Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | p2X purinoceptor 4 | 0.0547 | 0.417 | 0.417 |
Echinococcus multilocularis | acetylcholinesterase | 0.106 | 1 | 1 |
Onchocerca volvulus | 0.0179 | 0 | 0.5 | |
Brugia malayi | Carboxylesterase family protein | 0.106 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.106 | 1 | 1 |
Echinococcus granulosus | p2X purinoceptor 4 | 0.0547 | 0.417 | 0.417 |
Schistosoma mansoni | P2X receptor subunit | 0.0547 | 0.417 | 0.417 |
Loa Loa (eye worm) | carboxylesterase | 0.106 | 1 | 1 |
Schistosoma mansoni | P2X receptor subunit | 0.0547 | 0.417 | 0.417 |
Loa Loa (eye worm) | hypothetical protein | 0.106 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.106 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.106 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0179 | 0 | 0.5 |
Onchocerca volvulus | 0.0179 | 0 | 0.5 | |
Echinococcus granulosus | acetylcholinesterase | 0.106 | 1 | 1 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0179 | 0 | 0.5 |
Onchocerca volvulus | 0.0179 | 0 | 0.5 | |
Echinococcus granulosus | carboxylesterase 5A | 0.106 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.106 | 1 | 1 |
Echinococcus multilocularis | p2X purinoceptor 4 | 0.0547 | 0.417 | 0.417 |
Echinococcus multilocularis | p2X purinoceptor 4 | 0.0547 | 0.417 | 0.417 |
Onchocerca volvulus | 0.0179 | 0 | 0.5 | |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0179 | 0 | 0.5 |
Echinococcus granulosus | p2X purinoceptor 4 | 0.0547 | 0.417 | 0.417 |
Schistosoma mansoni | P2X receptor subunit | 0.0547 | 0.417 | 0.417 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.106 | 1 | 1 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0179 | 0 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.106 | 1 | 1 |
Onchocerca volvulus | 0.0179 | 0 | 0.5 | |
Echinococcus granulosus | p2X purinoceptor 4 | 0.0547 | 0.417 | 0.417 |
Schistosoma mansoni | P2X receptor subunit | 0.0547 | 0.417 | 0.417 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0179 | 0 | 0.5 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0179 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 9.285 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 10 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 29.081 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | 37.933 uM | PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] | ChEMBL. | No reference |
Potency (functional) | = 89.1251 um | PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.