267 0.0234 0.0233
Onchocerca volvulus 0.0035 0.0002 0.0005
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.014 0.0107 0.2598
Brugia malayi hypothetical protein 0.0145 0.0112 0.0112
Echinococcus granulosus c-Jun N-terminal kinases 0.0227 0.0194 0.0193
Echinococcus granulosus discoidin domain containing receptor 2 0.0043 0.001 0.0009
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0075 0.0041 0.0041
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.044 0.0408 0.0666
Loa Loa (eye worm) hypothetical protein 0.0037 0.0004 0.0004
Brugia malayi Reprolysin 0.0053 0.0019 0.0019
Plasmodium falciparum plasmepsin VIII, putative 0.0038 0.0005 0.008
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0038 0.0005 0.0003
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2434 0.2407 0.3943
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0107 0.0073 0.0117
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.014 0.0107 0.2598
Onchocerca volvulus 0.0035 0.0002 0.0005
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0051 0.0018 0.0228
Brugia malayi neuroendocrine convertase 1 precursor 0.6323 0.6306 0.6306
Echinococcus granulosus adam 0.0207 0.0174 0.0173
Schistosoma mansoni discoidin domain receptor 0.0043 0.001 0.0008
Plasmodium vivax NAD-dependent deacetylase, putative 0.0107 0.0073 0.1767
Echinococcus multilocularis nuclear receptor 2C2 associated protein 0.0043 0.001 0.001
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.044 0.0408 0.0508
Schistosoma mansoni chromatin regulatory protein sir2 0.0107 0.0073 0.0072
Brugia malayi GCC2 and GCC3 family protein 0.0044 0.0011 0.0011
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.044 0.0408 0.0666
Brugia malayi hypothetical protein 0.014 0.0107 0.0107
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.009 0.0056 0.0055
Trichomonas vaginalis set domain proteins, putative 0.0286 0.0253 0.0412
Mycobacterium ulcerans thioesterase 0.0067 0.0033 0.0767
Plasmodium vivax SET domain protein, putative 0.0036 0.0003 0.0026
Brugia malayi PHD-finger family protein 0.0035 0.0002 0.0002
Trypanosoma cruzi subtilisin peptidase 0.044 0.0408 0.5892
Mycobacterium tuberculosis Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) 0.044 0.0408 1
Onchocerca volvulus 0.0035 0.0002 0.0005
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0082 0.0049 0.0979
Echinococcus granulosus integrin beta 2 0.2329 0.2301 0.23
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0038 0.0005 0.0004
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.001 0.0013
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0107 0.0073 0.0117
Trypanosoma brucei Protein arginine N-methyltransferase 1 catalytic subunit 0.0145 0.0112 0.1599
Loa Loa (eye worm) transcriptional regulator 0.0107 0.0073 0.0073
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0234 0.0202 0.4911
Echinococcus multilocularis serine:threonine protein kinase N2 0.0086 0.0052 0.0063
Brugia malayi Kelch motif family protein 0.0506 0.0474 0.0474
Loa Loa (eye worm) hypothetical protein 0.0036 0.0003 0.0003
Brugia malayi Pepsin A precursor 0.0038 0.0005 0.0005
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0082 0.0049 0.0979
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0107 0.0073 0.0117
Schistosoma mansoni jumonji domain containing protein 0.0092 0.0058 0.0057
Giardia lamblia Tenascin-like 0.009 0.0057 0.015
Brugia malayi hypothetical protein 0.0035 0.0002 0.0002
Plasmodium vivax aspartyl protease, putative 0.0038 0.0005 0.008
Loa Loa (eye worm) hypothetical protein 0.0038 0.0005 0.0005
Plasmodium falciparum glutathione reductase 0.0103 0.007 0.1672
Giardia lamblia Tenascin-37 0.009 0.0057 0.015
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0038 0.0005 0.0004
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.2434 0.2407 0.2406
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0036 0.0003 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.001 0.0013
Trichomonas vaginalis conserved hypothetical protein 0.044 0.0408 0.0666
Toxoplasma gondii PA14 domain-containing protein 0.0043 0.001 0.0203
Mycobacterium ulcerans proline rich membrane-anchored mycosin MycP5 0.044 0.0408 1
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0048 0.0015 0.0013
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0077 0.0044 0.0854
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0117 0.0084 0.2004
Brugia malayi EGF-like domain containing protein 0.009 0.0057 0.0057
Loa Loa (eye worm) hypothetical protein 0.0038 0.0005 0.0005
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.044 0.0408 0.0407
Brugia malayi Pre-SET motif family protein 0.0036 0.0003 0.0003
Toxoplasma gondii type I fatty acid synthase, putative 0.0082 0.0049 0.1163
Loa Loa (eye worm) hypothetical protein 0.0035 0.0002 0.0002
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0107 0.0073 0.0117
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0261 0.0228 0.5472
Echinococcus multilocularis integrin alpha ps 0.0522 0.049 0.0611
Brugia malayi hypothetical protein 0.048 0.0448 0.0448
Echinococcus granulosus Coagulation factor 5 8 type C terminal 0.0043 0.001 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.1994 0.1965 0.3219
Toxoplasma gondii subtilisin SUB10 0.044 0.0408 1
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0173 0.014 0.1994
Brugia malayi Subtilase family protein 0.044 0.0408 0.0408
Mycobacterium ulcerans thioesterase TesA 0.0067 0.0033 0.0767
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.014 0.0107 0.2598
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0038 0.0005 0.0003
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.044 0.0408 0.0407
Trichomonas vaginalis teneurin and N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase, putative 0.009 0.0057 0.0089
Trichomonas vaginalis conserved hypothetical protein 0.1994 0.1965 0.3219
Brugia malayi Integrin alpha pat-2 precursor 0.097 0.0939 0.0939
Plasmodium vivax aspartyl protease, putative 0.0038 0.0005 0.008
Echinococcus granulosus integrin alpha 3 0.0698 0.0666 0.0665
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0003 0.0001
Giardia lamblia Transcriptional regulator, Sir2 family 0.0107 0.0073 0.0196
Loa Loa (eye worm) hypothetical protein 0.0071 0.0038 0.0038
Schistosoma mansoni integrin alpha 0.097 0.0939 0.0938
Echinococcus granulosus lysine specific histone demethylase 1A 0.014 0.0107 0.0106
Loa Loa (eye worm) hypothetical protein 0.0044 0.0011 0.0011
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0062 0.0029 0.0391
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0677 0.0645 0.0644
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0109 0.0076 0.0076
Mycobacterium leprae Polyketide synthase Pks13 0.0117 0.0084 0.185
Brugia malayi hypothetical protein 0.0117 0.0084 0.0084
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0149 0.0116 0.0116
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0036 0.0002 0.5
Giardia lamblia Neurogenic locus Notch protein precursor 0.009 0.0057 0.015
Echinococcus multilocularis fibrillin 2 0.009 0.0057 0.0069
Brugia malayi jmjC domain containing protein 0.0115 0.0082 0.0082
Echinococcus multilocularis protein kinase c epsilon type 0.0094 0.006 0.0073
Brugia malayi Disintegrin family protein 0.0037 0.0004 0.0004
Schistosoma mansoni hypothetical protein 0.0043 0.001 0.0008
Brugia malayi hypothetical protein 0.0035 0.0002 0.0002
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0054 0.0021 0.0019
Trichomonas vaginalis alpha-L-fucosidase, putative 0.0043 0.001 0.0013
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0082 0.0049 0.1149
Plasmodium vivax hypothetical protein, conserved 0.014 0.0107 0.2598
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0077 0.0044 0.1026
Trypanosoma brucei Silent information regulator 2 related protein 3 0.0107 0.0073 0.1033
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0067 0.0033 0.059
Brugia malayi EGF-like domain containing protein 0.009 0.0057 0.0057
Entamoeba histolytica hypothetical protein, conserved 0.0107 0.0073 0.0809
Loa Loa (eye worm) DEAH box polypeptide 35 0.0033 0.0000000000021417 0.0000000000021417
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0261 0.0228 0.5557
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0145 0.0112 0.1599
Leishmania major subtilisin-like serine peptidase 0.044 0.0408 0.5892
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0082 0.0049 0.1149
Loa Loa (eye worm) jmjC domain-containing protein 0.0073 0.0039 0.0039
Schistosoma mansoni integrin alpha-ps 0.0335 0.0302 0.0301
Loa Loa (eye worm) hypothetical protein 0.014 0.0107 0.0107
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.009 0.0056 0.0055
Toxoplasma gondii type I fatty acid synthase, putative 0.0057 0.0024 0.0541
Plasmodium falciparum subtilisin-like protease 3 0.044 0.0408 1
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.014 0.0107 0.0106
Echinococcus granulosus lysine specific histone demethylase 1A 0.0691 0.0659 0.0658
Schistosoma mansoni cathepsin D (A01 family) 0.0038 0.0005 0.0003
Onchocerca volvulus 0.0036 0.0003 0.002
Toxoplasma gondii subtilisin SUB8 0.044 0.0408 1
Schistosoma mansoni dock 0.0043 0.001 0.0008
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0077 0.0044 0.0044
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0723 0.0691 1
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0077 0.0044 0.1026
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2434 0.2407 0.3943
Plasmodium falciparum phd finger protein, putative 0.0035 0.0002 0.0005
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0036 0.0002 0.5
Mycobacterium ulcerans monoamine oxidase 0.014 0.0107 0.2586
Plasmodium falciparum protoporphyrinogen oxidase 0.014 0.0107 0.2598
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0038 0.0005 0.008
Onchocerca volvulus 0.0075 0.0041 0.0561
Giardia lamblia Tenascin-X 0.009 0.0057 0.015
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.014 0.0107 0.2444
Loa Loa (eye worm) subtilase 0.044 0.0408 0.0408
Onchocerca volvulus 0.0749 0.0717 1
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0075 0.0041 0.0966
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.1994 0.1965 0.3219
Echinococcus multilocularis NAD dependent deacetylase sirtuin 7 0.0107 0.0073 0.009
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.044 0.0408 0.0666
Trypanosoma brucei protein arginine n-methyltransferase 7 0.0052 0.0019 0.0244
Mycobacterium ulcerans Type I modular polyketide synthase 0.0077 0.0044 0.1026
Toxoplasma gondii F5/8 type C domain-containing protein 0.0043 0.001 0.0203
Plasmodium falciparum subtilisin-like protease 2 0.044 0.0408 1
Echinococcus multilocularis 0.014 0.0107 0.0132
Loa Loa (eye worm) hypothetical protein 0.0036 0.0003 0.0003
Plasmodium vivax thioredoxin reductase, putative 0.0103 0.007 0.1672
Plasmodium falciparum plasmepsin IV 0.0038 0.0005 0.008
Brugia malayi transcriptional regulator, Sir2 family protein 0.0723 0.0691 0.0691
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0227 0.0194 0.0194
Leishmania major UDP-galactopyranose mutase 0.014 0.0107 0.1524
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0038 0.0005 0.0003
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0082 0.0049 0.1149
Echinococcus granulosus protein arginine N methyltransferase 7 0.0052 0.0019 0.0018
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.0009 0.0008
Onchocerca volvulus 0.0175 0.0142 0.1971
Echinococcus multilocularis nmda type glutamate receptor 0.0113 0.008 0.0098
Echinococcus granulosus protein arginine methyltransferase 0.0093 0.006 0.0058
Giardia lamblia NADH oxidase lateral transfer candidate 0.0036 0.0002 0.0001
Loa Loa (eye worm) hypothetical protein 0.0104 0.0071 0.0071
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0078 0.0044 0.1036
Plasmodium vivax hypothetical protein, conserved 0.0107 0.0073 0.1767
Leishmania major NAD dependent deacetylase, putative,transcriptional regulator, Sir2 family protein, nicotinic acid mononucleotide 5,6-dimethylbe 0.0107 0.0073 0.1033
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.044 0.0408 0.0666
Trichomonas vaginalis beta-hexosaminidase B, putative 0.0043 0.001 0.0013
Brugia malayi proprotein convertase 2 0.6323 0.6306 0.6306
Loa Loa (eye worm) hypothetical protein 0.0036 0.0003 0.0003
Brugia malayi EGF-like domain containing protein 0.009 0.0057 0.0057
Toxoplasma gondii histone arginine methyltransferase PRMT4/CARM1 0.0052 0.0019 0.043
Mycobacterium tuberculosis Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5) 0.044 0.0408 1
Brugia malayi Sex muscle abnormal protein 5 0.0125 0.0091 0.0091
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0038 0.0005 0.0003
Onchocerca volvulus 0.0035 0.0002 0.0005
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0077 0.0044 0.1026
Echinococcus granulosus glutamate receptor 2 0.0048 0.0015 0.0013
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0234 0.0202 0.4911
Echinococcus granulosus MAM 0.0071 0.0038 0.0037
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.001 0.0013
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.044 0.0408 0.0666
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.0009 0.0008
Echinococcus multilocularis histone arginine methyltransferase CARMER 0.0052 0.0019 0.0022
Echinococcus granulosus discoidin domain containing receptor 2 0.0043 0.001 0.0009
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0234 0.0202 0.4911
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.044 0.0408 0.0666
Brugia malayi Integrin beta pat-3 precursor 0.3148 0.3123 0.3123
Toxoplasma gondii F5/8 type C domain-containing protein 0.0043 0.001 0.0203
Echinococcus multilocularis protoporphyrinogen oxidase 0.014 0.0107 0.0132
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0038 0.0005 0.0003
Echinococcus granulosus NAD dependent deacetylase sirtuin 7 0.0107 0.0073 0.0072
Echinococcus granulosus jumonji domain containing protein 0.0049 0.0016 0.0014
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.001 0.0013
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0036 0.0002 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.1994 0.1965 0.3219
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0107 0.0073 0.0117
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0038 0.0005 0.0003
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0107 0.0073 0.1033
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0093 0.006 0.0094
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.044 0.0408 0.0666
Loa Loa (eye worm) hypothetical protein 0.0035 0.0002 0.0002
Mycobacterium leprae Possible secreted protease 0.044 0.0408 1
Schistosoma mansoni chromatin regulatory protein sir2 0.0107 0.0073 0.0072
Toxoplasma gondii histone lysine-specific demethylase 0.014 0.0107 0.2598
Loa Loa (eye worm) hypothetical protein 0.0199 0.0166 0.0166
Echinococcus multilocularis thioredoxin glutathione reductase 0.0103 0.007 0.0086
Echinococcus multilocularis NAD dependent deacetylase sirtuin 6 0.0107 0.0073 0.009
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.001 0.0013
Onchocerca volvulus 0.009 0.0057 0.0775
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0643 0.0611 0.0611
Mycobacterium ulcerans polyketide synthase 0.0082 0.0049 0.1149
Echinococcus granulosus integrin alpha ps 0.0585 0.0553 0.0552
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0052 0.0019 0.0028
Loa Loa (eye worm) hypothetical protein 0.0063 0.0029 0.0029
Loa Loa (eye worm) apoptosis regulator protein 0.0054 0.0021 0.0021
Onchocerca volvulus 0.0071 0.0038 0.0515
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0048 0.0015 0.0016
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0048 0.0015 0.0016
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.001 0.0013
Toxoplasma gondii rhoptry neck protein RON9 0.0035 0.0002 0.000000037236
Loa Loa (eye worm) hypothetical protein 0.0132 0.0098 0.0098
Echinococcus multilocularis integrin alpha ps 0.025 0.0217 0.027
Echinococcus granulosus furin 1.0007 1 1
Trichomonas vaginalis conserved hypothetical protein 0.1994 0.1965 0.3219
Echinococcus multilocularis NAD dependent deacetylase sirtuin 3 0.0723 0.0691 0.0862
Trypanosoma cruzi UDP-galactopyranose mutase 0.014 0.0107 0.1524
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0125 0.0092 0.0113
Trichomonas vaginalis conserved hypothetical protein 0.1994 0.1965 0.3219
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.1994 0.1965 0.3219
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0173 0.014 0.1994
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0107 0.0073 0.0117
Giardia lamblia Hypothetical protein 0.0723 0.0691 0.1884
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.6118 0.6101 0.7624
Brugia malayi NAD-dependent deacetylase SIRT1 0.0107 0.0073 0.0073
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0082 0.0049 0.1149
Mycobacterium ulcerans membrane-anchored serine protease (mycosin), MycP4 0.044 0.0408 1
Toxoplasma gondii SWIRM domain-containing protein 0.0058 0.0025 0.0578
Loa Loa (eye worm) hypothetical protein 0.0035 0.0002 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.001 0.0013
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0054 0.0021 0.0019
Brugia malayi hypothetical protein 0.0035 0.0002 0.0002
Schistosoma mansoni hypothetical protein 0.0071 0.0038 0.0037
Giardia lamblia High cysteine protein 0.009 0.0057 0.015
Brugia malayi hypothetical protein 0.0071 0.0038 0.0038
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0074 0.004 0.0039
Loa Loa (eye worm) sirtuin 4 0.0107 0.0073 0.0073
Echinococcus multilocularis MAM 0.0071 0.0038 0.0046
Toxoplasma gondii histone arginine methyltransferase PRMT1 0.0093 0.006 0.1432
Schistosoma mansoni integrin alpha-ps 0.0522 0.049 0.0489
Schistosoma mansoni hypothetical protein 0.025 0.0217 0.0216
Plasmodium falciparum glutathione reductase 0.0036 0.0002 0.0015
Loa Loa (eye worm) hypothetical protein 0.0335 0.0302 0.0302
Brugia malayi Pre-SET motif family protein 0.0251 0.0218 0.0218
Loa Loa (eye worm) hypothetical protein 0.0043 0.001 0.001
Echinococcus multilocularis Blood coagulation inhibitor, Disintegrin 0.0037 0.0004 0.0003
Echinococcus granulosus Blood coagulation inhibitor Disintegrin 0.0037 0.0004 0.0002
Mycobacterium ulcerans polyketide synthase Pks13 0.0117 0.0084 0.2004
Schistosoma mansoni hypothetical protein 0.0054 0.0021 0.0019
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0723 0.0691 1
Brugia malayi ADAM-TS Spacer 1 family protein 0.0052 0.0019 0.0019
Plasmodium falciparum subtilisin-like protease 1 0.044 0.0408 1
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0125 0.0091 0.0091
Echinococcus granulosus lysine specific demethylase 5A 0.0043 0.0009 0.0008
Loa Loa (eye worm) jmjC domain-containing protein 0.0043 0.0009 0.0009
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0036 0.0002 0.0015
Loa Loa (eye worm) hypothetical protein 0.0038 0.0005 0.0005
Echinococcus multilocularis neuroendocrine convertase 2 0.6323 0.6306 0.7881
Trypanosoma brucei SIR2-like protein 4, putative 0.0107 0.0073 0.1033
Mycobacterium ulcerans polyketide synthase Pks9 0.005 0.0017 0.0357
Entamoeba histolytica NAD-dependent deacetylase 1, putative 0.0107 0.0073 0.0809
Echinococcus multilocularis jumonji domain containing protein 0.0049 0.0016 0.0018
Brugia malayi Angiotensin-converting enzyme family protein 0.0613 0.0581 0.0581
Schistosoma mansoni hypothetical protein 0.015 0.0117 0.0116
Toxoplasma gondii histone arginine methyltransferase PRMT3 0.0052 0.0019 0.043
Loa Loa (eye worm) hypothetical protein 0.009 0.0057 0.0057
Plasmodium falciparum transcriptional regulatory protein sir2a 0.0107 0.0073 0.1767
Echinococcus granulosus SWI:SNF complex subunit SMARCC2 0.0058 0.0025 0.0024
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.044 0.0408 0.0666
Loa Loa (eye worm) hypothetical protein 0.0042 0.0009 0.0009
Onchocerca volvulus 0.0035 0.0002 0.0005
Loa Loa (eye worm) hypothetical protein 0.048 0.0448 0.0448
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.044 0.0408 0.0666
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.001 0.0013
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0003 0.0001
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0094 0.006 0.006
Brugia malayi SWIRM domain containing protein 0.0749 0.0717 0.0717
Schistosoma mansoni chromatin regulatory protein sir2 0.0723 0.0691 0.069
Echinococcus granulosus adam 17 protease 0.0037 0.0004 0.0002
Loa Loa (eye worm) hypothetical protein 0.0313 0.028 0.028
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0003 0.0001
Trypanosoma cruzi serine peptidase, clan SB, family S8-like protein 0.044 0.0408 0.5892
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0723 0.0691 0.113
Loa Loa (eye worm) acyl carrier protein 0.0037 0.0003 0.0003
Schistosoma mansoni dihydroceramide desaturase 0.0037 0.0004 0.0002
Entamoeba histolytica SWIRM domain protein 0.0058 0.0025 0.009
Echinococcus multilocularis lysine specific demethylase 5A 0.0043 0.0009 0.001
Toxoplasma gondii subtilisin SUB2 0.044 0.0408 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0003 0.0026
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0081 0.0048 0.1127
Leishmania major arginine N-methyltransferase, type I 0.0052 0.0019 0.0244
Mycobacterium tuberculosis Possible arabinofuranosyltransferase AftD 0.0043 0.001 0.0188
Loa Loa (eye worm) reprolysin 0.009 0.0056 0.0056
Brugia malayi hypothetical protein 0.0035 0.0002 0.0002
Loa Loa (eye worm) TK/ALK protein kinase 0.0071 0.0038 0.0038
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0025 0.0037
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0063 0.0029 0.0666
Echinococcus granulosus protein will die slowly 0.015 0.0117 0.0116
Onchocerca volvulus Alhambra homolog 0.0035 0.0002 0.0008
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0018 0.0228
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.044 0.0408 0.0666
Loa Loa (eye worm) hypothetical protein 0.0052 0.0019 0.0019
Mycobacterium tuberculosis Probable thioesterase TesA 0.0067 0.0033 0.0767
Plasmodium vivax glutathione reductase, putative 0.0103 0.007 0.1672
Trichomonas vaginalis conserved hypothetical protein 0.044 0.0408 0.0666
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2434 0.2407 0.3943
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0365 0.0332 0.4789
Loa Loa (eye worm) fatty acid synthase 0.0079 0.0046 0.0046
Brugia malayi jmjC domain containing protein 0.0043 0.0009 0.0009
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0234 0.0202 0.4813
Echinococcus granulosus disintegrin and metalloproteinase 0.0037 0.0004 0.0002
Toxoplasma gondii histone deacetylase SIR2 0.0107 0.0073 0.1767
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0145 0.0112 0.1599
Chlamydia trachomatis protoporphyrinogen oxidase 0.014 0.0107 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0002 0.0002
Echinococcus multilocularis integrin alpha ps 0.0585 0.0553 0.0689
Onchocerca volvulus Fatty acid synthase homolog 0.0144 0.0111 0.1533
Loa Loa (eye worm) hypothetical protein 0.0071 0.0038 0.0038
Echinococcus granulosus membrane bound transcription factor site 1 0.044 0.0408 0.0407
Trypanosoma brucei Silent information regulator 2 related protein 1 0.0723 0.0691 1
Loa Loa (eye worm) hypothetical protein 0.009 0.0056 0.0056
Plasmodium falciparum plasmepsin I 0.0038 0.0005 0.008
Echinococcus multilocularis fibrillin 1 0.0092 0.0059 0.0072
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0036 0.0002 0.0015
Plasmodium vivax aspartyl proteinase, putative 0.0038 0.0005 0.008
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4) 0.044 0.0408 1
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0506 0.0474 0.0474
Schistosoma mansoni apoptosis regulator bax 0.0054 0.0021 0.0019
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0077 0.0044 0.0854
Mycobacterium tuberculosis Probable oxidoreductase 0.0261 0.0228 0.5557
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0051 0.0018 0.0228
Echinococcus multilocularis subfamily M12B unassigned peptidase 0.009 0.0056 0.0069
Brugia malayi AMP-binding enzyme family protein 0.0075 0.0041 0.0041
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) 0.2717 0.2691 0.269
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0054 0.0021 0.0021
Schistosoma mansoni serine/threonine protein kinase 0.0094 0.006 0.0059
Echinococcus multilocularis protein arginine N methyltransferase 8 0.0093 0.006 0.0073
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.001 0.0013
Schistosoma mansoni cathepsin D (A01 family) 0.0038 0.0005 0.0003
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0107 0.0073 0.0809
Plasmodium vivax plasmepsin V, putative 0.043 0.0398 0.9739
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0365 0.0332 0.4789
Brugia malayi Stress-activated protein kinase jnk-1 0.0227 0.0194 0.0194
Schistosoma mansoni glutamate receptor NMDA 0.0048 0.0015 0.0013
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.001 0.0013
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0039 0.0006 0.0004
Brugia malayi hypothetical protein 0.0035 0.0002 0.0002
Echinococcus granulosus subfamily M12B unassigned peptidase 0.009 0.0056 0.0055
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0052 0.0019 0.0028
Schistosoma mansoni site-1 peptidase (S08 family) 0.044 0.0408 0.0407
Giardia lamblia Neurogenic locus notch-like protein 0.009 0.0057 0.015
Onchocerca volvulus 0.0286 0.0253 0.3519
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.044 0.0408 0.0666
Trichomonas vaginalis conserved hypothetical protein 0.1994 0.1965 0.3219
Loa Loa (eye worm) hypothetical protein 0.0043 0.001 0.001
Echinococcus multilocularis adam 0.0207 0.0174 0.0216
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3) 0.044 0.0408 1
Trichomonas vaginalis alpha-L-fucosidase, putative 0.0043 0.001 0.0013
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.0218 0.0218
Entamoeba histolytica hypothetical protein 0.0145 0.0112 0.1388
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.014 0.0107 0.2586
Mycobacterium leprae PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5) 0.044 0.0408 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0003 0.0001
Loa Loa (eye worm) aspartyl protease 6 0.0038 0.0005 0.0005
Giardia lamblia hypothetical protein 0.0058 0.0025 0.0064
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.0466 0.0434 0.6265
Schistosoma mansoni amine oxidase 0.014 0.0107 0.0106
Toxoplasma gondii subtilisin SUB12 0.044 0.0408 1
Trypanosoma cruzi arginine N-methyltransferase, type I 0.0052 0.0019 0.0244
Loa Loa (eye worm) hypothetical protein 0.0035 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0448 0.0415 0.0415
Schistosoma mansoni protein kinase 0.0125 0.0092 0.009
Schistosoma mansoni memapsin-2 (A01 family) 0.0038 0.0005 0.0003
Giardia lamblia NAD-dependent histone deacetylase Sir2 0.0107 0.0073 0.0196
Brugia malayi hypothetical protein 0.0038 0.0005 0.0005
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0267 0.0234 0.0291
Mycobacterium tuberculosis Transcriptional regulatory protein 0.0107 0.0073 0.1754
Toxoplasma gondii hypothetical protein 0.0059 0.0025 0.0588
Plasmodium falciparum LCCL domain-containing protein 0.0043 0.001 0.0203
Loa Loa (eye worm) protein arginine N-methyltransferase 0.0052 0.0019 0.0019
Schistosoma mansoni hypothetical protein 0.0054 0.0021 0.0019
Toxoplasma gondii subtilisin SUB11 0.044 0.0408 1
Echinococcus granulosus nmda type glutamate receptor 0.0113 0.008 0.0078
Mycobacterium ulcerans polyketide synthase 0.0077 0.0044 0.1026
Plasmodium vivax protoporphyrinogen oxidase, putative 0.014 0.0107 0.2598
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0038 0.0005 0.0005
Onchocerca volvulus 0.0035 0.0002 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.1994 0.1965 0.3219
Plasmodium falciparum plasmepsin II 0.0038 0.0005 0.008
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0051 0.0018 0.0228
Echinococcus granulosus epidermal growth factor receptor 0.0648 0.0616 0.0615
Mycobacterium ulcerans Sir2-like regulatory protein 0.0107 0.0073 0.1754

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.3162 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 1.9953 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference
Potency (functional) 11.2202 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 12.5893 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 14.1254 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Fluorescein Labeled MLL-derived Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 37.933 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 44.6684 um PUBCHEM_BIOASSAY: Total Fluorescence Counterscreen for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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